MyD88 and Src are differentially regulated in Kupffer cells of males and proestrus females following hypoxia

Molecular Medicine

Volumn 12, Issue 4-6, 2006, Pages 65-73

  Zheng, Rui ^a   Pan, George ^b   Thobe, Bjoern M ^a   Choudhry, Mashkoor A ^a   Matsutani, Takeshi ^a   Samy, T S Anantha ^a   Kang, Shih Ching ^a   Bland, Kirby I ^a   Chaudry, Irshad H ^a,c  

^a Kentucky   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ESTRADIOL; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN INHIBITOR; PROTEIN SRC; PROTEIN TYROSINE KINASE; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; HYPOXIA; IMMUNE RESPONSE; INFLAMMATION; KUPFFER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROESTRUS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SEX DIFFERENCE;

ANIMALS; ANOXIA; CELL CULTURE TECHNIQUES; CELLS, CULTURED; ESTRADIOL; FEMALE; INTERLEUKIN-6; KUPFFER CELLS; MALE; MICE; MICE, INBRED C3H; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHORYLATION; PROESTRUS; PYRAZOLES; PYRIMIDINES; SEX CHARACTERISTICS; SRC-FAMILY KINASES; TOLL-LIKE RECEPTOR 4;

EID: 33749016242     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/2006-00030.Zheng     Document Type: Article

References (53)

1. George RL, McGwin G, Jr, Windham ST, Melton SM, Metzger J, Chaudry IH, Rue LW, III. (2003) Age-related gender differential in outcome after blunt or penetrating trauma. Shock 19:28-32.
2. Cohen J. (2002) The immunopathogenesis of sepsis. Nature 420:885-91.
3. Czura CJ, Friedman SG, Tracey KJ. (2003) Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway. J. Endotoxin Res. 9:409-13.
4. Harbrecht BG, Billiar TR. (1995) The role of nitric oxide in Kupffer cell-hepatocyte interactions. Shock 3:79-87.
5. Liu S et al. (2002) Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect. Immun. 70:3433-42.
6. Murphy TJ, Paterson HM, Mannick JA, Lederer JA. (2004) Injury, sepsis, and the regulation of Toll-like receptor responses. J. Leukoc. Biol. 75:400-7.
7. Paterson HM et al. (2003) Injury primes the innate immune system for enhanced Toll-like receptor reactivity. J. Immunol. 171:1473-83.
8. Shukla A, Hashiguchi N, Chen Y, Coimbra R, Hoyt DB, Junger WG. (2004) Osmotic regulation of cell function and possible clinical applications. Shock 21:391-400.
9. Hirani N, Antonicelli F, Stricter RM, Wiesener MS, Ratcliffe PJ, Haslett C, Donnelly SC. (2001) The regulation of interleukin-8 by hypoxia in human macrophages: a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS). Mol. Med. 7:685-97.
10. Angele MK et al. (1999) Hypoxemia in the absence of blood loss upregulates iNOS expression and activity in macrophages. Am. J. Physiol. 276:C285-90.
11. Knoferl MW et al. (2000) Severe hypoxemia in the absence of blood loss causes a gender dimorphic immune response. Am. J. Physiol. Cell. Physiol. 279:C2004-10.
12. Ayala A, Perrin MM, Wang P, Ertel W, Chaudry IH. (1991) Hemorrhage induces enhanced Kupffer cell cytotoxicity although decreasing peritoneal or splenic macrophage capacity: involvement of cell-associated TNF and reactive nitrogen. J. Immunol. 147:4147-54.
13. Angele MK, Schwacha MG, Ayala A, Chaudry IH. (2000) Effect of gender and sex hormones on immune responses following shock. Shock 14:81-90.
14. Takeuchi O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11:443-51.
15. Botchkina GI, Geimonen E, Bilof ML, Villarreal O, Tracey KJ. (1999) Loss of NF-kappaB activity during cerebral ischemia and TNF cytotoxicity. Mol. Med. 5:372-81.
16. Angele MK, Knoferl MW, Ayala A, Bland KI, Chaudry IH. (2001) Testosterone and estrogen differently effect Th1 and Th2 cytokine release following trauma-haemorrhage. Cytokine 16:22-30.
17. Chaudry IH, Ayala A, Ertel W, Stephan RN. (1990) Hemorrhage and resuscitation: immunological aspects. Am. J. Physiol. 259:R663-78.
18. Remick DG, Bolgos GR, Siddiqui J, Shin J, Nemzek JA. (2002) Six at six: interleukin-6 measured 6 h after the initiation of sepsis predicts mortality over 3 days. Shock 17:463-7.
19. Medzhitov R et al. (1998) MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2:253-8.
20. Hayashi F et al. (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410:1099-103.
21. Hemmi H et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408:740-5.
22. Poltorak A et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-8.
23. Underhill DM, Ozinsky A, Smith KD, Aderem A. (1999) Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc. Natl. Acad. Sci. U. S. A. 96:14459-63.
24. Burns K et al. (1998) MyD88, an adapter protein involved in interleukin-1 signaling. J. Biol. Chem. 273:12203-9.
25. Shi S et al. (2003) MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis. J. Exp. Med. 198:987-97.
26. Jordan MS, Singer AL, Koretzky GA. (2003) Adaptors as central mediators of signal transduction in immune cells. Nat. Immunol. 4:110-6.
27. O'Neill LA. (2002) Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal? Trends Immunol. 23:296-300.
28. Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. (1999) Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11:115-22.
29. Kawai T et al. (2001) Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167:5887-94.
30. Lomaga MA et al. (1999) TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13:1015-24.
31. Swantek JL, Tsen MF, Cobb MH, Thomas JA. (2000) IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. J. Immunol. 164:4301-6.
32. Fitzgerald KA et al. (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413:78-83.
33. Horng T, Barton GM, Medzhitov R. (2001) TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2:835-41.
34. Ding A, Nathan C. (1988) Analysis of the non-functional respiratory burst in murine Kupffer cells. J. Exp. Med. 167:1154-70.
35. Knoferl MW, Angele MK, Schwacha MG, Bland KI, Chaudry H. (2002) Preservation of splenic immune functions by female sex hormones after trauma-hemorrhage. Crit. Care Med. 30:888-93.
36. Beutler B, Hoebe K, Du X, Ulevitch RJ. (2003) How we detect microbes and respond to them: the Toll-like receptors and their transducers. J. Leukoc. Biol. 74:479-85.
37. Ryan KA, Smith MF, Jr, Sanders MK, Ernst PB. (2004) Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF-kappa B and interleukin-8 expression. Infect. Immun. 72:2123-30.
38. Akiyama C et al. (2004) Src family kinase inhibitor PP1 reduces secondary damage after spinal cord compression in rats. J. Neurotrauma 21:923-31.
39. Paul R et al. (2001) Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat. Med. 7:222-7.
40. Fan C, Li Q, Ross D, Engelhardt JF. (2003) Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation. J. Biol. Chem. 278:2072-80.
41. Ishida I et al. (2002) Hypoxia diminishes toll-like receptor 4 expression through reactive oxygen species generated by mitochondria in endothelial cells. J. Immunol. 169:2069-75.
42. Cavaillon JM, Adrie C, Fitting C, Adib-Conquy M. (2005) Reprogramming of circulatory cells in sepsis and SIRS. J. Endotoxin Res. 11:311-20.
43. Medvedev AE, Lentschat A, Wahl LM, Golenbock DT, Vogel SN. (2002) Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J. Immunol. 169:5209-16.
44. Adachi O et al. (1998) Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9:143-50.
45. Hazeki K et al. (2003) Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways. Eur. J. Immunol. 33:740-7.
46. Nomura F et al. (2000) Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J. Immunol. 164:3476-9.
47. Imler JL, Hoffmann JA. (2003) Toll signaling: the TIReless quest for specificity. Nat. Immunol. 4:105-6.
48. Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T. (2003) TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat. Immunol. 4:161-7.
49. Lee JY et al. (2005) The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem. Pharmacol. 70:1231-40.
50. Lowell CA. (2004) Src-family kinases: rheostats of immune cell signaling. Mol. Immunol. 41:631-43.
51. Henricson BE, Carboni JM, Burkhardt AL, Vogel SN. (1995) LPS and Taxol activate Lyn kinase autophosphorylation in Lps(n), but not in Lps(d), macrophages. Mol. Med. 1:428-35.
52. English BK, Ihle JN, Myracle A, Vi T. (1993) Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages. J. Exp. Med. 178:1017-22.
53. Ohashi K, Burkart V, Flohe S, Kolb H. (2000) heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 164:558-61.