Enzymatic procedure for site-specific pegylation of proteins

Advanced Drug Delivery Reviews

Volumn 54, Issue 4, 2002, Pages 487-504

  Sato, Haruya ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

Guinea pig liver; Interleukin 2; Microbial; Modification; Transglutaminase

Indexed keywords

CATALYSIS; PROTEINS; SUBSTRATES;

BIOACTIVITIES;

ENZYME KINETICS;

ALANYLGLUTAMINYLGLUTAMINYLISOLEUCYLVALYLMETHIONINE INTERLEUKIN 2; ALIPHATIC AMINE; CHIMERIC PROTEIN; MACROGOL DERIVATIVE; POLYETHYLENE GLYCOL 10; POLYETHYLENE GLYCOL 10 2 ALANYLGLUTAMINYLGLUTAMINYLISOLEUCYLVALYLMETHIONINE INTERLEUKIN 2 CONJUGATE; POLYETHYLENE GLYCOL 10 2 INTERLEUKIN 2 CONJUGATE; POLYETHYLENE GLYCOL 12 INTERLEUKIN 2 CONJUGATE; POLYETHYLENE GLYCOL 3; POLYETHYLENE GLYCOL 3 PROLYLLYSYLPROLYLGLUTAMINYLGLUTAMINYLPHENYLALANYLMETHIONINE INTERLEUKIN 2 CONJUGATE; POLYETHYLENE GLYCOL 3 TERT BUTYLOXYCARBONYL; POLYETHYLENE GLYCOL PROTEIN CONJUGATE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; RECOMBINANT INTERLEUKIN 12; UNCLASSIFIED DRUG;

ANALYTIC METHOD; AREA UNDER THE CURVE; CATALYSIS; DRUG CLEARANCE; DRUG CONJUGATION; DRUG HALF LIFE; DRUG SYNTHESIS; ENZYME MODIFICATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PEGYLATION; REVIEW; SEQUENCE ANALYSIS;

EID: 0037124507     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(02)00024-8     Document Type: Article

References (46)

1. Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol
2. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
3. Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase
4. Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates
5. Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity
6. Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner
7. Site-directed pegylation of recombinant interleukin-2 at its glycosylation site
8. Site-specific attachment of functionalized poly(ethylene glycol) to the amino terminus of proteins
9. The epsilon-(gamma-glutamyl)lysine crosslink and the catalytic role of transglutaminases
10. Transglutaminases
11. Transglutaminases
12. Structural features of glutamine substrates for human plasma factor XIIIa (activated blood coagulation factor XIII)
13. Structural features of glutamine substrates for transglutaminases. Role of extended interactions in the specificity of human plasma factor XIIIa and of the guinea pig liver enzyme
14. Factors that govern the specificity of transglutaminase-catalysed modification of proteins and peptides
15. Specificity of guinea pig liver transglutaminase for amine substrates
16. Selective modification by transglutaminase of a glutamine side chain in the hinge region of the histidine-388-glutamine mutant of yeast phosphoglycerate kinase
17. Selective labelling of melittin with a fluorescent dansylcadaverine probe using guinea-pig liver transglutaminase
18. Neoglycoproteins: In vitro introduction of glycosyl units at glutamines in beta-casein using transglutaminase
19. Identification of Gln726 in nidogen as the amine acceptor in transglutaminase-catalyzed cross-linking of laminin-nidogen complexes
20. Site-specific modification of interleukin-2 by the combined use of genetic engineering techniques and transglutaminase
21. Unique substrate specificities of two adjacent glutamine residues in EAQQIVM for transglutaminase: Identification and characterization of the reaction products by electrospray ionization tandem mass spectrometry
22. Transglutaminase-mediated dual and site-specific incorporation of poly(ethylene glycol) derivatives into a chimeric interleukin-2
23. Interleukin-2: Inception, impact, and implications
24. Transglutaminase amine substrates for photochemical labeling and cleavable cross-linking of proteins
25. Amino acid sequence of the factor XIIIa acceptor site in bovine plasma fibronectin
26. Three-dimensional structure of interleukin-2
27. Structure-activity studies of interleukin-2
28. High-level expression of human BSF-2/IL-6 cDNA in Escherichia coli using a new type of expression-preparation system
29. Characterization of disulfide bonds in recombinant proteins: Reduced human interleukin 2 in inclusion bodies and its oxidative refolding
30. Two adjacent N-terminal glutamines of BM-40 (osteonectin, SPARC) act as amine acceptor sites in transglutaminase C-catalyzed modification
31. A nonlinear least squares program based on differential equations, MULTI (RUNGE), for microcomputers
32. Biophysiology of glomerular filtration and proteinuria
33. Theoretical model for glomerular filtration of charged solutes
34. Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers
35. Purification and characterization of a novel transglutaminase derived from microorganisms
36. Primary structure of microbial transglutaminase from Streptoverticillium sp. strain s-8112
37. Further studies on the site-specific protein modification by microbial transglutaminase
38. Mechanism and basis for specificity of transglutaminase-catalyzed epsilon-(gamma-glutamyl) lysine bond formation
39. Specificity of guinea pig liver transglutaminase for amine substrates
40. Three-dimensional structure of interleukin-2
41. The structure of melittin. II. Interpretation of the structure
42. X-ray analysis of glucagon and its relationship to receptor binding
43. The solution structure of the F42A mutant of human interleukin 2
44. Unraveling the structure of IL-2 [letter]
45. Phase I trial of 40-kd branched pegylated interferon alpha-2a for patients with advanced renal cell carcinoma