메뉴 건너뛰기




Volumn 4, Issue 6, 2003, Pages 701-709

Polymer-protein and polymer-drug conjugates in cancer therapy

Author keywords

N (2 hydroxypropylmethacrylamide); PEGylation; Polyethyleneglycol (PEG); Polymer therapeutics; Tumor targeting

Indexed keywords

ALPHA FETOPROTEIN; AMINOELLIPTICINE; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; AP 5280; ASPARAGINASE MACROGOL; ASPARAGINE; CARBAMIC ACID; CISPLATIN; CT 2106; CYTOTOXIC AGENT; FCE 28068; FCE 28069; FUMAGILLOL CHLOROACETYLCARBAMATE; GALACTOSAMINE; GELDANAMYCIN; GRANULOCYTE COLONY STIMULATING FACTOR; IODINATED POPPYSEED OIL; MACROGOL; MACROGOL CAMPTOTHECIN; MYELIN ASSOCIATED GLYCOPROTEIN CAMPTOTHECIN; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER GALACTOSE DOXORUBICIN; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER GLUCOSE DOXORUBICIN; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER PACLITAXEL; PACLITAXEL POLIGLUMEX; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PK 1; PK 2; PNU 166148; PNU 166945; POLYGLUTAMIC ACID CAMPTOTHECIN; POLYGLUTAMIC ACID PACLITAXEL; POLYMER PLATINATE; POLYMER PROTEIN CONJUGATE; PROTHECAN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; WORTMANNIN; ZINOSTATIN; ZINOSTATIN MALEIC ACID STYRENE COPOLYMER;

EID: 0041664881     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (87)

References (71)
  • 1
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • note
    • Duncan R: The dawning era of polymer therapeutics. Nat Rev Drug Disc (2003) 2(5):347-360. A thorough review on the current status of polymer therapeutics.
    • (2003) Nat Rev Drug Disc , vol.2 , Issue.5 , pp. 347-360
    • Duncan, R.1
  • 2
    • 0001073783 scopus 로고    scopus 로고
    • Pendent drugs, release from polymers
    • Mathiowitz E (Ed), John Wiley & Sons, NY, USA
    • Brocchini S, Duncan R: Pendent drugs, release from polymers. Encyclopedia of Controlled Drug Delivery. Mathiowitz E (Ed), John Wiley & Sons, NY, USA (1999):786-816.
    • (1999) Encyclopedia of Controlled Drug Delivery , pp. 785-816
    • Brocchini, S.1    Duncan, R.2
  • 3
    • 0344378602 scopus 로고    scopus 로고
    • Polymer-anticancer drug conjugates
    • Budman D, Calvert H, Rowinsky E (Eds), Lippincott Williams & Wilkins, Baltimore, MD, USA; in press; note
    • Duncan R: Polymer-anticancer drug conjugates. In: Handbook of Anticancer Drug Development. Budman D, Calvert H, Rowinsky E (Eds), Lippincott Williams & Wilkins, Baltimore, MD, USA (2003) in press. Excellent review describing the current status of polymer-drug conjugates in clinical development and the issues of preclinical to clinical transfer.
    • (2003) Handbook of Anticancer Drug Development
    • Duncan, R.1
  • 4
    • 0037362655 scopus 로고    scopus 로고
    • Effect of pegylation on pharmaceuticals
    • Harris JM, Chess RB: Effect of pegylation on pharmaceuticals. Nat Rev Drug Disc (2003) 2(3):214-221.
    • (2003) Nat Rev Drug Disc , vol.2 , Issue.3 , pp. 214-221
    • Harris, J.M.1    Chess, R.B.2
  • 5
    • 0037124473 scopus 로고    scopus 로고
    • Introduction and overview of peptide and protein pegylation
    • note
    • Veronese FM, Harris JM: Introduction and overview of peptide and protein pegylation. Adv Drug Deliv Rev (2002) 54(4):453-456. This issue is dedicated to the topic of PEG-protein conjugates and their therapeutic applications.
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.4 , pp. 453-456
    • Veronese, F.M.1    Harris, J.M.2
  • 6
    • 0024839642 scopus 로고
    • Tumoritropic and lymphotropic principles of macromolecular drugs
    • note
    • Maeda H, Matsumura Y: Tumoritropic and lymphotropic principles of macromolecular drugs. Crit Rev Ther Drug Carrier Syst (1989) 6(3):193-210. One of the initial reviews introducing the EPR theory as an explanation for the prolonged therapeutic effect of polymer-drug conjugates.
    • (1989) Crit Rev Ther Drug Carrier Syst , vol.6 , Issue.3 , pp. 193-210
    • Maeda, H.1    Matsumura, Y.2
  • 7
    • 0041181628 scopus 로고    scopus 로고
    • HPMA copolymer-anticancer drug conjugates: Design, activity and mechanism of action
    • note
    • Kopecek J, Kopeckova P, Minko T, Lu Z: HPMA copolymer-anticancer drug conjugates: Design, activity and mechanism of action. Eur J Pharm Biopharm (2000) 50(1):61-81. Review describing the design and development of HPMA co-polymer conjugates.
    • (2000) Eur J Pharm Biopharm , vol.50 , Issue.1 , pp. 61-81
    • Kopecek, J.1    Kopeckova, P.2    Minko, T.3    Lu, Z.4
  • 8
    • 0042999388 scopus 로고    scopus 로고
    • PEG-aspargase: A review of clinical studies
    • in press
    • Graham ML: PEG-aspargase: A review of clinical studies. Adv Drug Deliv Rev (2003): in press.
    • (2003) Adv Drug Deliv Rev
    • Graham, M.L.1
  • 10
    • 0037124508 scopus 로고    scopus 로고
    • Use of PEG-interferonα-2a (40KD) (Pegasys) for the treatment of hepatitis C
    • Reddy KR, Modi MW, Pedder S: Use of PEG-interferonα-2a (40KD) (Pegasys) for the treatment of hepatitis C. Adv Drug Deliv Rev (2002) 54(4):571-586.
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.4 , pp. 571-586
    • Reddy, K.R.1    Modi, M.W.2    Pedder, S.3
  • 11
    • 0037124398 scopus 로고    scopus 로고
    • Structural and biological characterization of pegylated recombinant interferon α-2b and its therapeutic implications
    • Wang Y-S, Youngster S, Grace M, Bausch J, Bordens R, Wyss DF: Structural and biological characterization of pegylated recombinant interferon α-2b and its therapeutic implications. Adv Drug Deliv Rev (2002) 54(4):547-570.
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.4 , pp. 547-570
    • Wang, Y.-S.1    Youngster, S.2    Grace, M.3    Bausch, J.4    Bordens, R.5    Wyss, D.F.6
  • 12
    • 0037124547 scopus 로고    scopus 로고
    • Polyethylene glycol-superoxide dismutase, a conjugate in search of exploitation
    • Veronese FM, Caliceti P, Schiavon O, Sergi M: Polyethylene glycol-superoxide dismutase, a conjugate in search of exploitation. Adv Drug Deliv Rev (2002) 54(4):587-606.
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.4 , pp. 587-606
    • Veronese, F.M.1    Caliceti, P.2    Schiavon, O.3    Sergi, M.4
  • 13
    • 0035964623 scopus 로고    scopus 로고
    • PDEPT: Polymer-directed enzyme prodrug therapy. I. HPMA copolymer-cathepsin B and PK1 as a model combination
    • Satchi R, Connors TA, Duncan R: PDEPT: Polymer-directed enzyme prodrug therapy. I. HPMA copolymer-cathepsin B and PK1 as a model combination. Br J Cancer (2001) 85(7):1070-1076.
    • (2001) Br J Cancer , vol.85 , Issue.7 , pp. 1070-1076
    • Satchi, R.1    Connors, T.A.2    Duncan, R.3
  • 14
    • 0038793489 scopus 로고    scopus 로고
    • PDEPT: Polymer directed enzyme prodrug therapy II. HPMA copolymer-β-lactamase and HPMA-C-Dox as a model combination
    • in press
    • Satchi-Fainaro R, Hailu H, Davies JW, Summerford C, Duncan R: PDEPT: Polymer directed enzyme prodrug therapy II. HPMA copolymer-β-lactamase and HPMA-C-Dox as a model combination. Bioconjug Chem (2003): in press.
    • (2003) Bioconjug Chem
    • Satchi-Fainaro, R.1    Hailu, H.2    Davies, J.W.3    Summerford, C.4    Duncan, R.5
  • 15
    • 0037124546 scopus 로고    scopus 로고
    • The origin of pegnology
    • note
    • Davis FF: The origin of pegnology. Adv Drug Deliv Rev (2002) 54(4):457-458. Commentary on pegylation from one of the pioneers in the field.
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.4 , pp. 457-458
    • Davis, F.F.1
  • 18
    • 0037124507 scopus 로고    scopus 로고
    • Enzymatic procedure for site-specific pegylation of proteins
    • Sato H: Enzymatic procedure for site-specific pegylation of proteins. Adv Drug Deliv Rev (2002) 54(4):487-504.
    • (2002) Adv Drug Deliv Rev , vol.54 , Issue.4 , pp. 487-504
    • Sato, H.1
  • 19
    • 0019809191 scopus 로고
    • Pharmacology of Escherichia coli L-asparaginase polyethylene glycol adduct
    • Park YK, Abuchowski A, Davis S, Davis F: Pharmacology of Escherichia coli L-asparaginase polyethylene glycol adduct. Anticancer Res (1981) 1(6):373-376.
    • (1981) Anticancer Res , vol.1 , Issue.6 , pp. 373-376
    • Park, Y.K.1    Abuchowski, A.2    Davis, S.3    Davis, F.4
  • 20
    • 50549191387 scopus 로고
    • Tumor inhibition effect of L-asparaginase from Escherichia coli
    • Mashburn LT, Wriston JC: Tumor inhibition effect of L-asparaginase from Escherichia coli. Arch Biochem Biophys (1964) 105:450-452.
    • (1964) Arch Biochem Biophys , vol.105 , pp. 450-452
    • Mashburn, L.T.1    Wriston, J.C.2
  • 23
    • 0011829793 scopus 로고
    • A phase II study of polyethylene glycol (PEG) conjugated L-asparaginase in patients with refractory acute leukemia
    • Kurtzberg J, Moore JO, Scudiery D, Franklin A: A phase II study of polyethylene glycol (PEG) conjugated L-asparaginase in patients with refractory acute leukemia. Proc Am Assoc Cancer Res (1988) 29:213.
    • (1988) Proc Am Assoc Cancer Res , vol.29 , pp. 213
    • Kurtzberg, J.1    Moore, J.O.2    Scudiery, D.3    Franklin, A.4
  • 24
    • 0000973839 scopus 로고
    • Antibodies to asparaginase alter pharmacokinetics and decrease enzyme activity in patients on asparaginase therapy
    • Grebanier D, Chen A, Franklin A et al: Antibodies to asparaginase alter pharmacokinetics and decrease enzyme activity in patients on asparaginase therapy. Proc Am Assoc Cancer Res (1993) 34:304.
    • (1993) Proc Am Assoc Cancer Res , vol.34 , pp. 304
    • Grebanier, D.1    Chen, A.2    Franklin, A.3
  • 26
    • 0035990090 scopus 로고    scopus 로고
    • Comparable efficacy and safety profiles of a once-per-cycle pegfilgrastim and daily injection filgastrim in chemotherapy-induced neutropenia: A multicentre dose-finding study in women with breast cancer
    • Holmes FA, Jones SE, O'Shaughnessey J, Vukelja S, George T, Savin M, Richards D, Glaspy J, Meza L, Cohen G, Dhami M et al: Comparable efficacy and safety profiles of a once-per-cycle pegfilgrastim and daily injection filgastrim in chemotherapy-induced neutropenia: A multicentre dose-finding study in women with breast cancer. Ann Oncol (2002) 13(6):903-906.
    • (2002) Ann Oncol , vol.13 , Issue.6 , pp. 903-906
    • Holmes, F.A.1    Jones, S.E.2    O'Shaughnessey, J.3    Vukelja, S.4    George, T.5    Savin, M.6    Richards, D.7    Glaspy, J.8    Meza, L.9    Cohen, G.10    Dhami, M.11
  • 27
    • 6844251615 scopus 로고    scopus 로고
    • A randomised, double-blind placebo-controlled phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia
    • Heil G, Hoelzer D, Sanz MA, Lechner K, Liu Yin JA, Papa G, Noens L, Szer J, Ganser A, O'Brien C, Matcham J et al: A randomised, double-blind placebo-controlled phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia. Blood (1997) 90(12):4710-4718.
    • (1997) Blood , vol.90 , Issue.12 , pp. 4710-4718
    • Heil, G.1    Hoelzer, D.2    Sanz, M.A.3    Lechner, K.4    Liu Yin, J.A.5    Papa, G.6    Noens, L.7    Szer, J.8    Ganser, A.9    O'Brien, C.10    Matcham, J.11
  • 29
    • 0001064634 scopus 로고    scopus 로고
    • Metamorphosis of neocarzinostatin to SMANCS: Chemistry, biology, pharmacology, and clinical effect of the first prototype anticancer polymer therapeutic
    • Maeda H, Edo K, Ishida N (Eds), Springer Verlag, Berlin, Germany
    • Maeda H, Konno T: Metamorphosis of neocarzinostatin to SMANCS: Chemistry, biology, pharmacology, and clinical effect of the first prototype anticancer polymer therapeutic. In: Neocarzinostatin: The Past, Present, and Future of an Anticancer Drug. Maeda H, Edo K, Ishida N (Eds), Springer Verlag, Berlin, Germany (1997):227-267.
    • (1997) Neocarzinostatin: The Past, Present, and Future of an Anticancer Drug , pp. 227-267
    • Maeda, H.1    Konno, T.2
  • 30
    • 0035291191 scopus 로고    scopus 로고
    • SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy
    • Maeda H: SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy. Adv Drug Deliv Rev (2001) 46(1-3):169-185.
    • (2001) Adv Drug Deliv Rev , vol.46 , Issue.1-3 , pp. 169-185
    • Maeda, H.1
  • 31
    • 0002649813 scopus 로고
    • Targeting chemotherapy of hepatocellular carcinoma: Arterial administration of SMANCS/lipiodol
    • Okada K, Ishak KG (Eds), Springer-Verlag, New York, NY, USA
    • Konno T, Maeda H: Targeting chemotherapy of hepatocellular carcinoma: Arterial administration of SMANCS/lipiodol. In: Neoplasms of the Liver. Okada K, Ishak KG (Eds), Springer-Verlag, New York, NY, USA (1987):343-352.
    • (1987) Neoplasms of the Liver , pp. 343-352
    • Konno, T.1    Maeda, H.2
  • 32
    • 0016622773 scopus 로고
    • Structure and properties of pharmacologically active polymers
    • note
    • Ringsdorf H: Structure and properties of pharmacologically active polymers. J Polymer Sci Polymer Symposium (1975) 51:135-153. Landmark publication introducing the concept of polymer-drug conjugates as therapeutics.
    • (1975) J Polymer Sci Polymer Symposium , vol.51 , pp. 135-153
    • Ringsdorf, H.1
  • 33
    • 0026757191 scopus 로고
    • Drug-polymer conjugates: Potential for improved chemotherapy
    • Ducan R: Drug-polymer conjugates: Potential for improved chemotherapy. Anticancer Drugs (1992) 3(3):175-210.
    • (1992) Anticancer Drugs , vol.3 , Issue.3 , pp. 175-210
    • Ducan, R.1
  • 34
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapies in cancer chemotherapy: Mechanism of tumouritropic accumulation of proteins and the antitumor agent SMANCS
    • Matsumura Y, Maeda H: A new concept for macromolecular therapies in cancer chemotherapy: Mechanism of tumouritropic accumulation of proteins and the antitumor agent SMANCS. Cancer Res (1986) 46(12 Pt 1):6387-6292.
    • (1986) Cancer Res , vol.46 , Issue.PART 1 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 35
    • 0000859981 scopus 로고
    • Polymers containing enzymatically degradable bonds. 7. Design of oligopeptide side chains in poly [N-(2-hydroxypropyl)methacrylamide] copolymers to promote efficient degradation by lysosomal enzymes
    • note
    • Duncan R, Cable HC, Lloyd JB, Rejmanaova P, Kopecek J: Polymers containing enzymatically degradable bonds. 7. Design of oligopeptide side chains in poly [N-(2-hydroxypropyl)methacrylamide] copolymers to promote efficient degradation by lysosomal enzymes. Macromol Chem (1984) 184:1997-2008. This publication presents the smart design of enzymatically (cathepsin B) cleavable bonds between polymer and drug.
    • (1984) Macromol Chem , vol.184 , pp. 1997-2008
    • Duncan, R.1    Cable, H.C.2    Lloyd, J.B.3    Rejmanaova, P.4    Kopecek, J.5
  • 36
    • 0038298883 scopus 로고    scopus 로고
    • Metabolism of poly-L-glutamic acid (PG) paclitaxel (CT-2103); Proteolysis by lysosomal cathepsin B and identification of intermediate metabolites
    • Abs 2067
    • Shaffer SA, Lee CB, Nudelman E, Kumar A, Coon M, Stone I, De Vries P, Singer JW: Metabolism of poly-L-glutamic acid (PG) paclitaxel (CT-2103); Proteolysis by lysosomal cathepsin B and identification of intermediate metabolites. Proc Am Assoc Cancer Res (2002) 43:Abs 2067.
    • (2002) Proc Am Assoc Cancer Res , vol.43
    • Shaffer, S.A.1    Lee, C.B.2    Nudelman, E.3    Kumar, A.4    Coon, M.5    Stone, I.6    De Vries, P.7    Singer, J.W.8
  • 37
    • 0032959549 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: First member of a new class of chemotherapeutic agents - Drug-polymer conjugates
    • note
    • Vasey PA, Kaye SB, Morrison, R, Twelves C, Wilson P, Duncan R, Thomson AH, Murray LS, Hilditch TE, Murray T, Burtles S et al: Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: First member of a new class of chemotherapeutic agents - Drug-polymer conjugates. Clin Cancer Res (1999) 5(1):83-94. First phase I trial describing synthetic-polymer anticancer conjugate.
    • (1999) Clin Cancer Res , vol.5 , Issue.1 , pp. 83-94
    • Vasey, P.A.1    Kaye, S.B.2    Morrison, R.3    Twelves, C.4    Wilson, P.5    Duncan, R.6    Thomson, A.H.7    Murray, L.S.8    Hilditch, T.E.9    Murray, T.10    Burtles, S.11
  • 39
    • 0022635574 scopus 로고
    • Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendant galactosamine residues after intravenous administration to rats
    • note
    • Duncan R, Seymour LC, Scarlett L, Lloyd JB, Rejmanova P, Kopecek J: Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendant galactosamine residues after intravenous administration to rats. Biochem Biophy Acta (1986) 880(1):62-71. This paper describes an HPMA co-polymer-doxorubicin conjugate with pendant galactosamine demonstrating significant hepatocyte targeting.
    • (1986) Biochem Biophy Acta , vol.880 , Issue.1 , pp. 62-71
    • Duncan, R.1    Seymour, L.C.2    Scarlett, L.3    Lloyd, J.B.4    Rejmanova, P.5    Kopecek, J.6
  • 40
    • 0025809808 scopus 로고
    • N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: Pharmacokinetics in DBA2 mice
    • Seymour LW, Ulbrich K, Wedge SR, Hume IC, Strohalm J, Duncan R: N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: Pharmacokinetics in DBA2 mice. Br J Cancer (1991) 63(6):859-866.
    • (1991) Br J Cancer , vol.63 , Issue.6 , pp. 859-866
    • Seymour, L.W.1    Ulbrich, K.2    Wedge, S.R.3    Hume, I.C.4    Strohalm, J.5    Duncan, R.6
  • 44
    • 0033152928 scopus 로고    scopus 로고
    • HPMA copolymer platinates as novel antitutmor agents: In vitro properties, pharmacokinetics and antitumor activity in vivo
    • Gianasi E, Wasil M, Evagorou EG, Keddle A, Wilso G, Duncan R: HPMA copolymer platinates as novel antitutmor agents: In vitro properties, pharmacokinetics and antitumor activity in vivo. Eur J Cancer (1999) 35(6):994-1002.
    • (1999) Eur J Cancer , vol.35 , Issue.6 , pp. 994-1002
    • Gianasi, E.1    Wasil, M.2    Evagorou, E.G.3    Keddle, A.4    Wilso, G.5    Duncan, R.6
  • 45
    • 0036875839 scopus 로고    scopus 로고
    • HPMA copolymers platinates containing dicarboxylato ligands. Preparations, characterisation and in vitro and in vivo evaluation
    • Gianasi E, Buckley RG, Latigo J, Wasil M, Duncan R: HPMA copolymers platinates containing dicarboxylato ligands. Preparations, characterisation and in vitro and in vivo evaluation. J Drug Targeting (2002) 10(7):549-556.
    • (2002) J Drug Targeting , vol.10 , Issue.7 , pp. 549-556
    • Gianasi, E.1    Buckley, R.G.2    Latigo, J.3    Wasil, M.4    Duncan, R.5
  • 46
    • 0032101105 scopus 로고    scopus 로고
    • Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate
    • note
    • Li C, Yu DF, Newma RA, Cabral F, Stephens LC, Hunter N, Milas L, Wallace S: Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate. Cancer Res (1998) 58(11):2404-2409. The first polymer conjugate based on the biodegradable carrier poly(L-glutamic acid) to later progress into clinical testing.
    • (1998) Cancer Res , vol.58 , Issue.11 , pp. 2404-2409
    • Li, C.1    Yu, D.F.2    Newma, R.A.3    Cabral, F.4    Stephens, L.C.5    Hunter, N.6    Milas, L.7    Wallace, S.8
  • 48
    • 0033927015 scopus 로고    scopus 로고
    • Tumor irradiation enhances the tumor-specific distribution of poly(L-glutamic acid)-conjugated paclitaxel and its antitumor efficacy
    • Li C, Ke S, Wu QP, Tansey W, Hunter N, Buchmiller LM, Milas L, Charnsagavej C, Wallace S: Tumor irradiation enhances the tumor-specific distribution of poly(L-glutamic acid)-conjugated paclitaxel and its antitumor efficacy. Clin Cancer Res (2001) 6(7):2829-2834.
    • (2000) Clin Cancer Res , vol.6 , Issue.7 , pp. 2829-2834
    • Li, C.1    Ke, S.2    Wu, Q.P.3    Tansey, W.4    Hunter, N.5    Buchmiller, L.M.6    Milas, L.7    Charnsangavej, C.8    Wallace, S.9
  • 49
    • 0035322799 scopus 로고    scopus 로고
    • New form of paclitaxel shows promise
    • Garfield D: New form of paclitaxel shows promise. Lancet Oncol (2001) 2:192.
    • (2001) Lancet Oncol , vol.2 , pp. 192
    • Garfield, D.1
  • 50
    • 0042999390 scopus 로고    scopus 로고
    • Preliminary report of a phase I study of combination chemotherapy using CT-2103 and carboplatin in patients with solid tumors
    • Abs 2161
    • Garzone PD, Mitchell P, Bolton MG, Nemunaitis J: Preliminary report of a phase I study of combination chemotherapy using CT-2103 and carboplatin in patients with solid tumors. Proc Am Soc Clin Oncol (2002) 21(2 Pt 2):Abs 2161.
    • (2002) Proc Am Soc Clin Oncol , vol.21 , Issue.PART 2
    • Garzone, P.D.1    Mitchell, P.2    Bolton, M.G.3    Nemunaitis, J.4
  • 52
    • 0042498680 scopus 로고    scopus 로고
    • Phase II study of CT-2103 in patients with colorectal cancer having recurrent disease after treatment with a 5-fluorouracil-containing regimen
    • Abs 2330
    • Schulz J, Burris HA, Redfern C, Mitchell P, Warner M, Bolton MG: Phase II study of CT-2103 in patients with colorectal cancer having recurrent disease after treatment with a 5-fluorouracil-containing regimen. Proc Am Soc Clin Oncol (2002) 21(2 Pt 2):Abs 2330
    • (2002) Proc Am Soc Clin Oncol , vol.21 , Issue.PART 2
    • Schulz, J.1    Burris, H.A.2    Redfern, C.3    Mitchell, P.4    Warner, M.5    Bolton, M.G.6
  • 54
    • 0041997878 scopus 로고    scopus 로고
    • Phase II study of first line chemotherapy using CT-2103 in patients with non-small cell lung cancer who are ≥ 70 years of age or who have PS = 2
    • Abs 2685
    • Harper H, Marsland T, Mitchell P, Infortuno J, Bolton MG: Phase II study of first line chemotherapy using CT-2103 in patients with non-small cell lung cnacer who are ≥ 70 years of age or who have PS = 2. Proc Am Soc Clin Oncol (2002) 21 (2 Pt 2):Abs 2685.
    • (2002) Proc Am Soc Clin Oncol , vol.21 , Issue.PART 2
    • Harper, H.1    Marsland, T.2    Mitchell, P.3    Infortuno, J.4    Bolton, M.G.5
  • 55
    • 0242388297 scopus 로고    scopus 로고
    • Optimisation of CT2106: A water soluble poly L-glutamic acid (PG)-camptothecin conjugate with enhanced in vivo antitumor efficacy
    • Abs 100
    • De Vries P, Bhatt R, Stone I, Klein P, Singer J: Optimisation of CT2106: A water soluble poly L-glutamic acid (PG)-camptothecin conjugate with enhanced in vivo antitumor efficacy. Proc AACR-NCI-EORC Int Conf (2001):Abs 100
    • (2001) Proc AACR-NCI-EORC Int Conf
    • De Vries, P.1    Bhatt, R.2    Stone, I.3    Klein, P.4    Singer, J.5
  • 59
    • 0029039418 scopus 로고
    • Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier
    • note
    • Seymour LW, Miyamoto Y, Maeda H, Brereton M, Strohalm J, Ulbrich K, Duncan R: Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier. Eur J Cancer (1995) 31A:766-770. The HPMA co-polymers with prolonged plasma circulation times (ie, MW > 40 KDa) demonstrated an MW-dependent accumulation in Sarconma 180 and B16F10 melanoma models, up to an MW of ∼ 750 KDa.
    • (1995) Eur J Cancer , vol.31 A , pp. 766-770
    • Seymour, L.W.1    Miyamoto, Y.2    Maeda, H.3    Brereton, M.4    Strohalm, J.5    Ulbrich, K.6    Duncan, R.7
  • 60
    • 0037080616 scopus 로고    scopus 로고
    • Pendent chain functionalised polyacetals that display pH-dependent degradation: A platform for the development of novel polymer therapeutics
    • Tomlison R, Heller J, Duncan R, Brocchini S: Pendent chain functionalised polyacetals that display pH-dependent degradation: A platform for the development of novel polymer therapeutics. Macromolecules (2002) 35:473-480.
    • (2002) Macromolecules , vol.35 , pp. 473-480
    • Tomlison, R.1    Heller, J.2    Duncan, R.3    Brocchini, S.4
  • 61
    • 0035818460 scopus 로고    scopus 로고
    • Dextrins as potential carriers for drug targeting: Tailored rates of dextrin degradation by introduction of pendant groups
    • Hreczuk-Hirst D, Chicco D, German L, Duncan R: Dextrins as potential carriers for drug targeting: Tailored rates of dextrin degradation by introduction of pendant groups. Int J Pharm (2001) 230(1-2):57-66.
    • (2001) Int J Pharm , vol.230 , Issue.1-2 , pp. 57-66
    • Hreczuk-Hirst, D.1    Chicco, D.2    German, L.3    Duncan, R.4
  • 62
    • 0033376651 scopus 로고    scopus 로고
    • Dendrimer-platinate: A novel approach to cancer chemotherapy
    • Malik N, Evagorou EG, Duncan R: Dendrimer-platinate: A novel approach to cancer chemotherapy. Anticancer Drugs (1999) 10(8):767-776.
    • (1999) Anticancer Drugs , vol.10 , Issue.8 , pp. 767-776
    • Malik, N.1    Evagorou, G.2    Duncan, R.3
  • 64
    • 0035816143 scopus 로고    scopus 로고
    • Polymer-drug conjugates, PDEPT and PELT: Basic principles for design and transfer from the laboratory to the clinic
    • Duncan R, Gac-Breton S, Keane R, Musila R, Sat YN, Satchi R, Searle F: Polymer-drug conjugates, PDEPT and PELT: Basic principles for design and transfer from the laboratory to the clinic. J Control Release (2001) 74(1-3):135-146.
    • (2001) J Control Release , vol.74 , Issue.1-3 , pp. 135-146
    • Duncan, R.1    Gac-Breton, S.2    Keane, R.3    Musila, R.4    Sat, Y.N.5    Satchi, R.6    Searle, F.7
  • 65
    • 0034814014 scopus 로고    scopus 로고
    • N-(2-hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis in vitro and preliminary in vivo evaluation
    • Searle F, Gac-Breton S, Keane R, Dimitrijevic S, Brocchini S, Sausville EA, Duncan R: N-(2-hydroxypropyl)methacrylamide copolymer-6-(3-aminopropyl)-ellipticine conjugates. Synthesis in vitro and preliminary in vivo evaluation. Bioconjug Chem (2001) 12(5):711-718.
    • (2001) Bioconjug Chem , vol.12 , Issue.5 , pp. 711-718
    • Searle, F.1    Gac-Breton, S.2    Keane, R.3    Dimitrijevic, S.4    Brocchini, S.5    Sausville, E.A.6    Duncan, R.7
  • 66
    • 0036176019 scopus 로고    scopus 로고
    • Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates
    • Kasuya Y, Lu ZR, Kopeckova P, Tabibi SE, Kopecek J: Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates. Pharm Res (2002) 19(2):115-123.
    • (2002) Pharm Res , vol.19 , Issue.2 , pp. 115-123
    • Kasuya, Y.1    Lu, Z.R.2    Kopeckova, P.3    Tabibi, S.E.4    Kopecek, J.5
  • 67
    • 0035816203 scopus 로고    scopus 로고
    • Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo
    • Varticovski L, Lu ZR, Mitchell K, De Aos I, Kopecek J: Water-soluble HPMA copolymer-wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo. J Control Release (2001) 74(1-3):275-281.
    • (2001) J Control Release , vol.74 , Issue.1-3 , pp. 275-281
    • Varticovski, L.1    Lu, Z.R.2    Mitchell, K.3    De Aos, I.4    Kopecek, J.5
  • 68
    • 0036781811 scopus 로고    scopus 로고
    • Ligand-targeted therapeutics in anticancer therapy
    • Allen TM: Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer (2002) 2(10):750-763.
    • (2002) Nat Rev Cancer , vol.2 , Issue.10 , pp. 750-763
    • Allen, T.M.1
  • 70
    • 0035253404 scopus 로고    scopus 로고
    • Drug-targeting strategies in cancer therapy
    • Huang PS, Oliff A: Drug-targeting strategies in cancer therapy. Curr Opin Genet Dev (2001) 11(1):104-110.
    • (2001) Curr Opin Genet Dev , vol.11 , Issue.1 , pp. 104-110
    • Huang, P.S.1    Oliff, A.2
  • 71
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel R, Folkman J. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer (2002) 2(10): 727-739.
    • (2002) Nat Rev Cancer , vol.2 , Issue.10 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.