MyD88 primes macrophages for full-scale activation by interferon-γ yet mediates few responses to Mycobacterium tuberculosis

Journal of Experimental Medicine

Volumn 198, Issue 7, 2003, Pages 987-997

  Shi, Shuangping ^a   Nathan, Carl ^a,b   Schnappinger, Dirk ^b   Drenkow, Jörg ^c   Fuortes, Michele ^b   Block, Ellen ^a   Ding, Aihao ^b   Gingeras, Thomas R ^c   Schoolnik, Gary ^d   Akira, Shizuo ^e   Takeda, Kiyoshi ^e   Ehrt, Sabine ^b  

^a Weill Cornell Graduate School of Biomedical Sciences   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c Thermo Fisher Scientific   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e OSAKA UNIVERSITY   (Japan)

Author keywords

Innate immunity; Macrophage activation; Microarray gene expression analysis; NF B; Toll like receptors

Indexed keywords

ALPHA INTERFERON; DIFFERENTIATION INDUCING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE SYNTHASE; RANTES; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL KILLING; CONTROLLED STUDY; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC REGULATION; IMMUNE RESPONSE; MACROPHAGE ACTIVATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; GENE EXPRESSION REGULATION; INTERFERON TYPE II; INTERLEUKIN-1; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0141959255     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030603     Document Type: Article

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