The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4

Biochemical Pharmacology

Volumn 70, Issue 8, 2005, Pages 1231-1240

  Lee, Joo Y ^a,e   Lowell, Clifford A ^b   Lemay, Danielle G ^a   Youn, Hyung S ^a   Rhee, Sang H ^c   Sohn, Kyung H ^c   Jang, Byeong ^c   Ye, Jianping ^c   Chung, Jin H ^d   Hwang, Daniel H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^d Seoul National University   (South Korea)

^e Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

IFN beta; Lipopolysaccharide; Nitric oxide synthase; Src family tyrosine kinases; Toll like receptor; TRIF

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; BACTERIUM LIPOPOLYSACCHARIDE; BETA INTERFERON RECEPTOR; ENZYME INHIBITOR; HEMATOPOIETIC CELL KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; BASE SEQUENCE; BLOTTING, WESTERN; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHORYLATION; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TOLL-LIKE RECEPTOR 4;

EID: 24944549093     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.07.020     Document Type: Article

References (39)

1. D. Hwang Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived signaling pathways FASEB J 15 14 2001 2556 2564
2. B. Beutler, and E.T. Rietschel Innate immune sensing and its roots: the story of endotoxin Nat Rev Immunol 3 2 2003 169 176
3. S.H. Rhee, and D. Hwang Murine Toll-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase J Biol Chem 275 44 2000 34035 34040
4. A. Poltorak, X. He, I. Smirnova, M.Y. Liu, C. Van Huffel, and X. Du Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 5396 1998 2085 2088
5. R. Medzhitov, P. Preston-Hurlburt, and C.A. Janeway Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature 388 6640 1997 394 397
6. S. Akira, and K. Takeda Toll-like receptor signaling Nat Rev Immunol 4 7 2004 499 511
7. T. Kawai, O. Takeuchi, T. Fujita, J. Inoue, P.F. Muhlradt, and S. Sato Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes J Immunol 167 10 2001 5887 5894
8. K.A. Fitzgerald, S.M. McWhirter, K.L. Faia, D.C. Rowe, E. Latz, and D.T. Golenbock IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway Nat Immunol 4 5 2003 491 496
9. M.M. Brierley, and E.N. Fish Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry J Interf Cytokine Res 22 8 2002 835 845
10. Y. Ohmori, and T.A. Hamilton Requirement for STAT1 in LPS-induced gene expression in macrophages J Leukoc Biol 69 4 2001 598 604
11. J.J. Gao, M.B. Filla, M.J. Fultz, S.N. Vogel, S.W. Russell, and W.J. Murphy Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene J Immunol 161 9 1998 4803 4810
12. C.A. Lowell Src-family kinases: rheostats of immune cell signaling Mol Immunol 41 6/7 2004 631 643
13. I. Stefanova, M.L. Corcoran, E.M. Horak, L.M. Wahl, J.B. Bolen, and I.D. Horak Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn J Biol Chem 268 28 1993 20725 20728
14. C.D. Beaty, T.L. Franklin, Y. Uehara, and C.B. Wilson Lipopolysaccharide-induced cytokine production in human monocytes: role of tyrosine phosphorylation in transmembrane signal transduction Eur J Immunol 24 6 1994 1278 1284
15. B.E. Henricson, J.M. Carboni, A.L. Burkhardt, and S.N. Vogel LPS and Taxol activate Lyn kinase autophosphorylation in Lps(n), but not in Lps(d), macrophages Mol Med 1 4 1995 428 435
16. B.K. English, J.N. Ihle, A. Myracle, and T. Yi Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages J Exp Med 178 3 1993 1017 1022
17. F. Meng, and C.A. Lowell Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn J Exp Med 185 9 1997 1661 1670
18. D. Hwang, D. Scollard, J. Byrne, and E. Levine Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer J Natl Cancer Inst 90 6 1998 455 460
19. H. Kawakatsu, T. Sakai, Y. Takagaki, Y. Shinoda, M. Saito, and M.K. Owada A new monoclonal antibody which selectively recognizes the active form of Src tyrosine kinase J Biol Chem 271 10 1996 5680 5685
20. J. Wessells, S. Yakar, and P.F. Johnson Critical prosurvival roles for C/EBP beta and insulin-like growth factor I in macrophage tumor cells Mol Cell Biol 24 8 2004 3238 3250
21. J.H. Paik, J.H. Ju, J.Y. Lee, M.D. Boudreau, and D.H. Hwang Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways J Biol Chem 275 36 2000 28173 28179
22. J.Y. Lee, A. Plakidas, W.H. Lee, A. Heikkinen, P. Chanmugam, and G. Bray Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids J Lipid Res 44 3 2003 479 486
23. D. Hwang, B.C. Jang, G. Yu, and M. Boudreau Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: mediation through both mitogen-activated protein kinase and NF-kappaB signaling pathways in macrophages Biochem Pharmacol 54 1 1997 87 96
24. J.Y. Lee, K.H. Sohn, S.H. Rhee, and D. Hwang Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4 J Biol Chem 276 2001 16683 16689
25. R.A. Blake, M.A. Broome, X. Liu, J. Wu, M. Gishizky, and L. Sun SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling Mol Cell Biol 20 23 2000 9018 9027
26. P. Chanmugam, L. Feng, S. Liou, B.C. Jang, M. Boudreau, and G. Yu Radicicol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide in an experimental glomerulonephritis J Biol Chem 270 1995 5418 5426
27. J.Y. Lee, J. Ye, Z. Gao, H.S. Youn, W.H. Lee, and L. Zhao Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/akt by saturated and polyunsaturated fatty acids J Biol Chem 278 39 2003 37041 37051
28. J.Y. Lee, L. Zhao, H.S. Youn, A.R. Weatherill, R. Tapping, and L. Feng Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1 J Biol Chem 279 17 2004 16971 16979
29. P.A. Tilbrook, E. Ingley, J.H. Williams, M.L. Hibbs, and S.P. Klinken Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells Embo J 16 7 1997 1610 1619
30. C.A. Lowell, and P. Soriano Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories Genes Dev 10 15 1996 1845 1857
31. A.C. Bishop, J.A. Ubersax, D.T. Petsch, D.P. Matheos, N.S. Gray, and J. Blethrow A chemical switch for inhibitor-sensitive alleles of any protein kinase Nature 407 6802 2000 395 401
32. J.H. Hanke, J.P. Gardner, R.L. Dow, P.S. Changelian, W.H. Brissette, and E.J. Weringer Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation J Biol Chem 271 2 1996 695 701
33. V. Toshchakov, B.W. Jones, P.Y. Perera, K. Thomas, M.J. Cody, and S. Zhang TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages Nat Immunol 3 4 2002 392 398
34. U. Muller, U. Steinhoff, L.F. Reis, S. Hemmi, J. Pavlovic, and R.M. Zinkernagel Functional role of types I and II interferons in antiviral defense Science 264 5167 1994 1918 1921
35. R. Deonarain, D. Cerullo, K. Fuse, P.P. Liu, and E.N. Fish Protective role for interferon-beta in coxsackievirus B3 infection Circulation 110 23 2004 3540 3543
36. C. Bogdan Nitric oxide and the immune response Nat Immunol 2 10 2001 907 916
37. M. Karaghiosoff, R. Steinborn, P. Kovarik, G. Kriegshauser, M. Baccarini, and B. Donabauer Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock Nat Immunol 4 5 2003 471 477
38. R.M. O'Connell, S.K. Saha, S.A. Vaidya, K.W. Bruhn, G.A. Miranda, and B. Zarnegar Type I interferon production enhances susceptibility to Listeria monocytogenes infection J Exp Med 200 4 2004 437 445
39. H. Bjorkbacka, K.A. Fitzgerald, F. Huet, X. Li, J.A. Gregory, and M.A. Lee The induction of macrophage gene expression by LPS predominantly utilizes MyD88-independent signaling cascades Physiol Genomics 19 3 2004 319 330