Loss of NF-κB activity during cerebral ischemia and TNF cytotoxicity

Molecular Medicine

Volumn 5, Issue 6, 1999, Pages 372-381

  Botchkina, Galina I ^a   Geimonen, Erika ^b   Bilof, Michael L ^a,c   Villarreal, Omar ^d   Tracey, Kevin J ^a,c  

^a PICOWER INST FOR MEDICAL RESEARCH   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^d TRINITY COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR FACTOR; TUMOR NECROSIS FACTOR; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CYSTEINE PROTEINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUPEPTIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CYTOTOXICITY; IMMUNOREACTIVITY; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; LEWIS RAT; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS; TIME; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN ISCHEMIA; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; LEUPEPTINS; MALE; NF-KAPPA B; RATS; RATS, INBRED LEW; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0033144253     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03402126     Document Type: Article

References (47)

1. Kessler JA, Ludlam WH, Freidin MM, et al. (1993) Cytokine-induced programmed death of cultured sympathetic neurons. Neuron 11: 1123-1132.
2. Whittenmore ER, Loo DT, Cotman CW. (1994) Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons. Neuroreport 5: 1485-1488.
3. 2 in vitro. Brain Res. 671: 181-186.
4. Kaltschmidt C, Kaltschmidt B, Baeuerle PA. (1995) Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons. Proc. Natl. Acad. Sci. U.S.A. 92: 9618-9622.
5. Thompson CB. (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462.
6. Talley AK, Dewhurst S, Perry SW, et al. (1995) Tumor necrosis factor alpha-induced apoptosis in human neuronal cell: protection by the antioxidant N-acetylcysteine and the genes bcl 2 and crm A. Mol. Cell Biol. 15: 2359-2366.
7. Baldwin AS. (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14: 649-683.
8. Barger SW, Mattson MP. (1996) Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta amyloid precursor. Mol. Brain Res. 40: 116-126.
9. Beg AA, Baltimore D. (1996) An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274: 782-784.
10. Goodman Y, Mattson MP. (1996) Ceramide protects hippocampal neurons against excitotoxic and oxidative insults and amyloid β-peptide toxicity. J. Neurochem. 66: 869-872.
11. Liu ZG, Hsu H, Goeddel DV, Karin M. (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappa B activation prevents cell death. Cell 87: 3:565-576.
12. Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM. (1996) Suppression of TNF-α-induced apoptosis by NF-κB. Science 274: 787-789.
13. Wang C-Y, Mayo MW, Baldwin AS Jr. (1996) TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274: 784-787.
14. Wang CY, Mayo MW, Korncluk RG, Goeddel DV, Baldwin AS. (1998) NF-kappa B antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281: 1680-1683.
15. Chu ZL, McKinsey TA, Liu L, Gentry JJ, Malim MH, Ballard DW. (1997) Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappa B control. Proc. Natl. Acad. Sci. U.S.A. 94: 10057-10062.
16. Crawford MJ, Krishnamoorthy R, Rudick VL, Al-Abaidi M, Agarwal N. (1998) Overexpression of Bcl-2 in cultured photoreceptor cells protects from photo-oxidative damage induced apoptosis by sustaining NF-κB levels. Invest. Ophthalmol. Vis. Sci. 39: S1105.
17. Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K. (1997) Activation of NF-kappa B protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J. Neurosci. Res. 49: 681-697.
18. Mohan RR, Kim W-J, Mohan RR, Wilson SE. (1998) Active role of transcription factor NF-κB in suppression of the TNF alpha-induced apoptosis in corneal fibroblasts. Invest. Ophthalmol. Vis. Sci. 39: S1027.
19. Lesoualc'h F, Sagara Y, Holsboer F, Behl C. (1998) High constitutive NF-kappa B activity mediates resistance to oxidative stress in neuronal cells. J. Neurosci. 18: 3224-3232.
20. Kaltschmidt C, Kaltschmidt B, Baeuerle PA. (1993) Brain synapses contain inducible form of the transcription factor NF-kappa B. Mech. Dev. 43: 135-247.
21. Kitajima I, Soejima Y, Takasaki I, Beppu H, Tokioka T, Maruyama I. (1996) Ceramide-induced nuclear translokation of NF-κB is a potential mediator of the apoptotic response to TNF-α in murine clonal osteoblasts. Bone 19: 263-270.
22. Grilli M, Pizzi M, Memo M, Spano P. (1996) Neuroprotection by aspirin and sodium salicylate trough blocade of NF-κB activation. Science 274: 1383-1385.
23. Grimm S, Bauer MK, Baeuerle PA, Schulze-Osthoff K. (1996) Bcl-2 down-regulates the activity of transcription factor NF-kappa B induced upon apoptosis. J. Cell Biol. 134: 13-23.
24. Clemens JA, Stephenson DT, Smalstig EB, Dixon EP, Little SP. (1997) Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats. Stroke 28: 1073-1080.
25. Baeuerle P, Henkel T. (1994) Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12: 141-179.
26. Grilli M, Chiu JJ-S, Lenardo MJ. (1993) NF-κB and Rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143: 1-62.
27. Korner M, Rattner A, Mauxion F, Sen R, Citri Y. (1989) A brain specific transcription activator. Neuron 3: 563-572.
28. Kaltschmidt C, Kaltschmidt B, Neumann H, Wekerle H, Baeuerle PA. (1994) Constitutive NF-kappa B activity in neurons. Mol Cell Biol. 14: 3981-3992.
29. Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C. (1997) Transcription factor NF-kappa B is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from pations with Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 94: 2642-2647.
30. Liu T, Clark RK, McDonnell PC, et al. (1994) Tumor necrosis factor-α expression in ischemic neurons. Stroke 25: 1481-1488.
31. Szaflarski J, Burtrum D, Silverstein FS. (1995) Cerebral hypoxia-ischemia stimulates cytokine gene expression in perinatal rats. Stroke 26: 1093-1100.
32. Buttini M, Appel K, Sauter A, Gebicke-Haerter P-J, Boddeke H. (1996) Expression of tumor necrosis factor alpha after focal cerebral ischemia in the rat. Neuroscience 71: 1-16.
33. Botchkina GI, Meistrell ME III, Botchkina IL, Tracey KJ. (1997) Expression of TNF and TNF receptors (p55 and P75) in the rat brain after focal cerebral ischemia. Mol. Med. 3: 765-781.
34. Uno H, Matsuyama T, Akita H, Nishimura H, Sugita M. (1997) Induction of tumor necrosis factor-α in the mouse hippocampus Following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 17: 491-499.
35. Barone FC, Arvin B, White RF, et al. (1997) Tumor necrosis factor-α. A mediator of focal ischemic brain injury. Stroke 28: 1233-1244.
36. Meistrell ME III, Botchkina CI, Wang H, et al. (1997) Tumor necrosis factor is a brain damaging cytokine in cerebral ischemia. Shock 8: 341-348.
37. Lavine SD, Hoffman FM, Zlokovic BV. (1998) Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury. J. Cereb. Blood Flow Metab. 18: 52-58.
38. Dawson DA, Martin D, Hallenbeck JM. (1996) Inhibition of tumor necrosis factor-alpha reduces focal cerebral ischemic injury in the spontaneously hypertensive rat. Neurosci. Lett. 218: 41-44.
39. Navashiro H, Martin D, Hallenbeck JM. (1997) Inhibition of tumor necrosis factor and amelioration of brain infarction in mice. J. Cereb. Blood Flow Metab. 17: 229-232.
40. Rubin BY, Smith LJ, Hellermann GR, Lunn RM, Richardson NK, Anderson SL. (1988) Correlation between the anticellular and DNA fragmenting activities of tumor necrosis factor. Cancer Res. 48: 6006-6010.
41. Holtmann H, Hahn T, Wallach D. (1988) Interrelated effects of tumor necrosis factor and interleukin 1 on cell viability. Immunobiology 177: 7-22.
42. Wu M, Lee H, Bellas RE, et al. (1996) Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 15: 4682-4690.
43. Zimmerman GA, Meistrell M III, Bloom O, et al. (1995) Neurotoxicity of advanced glycation endproducts (AGEs) during focal stroke, and neuro-protective effects of aminoguanidine. Proc. Natl Acad. Sci. U.S.A. 92: 3744-3748.
44. Dignam JD, Lebovitz RM, Roeder RG. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl. Acids Res. 11: 1475-1489.
45. Goldfeld AE. (1998) Cell type and inducer specific human TNF-α gene regulation. J. Interferon Cytokine Res. 18: A-22.
46. Salminen A, Liu PK, Hsu CY. (1995) Alteration of transcription factor binding activities in the ischemic rat brain. Biochem. Biophys. Res. Commun. 21: 939-944.
47. Kawamata T, Speliotes EK, Finkelstein SP. (1997) The role of polypeptide growth factors in recovery from stroke. Adv. Neurol 73: 377-382.