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Volumn 19, Issue 3, 1996, Pages 445-467

Importance of receptor-mediated endocytosis in peptide delivery and targeting: Kinetic aspects

Author keywords

Peptide delivery and targeting; Receptor recycling; Receptor mediated endocytosis (RME)

Indexed keywords

CELLS; DRUG DOSAGE; ESTIMATION; MATHEMATICAL MODELS; PHARMACOKINETICS; POLYPEPTIDES; REACTION KINETICS;

EID: 0030580944     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-409X(96)00013-0     Document Type: Review
Times cited : (26)

References (187)
  • 1
    • 0022481626 scopus 로고
    • Receptor-mediated endocytosis
    • [1] Stahl, P. and Schwartz, A.L. (1986) Receptor-mediated endocytosis. J. Clin. Invest. 77, 657-662.
    • (1986) J. Clin. Invest. , vol.77 , pp. 657-662
    • Stahl, P.1    Schwartz, A.L.2
  • 2
    • 0022340897 scopus 로고
    • Receptor-mediated endocytosis
    • [2] Wileman, T., Harding, C. and Stahl, P. (1985) Receptor-mediated endocytosis. Biochem. J. 232, 1-14.
    • (1985) Biochem. J. , vol.232 , pp. 1-14
    • Wileman, T.1    Harding, C.2    Stahl, P.3
  • 4
    • 0021749497 scopus 로고
    • Receptor-mediated endocytosis of polypeptide hormones: Mechanism and significance
    • [4] Carpentier, J.L. (1984) Receptor-mediated endocytosis of polypeptide hormones: mechanism and significance. Mol. Immunol. 21, 1157-1159.
    • (1984) Mol. Immunol. , vol.21 , pp. 1157-1159
    • Carpentier, J.L.1
  • 5
    • 0019859435 scopus 로고
    • Journey to the center of the cell: Role of the receptosome
    • [5] Pastan, I.H. and Willingham, M.C. (1981) Journey to the center of the cell: role of the receptosome. Science 214, 504-509.
    • (1981) Science , vol.214 , pp. 504-509
    • Pastan, I.H.1    Willingham, M.C.2
  • 6
    • 0018840715 scopus 로고
    • Internalization of polypeptide hormones: Mechanism, intracellular localization and significance
    • [6] Gorden, P., Carpentier, J.L., Freychet, P.O. and Orci, L. (1980) Internalization of polypeptide hormones: mechanism, intracellular localization and significance. Diabetologia 18, 263-274.
    • (1980) Diabetologia , vol.18 , pp. 263-274
    • Gorden, P.1    Carpentier, J.L.2    Freychet, P.O.3    Orci, L.4
  • 7
    • 3242823479 scopus 로고
    • Receptor-mediated endocytosis: Insights from the lipoprotein receptor system
    • [7] Brown, M.S. and Goldstein, J.L. (1979) Receptor-mediated endocytosis: insights from the lipoprotein receptor system. Proc. Natl. Acad. Sci. U.S.A. 76, 3330-3337.
    • (1979) Proc. Natl. Acad. Sci. U.S.A. , vol.76 , pp. 3330-3337
    • Brown, M.S.1    Goldstein, J.L.2
  • 8
    • 0018746767 scopus 로고
    • Coated pits, coated vesicles, and receptor-mediated endocytosis
    • [8] Goldstein, J.L., Anderson, R.G. and Brown, M.S. (1979) Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature 279, 679-685.
    • (1979) Nature , vol.279 , pp. 679-685
    • Goldstein, J.L.1    Anderson, R.G.2    Brown, M.S.3
  • 9
    • 0026102861 scopus 로고
    • Bacterial protein toxins acting on intracellular targets
    • [9] Olsnes, S., Kozlov, J.V., van Deurs, B. and Sandvig, K. (1991) Bacterial protein toxins acting on intracellular targets. Sem. Cell Biol. 2, 7-14.
    • (1991) Sem. Cell Biol. , vol.2 , pp. 7-14
    • Olsnes, S.1    Kozlov, J.V.2    Van Deurs, B.3    Sandvig, K.4
  • 10
    • 0026102540 scopus 로고
    • Redirecting Pseudomonas exotoxin
    • [10] FitzGerald, D. and Pastan, I. (1991) Redirecting Pseudomonas exotoxin. Sem. Cell Biol. 2, 31-37.
    • (1991) Sem. Cell Biol. , vol.2 , pp. 31-37
    • FitzGerald, D.1    Pastan, I.2
  • 11
    • 0027966106 scopus 로고
    • Entry of animal viruses and macromolecules into cells
    • [11] Carrasco, L. (1994) Entry of animal viruses and macromolecules into cells. FEBS Lett. 350, 151-154.
    • (1994) FEBS Lett. , vol.350 , pp. 151-154
    • Carrasco, L.1
  • 12
    • 0026060560 scopus 로고
    • The endocytic pathway for human immunodeficiency virus infection
    • [12] Pauza, C.D. (1991) The endocytic pathway for human immunodeficiency virus infection. Adv. Exp. Med. Biol. 300, 111-138.
    • (1991) Adv. Exp. Med. Biol. , vol.300 , pp. 111-138
    • Pauza, C.D.1
  • 13
    • 0028315948 scopus 로고
    • Pharmacokinetic aspects of peptide delivery and targeting: Importance of receptor-mediated endocytosis
    • [13] Sugiyama, Y. and Kato, Y. (1994) Pharmacokinetic aspects of peptide delivery and targeting: importance of receptor-mediated endocytosis. Drug Develop. Ind. Pharm. 20, 591-614.
    • (1994) Drug Develop. Ind. Pharm. , vol.20 , pp. 591-614
    • Sugiyama, Y.1    Kato, Y.2
  • 14
    • 0026695276 scopus 로고
    • Recent developments in peptide drug delivery to the brain
    • [14] Pardridge, W.M. (1992) Recent developments in peptide drug delivery to the brain. Pharmacol. Toxicol. 71, 3-10.
    • (1992) Pharmacol. Toxicol. , vol.71 , pp. 3-10
    • Pardridge, W.M.1
  • 15
    • 0025064922 scopus 로고
    • Receptor-mediated endocytosis of macromolecular conjugates in selective drug delivery
    • [15] Basu, S.K. (1990) Receptor-mediated endocytosis of macromolecular conjugates in selective drug delivery. Biochem. Pharmacol. 40, 1941-1946.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 1941-1946
    • Basu, S.K.1
  • 16
    • 0024510074 scopus 로고
    • Covalent and noncovalent protein binding of drugs: Implications for hepatic clearance, storage, and cell-specific drug delivery
    • [16] Meijer, D.K. and van der Sluijs, P. (1989) Covalent and noncovalent protein binding of drugs: implications for hepatic clearance, storage, and cell-specific drug delivery. Pharm. Res. 6, 105-118.
    • (1989) Pharm. Res. , vol.6 , pp. 105-118
    • Meijer, D.K.1    Van Der Sluijs, P.2
  • 18
    • 0023647663 scopus 로고
    • Drug delivery using vesicles targeted to the hepatic asialoglycoprotein receptor
    • [18] Dragsten, P.R., Mitchell, D.B., Covert, G. and Baker, T. (1987) Drug delivery using vesicles targeted to the hepatic asialoglycoprotein receptor. Biochim. Biophys. Acta 926, 270-279.
    • (1987) Biochim. Biophys. Acta , vol.926 , pp. 270-279
    • Dragsten, P.R.1    Mitchell, D.B.2    Covert, G.3    Baker, T.4
  • 19
    • 0022007491 scopus 로고
    • Receptor-mediated endocytosis and targeted drug delivery
    • [19] Fallon, R.J. and Schwartz, A.L. (1985) Receptor-mediated endocytosis and targeted drug delivery. Hepatology 5, 899-901.
    • (1985) Hepatology , vol.5 , pp. 899-901
    • Fallon, R.J.1    Schwartz, A.L.2
  • 20
    • 0020579936 scopus 로고
    • Targeting of antiviral drugs by coupling with protein carriers
    • [20] Fiume, L., Busi, C. and Mattioli, A. (1983) Targeting of antiviral drugs by coupling with protein carriers. FEBS Lett. 153, 6-10.
    • (1983) FEBS Lett. , vol.153 , pp. 6-10
    • Fiume, L.1    Busi, C.2    Mattioli, A.3
  • 21
    • 0026321498 scopus 로고
    • Recombinant toxins for cancer treatment
    • [21] Pastan, I. and FitzGerald, D. (1991) Recombinant toxins for cancer treatment. Science 254, 1173-1177.
    • (1991) Science , vol.254 , pp. 1173-1177
    • Pastan, I.1    FitzGerald, D.2
  • 22
    • 0024433513 scopus 로고
    • Pseudomonas exotoxin: Chimeric toxins
    • [22] Pastan, I. and FitzGerald, D. (1989) Pseudomonas exotoxin: chimeric toxins. J. Biol. Chem. 264, 15157-15160.
    • (1989) J. Biol. Chem. , vol.264 , pp. 15157-15160
    • Pastan, I.1    FitzGerald, D.2
  • 23
    • 0020550999 scopus 로고
    • Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents
    • [23] Ciechanover, A., Schwartz, A.L., Dautry-Varsat, A. and Lodish, H.F. (1983) Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. J. Biol. Chem. 258, 9681-9689.
    • (1983) J. Biol. Chem. , vol.258 , pp. 9681-9689
    • Ciechanover, A.1    Schwartz, A.L.2    Dautry-Varsat, A.3    Lodish, H.F.4
  • 25
    • 0000241799 scopus 로고
    • pH and the recycling of transferrin during receptor-mediated endocytosis
    • [25] Dautry-Varsat, A., Ciechanover, A. and Lodish, H.F. (1983) pH and the recycling of transferrin during receptor-mediated endocytosis. Proc. Natl. Acad. Sci. U.S.A. 80, 2258-2262.
    • (1983) Proc. Natl. Acad. Sci. U.S.A. , vol.80 , pp. 2258-2262
    • Dautry-Varsat, A.1    Ciechanover, A.2    Lodish, H.F.3
  • 26
    • 0020601856 scopus 로고
    • Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells
    • [26] Hopkins, C.R. and Trowbridge, I.S. (1983) Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells. J. Cell Biol. 97, 508-521.
    • (1983) J. Cell Biol. , vol.97 , pp. 508-521
    • Hopkins, C.R.1    Trowbridge, I.S.2
  • 27
    • 0028304450 scopus 로고
    • Transcytosis and processing of intrinsic factor-cobalamin in Caco-2 cells
    • [27] Dan, N. and Cutler, D.F. (1994) Transcytosis and processing of intrinsic factor-cobalamin in Caco-2 cells. J. Biol. Chem. 269, 18849-18855.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18849-18855
    • Dan, N.1    Cutler, D.F.2
  • 28
    • 0028004805 scopus 로고
    • How protein hormones reach their target cells. Receptor-mediated transcytosis of hCG through endothelial cells
    • [28] Ghinea, N., Mai, T.V., Groyer-Picard, M.T. and Milgrom, E. (1994) How protein hormones reach their target cells. Receptor-mediated transcytosis of hCG through endothelial cells. J. Cell Biol. 125, 87-97.
    • (1994) J. Cell Biol. , vol.125 , pp. 87-97
    • Ghinea, N.1    Mai, T.V.2    Groyer-Picard, M.T.3    Milgrom, E.4
  • 29
    • 0026786937 scopus 로고
    • Characterization of retroendocytosis in rat liver parenchymal cells and sinusoidal endothelial cells
    • [29] Magnusson, S., Faerevik, I. and Berg, T. (1992) Characterization of retroendocytosis in rat liver parenchymal cells and sinusoidal endothelial cells. Biochem. J. 287, 241-246.
    • (1992) Biochem. J. , vol.287 , pp. 241-246
    • Magnusson, S.1    Faerevik, I.2    Berg, T.3
  • 30
    • 0023428383 scopus 로고
    • Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells
    • [30] Maratos-Flier, E., Kao, C.Y., Verdin, E.M. and King, G.L. (1987) Receptor-mediated vectorial transcytosis of epidermal growth factor by Madin-Darby canine kidney cells. J. Cell Biol. 105, 1595-1601.
    • (1987) J. Cell Biol. , vol.105 , pp. 1595-1601
    • Maratos-Flier, E.1    Kao, C.Y.2    Verdin, E.M.3    King, G.L.4
  • 31
    • 0028062850 scopus 로고
    • Insulin fragments as a carrier for peptide delivery across the blood-brain barrier
    • [31] Fukuta, M., Okada, H., Iinuma, S., Yanai, S. and Toguchi, H. (1994) Insulin fragments as a carrier for peptide delivery across the blood-brain barrier. Pharm. Res. 11, 1681-1688.
    • (1994) Pharm. Res. , vol.11 , pp. 1681-1688
    • Fukuta, M.1    Okada, H.2    Iinuma, S.3    Yanai, S.4    Toguchi, H.5
  • 33
    • 0023186714 scopus 로고
    • Chimeric peptides as a vehicle for peptide pharmaceutical delivery through the blood-brain barrier
    • [33] Pardridge, W.M., Kumagai, A.K. and Eisenberg, J.B. (1987) Chimeric peptides as a vehicle for peptide pharmaceutical delivery through the blood-brain barrier. Biochem. Biophys. Res. Commun. 146, 307-313.
    • (1987) Biochem. Biophys. Res. Commun. , vol.146 , pp. 307-313
    • Pardridge, W.M.1    Kumagai, A.K.2    Eisenberg, J.B.3
  • 34
    • 0028956176 scopus 로고
    • Insulin-mediated intracellular targeting enhances the photodynamic activity of chlorin e6
    • [34] Akhlynina, T.V., Rosenkranz, A.A., Jans, D.A. and Sobolev, A.S. (1995) Insulin-mediated intracellular targeting enhances the photodynamic activity of chlorin e6. Cancer Res. 55, 1014-1019.
    • (1995) Cancer Res. , vol.55 , pp. 1014-1019
    • Akhlynina, T.V.1    Rosenkranz, A.A.2    Jans, D.A.3    Sobolev, A.S.4
  • 35
    • 0027943685 scopus 로고
    • Nuclear translocation of angiogenic proteins in endothelial cells: An essential step in angiogenesis
    • [35] Moroianu, J. and Riordan, J.F. (1994) Nuclear translocation of angiogenic proteins in endothelial cells: an essential step in angiogenesis. Biochemistry 33, 12535-12539.
    • (1994) Biochemistry , vol.33 , pp. 12535-12539
    • Moroianu, J.1    Riordan, J.F.2
  • 36
    • 0028032075 scopus 로고
    • From receptor internalization to nuclear translocation. New targets for long-term pharmacology
    • [36] Laduron, P.M. (1994) From receptor internalization to nuclear translocation. New targets for long-term pharmacology. Biochem. Pharmacol. 47, 3-13.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 3-13
    • Laduron, P.M.1
  • 38
    • 0027941844 scopus 로고
    • Identification of the nucleolar targeting signal of human angiogenin
    • [38] Moroianu, J. and Riordan, J.F. (1994) Identification of the nucleolar targeting signal of human angiogenin. Biochem. Biophys. Res. Commun. 203, 1765-1772.
    • (1994) Biochem. Biophys. Res. Commun. , vol.203 , pp. 1765-1772
    • Moroianu, J.1    Riordan, J.F.2
  • 39
    • 0028199067 scopus 로고
    • The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems
    • [39] Plank, C., Oberhauser, B., Mechtler, K., Koch, C. and Wagner, E. (1994) The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J. Biol. Chem. 269, 12918-12924.
    • (1994) J. Biol. Chem. , vol.269 , pp. 12918-12924
    • Plank, C.1    Oberhauser, B.2    Mechtler, K.3    Koch, C.4    Wagner, E.5
  • 40
    • 0028271118 scopus 로고
    • Gene therapy for neurological disorders
    • [40] Friedmann, T. (1994) Gene therapy for neurological disorders. Trends Genet. 10, 210-214.
    • (1994) Trends Genet. , vol.10 , pp. 210-214
    • Friedmann, T.1
  • 41
    • 0026775132 scopus 로고
    • Concepts and strategies for human gene therapy
    • [41] Roemer, K. and Friedmann, T. (1992) Concepts and strategies for human gene therapy. Eur. J. Biochem. 208, 211-225.
    • (1992) Eur. J. Biochem. , vol.208 , pp. 211-225
    • Roemer, K.1    Friedmann, T.2
  • 42
    • 0024411916 scopus 로고
    • Progress toward human gene therapy
    • [42] Friedmann, T. (1989) Progress toward human gene therapy. Science 244, 1275-1281.
    • (1989) Science , vol.244 , pp. 1275-1281
    • Friedmann, T.1
  • 43
    • 0025352717 scopus 로고
    • Evidence for targeted gene transfer by receptor-mediated endocytosis. Stable expression following insulin-directed entry of NEO into HepG2 cells
    • [43] Huckett, B., Ariatti, M. and Hawtrey, A.O. (1990) Evidence for targeted gene transfer by receptor-mediated endocytosis. Stable expression following insulin-directed entry of NEO into HepG2 cells. Biochem. Pharmacol. 40, 253-263.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 253-263
    • Huckett, B.1    Ariatti, M.2    Hawtrey, A.O.3
  • 44
    • 0024415067 scopus 로고
    • Molecular sieving, receptor processing and peptidolysis as major determinants of peptide pharmacokinetics in vivo
    • [44] McMartin, C. (1989) Molecular sieving, receptor processing and peptidolysis as major determinants of peptide pharmacokinetics in vivo. Biochem. Soc. Trans. 17, 931-934.
    • (1989) Biochem. Soc. Trans. , vol.17 , pp. 931-934
    • McMartin, C.1
  • 45
    • 0018045663 scopus 로고
    • Peptide hormones and their analogues: Distribution, clearance from the circulation, and inactivation in vivo
    • [45] Bennett, H.P. and McMartin, C. (1978) Peptide hormones and their analogues: distribution, clearance from the circulation, and inactivation in vivo. Pharmacol. Rev. 30, 247-292.
    • (1978) Pharmacol. Rev. , vol.30 , pp. 247-292
    • Bennett, H.P.1    McMartin, C.2
  • 46
    • 0020963903 scopus 로고
    • Physiologically based pharmacokinetic modeling: Principles and applications
    • [46] Gerlowski, L.E. and Jain, R.K. (1983) Physiologically based pharmacokinetic modeling: principles and applications. J. Pharm. Sci. 72, 1103-1127.
    • (1983) J. Pharm. Sci. , vol.72 , pp. 1103-1127
    • Gerlowski, L.E.1    Jain, R.K.2
  • 47
    • 0020279521 scopus 로고
    • Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data
    • [47] Lin, J.H., Sugiyama, Y., Awazu, S. and Hanano, M. (1982) Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data. J. Pharm. Sci. 10, 649-661.
    • (1982) J. Pharm. Sci. , vol.10 , pp. 649-661
    • Lin, J.H.1    Sugiyama, Y.2    Awazu, S.3    Hanano, M.4
  • 49
    • 0014315369 scopus 로고
    • Thiopental pharmacokinetics
    • [49] Bischoff, K.B. and Dedrick, R.L. (1968) Thiopental pharmacokinetics. J. Pharm. Sci. 57, 1346-1351.
    • (1968) J. Pharm. Sci. , vol.57 , pp. 1346-1351
    • Bischoff, K.B.1    Dedrick, R.L.2
  • 50
    • 0028268634 scopus 로고
    • Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice
    • [50] Baxter, L.T., Zhu, H., Mackensen, D.G. and Jain, R.K. (1994) Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice. Cancer Res. 54, 1517-1528.
    • (1994) Cancer Res. , vol.54 , pp. 1517-1528
    • Baxter, L.T.1    Zhu, H.2    Mackensen, D.G.3    Jain, R.K.4
  • 51
    • 0023232114 scopus 로고
    • Physiologically based pharmacokinetics of radioiodinated human β-endorphin in rats. An application of the capillary membrane-limited model
    • [51] Sato, H., Sugiyama, Y., Sawada, Y., Iga, T. and Hanano, M. (1987) Physiologically based pharmacokinetics of radioiodinated human β-endorphin in rats. An application of the capillary membrane-limited model. Drug Metab. Dispos. 15, 540-550.
    • (1987) Drug Metab. Dispos. , vol.15 , pp. 540-550
    • Sato, H.1    Sugiyama, Y.2    Sawada, Y.3    Iga, T.4    Hanano, M.5
  • 53
    • 0021840444 scopus 로고
    • Binding of radioiodinated human β-endorphin to serum proteins from rats and humans, determined by several methods
    • [53] Sato, H., Sugiyama, Y., Sawada, Y., Iga, T. and Hanano, M. (1985) Binding of radioiodinated human β-endorphin to serum proteins from rats and humans, determined by several methods. Life Sci. 37, 1309-1318.
    • (1985) Life Sci. , vol.37 , pp. 1309-1318
    • Sato, H.1    Sugiyama, Y.2    Sawada, Y.3    Iga, T.4    Hanano, M.5
  • 54
    • 0027414328 scopus 로고
    • 2-macroglobulin and the binding is inhibited by heparin
    • 2-macroglobulin and the binding is inhibited by heparin. J. Biol. Chem. 268, 7685-7691.
    • (1993) J. Biol. Chem. , vol.268 , pp. 7685-7691
    • Soker, S.1    Svahn, C.M.2    Neufeld, G.3
  • 59
    • 0026340085 scopus 로고
    • On the binding of tumor necrosis factor (TNF) to heparin and the release in vivo of the TNF-binding protein I by heparin
    • [59] Lantz, M., Thysell, H., Nilsson, E. and Olsson, I. (1991) On the binding of tumor necrosis factor (TNF) to heparin and the release in vivo of the TNF-binding protein I by heparin. J. Clin. Invest. 88, 2026-2031.
    • (1991) J. Clin. Invest. , vol.88 , pp. 2026-2031
    • Lantz, M.1    Thysell, H.2    Nilsson, E.3    Olsson, I.4
  • 61
    • 0024121553 scopus 로고
    • Receptor-and heparin-binding domains of basic fibroblast growth factor
    • [61] Baird, A., Schubert, D., Ling, N. and Guillemin, R. (1988) Receptor-and heparin-binding domains of basic fibroblast growth factor. Proc. Natl. Acad. Sci. U.S.A. 85, 2324-2328.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 2324-2328
    • Baird, A.1    Schubert, D.2    Ling, N.3    Guillemin, R.4
  • 62
    • 0028117235 scopus 로고
    • Importance of transcapillary insulin transport to dynamics of insulin action after intravenous glucose
    • [62] Ader, M. and Bergman, R.N. (1994) Importance of transcapillary insulin transport to dynamics of insulin action after intravenous glucose. Am. J. Physiol. 266, E17-E25.
    • (1994) Am. J. Physiol. , vol.266
    • Ader, M.1    Bergman, R.N.2
  • 63
    • 0025200957 scopus 로고
    • Pharmacokinetic analysis of immunotoxin uptake in solid tumors: Role of plasma kinetics, capillary permeability, and binding
    • [63] Sung, C., Youle, R.J. and Dedrick, R.L. (1990) Pharmacokinetic analysis of immunotoxin uptake in solid tumors: role of plasma kinetics, capillary permeability, and binding. Cancer Res. 50, 7382-7392.
    • (1990) Cancer Res. , vol.50 , pp. 7382-7392
    • Sung, C.1    Youle, R.J.2    Dedrick, R.L.3
  • 64
    • 0024423823 scopus 로고
    • Insulin transport across capillaries is rate limiting for insulin action in dogs
    • [64] Yang, Y.J., Hope, I.D., Ader, M. and Bergman, R.N. (1989) Insulin transport across capillaries is rate limiting for insulin action in dogs. J. Clin. Invest. 84, 1620-1628.
    • (1989) J. Clin. Invest. , vol.84 , pp. 1620-1628
    • Yang, Y.J.1    Hope, I.D.2    Ader, M.3    Bergman, R.N.4
  • 65
    • 0020059232 scopus 로고
    • The capillary barrier to circulating insulin
    • [65] Rasio, E. (1982) The capillary barrier to circulating insulin. Diabetes Care 5, 158-161.
    • (1982) Diabetes Care , vol.5 , pp. 158-161
    • Rasio, E.1
  • 66
    • 0024505574 scopus 로고
    • Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies
    • [66] Jain, R.K. (1989) Delivery of novel therapeutic agents in tumors: physiological barriers and strategies. J. Natl. Cancer Inst. 81, 570-576.
    • (1989) J. Natl. Cancer Inst. , vol.81 , pp. 570-576
    • Jain, R.K.1
  • 67
    • 0023219734 scopus 로고
    • Transport of molecules in the tumor interstitium: A review
    • [67] Jain, R.K. (1987) Transport of molecules in the tumor interstitium: a review. Cancer Res. 47, 3039-3051.
    • (1987) Cancer Res. , vol.47 , pp. 3039-3051
    • Jain, R.K.1
  • 68
    • 0026739369 scopus 로고
    • Micropharmacology of monoclonal antibodies in solid tumors: Direct experimental evidence for a binding site barrier
    • [68] Juweid, M., Neumann, R., Paik, C., Perez-Bacete, M.J., Sato, J., van Osdol, W. and Weinstein, J.N. (1992) Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res. 52, 5144-5153.
    • (1992) Cancer Res. , vol.52 , pp. 5144-5153
    • Juweid, M.1    Neumann, R.2    Paik, C.3    Perez-Bacete, M.J.4    Sato, J.5    Van Osdol, W.6    Weinstein, J.N.7
  • 69
    • 0026747885 scopus 로고
    • Early intervention in cancer using monoclonal antibodies and other biological ligands: Micropharmacology and the "binding site barrier"
    • [69] Weinstein, J.N. and van Osdol, W. (1992) Early intervention in cancer using monoclonal antibodies and other biological ligands: micropharmacology and the "binding site barrier". Cancer Res. 52, 2747s-2751s.
    • (1992) Cancer Res. , vol.52
    • Weinstein, J.N.1    Van Osdol, W.2
  • 70
    • 0026425598 scopus 로고
    • Integrated microscopic-macroscopic pharmacology of monoclonal antibody radioconjugates: The radiation dose distribution
    • [70] Fujimori, K., Fisher, D.R. and Weinstein, J.N. (1991) Integrated microscopic-macroscopic pharmacology of monoclonal antibody radioconjugates: the radiation dose distribution. Cancer Res. 51, 4821-4827.
    • (1991) Cancer Res. , vol.51 , pp. 4821-4827
    • Fujimori, K.1    Fisher, D.R.2    Weinstein, J.N.3
  • 71
    • 0028114416 scopus 로고
    • Nonlinear pharmacokinetics of a recombinant human granulocyte colony-stimulating factor derivative (nartograstim): Species differences among rats, monkeys and humans
    • [71] Kuwabara, T., Kato, Y., Kobayashi, S., Suzuki, H. and Sugiyama, Y. (1994) Nonlinear pharmacokinetics of a recombinant human granulocyte colony-stimulating factor derivative (nartograstim): species differences among rats, monkeys and humans. J. Pharmacol. Exp. Ther. 271, 1535-1543.
    • (1994) J. Pharmacol. Exp. Ther. , vol.271 , pp. 1535-1543
    • Kuwabara, T.1    Kato, Y.2    Kobayashi, S.3    Suzuki, H.4    Sugiyama, Y.5
  • 72
    • 0026452853 scopus 로고
    • Pharmacokinetics of ANF and urodilatin during cANF receptor blockade and neutral endopeptidase inhibition
    • [72] Abassi, Z.A., Tate, J., Hunsberger, S., Klein, H., Trachewsky, D. and Keiser, H.R. (1992) Pharmacokinetics of ANF and urodilatin during cANF receptor blockade and neutral endopeptidase inhibition. Am. J. Physiol. 263, E870-E876.
    • (1992) Am. J. Physiol. , vol.263
    • Abassi, Z.A.1    Tate, J.2    Hunsberger, S.3    Klein, H.4    Trachewsky, D.5    Keiser, H.R.6
  • 74
    • 0026073182 scopus 로고
    • Influence of C-ANF receptor and neutral endopeptidase on pharmacokinetics of ANF in rats
    • [74] Chiu, P.J., Tetzloff, G., Romano, M.T., Foster, C.J. and Sybertz, E.J. (1991) Influence of C-ANF receptor and neutral endopeptidase on pharmacokinetics of ANF in rats. Am. J. Physiol. 260, R208-R216.
    • (1991) Am. J. Physiol. , vol.260
    • Chiu, P.J.1    Tetzloff, G.2    Romano, M.T.3    Foster, C.J.4    Sybertz, E.J.5
  • 76
    • 0022399101 scopus 로고
    • The relationship between plasma concentration and disappearance rate of immunoreactive insulin in the conscious dog
    • [76] Stevenson, R.W., Cherrington, A.D. and Steiner, K.E. (1985) The relationship between plasma concentration and disappearance rate of immunoreactive insulin in the conscious dog. Horm. Metab. Res. 17, 551-553.
    • (1985) Horm. Metab. Res. , vol.17 , pp. 551-553
    • Stevenson, R.W.1    Cherrington, A.D.2    Steiner, K.E.3
  • 77
    • 0021355308 scopus 로고
    • Insulin removal in man: In vivo evidence for a receptor-mediated process
    • [77] Eaton, R.P., Friedman, N., Allen, R.C. and Schade, D.S. (1984) Insulin removal in man: in vivo evidence for a receptor-mediated process. J. Clin. Endocrinol. Metab. 69, 555-559.
    • (1984) J. Clin. Endocrinol. Metab. , vol.69 , pp. 555-559
    • Eaton, R.P.1    Friedman, N.2    Allen, R.C.3    Schade, D.S.4
  • 78
    • 0018066617 scopus 로고
    • Arginine vasopressin metabolism in dogs. I. Evidence for a receptor-mediated mechanism
    • [78] Weitzman, R.E. and Fisher, D.A. (1978) Arginine vasopressin metabolism in dogs. I. Evidence for a receptor-mediated mechanism. Am. J. Physiol. 235, E591-E597.
    • (1978) Am. J. Physiol. , vol.235
    • Weitzman, R.E.1    Fisher, D.A.2
  • 79
    • 0025610718 scopus 로고
    • Cellular mechanisms of the clearance function of type C receptors of atrial natriuretic factor
    • [79] Nussenzveig, D.R., Lewicki, J.A. and Maack, T. (1990) Cellular mechanisms of the clearance function of type C receptors of atrial natriuretic factor. J. Biol. Chem. 265, 20952-20958.
    • (1990) J. Biol. Chem. , vol.265 , pp. 20952-20958
    • Nussenzveig, D.R.1    Lewicki, J.A.2    Maack, T.3
  • 80
    • 0026665240 scopus 로고
    • Clearance receptor and neutral endopeptidase-mediated metabolism of atrial natriuretic factor
    • [80] Okolicany, J., McEnroe, G.A., Koh, G.Y., Lewicki, J.A. and Maack, T. (1992) Clearance receptor and neutral endopeptidase-mediated metabolism of atrial natriuretic factor. Am. J. Physiol. 263, F546-F553.
    • (1992) Am. J. Physiol. , vol.263
    • Okolicany, J.1    McEnroe, G.A.2    Koh, G.Y.3    Lewicki, J.A.4    Maack, T.5
  • 81
    • 0018166426 scopus 로고
    • Demonstration of the insulin receptor in vivo in rabbits and its possible role as a reservoir for the plasma hormone
    • [81] Zeleznik, A.J. and Roth, J. (1978) Demonstration of the insulin receptor in vivo in rabbits and its possible role as a reservoir for the plasma hormone. J. Clin. Invest. 61, 1363-1374.
    • (1978) J. Clin. Invest. , vol.61 , pp. 1363-1374
    • Zeleznik, A.J.1    Roth, J.2
  • 82
    • 0025666752 scopus 로고
    • 3H]dynorphin (1-13) in the perfused rat lung: An application of the multiple-indicator dilution method
    • 3H]dynorphin (1-13) in the perfused rat lung: an application of the multiple-indicator dilution method. J. Pharm. Pharmacol. 42, 879-882.
    • (1990) J. Pharm. Pharmacol. , vol.42 , pp. 879-882
    • Sato, H.1    Terasaki, T.2    Tsuji, A.3
  • 83
    • 0023798828 scopus 로고
    • Dynamic determination of kinetic parameters for the interaction between polypeptide hormones and cell-surface receptors in the perfused rat liver by the multiple-indicator dilution method
    • [83] Sato, H., Sugiyama, Y., Sawada, Y., Iga, T., Sakamoto, S., Fuwa, T. and Hanano, M. (1988) Dynamic determination of kinetic parameters for the interaction between polypeptide hormones and cell-surface receptors in the perfused rat liver by the multiple-indicator dilution method. Proc. Natl. Acad. Sci. U.S.A. 85, 8355-8359.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 8355-8359
    • Sato, H.1    Sugiyama, Y.2    Sawada, Y.3    Iga, T.4    Sakamoto, S.5    Fuwa, T.6    Hanano, M.7
  • 84
    • 0023707091 scopus 로고
    • Kinetic analysis of in vivo receptor-dependent binding of human epidermal growth factor by rat tissues
    • [84] Kim, D.C., Sugiyama, Y., Satoh, H., Fuwa, T., Iga, T. and Hanano, M. (1988) Kinetic analysis of in vivo receptor-dependent binding of human epidermal growth factor by rat tissues. J. Pharm. Sci. 77, 200-207.
    • (1988) J. Pharm. Sci. , vol.77 , pp. 200-207
    • Kim, D.C.1    Sugiyama, Y.2    Satoh, H.3    Fuwa, T.4    Iga, T.5    Hanano, M.6
  • 85
    • 0023936664 scopus 로고
    • In vivo evidence for the specific binding of human β-endorphin to the lung and liver of the rat
    • [85] Sato, H., Sugiyama, Y., Sawada, Y., Iga, T. and Hanano, M. (1988) In vivo evidence for the specific binding of human β-endorphin to the lung and liver of the rat. Biochem. Pharmacol. 37, 2273-2278.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 2273-2278
    • Sato, H.1    Sugiyama, Y.2    Sawada, Y.3    Iga, T.4    Hanano, M.5
  • 87
    • 0025756693 scopus 로고
    • Effect of receptor up-regulation on insulin pharmacokinetics in streptozotocin-treated diabetic rats
    • [87] Sato, H., Terasaki, T., Okumura, K. and Tsuji, A. (1991) Effect of receptor up-regulation on insulin pharmacokinetics in streptozotocin-treated diabetic rats. Pharm. Res. 8, 563-569.
    • (1991) Pharm. Res. , vol.8 , pp. 563-569
    • Sato, H.1    Terasaki, T.2    Okumura, K.3    Tsuji, A.4
  • 88
    • 0025361244 scopus 로고
    • Kinetic analysis of the downregulation of epidermal growth factor receptors in rats in vivo
    • [88] Yanai, S., Sugiyama, Y., Iga, T., Fuwa, T. and Hanano, M. (1990) Kinetic analysis of the downregulation of epidermal growth factor receptors in rats in vivo. Am. J. Physiol. 258, C593-C598.
    • (1990) Am. J. Physiol. , vol.258
    • Yanai, S.1    Sugiyama, Y.2    Iga, T.3    Fuwa, T.4    Hanano, M.5
  • 89
    • 0024375737 scopus 로고
    • Decrease in the number of receptors for epidermal growth factor in the liver of D-galactosamine-intoxicated rats
    • [89] Sato, H., Sugiyama, Y., Kim, D.C., Yanai, S., Kurita, M., Fuwa, T., Iga, T. and Hanano, M. (1989) Decrease in the number of receptors for epidermal growth factor in the liver of D-galactosamine-intoxicated rats. Biochem. Pharmacol. 38, 2663-2671.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 2663-2671
    • Sato, H.1    Sugiyama, Y.2    Kim, D.C.3    Yanai, S.4    Kurita, M.5    Fuwa, T.6    Iga, T.7    Hanano, M.8
  • 90
    • 0018691375 scopus 로고
    • Evidence for reduced uptake of asialo-α1-acid glycoprotein during the acute phase response to inflammation
    • [90] Wong, M.W. and Jamieson, J.C. (1979) Evidence for reduced uptake of asialo-α1-acid glycoprotein during the acute phase response to inflammation. Life Sci. 25, 827-834.
    • (1979) Life Sci. , vol.25 , pp. 827-834
    • Wong, M.W.1    Jamieson, J.C.2
  • 92
    • 0028986977 scopus 로고
    • Cytokine-binding proteins: Stimulating antagonists
    • [92] Klein, B. and Brailly, H. (1995) Cytokine-binding proteins: stimulating antagonists. Immunol. Today 16, 216-220.
    • (1995) Immunol. Today , vol.16 , pp. 216-220
    • Klein, B.1    Brailly, H.2
  • 93
    • 0028150823 scopus 로고
    • Cytokine antagonists and their potential therapeutic use
    • [93] Debets, R. and Savelkoul, H.F. (1994) Cytokine antagonists and their potential therapeutic use. Immunol. Today 15, 455-458.
    • (1994) Immunol. Today , vol.15 , pp. 455-458
    • Debets, R.1    Savelkoul, H.F.2
  • 94
    • 0027198002 scopus 로고
    • Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists
    • [94] Mohler, K.M., Torrance, D.S., Smith, C.A., Goodwin, R.G., Stremler, K.E., Fung, V.P., Madani, H. and Widmer, M.B. (1993) Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J. Immunol. 151, 1548-1561.
    • (1993) J. Immunol. , vol.151 , pp. 1548-1561
    • Mohler, K.M.1    Torrance, D.S.2    Smith, C.A.3    Goodwin, R.G.4    Stremler, K.E.5    Fung, V.P.6    Madani, H.7    Widmer, M.B.8
  • 95
    • 0026546708 scopus 로고
    • The soluble transferrin receptor: Biological aspects and clinical usefulness as quantitative measure of erythropoiesis
    • [95] Beguin, Y. (1992) The soluble transferrin receptor: biological aspects and clinical usefulness as quantitative measure of erythropoiesis. Haematologica 77, 1-10.
    • (1992) Haematologica , vol.77 , pp. 1-10
    • Beguin, Y.1
  • 96
    • 0026003337 scopus 로고
    • Insulin-like growth factor binding protein (IGFBP) inhibits IGF action on human osteosarcoma cells
    • [96] Campbell, P.G. and Novak, J.F. (1991) Insulin-like growth factor binding protein (IGFBP) inhibits IGF action on human osteosarcoma cells. J. Cell. Physiol. 149, 293-300.
    • (1991) J. Cell. Physiol. , vol.149 , pp. 293-300
    • Campbell, P.G.1    Novak, J.F.2
  • 97
    • 0001232787 scopus 로고
    • In vitro models of hepatic clearance: Methods to determine the kinetic parameters for receptor-mediated hepatic uptake
    • M.D. Taylor and G.L. Amidon (Eds.), ACS Professional Reference Books, Washington, DC
    • [97] Sugiyama, Y. and Kato, Y. (1995) In vitro models of hepatic clearance: Methods to determine the kinetic parameters for receptor-mediated hepatic uptake. In: M.D. Taylor and G.L. Amidon (Eds.), Peptide Based Drug Design: Controlling Transport and Metabolism, ACS Professional Reference Books, Washington, DC, pp. 525-551.
    • (1995) Peptide Based Drug Design: Controlling Transport and Metabolism , pp. 525-551
    • Sugiyama, Y.1    Kato, Y.2
  • 98
    • 0024996478 scopus 로고
    • Receptor-mediated disposition of polypeptides: Kinetic analysis of the transport of epidermal growth factor as a model peptide using in vitro isolated perfused organs and in vivo system
    • [98] Sugiyama, Y., Kim, D.-C., Satoh, H., Yanai, S., Sato, H., Iga, T. and Hanano, M. (1990) Receptor-mediated disposition of polypeptides: Kinetic analysis of the transport of epidermal growth factor as a model peptide using in vitro isolated perfused organs and in vivo system. J. Control. Rel. 13, 157-174.
    • (1990) J. Control. Rel. , vol.13 , pp. 157-174
    • Sugiyama, Y.1    Kim, D.-C.2    Satoh, H.3    Yanai, S.4    Sato, H.5    Iga, T.6    Hanano, M.7
  • 99
    • 0024634393 scopus 로고
    • Receptor-mediated transport of peptide hormones and its importance in the overall hormone disposition in the body
    • [99] Sugiyama, Y. and Hanano, M. (1989) Receptor-mediated transport of peptide hormones and its importance in the overall hormone disposition in the body. Pharm. Res. 6, 192-202.
    • (1989) Pharm. Res. , vol.6 , pp. 192-202
    • Sugiyama, Y.1    Hanano, M.2
  • 100
    • 0024462034 scopus 로고
    • Receptor-mediated delivery of drugs to hepatocytes
    • [100] Fallon, R.J. and Schwartz, A.L. (1989) Receptor-mediated delivery of drugs to hepatocytes. Adv. Drug Delivery Rev. 4, 49-63.
    • (1989) Adv. Drug Delivery Rev. , vol.4 , pp. 49-63
    • Fallon, R.J.1    Schwartz, A.L.2
  • 102
    • 0021357886 scopus 로고
    • Down regulation of epidermal growth factor receptors: Direct demonstration of receptor degradation in human fibroblasts
    • [102] Stoscheck, C.M. and Carpenter, G. (1984) Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts. J. Cell Biol. 98, 1048-1053.
    • (1984) J. Cell Biol. , vol.98 , pp. 1048-1053
    • Stoscheck, C.M.1    Carpenter, G.2
  • 103
    • 0024435665 scopus 로고
    • Attenuated processing of epidermal growth factor in the face of marked degradation of transforming growth factor-α
    • [103] Korc, M. and Finman, J.E. (1989) Attenuated processing of epidermal growth factor in the face of marked degradation of transforming growth factor-α. J. Biol. Chem. 264, 14990-14999.
    • (1989) J. Biol. Chem. , vol.264 , pp. 14990-14999
    • Korc, M.1    Finman, J.E.2
  • 104
    • 0019425011 scopus 로고
    • Method for rapidly estimating specific radioactivity and radiochemical purity of radioiodinated peptide hormones used in radioimmunoassays
    • [104] Chen, M., Berman, J.R., MaCarroll, M.C. and Chen, I.W. (1981) Method for rapidly estimating specific radioactivity and radiochemical purity of radioiodinated peptide hormones used in radioimmunoassays. Clin. Chem. 27, 632-633.
    • (1981) Clin. Chem. , vol.27 , pp. 632-633
    • Chen, M.1    Berman, J.R.2    MaCarroll, M.C.3    Chen, I.W.4
  • 106
    • 0020533266 scopus 로고
    • 125I-insulin in human fibroblasts by the use of high performance liquid chromatography
    • 125I-insulin in human fibroblasts by the use of high performance liquid chromatography. Diabetes 32, 474-477.
    • (1983) Diabetes , vol.32 , pp. 474-477
    • Stentz, F.B.1    Harris, H.L.2    Kitabchi, A.E.3
  • 108
    • 0021219724 scopus 로고
    • Evidence for separate handling in vivo of different regions of the insulin molecule using A14-and B1-labeled insulin tracers
    • [108] Cockram, C.S., Jones, R.H., Boroujerdi, M.A. and Sonksen, P.H. (1984) Evidence for separate handling in vivo of different regions of the insulin molecule using A14-and B1-labeled insulin tracers. Diabetes 33, 721-727.
    • (1984) Diabetes , vol.33 , pp. 721-727
    • Cockram, C.S.1    Jones, R.H.2    Boroujerdi, M.A.3    Sonksen, P.H.4
  • 109
    • 0018841438 scopus 로고
    • Kinetic modeling of insulin binding to receptors and degradation in vivo in the rabbit
    • [109] Berman, M., McGuire, E.A., Roth, J. and Zeleznik, A.J. (1980) Kinetic modeling of insulin binding to receptors and degradation in vivo in the rabbit. Diabetes 29, 50-59.
    • (1980) Diabetes , vol.29 , pp. 50-59
    • Berman, M.1    McGuire, E.A.2    Roth, J.3    Zeleznik, A.J.4
  • 110
    • 0019945866 scopus 로고
    • The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis
    • [110] Wiley, H.S. and Cunningham, D.D. (1982) The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis. J. Biol. Chem. 257, 4222-4229.
    • (1982) J. Biol. Chem. , vol.257 , pp. 4222-4229
    • Wiley, H.S.1    Cunningham, D.D.2
  • 111
    • 0019404817 scopus 로고
    • A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands
    • [111] Wiley, H.S. and Cunningham, D.D. (1981) A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands. Cell 25, 433-440.
    • (1981) Cell , vol.25 , pp. 433-440
    • Wiley, H.S.1    Cunningham, D.D.2
  • 112
    • 0022530295 scopus 로고
    • Regulation of interacting populations during endocytosis: Models of growth factor-tumor promoter dynamics
    • [112] Gex-Fabry, M. and DeLisi, C. (1986) Regulation of interacting populations during endocytosis: models of growth factor-tumor promoter dynamics. Am. J. Physiol. 250, R1123-R1132.
    • (1986) Am. J. Physiol. , vol.250
    • Gex-Fabry, M.1    DeLisi, C.2
  • 113
    • 0021520019 scopus 로고
    • Receptor-mediated endocytosis: A model and its implications for experimental analysis
    • [113] Gex-Fabry, M. and DeLisi, C. (1984) Receptor-mediated endocytosis: a model and its implications for experimental analysis. Am. J. Physiol. 247, R768-R779.
    • (1984) Am. J. Physiol. , vol.247
    • Gex-Fabry, M.1    DeLisi, C.2
  • 114
    • 0026701924 scopus 로고
    • Existence of two pathways for the endocytosis of epidermal growth factor by rat liver: Phenylarsine oxide-sensitive and -insensitive pathways
    • [114] Kato, Y., Sato, H., Ichikawa, M., Suzuki, H., Sawada, Y., Hanano, M., Fuwa, T. and Sugiyama, Y. (1992) Existence of two pathways for the endocytosis of epidermal growth factor by rat liver: phenylarsine oxide-sensitive and -insensitive pathways. Proc. Natl. Acad. Sci. U.S.A. 89, 8507-8511.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 8507-8511
    • Kato, Y.1    Sato, H.2    Ichikawa, M.3    Suzuki, H.4    Sawada, Y.5    Hanano, M.6    Fuwa, T.7    Sugiyama, Y.8
  • 115
    • 0025752684 scopus 로고
    • Comparison of the methods for determining cell-surface and intracellular receptors for epidermal growth factor in the rat liver
    • [115] Yanai, S., Sugiyama, Y., Iga, T., Fuwa, T. and Hanano, M. (1991) Comparison of the methods for determining cell-surface and intracellular receptors for epidermal growth factor in the rat liver. Pharm. Res. 8, 557-562.
    • (1991) Pharm. Res. , vol.8 , pp. 557-562
    • Yanai, S.1    Sugiyama, Y.2    Iga, T.3    Fuwa, T.4    Hanano, M.5
  • 116
    • 0026081301 scopus 로고
    • Trafficking of the epidermal growth factor receptor and transferrin in three hepatocytic endosomal fractions
    • [116] Jackle, S., Runquist, E.A., Miranda-Brady, S. and Havel, R.J. (1991) Trafficking of the epidermal growth factor receptor and transferrin in three hepatocytic endosomal fractions. J. Biol. Chem. 266, 1396-1402.
    • (1991) J. Biol. Chem. , vol.266 , pp. 1396-1402
    • Jackle, S.1    Runquist, E.A.2    Miranda-Brady, S.3    Havel, R.J.4
  • 117
    • 0023117344 scopus 로고
    • The hepatic binding and uptake kinetics of epidermal growth factor: Studies with isolated rat hepatocytes
    • [117] Rush, G.F. and Alberts, D. (1987) The hepatic binding and uptake kinetics of epidermal growth factor: studies with isolated rat hepatocytes. Life Sci. 40, 679-685.
    • (1987) Life Sci. , vol.40 , pp. 679-685
    • Rush, G.F.1    Alberts, D.2
  • 118
    • 0022639836 scopus 로고
    • Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: Receptor pathway
    • [118] Dunn, W.A., Connolly, T.P. and Hubbard, A.L. (1986) Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway. J. Cell Biol. 102, 24-36.
    • (1986) J. Cell Biol. , vol.102 , pp. 24-36
    • Dunn, W.A.1    Connolly, T.P.2    Hubbard, A.L.3
  • 119
    • 0025313718 scopus 로고
    • Internalization of EGF in perfused rat liver is independent of the degree of receptor occupancy
    • [119] Sato, H., Sugiyama, Y., Sawada, Y., Iga, T., Fuwa, T. and Hanano, M. (1990) Internalization of EGF in perfused rat liver is independent of the degree of receptor occupancy. Am. J. Physiol. 258, G682-G689.
    • (1990) Am. J. Physiol. , vol.258
    • Sato, H.1    Sugiyama, Y.2    Sawada, Y.3    Iga, T.4    Fuwa, T.5    Hanano, M.6
  • 120
    • 0021234231 scopus 로고
    • Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: Ligand and receptor dynamics
    • [120] Dunn, W.A. and Hubbard, A.L. (1984) Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics. J. Cell Biol. 98, 2148-2159.
    • (1984) J. Cell Biol. , vol.98 , pp. 2148-2159
    • Dunn, W.A.1    Hubbard, A.L.2
  • 121
    • 0021234001 scopus 로고
    • Potential mechanism of the stimulatory action of insulin on insulin-like growth factor II binding to the isolated rat adipose cell. Apparent redistribution of receptors cycling between a large intracellular pool and the plasma membrane
    • [121] Wardzala, L.J., Simpson, I.A., Rechler, M.M. and Cushman, S.W. (1984) Potential mechanism of the stimulatory action of insulin on insulin-like growth factor II binding to the isolated rat adipose cell. Apparent redistribution of receptors cycling between a large intracellular pool and the plasma membrane. J. Biol. Chem. 259, 8378-8383.
    • (1984) J. Biol. Chem. , vol.259 , pp. 8378-8383
    • Wardzala, L.J.1    Simpson, I.A.2    Rechler, M.M.3    Cushman, S.W.4
  • 122
    • 0021332650 scopus 로고
    • Quantitative studies of the rate of insulin internalization in isolated rat hepatocytes
    • [122] Draznin, B., Trowbridge, M. and Ferguson, L. (1984) Quantitative studies of the rate of insulin internalization in isolated rat hepatocytes. Biochem. J. 218, 307-312.
    • (1984) Biochem. J. , vol.218 , pp. 307-312
    • Draznin, B.1    Trowbridge, M.2    Ferguson, L.3
  • 123
    • 0020794767 scopus 로고
    • Kinetic interpretation of hepatic multiple-indicator dilution studies
    • [123] Goresky, C.A. (1983) Kinetic interpretation of hepatic multiple-indicator dilution studies. Am. J. Physiol. 245, G1-G12.
    • (1983) Am. J. Physiol. , vol.245
    • Goresky, C.A.1
  • 124
    • 0015620354 scopus 로고
    • On the uptake of materials by the intact liver. The transport and net removal of galactose
    • [124] Goresky, C.A., Bach, G.C. and Nadeau, B.E. (1973) On the uptake of materials by the intact liver. The transport and net removal of galactose. J. Clin. Invest. 52, 991-1009.
    • (1973) J. Clin. Invest. , vol.52 , pp. 991-1009
    • Goresky, C.A.1    Bach, G.C.2    Nadeau, B.E.3
  • 125
    • 0023712781 scopus 로고
    • In vivo characterization of insulin uptake by dog renal cortical epithelium
    • [125] Whiteside, C.I., Lumsden, C.J. and Silverman, M. (1988) In vivo characterization of insulin uptake by dog renal cortical epithelium. Am. J. Physiol. 255, E357-E365.
    • (1988) Am. J. Physiol. , vol.255
    • Whiteside, C.I.1    Lumsden, C.J.2    Silverman, M.3
  • 126
    • 0018166426 scopus 로고
    • Demonstration of the insulin receptor in vivo in rabbits and its possible role as a reservoir for the plasma hormone
    • [126] Zeleznik, A.J. and Roth, J. (1978) Demonstration of the insulin receptor in vivo in rabbits and its possible role as a reservoir for the plasma hormone. J. Clin. Invest. 61, 1363-1374.
    • (1978) J. Clin. Invest. , vol.61 , pp. 1363-1374
    • Zeleznik, A.J.1    Roth, J.2
  • 127
    • 0025756553 scopus 로고
    • Kinetic analysis of receptor-mediated endocytosis of epidermal growth factor by isolated rat hepatocytes
    • [127] Yanai, S., Sugiyama, Y., Kim, D.C., Iga, T., Fuwa, T. and Hanano, M. (1991) Kinetic analysis of receptor-mediated endocytosis of epidermal growth factor by isolated rat hepatocytes. Am. J. Physiol. 260, C457-C467.
    • (1991) Am. J. Physiol. , vol.260
    • Yanai, S.1    Sugiyama, Y.2    Kim, D.C.3    Iga, T.4    Fuwa, T.5    Hanano, M.6
  • 128
    • 0025864656 scopus 로고
    • Receptor-recycling model of clearance and distribution of insulin in the perfused mouse liver
    • [128] Sato, H., Terasaki, T., Mizuguchi, H., Okumura, K. and Tsuji, A. (1991) Receptor-recycling model of clearance and distribution of insulin in the perfused mouse liver. Diabetologia 34, 613-621.
    • (1991) Diabetologia , vol.34 , pp. 613-621
    • Sato, H.1    Terasaki, T.2    Mizuguchi, H.3    Okumura, K.4    Tsuji, A.5
  • 129
    • 0023935382 scopus 로고
    • Analysis of intracellular receptor/ligand sorting in endosomes
    • [129] Linderman, J.J. and Lauffenburger, D.A. (1988) Analysis of intracellular receptor/ligand sorting in endosomes. J. Theor. Biol. 132, 203-245.
    • (1988) J. Theor. Biol. , vol.132 , pp. 203-245
    • Linderman, J.J.1    Lauffenburger, D.A.2
  • 130
    • 0022759528 scopus 로고
    • Analysis of intracellular receptor/ligand sorting. Calculation of mean surface and bulk diffusion times within a sphere
    • [130] Linderman, J.J. and Lauffenburger, D.A. (1986) Analysis of intracellular receptor/ligand sorting. Calculation of mean surface and bulk diffusion times within a sphere. Biophys. J. 50, 295-305.
    • (1986) Biophys. J. , vol.50 , pp. 295-305
    • Linderman, J.J.1    Lauffenburger, D.A.2
  • 131
    • 0018849228 scopus 로고
    • Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells
    • [131] Haigler, H.T., Maxfield, F.R., Willingham, M.C. and Pastan, I. (1980) Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. J. Biol. Chem. 255, 1239-1241.
    • (1980) J. Biol. Chem. , vol.255 , pp. 1239-1241
    • Haigler, H.T.1    Maxfield, F.R.2    Willingham, M.C.3    Pastan, I.4
  • 133
    • 0025232831 scopus 로고
    • ET-1 receptors in C-6 cells: Homologous downregulation and modulation by protein kinase C
    • [133] Cozza, E.N., Vila, M.C. and Gomez-Sanchez, C.E. (1990) ET-1 receptors in C-6 cells: homologous downregulation and modulation by protein kinase C. Mol. Cell. Endocrinol. 70, 155-164.
    • (1990) Mol. Cell. Endocrinol. , vol.70 , pp. 155-164
    • Cozza, E.N.1    Vila, M.C.2    Gomez-Sanchez, C.E.3
  • 134
    • 0024571615 scopus 로고
    • Intracellular transport of formaldehyde-treated serum albumin in liver endothelial cells after uptake via scavenger receptors
    • [134] Eskild, W., Kindberg, G.M., Smedsrod, B., Blomhoff, R., Norum, K.R. and Berg, T. (1989) Intracellular transport of formaldehyde-treated serum albumin in liver endothelial cells after uptake via scavenger receptors. Biochem. J. 258, 511-520.
    • (1989) Biochem. J. , vol.258 , pp. 511-520
    • Eskild, W.1    Kindberg, G.M.2    Smedsrod, B.3    Blomhoff, R.4    Norum, K.R.5    Berg, T.6
  • 136
    • 0022997416 scopus 로고
    • A differential effect between the acute and chronic administration of ethanol on the endocytotic rate constant, ke, for the internalisation of asialoglycoproteins by hepatocytes
    • [136] Sharma, R.J. and Grant, D.A. (1986) A differential effect between the acute and chronic administration of ethanol on the endocytotic rate constant, ke, for the internalisation of asialoglycoproteins by hepatocytes. Biochim. Biophys. Acta 862, 199-204.
    • (1986) Biochim. Biophys. Acta , vol.862 , pp. 199-204
    • Sharma, R.J.1    Grant, D.A.2
  • 137
    • 0027478333 scopus 로고
    • Binding, internalization, degradation, and mitogenic effect of epidermal growth factor in cultured rat hepatocytes
    • [137] Kato, Y. and Sugiyama, Y. (1993) Binding, internalization, degradation, and mitogenic effect of epidermal growth factor in cultured rat hepatocytes. S.T.P. Pharma Sci. 3, 75-82.
    • (1993) S.t.p. Pharma Sci. , vol.3 , pp. 75-82
    • Kato, Y.1    Sugiyama, Y.2
  • 138
    • 0025070201 scopus 로고
    • Epidermal growth factor and transforming growth factor-α induce differential processing of the epidermal growth factor receptor
    • [138] Decker, S.J. (1990) Epidermal growth factor and transforming growth factor-α induce differential processing of the epidermal growth factor receptor. Biochem. Biophys. Res. Commun. 166, 615-621.
    • (1990) Biochem. Biophys. Res. Commun. , vol.166 , pp. 615-621
    • Decker, S.J.1
  • 139
    • 0024230493 scopus 로고
    • Rapid constitutive internalization and externalization of epidermal growth factor receptors in isolated rat hepatocytes. Monensin inhibits receptor externalization and reduces the capacity for continued endocytosis of epidermal growth factor
    • [139] Gladhaug, I.P. and Christoffersen, T. (1988) Rapid constitutive internalization and externalization of epidermal growth factor receptors in isolated rat hepatocytes. Monensin inhibits receptor externalization and reduces the capacity for continued endocytosis of epidermal growth factor. J. Biol. Chem. 263, 12199-12203.
    • (1988) J. Biol. Chem. , vol.263 , pp. 12199-12203
    • Gladhaug, I.P.1    Christoffersen, T.2
  • 140
    • 0022472567 scopus 로고
    • Receptor-bound somatostatin and epidermal growth factor are processed differently in GH4C1 rat pituitary cells
    • [140] Presky, D.H. and Schonbrunn, A. (1986) Receptor-bound somatostatin and epidermal growth factor are processed differently in GH4C1 rat pituitary cells. J. Cell Biol. 102, 878-888.
    • (1986) J. Cell Biol. , vol.102 , pp. 878-888
    • Presky, D.H.1    Schonbrunn, A.2
  • 141
    • 0021929030 scopus 로고
    • Recycling of the asialoglycoprotein receptor in isolated rat hepatocytes. ATP depletion blocks receptor recycling but not a single round of endocytosis
    • [141] Clarke, B.L. and Weigel, P.H. (1985) Recycling of the asialoglycoprotein receptor in isolated rat hepatocytes. ATP depletion blocks receptor recycling but not a single round of endocytosis. J. Biol. Chem. 260, 128-133.
    • (1985) J. Biol. Chem. , vol.260 , pp. 128-133
    • Clarke, B.L.1    Weigel, P.H.2
  • 143
    • 0021323639 scopus 로고
    • Equilibrium model for insulin-induced receptor down-regulation. Regulation of insulin receptors in differentiated BC3H-1 myocytes
    • [143] Standaert, M.L. and Pollet, R.J. (1984) Equilibrium model for insulin-induced receptor down-regulation. Regulation of insulin receptors in differentiated BC3H-1 myocytes. J. Biol. Chem. 259, 2346-2354.
    • (1984) J. Biol. Chem. , vol.259 , pp. 2346-2354
    • Standaert, M.L.1    Pollet, R.J.2
  • 144
    • 0020440996 scopus 로고
    • Ligand-induced translocation of insulin receptors in intact rat liver
    • [144] Desbuquois, B., Lopez, S. and Burlet, H. (1982) Ligand-induced translocation of insulin receptors in intact rat liver. J. Biol. Chem. 257, 10852-10860.
    • (1982) J. Biol. Chem. , vol.257 , pp. 10852-10860
    • Desbuquois, B.1    Lopez, S.2    Burlet, H.3
  • 145
    • 0022398526 scopus 로고
    • Effect of glyburide on in vivo recycling of the hepatic insulin receptor
    • [145] Frank, H.J., Donohoe, M.T. and Morris, W.L. (1985) Effect of glyburide on in vivo recycling of the hepatic insulin receptor. Am. J. Med. 79, 53-58.
    • (1985) Am. J. Med. , vol.79 , pp. 53-58
    • Frank, H.J.1    Donohoe, M.T.2    Morris, W.L.3
  • 146
    • 0024324406 scopus 로고
    • An analysis of the relationship between the cellular distribution and the rate of turnover for the separate classes of unoccupied, noncovalently occupied, and covalently occupied insulin receptor
    • [146] Reed, D.K., Newton, C., Fraga, M., Glastad, K., Bagheri, A., Harris, S. and Reed, B.C. (1989) An analysis of the relationship between the cellular distribution and the rate of turnover for the separate classes of unoccupied, noncovalently occupied, and covalently occupied insulin receptor. J. Biol. Chem. 264, 12673-12679.
    • (1989) J. Biol. Chem. , vol.264 , pp. 12673-12679
    • Reed, D.K.1    Newton, C.2    Fraga, M.3    Glastad, K.4    Bagheri, A.5    Harris, S.6    Reed, B.C.7
  • 147
    • 0024807218 scopus 로고
    • Ligand-mediated internalization, recycling, and downregulation of the epidermal growth factor receptor in vivo
    • [147] Lai, W.H., Cameron, P.H., Wada, I., Doherty, J.J., Kay, D.G., Posner, B.I. and Bergeron, J.J. (1989) Ligand-mediated internalization, recycling, and downregulation of the epidermal growth factor receptor in vivo. J. Cell Biol. 109, 2741-2749.
    • (1989) J. Cell Biol. , vol.109 , pp. 2741-2749
    • Lai, W.H.1    Cameron, P.H.2    Wada, I.3    Doherty, J.J.4    Kay, D.G.5    Posner, B.I.6    Bergeron, J.J.7
  • 149
    • 0022574984 scopus 로고
    • A simulation study on the effect of a uniform diffusional barrier across hepatocytes on drug metabolism by evenly or unevenly distributed uni-enzyme in the liver
    • [149] Sato, H., Sugiyama, Y., Miyauchi, S., Sawada, Y., Iga, T. and Hanano, M. (1986) A simulation study on the effect of a uniform diffusional barrier across hepatocytes on drug metabolism by evenly or unevenly distributed uni-enzyme in the liver. J. Pharm. Sci. 75, 3-8.
    • (1986) J. Pharm. Sci. , vol.75 , pp. 3-8
    • Sato, H.1    Sugiyama, Y.2    Miyauchi, S.3    Sawada, Y.4    Iga, T.5    Hanano, M.6
  • 150
    • 0029022213 scopus 로고
    • Pulsatile i.v. Insulin therapy for severely out of control diabetes
    • [150] Logan-Darrough, M. (1995) Pulsatile i.v. insulin therapy for severely out of control diabetes. J. Intrav. Nurs. 18, 124-128.
    • (1995) J. Intrav. Nurs. , vol.18 , pp. 124-128
    • Logan-Darrough, M.1
  • 151
    • 0028287802 scopus 로고
    • Augmented effect of shortterm pulsatile versus continuous insulin delivery on lipid metabolism but similar effect on whole-body glucose metabolism in obese subjects
    • [151] Schmitz, O., Pedersen, S.B., Mengel, A., Porksen, N., Bak, J., Moller, N., Richelsen, B., Alberti, K.G., Butler, P.C. and Orskov, H. (1994) Augmented effect of shortterm pulsatile versus continuous insulin delivery on lipid metabolism but similar effect on whole-body glucose metabolism in obese subjects. Metab. Clin. Exp. 43, 842-846.
    • (1994) Metab. Clin. Exp. , vol.43 , pp. 842-846
    • Schmitz, O.1    Pedersen, S.B.2    Mengel, A.3    Porksen, N.4    Bak, J.5    Moller, N.6    Richelsen, B.7    Alberti, K.G.8    Butler, P.C.9    Orskov, H.10
  • 153
    • 0022497629 scopus 로고
    • Efficacy of pulsatile versus continuous insulin administration on hepatic glucose production and glucose utilization in type I diabetic humans
    • [153] Bratusch-Marrain, P.R., Komjati, M. and Waldhausl, W.K. (1986) Efficacy of pulsatile versus continuous insulin administration on hepatic glucose production and glucose utilization in type I diabetic humans. Diabetes 35, 922-926.
    • (1986) Diabetes , vol.35 , pp. 922-926
    • Bratusch-Marrain, P.R.1    Komjati, M.2    Waldhausl, W.K.3
  • 154
    • 0020791738 scopus 로고
    • Pulsatile insulin has greater hypoglycemic effect than continuous delivery
    • [154] Matthews, D.R., Naylor, B.A., Jones, R.G., Ward, G.M. and Turner, R.C. (1983) Pulsatile insulin has greater hypoglycemic effect than continuous delivery. Diabetes 32, 617-621.
    • (1983) Diabetes , vol.32 , pp. 617-621
    • Matthews, D.R.1    Naylor, B.A.2    Jones, R.G.3    Ward, G.M.4    Turner, R.C.5
  • 155
    • 0027403383 scopus 로고
    • Decrease in the hepatic clearance of hepatocyte growth factor in carbon tetrachloride-intoxicated rats
    • [155] Liu, K.X., Kato, Y., Yamazaki, M., Higuchi, O., Nakamura, T. and Sugiyama, Y. (1993) Decrease in the hepatic clearance of hepatocyte growth factor in carbon tetrachloride-intoxicated rats. Hepatology 17, 651-660.
    • (1993) Hepatology , vol.17 , pp. 651-660
    • Liu, K.X.1    Kato, Y.2    Yamazaki, M.3    Higuchi, O.4    Nakamura, T.5    Sugiyama, Y.6
  • 156
    • 0028384750 scopus 로고
    • "Carobohydrate handles" as natural resources in drug delivery
    • [156] Palomino, E. (1994) "Carobohydrate handles" as natural resources in drug delivery. Adv. Drug Deliv. Rev. 13, 311-323.
    • (1994) Adv. Drug Deliv. Rev. , vol.13 , pp. 311-323
    • Palomino, E.1
  • 157
    • 0011946124 scopus 로고    scopus 로고
    • Tabular lexicon of cytokine structure and function
    • B.A. Chabner and D. Longo (Eds.), Lippincott-Raven Publ., Philadelphia
    • [157] Casciari, J., Sato, H., Durum, S.K., Fiege, J. and Weinstein, J.N. (1996) Tabular lexicon of cytokine structure and function. In: B.A. Chabner and D. Longo (Eds.), Cancer Chemotherapy: Principles and Practice. Lippincott-Raven Publ., Philadelphia, pp. 785-808.
    • (1996) Cancer Chemotherapy: Principles and Practice , pp. 785-808
    • Casciari, J.1    Sato, H.2    Durum, S.K.3    Fiege, J.4    Weinstein, J.N.5
  • 159
    • 0028969961 scopus 로고
    • Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction
    • [159] French, A.R., Tadaki, D.K., Niyogi, S.K. and Lauffenburger, D.A. (1995) Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction. J. Biol. Chem. 270, 4334-4340.
    • (1995) J. Biol. Chem. , vol.270 , pp. 4334-4340
    • French, A.R.1    Tadaki, D.K.2    Niyogi, S.K.3    Lauffenburger, D.A.4
  • 160
    • 0023091262 scopus 로고
    • Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region
    • [160] Davis, C.G., Goldstein, J.L., Sudhof, T.C., Anderson, R.G., Russell, D.W. and Brown, M.S. (1987) Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. Nature 326, 760-765.
    • (1987) Nature , vol.326 , pp. 760-765
    • Davis, C.G.1    Goldstein, J.L.2    Sudhof, T.C.3    Anderson, R.G.4    Russell, D.W.5    Brown, M.S.6
  • 161
    • 0028914182 scopus 로고
    • A regulatory role for ARF6 in receptor-mediated endocytosis
    • [161] D'Souza-Schorey, C., Li, G., Colombo, M.I. and Stahl, P.D. (1995) A regulatory role for ARF6 in receptor-mediated endocytosis. Science 267, 1175-1178.
    • (1995) Science , vol.267 , pp. 1175-1178
    • D'Souza-Schorey, C.1    Li, G.2    Colombo, M.I.3    Stahl, P.D.4
  • 162
    • 0028224965 scopus 로고
    • Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions
    • [162] French, A.R., Sudlow, G.P., Wiley, S. and Lauffenburger, D.A. (1994) Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions. J. Biol. Chem. 269, 15749-15755.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15749-15755
    • French, A.R.1    Sudlow, G.P.2    Wiley, S.3    Lauffenburger, D.A.4
  • 163
    • 0028308384 scopus 로고
    • Receptor extracellular domains may contain trafficking information. Studies of the 300-kDa mannose 6-phosphate receptor
    • [163] Dintzis, S.M., Velculescu, V.E. and Pfeffers, S.R. (1994) Receptor extracellular domains may contain trafficking information. Studies of the 300-kDa mannose 6-phosphate receptor. J. Biol. Chem. 269, 12159-12166.
    • (1994) J. Biol. Chem. , vol.269 , pp. 12159-12166
    • Dintzis, S.M.1    Velculescu, V.E.2    Pfeffers, S.R.3
  • 164
    • 0028223310 scopus 로고
    • Gene transfer in vivo: Sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake
    • [164] Perales, J.C., Ferkol, T., Beegen, H., Ratnoff, O.D. and Hanson, R.W. (1994) Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake. Proc. Natl. Acad. Sci. U.S.A. 91, 4086-4090.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 4086-4090
    • Perales, J.C.1    Ferkol, T.2    Beegen, H.3    Ratnoff, O.D.4    Hanson, R.W.5
  • 165
    • 0028168773 scopus 로고
    • Galactosylated histone-mediated gene transfer and expression
    • [165] Chen, J., Stickles, R.J. and Daichendt, K.A. (1994) Galactosylated histone-mediated gene transfer and expression. Hum. Gene Ther. 5, 429-435.
    • (1994) Hum. Gene Ther. , vol.5 , pp. 429-435
    • Chen, J.1    Stickles, R.J.2    Daichendt, K.A.3
  • 167
    • 0026651984 scopus 로고
    • Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides
    • [167] Citro, G., Perrotti, D., Cucco, C., D'Agnano, I., Sacchi, A., Zupi, G. and Calabretta, B. (1992) Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides. Proc. Natl. Acad. Sci. U.S.A. 89, 7031-7035.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 7031-7035
    • Citro, G.1    Perrotti, D.2    Cucco, C.3    D'Agnano, I.4    Sacchi, A.5    Zupi, G.6    Calabretta, B.7
  • 169
    • 0025297898 scopus 로고
    • Receptor-mediated endocytosis of transferrin-polycation conjugates: An efficient way to introduce DNA into hematopoietic cells
    • [169] Zenke, M., Steinlein, P., Wagner, E., Cotten, M., Beug, H. and Birnstiel, M.L. (1990) Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells. Proc. Natl. Acad. Sci. U.S.A. 87, 3655-3659.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 3655-3659
    • Zenke, M.1    Steinlein, P.2    Wagner, E.3    Cotten, M.4    Beug, H.5    Birnstiel, M.L.6
  • 170
    • 0027233696 scopus 로고
    • Fate of DNA targeted to the liver by asialoglycoprotein receptor-mediated endocytosis in vivo. Prolonged persistence in cytoplasmic vesicles after partial hepatectomy
    • [170] Chowdhury, N.R., Wu, C.H., Wu, G.Y., Yerneni, P.C., Bommineni, V.R. and Chowdhury, J.R. (1993) Fate of DNA targeted to the liver by asialoglycoprotein receptor-mediated endocytosis in vivo. Prolonged persistence in cytoplasmic vesicles after partial hepatectomy. J. Biol. Chem. 268, 11265-11271.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11265-11271
    • Chowdhury, N.R.1    Wu, C.H.2    Wu, G.Y.3    Yerneni, P.C.4    Bommineni, V.R.5    Chowdhury, J.R.6
  • 171
    • 0027078363 scopus 로고
    • Targeted delivery of antisense oligonucleotides by molecular conjugates
    • [171] Bunnell, B.A., Askari, F.K. and Wilson, J.M. (1992) Targeted delivery of antisense oligonucleotides by molecular conjugates. Somat. Cell. Mol. Genet. 18, 559-569.
    • (1992) Somat. Cell. Mol. Genet. , vol.18 , pp. 559-569
    • Bunnell, B.A.1    Askari, F.K.2    Wilson, J.M.3
  • 172
    • 0028172330 scopus 로고
    • Effect of rate of intracellular transport and diacytosis on cytotoxicity of hybrid toxins. Study with hybrids using hepatic asialoglycoprotein receptor-mediated endocytosis
    • [172] Chang, T.M., Hossain, A. and Chang, C.H. (1994) Effect of rate of intracellular transport and diacytosis on cytotoxicity of hybrid toxins. Study with hybrids using hepatic asialoglycoprotein receptor-mediated endocytosis. Biochim. Biophys. Acta 1224, 77-88.
    • (1994) Biochim. Biophys. Acta , vol.1224 , pp. 77-88
    • Chang, T.M.1    Hossain, A.2    Chang, C.H.3
  • 173
    • 0027413188 scopus 로고
    • Receptor-mediated transport of oligodeoxynucleotides into hepatic cells
    • [173] Reinis, M., Darnkova, M. and Koree, E. (1993) Receptor-mediated transport of oligodeoxynucleotides into hepatic cells. J. Virol. Methods 42, 99-105.
    • (1993) J. Virol. Methods , vol.42 , pp. 99-105
    • Reinis, M.1    Darnkova, M.2    Koree, E.3
  • 174
    • 0027133660 scopus 로고
    • Hepatic gene therapy: Efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex
    • [174] Cristiano, R.J., Smith, L.C., Kay, M.A., Brinkley, B.R. and Woo, S.L. (1993) Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex. Proc. Natl. Acad. Sci. U.S.A. 90, 11548-11552.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 11548-11552
    • Cristiano, R.J.1    Smith, L.C.2    Kay, M.A.3    Brinkley, B.R.4    Woo, S.L.5
  • 175
    • 0028085720 scopus 로고
    • Cellular cytoplasmic delivery of a polypeptide toxin by reconstituted influenza virus envelopes (virosomes)
    • [175] Bron, R., Ortiz, A. and Wilschut, J. (1994) Cellular cytoplasmic delivery of a polypeptide toxin by reconstituted influenza virus envelopes (virosomes). Biochemistry 33, 9110-9117.
    • (1994) Biochemistry , vol.33 , pp. 9110-9117
    • Bron, R.1    Ortiz, A.2    Wilschut, J.3
  • 176
    • 0026328791 scopus 로고
    • Diphtheria toxin receptor-binding domain substitution with interleukin 6: Genetic construction and interleukin 6 receptor-specific action of a diphtheria toxin-related interleukin 6 fusion protein
    • [176] Jean, L.F. and Murphy, J.R. (1991) Diphtheria toxin receptor-binding domain substitution with interleukin 6: genetic construction and interleukin 6 receptor-specific action of a diphtheria toxin-related interleukin 6 fusion protein. Prot. Eng. 4, 989-994.
    • (1991) Prot. Eng. , vol.4 , pp. 989-994
    • Jean, L.F.1    Murphy, J.R.2
  • 177
    • 0028315953 scopus 로고
    • Enhanced intracellular delivery of doxorubicin by scavenger receptor-mediated endocytosis for preferential killing of histiocytic lymphoma cells in culture
    • [177] Basu, S., Mukhopadhyay, B., Basu, S.K. and Mukhopadhyay, A. (1994) Enhanced intracellular delivery of doxorubicin by scavenger receptor-mediated endocytosis for preferential killing of histiocytic lymphoma cells in culture. FEBS Lett. 342, 249-254.
    • (1994) FEBS Lett. , vol.342 , pp. 249-254
    • Basu, S.1    Mukhopadhyay, B.2    Basu, S.K.3    Mukhopadhyay, A.4
  • 178
    • 0025109712 scopus 로고
    • Enhanced intracellular delivery of methotrexate by a receptor-mediated process
    • [178] Mukhopadhyay, A. and Basu, S.K. (1990) Enhanced intracellular delivery of methotrexate by a receptor-mediated process. Biotechnol. App. Biochem. 12, 529-536.
    • (1990) Biotechnol. App. Biochem. , vol.12 , pp. 529-536
    • Mukhopadhyay, A.1    Basu, S.K.2
  • 179
    • 0027281928 scopus 로고
    • Low density lipoprotein for cytotoxic drug targeting: Improved activity of elliptinium derivative against B16 melanoma in mice
    • [179] Samadi-Baboli, M., Favre, G., Canal, P. and Soula, G. (1993) Low density lipoprotein for cytotoxic drug targeting: improved activity of elliptinium derivative against B16 melanoma in mice. Br. J. Cancer 68, 319-326.
    • (1993) Br. J. Cancer , vol.68 , pp. 319-326
    • Samadi-Baboli, M.1    Favre, G.2    Canal, P.3    Soula, G.4
  • 181
    • 0027185699 scopus 로고
    • Synthesis and pharmacokinetics of a new liver-specific carrier, glycosylated carboxymethyl-dextran, and its application to drug targeting
    • [181] Nishikawa, M., Kamijo, A., Fujita, T., Takakura, Y., Sezaki, H. and Hashida, M. (1993) Synthesis and pharmacokinetics of a new liver-specific carrier, glycosylated carboxymethyl-dextran, and its application to drug targeting. Pharm. Res. 10, 1253-1261.
    • (1993) Pharm. Res. , vol.10 , pp. 1253-1261
    • Nishikawa, M.1    Kamijo, A.2    Fujita, T.3    Takakura, Y.4    Sezaki, H.5    Hashida, M.6
  • 182
    • 0025605531 scopus 로고
    • Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro
    • [182] Molema, G., Jansen, R.W., Pauwels, R., de Clercq, E. and Meijer, D.K. (1990) Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro. Biochem. Pharmacol. 40, 2603-2610.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 2603-2610
    • Molema, G.1    Jansen, R.W.2    Pauwels, R.3    De Clercq, E.4    Meijer, D.K.5
  • 184
    • 0028297535 scopus 로고
    • Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism
    • [184] Takakura, Y., Masuda, S., Tokuda, H., Nishikawa, M. and Hashida, M. (1994) Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism. Biochem. Pharmacol. 47, 853-858.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 853-858
    • Takakura, Y.1    Masuda, S.2    Tokuda, H.3    Nishikawa, M.4    Hashida, M.5
  • 186
    • 0027166291 scopus 로고
    • Low molecular weight proteins as carriers for renal drug targeting: Naproxen coupled to lysozyme via the spacer L-lactic acid
    • [186] Franssen, E.J., Moolenaar, F., de Zeeuw, D. and Meijer, D.K. (1993) Low molecular weight proteins as carriers for renal drug targeting: naproxen coupled to lysozyme via the spacer L-lactic acid. Pharm. Res. 10, 963-969.
    • (1993) Pharm. Res. , vol.10 , pp. 963-969
    • Franssen, E.J.1    Moolenaar, F.2    De Zeeuw, D.3    Meijer, D.K.4
  • 187
    • 0025569428 scopus 로고
    • Identification and partial characterization of receptor binding sites for HGF on rat hepatocytes
    • [187] Zarnegar, R., DeFrances, M.C., Oliver, L. and Michalopoulos, G. (1990) Identification and partial characterization of receptor binding sites for HGF on rat hepatocytes. Biochem. Biophys. Res. Commun. 173, 1179-85.
    • (1990) Biochem. Biophys. Res. Commun. , vol.173 , pp. 1179-1185
    • Zarnegar, R.1    DeFrances, M.C.2    Oliver, L.3    Michalopoulos, G.4


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