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Volumn 43, Issue 5, 2006, Pages 422-436

Molecular mediators of αvβ3-induced endothelial cell survival

Author keywords

Angiogenesis; Cell survival; Integrin; NF B

Indexed keywords

I KAPPA B ALPHA; I KAPPA B BETA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN INDUCING KINASE; OSTEOPONTIN; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; I KAPPA B KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NF KAPPA B KINASE; NF-KAPPA B KINASE; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; SIALOGLYCOPROTEIN; SPP1 PROTEIN, MOUSE; SPP1 PROTEIN, RAT;

EID: 33748753422     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094884     Document Type: Article
Times cited : (26)

References (87)
  • 1
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch SM, Francis H: Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994;124:619-626.
    • (1994) J Cell Biol , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 2
    • 0033615961 scopus 로고    scopus 로고
    • p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB
    • Bachelder RE, Ribick MJ, Marchetti A, Falcioni R, Soddu S, Davis KR, Mercurio AM: p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB. J Cell Biol 1999;147:1063-1072.
    • (1999) J Cell Biol , vol.147 , pp. 1063-1072
    • Bachelder, R.E.1    Ribick, M.J.2    Marchetti, A.3    Falcioni, R.4    Soddu, S.5    Davis, K.R.6    Mercurio, A.M.7
  • 3
    • 0033594105 scopus 로고    scopus 로고
    • Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signaling
    • Farrelly N, Lee YJ, Oliver J, Dive C, Streuli CH: Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signaling. J Cell Biol 1999;144:1337-1348.
    • (1999) J Cell Biol , vol.144 , pp. 1337-1348
    • Farrelly, N.1    Lee, Y.J.2    Oliver, J.3    Dive, C.4    Streuli, C.H.5
  • 4
  • 5
    • 0029984473 scopus 로고    scopus 로고
    • Expression of the integrin alpha 5 subunit in HT29 colon carcinoma cells suppresses apoptosis triggered by serum deprivation
    • O'Brien V, Frisch SM, Juliano RL: Expression of the integrin alpha 5 subunit in HT29 colon carcinoma cells suppresses apoptosis triggered by serum deprivation. Exp Cell Res 1996;224:208-213.
    • (1996) Exp Cell Res , vol.224 , pp. 208-213
    • O'Brien, V.1    Frisch, S.M.2    Juliano, R.L.3
  • 7
    • 0028983407 scopus 로고
    • The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression
    • Zhang Z, Vuori K, Reed JC, Ruoslahti E: The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci USA 1995;92:6161-6165.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6161-6165
    • Zhang, Z.1    Vuori, K.2    Reed, J.C.3    Ruoslahti, E.4
  • 8
    • 0023234083 scopus 로고
    • Arg-Gly-Asp recognition by a cell adhesion receptor requires its 130-kDa alpha subunit
    • Cheresh DA, Harper JR: Arg-Gly-Asp recognition by a cell adhesion receptor requires its 130-kDa alpha subunit. J Biol Chem 1987;262:1434-1437.
    • (1987) J Biol Chem , vol.262 , pp. 1434-1437
    • Cheresh, D.A.1    Harper, J.R.2
  • 9
    • 0026334978 scopus 로고
    • Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells
    • Gladson CL, Cheresh DA: Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells. J Clin Invest 1991;88:1924-1932.
    • (1991) J Clin Invest , vol.88 , pp. 1924-1932
    • Gladson, C.L.1    Cheresh, D.A.2
  • 10
    • 0034040525 scopus 로고    scopus 로고
    • alpha(v)beta(3) integrin antagonists as inhibitors of bone resorption
    • Hartman GD, Duggan ME: alpha(v)beta(3) integrin antagonists as inhibitors of bone resorption. Expert Opin Investig Drugs 2000;9:1281-1291.
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 1281-1291
    • Hartman, G.D.1    Duggan, M.E.2
  • 13
    • 0028670833 scopus 로고
    • Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA: Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994;79:1157-1164.
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1    Montgomery, A.M.2    Rosenfeld, M.3    Reisfeld, R.A.4    Hu, T.5    Klier, G.6    Cheresh, D.A.7
  • 14
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • Brooks PC, Clark RA, Cheresh DA: Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994;264:569-571.
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 16
    • 0028670298 scopus 로고
    • Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen
    • Montgomery AM, Reisfeld RA, Cheresh DA: Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc Natl Acad Sci USA 1994;91:8856-8860.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8856-8860
    • Montgomery, A.M.1    Reisfeld, R.A.2    Cheresh, D.A.3
  • 19
    • 0031027505 scopus 로고    scopus 로고
    • Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-kappa B
    • Anrather J, Csizmadia V, Brostjan C, Soares MP, Bach FH, Winkler H: Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-kappa B. J Clin Invest 1997;99:763-772.
    • (1997) J Clin Invest , vol.99 , pp. 763-772
    • Anrather, J.1    Csizmadia, V.2    Brostjan, C.3    Soares, M.P.4    Bach, F.H.5    Winkler, H.6
  • 20
    • 0030271387 scopus 로고    scopus 로고
    • NF-kappa B: Ten years after
    • Baeuerle PA, Baltimore D: NF-kappa B: ten years after. Cell 1996;87:13-20.
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 21
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: New discoveries and insights
    • Baldwin AS, Jr: The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-683.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 22
    • 0033996762 scopus 로고    scopus 로고
    • The I kappa B kinase (IKK) and NF-kappa B: Key elements of proinflammatory signalling
    • Karin M, Delhase M: The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol 2000;12:85-98.
    • (2000) Semin Immunol , vol.12 , pp. 85-98
    • Karin, M.1    Delhase, M.2
  • 24
    • 0032541657 scopus 로고    scopus 로고
    • IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
    • Rothwarf DM, Zandi E, Natoli G, Karin M: IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 1998;395:297-300.
    • (1998) Nature , vol.395 , pp. 297-300
    • Rothwarf, D.M.1    Zandi, E.2    Natoli, G.3    Karin, M.4
  • 25
    • 0031017618 scopus 로고    scopus 로고
    • MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
    • Malinin NL, Boldin MP, Kovalenko AV, Wallach D: MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 1997;385:540-544.
    • (1997) Nature , vol.385 , pp. 540-544
    • Malinin, N.L.1    Boldin, M.P.2    Kovalenko, A.V.3    Wallach, D.4
  • 26
    • 0342656129 scopus 로고    scopus 로고
    • Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain
    • Xiao G, Sun SC: Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain. J Biol Chem 2000;275:21081-21085.
    • (2000) J Biol Chem , vol.275 , pp. 21081-21085
    • Xiao, G.1    Sun, S.C.2
  • 27
    • 0031597368 scopus 로고    scopus 로고
    • Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase
    • Nemoto S, DiDonato JA, Lin A: Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. Mol Cell Biol 1998;18:7336-7343.
    • (1998) Mol Cell Biol , vol.18 , pp. 7336-7343
    • Nemoto, S.1    DiDonato, J.A.2    Lin, A.3
  • 28
    • 0035957951 scopus 로고    scopus 로고
    • Interferon alpha/beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt
    • Yang CH, Murti A, Pfeffer SR, Kim JG, Donner DB, Pfeffer LM: Interferon alpha/beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt. J Biol Chem 2001;276:13756-13761.
    • (2001) J Biol Chem , vol.276 , pp. 13756-13761
    • Yang, C.H.1    Murti, A.2    Pfeffer, S.R.3    Kim, J.G.4    Donner, D.B.5    Pfeffer, L.M.6
  • 29
    • 0030851775 scopus 로고    scopus 로고
    • The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro
    • Ghoda L, Lin X, Greene WC: The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro. J Biol Chem 1997;272:21281-21288.
    • (1997) J Biol Chem , vol.272 , pp. 21281-21288
    • Ghoda, L.1    Lin, X.2    Greene, W.C.3
  • 31
    • 0034698053 scopus 로고    scopus 로고
    • Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1
    • Hofer-Warbinek R, Schmid JA, Stehlik C, Binder BR, Lipp J, de Martin R: Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1. J Biol Chem 2000;275:22064-22068.
    • (2000) J Biol Chem , vol.275 , pp. 22064-22068
    • Hofer-Warbinek, R.1    Schmid, J.A.2    Stehlik, C.3    Binder, B.R.4    Lipp, J.5    De Martin, R.6
  • 32
    • 0031860923 scopus 로고    scopus 로고
    • DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties
    • Liu L, Kwak YT, Bex F, Garcia-Martinez LF, Li XH, Meek K, Lane WS, Gaynor RB: DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties. Mol Cell Biol 1998;18:4221-4234.
    • (1998) Mol Cell Biol , vol.18 , pp. 4221-4234
    • Liu, L.1    Kwak, Y.T.2    Bex, F.3    Garcia-Martinez, L.F.4    Li, X.H.5    Meek, K.6    Lane, W.S.7    Gaynor, R.B.8
  • 34
    • 0030611595 scopus 로고    scopus 로고
    • IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
    • Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV: IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 1997;278:866-869.
    • (1997) Science , vol.278 , pp. 866-869
    • Woronicz, J.D.1    Gao, X.2    Cao, Z.3    Rothe, M.4    Goeddel, D.V.5
  • 35
    • 0033174072 scopus 로고    scopus 로고
    • Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop
    • Levkau B, Scatena M, Giachelli CM, Ross R, Raines EW: Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop. Nat Cell Biol 1999;1:227-233.
    • (1999) Nat Cell Biol , vol.1 , pp. 227-233
    • Levkau, B.1    Scatena, M.2    Giachelli, C.M.3    Ross, R.4    Raines, E.W.5
  • 36
    • 0034647341 scopus 로고    scopus 로고
    • Osteoprotegerin is an alpha v beta 3-induced, NF-kappa B-dependent survival factor for endothelial cells
    • Malyankar UM, Scatena M, Suchland KL, Yun TJ, Clark EA, Giachelli CM: Osteoprotegerin is an alpha v beta 3-induced, NF-kappa B-dependent survival factor for endothelial cells. J Biol Chem 2000;275:20959-20962.
    • (2000) J Biol Chem , vol.275 , pp. 20959-20962
    • Malyankar, U.M.1    Scatena, M.2    Suchland, K.L.3    Yun, T.J.4    Clark, E.A.5    Giachelli, C.M.6
  • 37
    • 2542466752 scopus 로고    scopus 로고
    • The role of osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand in human microvascular endothelial cell survival
    • Pritzker LB, Scatena M, Giachelli CM: The role of osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand in human microvascular endothelial cell survival. Mol Biol Cell 2004;15:2834-2841.
    • (2004) Mol Biol Cell , vol.15 , pp. 2834-2841
    • Pritzker, L.B.1    Scatena, M.2    Giachelli, C.M.3
  • 39
    • 0037827712 scopus 로고    scopus 로고
    • An NF-kappaB-dependent transcriptional program is required for collagen remodeling by human smooth muscle cells
    • Ferri N, Garton KJ, Raines EW: An NF-kappaB-dependent transcriptional program is required for collagen remodeling by human smooth muscle cells. J Biol Chem 2003;278:19757-19764.
    • (2003) J Biol Chem , vol.278 , pp. 19757-19764
    • Ferri, N.1    Garton, K.J.2    Raines, E.W.3
  • 41
    • 12644272789 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
    • Song HY, Regnier CH, Kirschning CJ, Goeddel DV, Rothe M: Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci USA 1997;94:9792-9796.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9792-9796
    • Song, H.Y.1    Regnier, C.H.2    Kirschning, C.J.3    Goeddel, D.V.4    Rothe, M.5
  • 42
    • 0036218202 scopus 로고    scopus 로고
    • Efficient expression of exogenous genes in primary vascular cells using IRES-based retroviral vectors
    • Garton KJ, Ferri N, Raines EW: Efficient expression of exogenous genes in primary vascular cells using IRES-based retroviral vectors. Biotechniques 2002;32:830, 832, 834 passim.
    • (2002) Biotechniques , vol.32 , pp. 830
    • Garton, K.J.1    Ferri, N.2    Raines, E.W.3
  • 43
    • 0030844823 scopus 로고    scopus 로고
    • High-efficiency retroviral infection of primary myoblasts
    • Springer ML, Blau HM: High-efficiency retroviral infection of primary myoblasts. Somat Cell Mol Genet 1997;23:203-209.
    • (1997) Somat Cell Mol Genet , vol.23 , pp. 203-209
    • Springer, M.L.1    Blau, H.M.2
  • 44
    • 16844377086 scopus 로고    scopus 로고
    • Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB
    • Courter DL, Lomas L, Scatena M, Giachelli CM: Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB. J Biol Chem 2005;280:12145-12151.
    • (2005) J Biol Chem , vol.280 , pp. 12145-12151
    • Courter, D.L.1    Lomas, L.2    Scatena, M.3    Giachelli, C.M.4
  • 45
    • 0032491410 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha
    • Abu-Amer Y, Ross FP, McHugh KP, Livolsi A, Peyron JF, Teitelbaum SL: Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha. J Biol Chem 1998;273:29417-29423.
    • (1998) J Biol Chem , vol.273 , pp. 29417-29423
    • Abu-Amer, Y.1    Ross, F.P.2    McHugh, K.P.3    Livolsi, A.4    Peyron, J.F.5    Teitelbaum, S.L.6
  • 46
    • 0030613551 scopus 로고    scopus 로고
    • The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
    • Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M: The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 1997;91:243-252.
    • (1997) Cell , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3    Hayakawa, M.4    Karin, M.5
  • 47
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
    • Delhase M, Hayakawa M, Chen Y, Karin M: Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 1999;284:309-313.
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 49
    • 0013265232 scopus 로고    scopus 로고
    • c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression
    • Huang WC, Chen JJ, Chen CC: c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression. J Biol Chem 2003;278:9944-9952.
    • (2003) J Biol Chem , vol.278 , pp. 9944-9952
    • Huang, W.C.1    Chen, J.J.2    Chen, C.C.3
  • 50
    • 0037406703 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression
    • Huang WC, Chen JJ, Inoue H, Chen CC: Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression. J Immunol 2003;170:4767-4775.
    • (2003) J Immunol , vol.170 , pp. 4767-4775
    • Huang, W.C.1    Chen, J.J.2    Inoue, H.3    Chen, C.C.4
  • 51
    • 0033136695 scopus 로고    scopus 로고
    • NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells
    • Awane M, Andres PG, Li DJ, Reinecker HC: NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells. J Immunol 1999;162:5337-5344.
    • (1999) J Immunol , vol.162 , pp. 5337-5344
    • Awane, M.1    Andres, P.G.2    Li, D.J.3    Reinecker, H.C.4
  • 53
    • 0035809310 scopus 로고    scopus 로고
    • Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I
    • Matsushima A, Kaisho T, Rennert PD, Nakano H, Kurosawa K, Uchida D, Takeda K, Akira S, Matsumoto M: Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. J Exp Med 2001;193:631-636.
    • (2001) J Exp Med , vol.193 , pp. 631-636
    • Matsushima, A.1    Kaisho, T.2    Rennert, P.D.3    Nakano, H.4    Kurosawa, K.5    Uchida, D.6    Takeda, K.7    Akira, S.8    Matsumoto, M.9
  • 55
    • 0033998441 scopus 로고    scopus 로고
    • Cytoplasmic sequestration of rel proteins by IkappaBalpha requires CRM1-dependent nuclear export
    • Tam WF, Lee LH, Davis L, Sen R: Cytoplasmic sequestration of rel proteins by IkappaBalpha requires CRM1-dependent nuclear export. Mol Cell Biol 2000;20:2269-2284.
    • (2000) Mol Cell Biol , vol.20 , pp. 2269-2284
    • Tam, W.F.1    Lee, L.H.2    Davis, L.3    Sen, R.4
  • 56
    • 85047689695 scopus 로고    scopus 로고
    • IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation
    • Fan C, Li Q, Zhang Y, Liu X, Luo M, Abbott D, Zhou W, Engelhardt JF: IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. J Clin Invest 2004;113:746-755.
    • (2004) J Clin Invest , vol.113 , pp. 746-755
    • Fan, C.1    Li, Q.2    Zhang, Y.3    Liu, X.4    Luo, M.5    Abbott, D.6    Zhou, W.7    Engelhardt, J.F.8
  • 57
    • 0033545909 scopus 로고    scopus 로고
    • The kinetics of association and phosphorylation of IkappaB isoforms by IkappaB kinase 2 correlate with their cellular regulation in human endothelial cells
    • Heilker R, Freuler F, Vanek M, Pulfer R, Kobel T, Peter J, Zerwes HG, Hofstetter H, Eder J: The kinetics of association and phosphorylation of IkappaB isoforms by IkappaB kinase 2 correlate with their cellular regulation in human endothelial cells. Biochemistry 1999;38:6231-6238.
    • (1999) Biochemistry , vol.38 , pp. 6231-6238
    • Heilker, R.1    Freuler, F.2    Vanek, M.3    Pulfer, R.4    Kobel, T.5    Peter, J.6    Zerwes, H.G.7    Hofstetter, H.8    Eder, J.9
  • 58
    • 0037044575 scopus 로고    scopus 로고
    • The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation
    • Hoffmann A, Levchenko A, Scott ML, Baltimore D: The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 2002;298:1241-1245.
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 59
    • 0029666281 scopus 로고    scopus 로고
    • A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human endothelial cells
    • Johnson DR, Douglas I, Jahnke A, Ghosh S, Pober JS: A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human endothelial cells. J Biol Chem 1996;271:16317-16322.
    • (1996) J Biol Chem , vol.271 , pp. 16317-16322
    • Johnson, D.R.1    Douglas, I.2    Jahnke, A.3    Ghosh, S.4    Pober, J.S.5
  • 60
    • 0035911153 scopus 로고    scopus 로고
    • Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha
    • Bui NT, Livolsi A, Peyron JF, Prehn JH: Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha. J Cell Biol 2001;152:753-764.
    • (2001) J Cell Biol , vol.152 , pp. 753-764
    • Bui, N.T.1    Livolsi, A.2    Peyron, J.F.3    Prehn, J.H.4
  • 61
    • 0037449777 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation
    • Fan C, Li Q, Ross D, Engelhardt JF: Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation. J Biol Chem 2003;278:2072-2080.
    • (2003) J Biol Chem , vol.278 , pp. 2072-2080
    • Fan, C.1    Li, Q.2    Ross, D.3    Engelhardt, J.F.4
  • 63
    • 0033532386 scopus 로고    scopus 로고
    • The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
    • Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M: The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 1999;189:1839-1845.
    • (1999) J Exp Med , vol.189 , pp. 1839-1845
    • Li, Z.W.1    Chu, W.2    Hu, Y.3    Delhase, M.4    Deerinck, T.5    Ellisman, M.6    Johnson, R.7    Karin, M.8
  • 64
    • 0034745021 scopus 로고    scopus 로고
    • IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis
    • Senftleben U, Li ZW, Baud V, Karin M: IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis. Immunity 2001;14:217-230.
    • (2001) Immunity , vol.14 , pp. 217-230
    • Senftleben, U.1    Li, Z.W.2    Baud, V.3    Karin, M.4
  • 67
    • 0033537739 scopus 로고    scopus 로고
    • Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
    • Li Q, Van Antwerp D, Mercuric F, Lee KF, Verma IM: Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 1999;284:321-325.
    • (1999) Science , vol.284 , pp. 321-325
    • Li, Q.1    Van Antwerp, D.2    Mercuric, F.3    Lee, K.F.4    Verma, I.M.5
  • 70
    • 4644231399 scopus 로고    scopus 로고
    • Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation
    • Rangaswami H, Bulbule A, Kundu GC: Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation. J Biol Chem 2004;279:38921-38935.
    • (2004) J Biol Chem , vol.279 , pp. 38921-38935
    • Rangaswami, H.1    Bulbule, A.2    Kundu, G.C.3
  • 71
    • 0037039665 scopus 로고    scopus 로고
    • Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B
    • Sizemore N, Lerner N, Dombrowski N, Sakurai H, Stark GR: Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J Biol Chem 2002;277:3863-3869.
    • (2002) J Biol Chem , vol.277 , pp. 3863-3869
    • Sizemore, N.1    Lerner, N.2    Dombrowski, N.3    Sakurai, H.4    Stark, G.R.5
  • 72
    • 0344825070 scopus 로고    scopus 로고
    • AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cells
    • Frelin C, Imbert V, Griessinger E, Loubat A, Dreano M, Peyron JF: AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cells. Oncogene 2003;22:8187-8194.
    • (2003) Oncogene , vol.22 , pp. 8187-8194
    • Frelin, C.1    Imbert, V.2    Griessinger, E.3    Loubat, A.4    Dreano, M.5    Peyron, J.F.6
  • 74
    • 0032583947 scopus 로고    scopus 로고
    • NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
    • Ling L, Cao Z, Goeddel DV: NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc Natl Acad Sci USA 1998;95:3792-3797.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3792-3797
    • Ling, L.1    Cao, Z.2    Goeddel, D.V.3
  • 75
    • 0035896422 scopus 로고    scopus 로고
    • Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice
    • Yin L, Wu L, Wesche H, Arthur CD, White JM, Goeddel DV, Schreiber RD: Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science 2001;291:2162-2165.
    • (2001) Science , vol.291 , pp. 2162-2165
    • Yin, L.1    Wu, L.2    Wesche, H.3    Arthur, C.D.4    White, J.M.5    Goeddel, D.V.6    Schreiber, R.D.7
  • 76
    • 5644302162 scopus 로고    scopus 로고
    • Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase
    • Ramakrishnan P, Wang W, Wallach D: Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase. Immunity 2004;21:477-489.
    • (2004) Immunity , vol.21 , pp. 477-489
    • Ramakrishnan, P.1    Wang, W.2    Wallach, D.3
  • 77
    • 0033565516 scopus 로고    scopus 로고
    • The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma
    • Dong G, Chen Z, Kato T, Van Waes C: The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma. Cancer Res 1999;59:3495-3504.
    • (1999) Cancer Res , vol.59 , pp. 3495-3504
    • Dong, G.1    Chen, Z.2    Kato, T.3    Van Waes, C.4
  • 78
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • Huang S, Pettaway CA, Uehara H, Bucana CD, Fidler IJ: Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 2001;20:4188-4197.
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1    Pettaway, C.A.2    Uehara, H.3    Bucana, C.D.4    Fidler, I.J.5
  • 79
    • 0034902354 scopus 로고    scopus 로고
    • Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    • Sunwoo JB, Chen Z, Dong G, Yeh N, Crowl Bancroft C, Sausville E, Adams J, Elliott P, Van Waes C: Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res 2001;7:1419-1428.
    • (2001) Clin Cancer Res , vol.7 , pp. 1419-1428
    • Sunwoo, J.B.1    Chen, Z.2    Dong, G.3    Yeh, N.4    Crowl Bancroft, C.5    Sausville, E.6    Adams, J.7    Elliott, P.8    Van Waes, C.9
  • 81
    • 0030014964 scopus 로고    scopus 로고
    • Involvement of the transcription factor NF-kappaB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress
    • Shono T, Ono M, Izumi H, Jimi SI, Matsushima K, Okamoto T, Kohno K, Kuwano M: Involvement of the transcription factor NF-kappaB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress. Mol Cell Biol 1996;16:4231-4239.
    • (1996) Mol Cell Biol , vol.16 , pp. 4231-4239
    • Shono, T.1    Ono, M.2    Izumi, H.3    Jimi, S.I.4    Matsushima, K.5    Okamoto, T.6    Kohno, K.7    Kuwano, M.8
  • 82
    • 0033020061 scopus 로고    scopus 로고
    • Suppression of retinal neovascularization by the NF-kappaB inhibitor pyrrolidine dithiocarbamate in mice
    • Yoshida A, Yoshida S, Ishibashi T, Kuwano M, Inomata H: Suppression of retinal neovascularization by the NF-kappaB inhibitor pyrrolidine dithiocarbamate in mice. Invest Ophthalmol Vis Sci 1999;40:1624-1629.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 1624-1629
    • Yoshida, A.1    Yoshida, S.2    Ishibashi, T.3    Kuwano, M.4    Inomata, H.5
  • 83
    • 0035869252 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of a mutant IkappaB kinase 2 inhibits the response of endothelial cells to inflammatory stimuli
    • Oitzinger W, Hofer-Warbinek R, Schmid JA, Koshelnick Y, Binder BR, de Martin R: Adenovirus-mediated expression of a mutant IkappaB kinase 2 inhibits the response of endothelial cells to inflammatory stimuli. Blood 2001;97:1611-1617.
    • (2001) Blood , vol.97 , pp. 1611-1617
    • Oitzinger, W.1    Hofer-Warbinek, R.2    Schmid, J.A.3    Koshelnick, Y.4    Binder, B.R.5    De Martin, R.6
  • 84
  • 85
    • 1642433233 scopus 로고    scopus 로고
    • Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins
    • Taverna D, Moher H, Crowley D, Borsig L, Varki A, Hynes RO: Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins. Proc Natl Acad Sci USA 2004;101:763-768.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 763-768
    • Taverna, D.1    Moher, H.2    Crowley, D.3    Borsig, L.4    Varki, A.5    Hynes, R.O.6
  • 87
    • 0035955645 scopus 로고    scopus 로고
    • Specific interaction of angiostatin with integrin alpha(v) beta(3) in endothelial cells
    • Tarui T, Miles LA, Takada Y: Specific interaction of angiostatin with integrin alpha(v) beta(3) in endothelial cells. J Biol Chem 2001;276:39562- 39568.
    • (2001) J Biol Chem , vol.276 , pp. 39562-39568
    • Tarui, T.1    Miles, L.A.2    Takada, Y.3


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