Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: Implications for chemoprevention in smokers

Lung Cancer

Volumn 45, Issue 1, 2004, Pages 11-18

  Schuller, Hildegard M ^a   Porter, B ^a   Riechert, A ^a   Walker, K ^a   Schmoyer, R ^b  

^a UNIVERSITY OF TENNESSEE   (United States)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

Cancer prevention; Cancer promotion; Green tea; Hamster model; Pulmonary adenocarcinoma; Pulmonary neuroendocrine carcinoma; Theophylline

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; AMINOPHYLLINE; ARACHIDONIC ACID; CYCLIC AMP; CYCLIC AMP PHOSPHODIESTERASE; GREEN TEA EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; THEOPHYLLINE DERIVATIVE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL LINEAGE; CHEMOPROPHYLAXIS; CLARA CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HAMSTER; HYPOXIA; LUNG ADENOCARCINOMA; LUNG CARCINOGENESIS; LUNG INJURY; MALE; NEUROENDOCRINE TUMOR; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOKING; TEA; TOBACCO; TUMOR GROWTH; TUMOR PROMOTION;

ADENOCARCINOMA; ANIMALS; BRONCHODILATOR AGENTS; CELL TRANSFORMATION, NEOPLASTIC; CHEMOPREVENTION; CRICETINAE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; LUNG NEOPLASMS; MALE; MESOCRICETUS; NEOPLASMS, EXPERIMENTAL; NEUROENDOCRINE TUMORS; SMOKING; TEA; THEOPHYLLINE;

EID: 2942604370     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2003.12.007     Document Type: Article

References (58)

1. Bunn P.A. Jr., Soriano A., Johnson G., Heasley L. New therapeutic strategies for lung cancer: biology and molecular biology come of age. Chest. 117(4 Suppl. 1):2000;163S-168S
2. Daniel P.B., Walker W.H., Habener J.F. Cyclic AMP signaling and gene regulation. Annu. Rev. Nutr. 18:1998;353-383
3. Heasley L.E. Autocrine and paracrine signaling through neuropeptide receptors in human cancer. Oncogene. 20(13):2001;1563-1569
4. Bertram B., Bartsch H. Cancer prevention with green tea: reality and wishful thinking. Wien. Med. Wochenschr. 152(5/6):2002;153-158
5. Bushman J.L. Green tea and cancer in humans: a review of the literature. Nutr. Cancer. 31(3):1998;151-159
6. Das M., Sur P., Gomes A., Vedasiromoni J.R., Ganguly D.K. Inhibition of tumour growth and inflammation by consumption of tea. Phytother. Res. 16(Suppl. 1):2002;S40-4
7. Fujimoto N., Sueoka N., Sueoka E., Okabe S., Suganuma M., Harada M., et al. Lung cancer prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1. Int. J. Oncol. 20(6):2002;1233-1239
8. Iwai N., Ohshiro H., Kurozawa Y., Hosoda T., Morita H., Funakawa K., et al. Relationship between coffee and green tea consumption and all-cause mortality in a cohort of a rural Japanese population. J. Epidemiol. 12(3):2002;191-198
9. Tewes F.J., Koo L.C., Meisgen T.J., Rylander R. Lung cancer risk and mutagenicity of tea. Environ. Res. 52(1):1990;23-33
10. Shi S.T., Wang Z.Y., Smith T.J., Hong J.Y., Chen W.F., Ho C.T., et al. Effects of green tea and black tea on 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone bioactivation, DNA methylation, and lung tumorigenesis in A/J mice. Cancer Res. 54(17):1994;4641-4647
11. Xu Y., Ho C.T., Amin S.G., Han C., Chung F.L. Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants. Cancer Res. 52(14):1992;3875-3879
12. Embola C.W., Sohn O.S., Fiala E.S., Weisburger J.H. Induction of UDP-glucuronosyltransferase 1 (UDP-GT1) gene complex by green tea in male F344 rats. Food Chem. Toxicol. 40(6):2002;841-844
13. Chung F.L. The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black tea. Proc. Soc. Exp. Biol. Med. 220(4):1999;244-248
14. Chung F.L., Wang M., Rivenson A., Iatropoulos M.J., Reinhardt J.C., Pittman B., et al. Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituent. Cancer Res. 58(18):1998;4096-4101
15. Rehm S., Devor D.E., Henneman J.R., Ward J.M. Origin of spontaneous and transplacentally induced mouse lung tumors from alveolar type II cells. Exp. Lung Res. 17(2):1991;181-195
16. Rehm S., Kelloff G.J. Histologic characterization of mouse bronchiolar cell hyperplasia, metaplasia, and neoplasia induced intratracheally by 3-methylcholanthrene. Exp. Lung Res. 17(2):1991;229-244
17. Sakai K., Kohri T., Mizunuma T., Ichinose T., Sagai M., Kishino Y. Immunohistochemical localization of surfactant protein A in N-bis(2- hydroxypropyl)nitrosamine-induced lung tumors in rats. Tokushima J. Exp. Med. 43(1/2):1996;55-59
18. Dhawan A., Anderson D., de Pascual-Teresa S., Santos-Buelga C., Clifford M.N., Ioannides C. Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay. Mutat. Res. 515(1/2):2002;39-56
19. Feng Q., Torii Y., Uchida K., Nakamura Y., Hara Y., Osawa T. Black tea polyphenols, theaflavins, prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytochrome P450 1A1 in cell cultures. J. Agric. Food Chem. 50(1):2002;213-220
20. Yang C.S., Yang G.Y., Landau J.M., Kim S., Liao J. Tea and tea polyphenols inhibit cell hyperproliferation, lung tumorigenesis, and tumor progression. Exp. Lung Res. 24(4):1998;629-639
21. Jull B.A., Plummer H.K. III, Schuller H.M. Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells. J. Cancer Res. Clin. Oncol. 127(12):2001;707-717
22. Schuller H.M., Jull B.A., Sheppard B.J., Plummer H.K. Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders. Eur. J. Pharmacol. 393(1-3):2000;265-277
23. Schuller H.M., Plummer H.K. III, Jull B.A. Receptor-mediated effects of nicotine and its nitrosated derivative NNK on pulmonary neuroendocrine cells. Anat. Rec. 270(1):2003;51-58
24. Schuller H.M., Orloff M. Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells. Biochem. Pharmacol. 55(9):1998;1377-1384
25. Park P.G., Merryman J., Orloff M., Schuller H.M. Beta-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: implications for individuals with preexisting chronic lung disease. Cancer Res. 55(16):1995;3504-3508
26. Schuller H.M., Tithof P.K., Williams M., Plummer H. III The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid. Cancer Res. 59(18):1999;4510-4515
27. 2+/calmodulin. Cancer Res. 50(5):1990;1645-1649
28. Schuller H.M., Porter B., Riechert A. Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters. J. Cancer Res. Clin. Oncol. 126(11):2000;624-630
29. Rall TW. Drugs used in the treatment of asthma. In: Goodman-Gilman A, Rall TW, Nies AS, Taylor P, editors. The pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990. p. 618-37.
30. Schuller H.M., Becker K.L., Witschi H.P. An animal model for neuroendocrine lung cancer. Carcinogenesis. 9(2):1988;293-296
31. 2+/calmodulin antagonists. Cancer Res. 52(Suppl. 9):1992;2723s-2726s
32. Miller M.S., Baxter J.L., Moore J.D., Schuller H.M. Molecular characterization of neuroendocrine lung tumors induced in hamsters by treatment with nitrosamine and hyperoxia. Int. J. Oncol. 4:1994;5-12
33. Schuller H.M., Witschi H.P., Nylen E., Joshi P.A., Correa E., Becker K.L. Pathobiology of lung tumors induced in hamsters by 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone and the modulating effect of hyperoxia. Cancer Res. 50(6):1990;1960-1965
34. Hoffmann D., Castonguay A., Rivenson A., Hecht S.S. Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N′-nitrosonornicotine in Syrian golden hamsters. Cancer Res. 41(6):1981;2386-2393
35. Schuller H.M., McGavin M.D., Orloff M., Riechert A., Porter B. Simultaneous exposure to nicotine and hyperoxia causes tumors in hamsters. Lab. Invest. 73(3):1995;448-456
36. Gazdar A.F., Helman L.J., Israel M.A., Russell E.K., Linnoila R.I., Mulshine J.L., et al. Expression of neuroendocrine cell markers L-dopa decarboxylase, chromogranin A, and dense core granules in human tumors of endocrine and nonendocrine origin. Cancer Res. 48(14):1988;4078-4082
37. Mitsudomi T., Viallet J., Mulshine J.L., Linnoila R.I., Minna J.D., Gazdar A.F. Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines. Oncogene. 6(8):1991;1353-1362
38. Salgia R., Skarin A.T. Molecular abnormalities in lung cancer. J. Clin. Oncol. 16(3):1998;1207-1217
39. Budillon A., Di Gennaro E., Caraglia M., Barbarulo D., Abbruzzese A., Tagliaferri P. 8-Cl-cAMP antagonizes mitogen-activated protein kinase activation and cell growth stimulation induced by epidermal growth factor. Br. J. Cancer. 81(7):1999;1134-1141
40. Ramstad C., Sundvold V., Johansen H.K., Lea T. cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating ser-43 of Raf-1 in the MAPK/ERK pathway. Cell Signal. 12(8):2000;557-563
41. Schuller H.M., Cole B. Regulation of cell proliferation by beta-adrenergic receptors in a human lung adenocarcinoma cell line. Carcinogenesis. 10(9):1989;1753-1755
42. Schuller H.M. Mechanisms of smoking-related lung and pancreatic adenocarcinoma development. Nat. Rev. Cancer. 2:2002;455-463
43. Shukla Y., Taneja P. Anticarcinogenic effect of black tea on pulmonary tumors in Swiss albino mice. Cancer Lett. 176(2):2002;137-141
44. Belinsky S.A., Devereux T.R., Foley J.F., Maronpot R.R., Anderson M.W. Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse. Cancer Res. 52(11):1992;3164-3173
45. Belinsky S.A., Devereux T.R., White C.M., Foley J.F., Maronpot R.R., Anderson M.W. Role of Clara cells and type II cells in the development of pulmonary tumors in rats and mice following exposure to a tobacco-specific nitrosamine. Exp. Lung Res. 17(2):1991;263-278
46. Schuller H.M., Plummer H.K. III, Bochsler P.N., Dudric P., Bell J.L., Harris R.E. Co-expression of beta-adrenergic receptors and cyclooxygenase-2 in pulmonary adenocarcinoma. Int. J. Oncol. 19(3):2001;445-449
47. Malkinson A.M., Dwyer-Nield L.D., Rice P.L., Dinsdale D. Mouse lung epithelial cell lines - tools for the study of differentiation and the neoplastic phenotype. Toxicology. 123(1/2):1997;53-100
48. Malkinson A.M. Molecular comparison of human and mouse pulmonary adenocarcinomas. Exp. Lung Res. 24(4):1998;541-555
49. Malkinson A.M. Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung. Lung Cancer. 32(3):2001;265-279
50. Porter S.E., Dwyer-Nield L.D., Malkinson A.M. Regulation of lung epithelial cell morphology by cAMP-dependent protein kinase type I isozyme. Am. J. Physiol. Lung Cell Mol. Physiol. 280(6):2001;L1282-9
51. Hsieh E.T., Shepherd F.A., Tsao M.S. Co-expression of epidermal growth factor receptor and transforming growth factor-alpha is independent of ras mutations in lung adenocarcinoma. Lung Cancer. 29(2):2000;151-157
52. Shafer S.H., Phelps S.H., Williams C.L. Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors. Biochem. Pharmacol. 56(9):1998;1229-1236
53. Omenn G.S., Goodman G.E., Thornquist M.D., Balmes J., Cullen M.R., Glass A., et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N. Engl. J. Med. 334(18):1996;1150-1155
54. Brodkin C.A., McCullough J., Stover B., Balmes J., Hammar S., Omenn G.S., et al. Lobe of origin and histologic type of lung cancer associated with asbestos exposure in the Carotene and Retinol Efficacy Trial (CARET). Am. J. Ind. Med. 32(6):1997;582-591
55. Kaplan J.R., Manuck S.B. Antiatherogenic effects of beta-adrenergic blocking agents: theoretical, experimental, and epidemiologic considerations. Am. Heart J. 128(6 Part 2):1994;1316-1328
56. Prasad K.N., Kentroti S., Edwards-Prasad J., Vernadakis A., Imam M., Carvalho E., et al. Modification of the expression of adenosine 3′, 5′-cyclic monophosphate-induced differentiated functions in neuroblastoma cells by beta-carotene and D-alpha-tocopheryl succinate. J. Am. Coll. Nutr. 13(3):1994;298-303
57. Bahouth S.W., Beauchamp M.J., Park E.A. Identification of a retinoic acid response domain involved in the activation of the beta 1-adrenergic receptor gene by retinoic acid in F9 teratocarcinoma cells. Biochem. Pharmacol. 55(2):1998;215-225
58. Lopez-Barahona M., Iglesias T., Garcia-Higuera I., Mayor F. Jr., Zaballos A., Bernal J. Post-transcriptional induction of beta 1-adrenergic receptor by retinoic acid, but not triiodothyronine, in C6 glioma cells expressing thyroid hormone receptors. Eur. J. Endocrinol. 135(6):1996;709-715