Endogenous polyamine levels in macrophages is sufficient to support growth of Toxoplasma gondii

Journal of Parasitology

Volumn 90, Issue 3, 2004, Pages 455-460

  Seabra, Sergio Henrique ^a   DaMatta, Renato Augusto ^a,b   De Mello, Fernando Garcia ^a   De Souza, Wanderley ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSIDADE ESTADUAL DO NORTE FLUMINENSE DARCY RIBEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; POLYAMINE; PUTRESCINE; ARGININE DECARBOXYLASE; CARBOXYLYASE; NITRIC OXIDE; ORNITHINE; ORNITHINE DECARBOXYLASE; SPERMIDINE;

ADHESION; CHEMICAL COMPOUND; ENZYME ACTIVITY; INDEX METHOD; METABOLISM; NITRIC OXIDE; PARASITE; PROTOZOAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GROWTH; LYSOSOME; MACROPHAGE; MALE; MOUSE; NONHUMAN; PARASITE; PARASITE SURVIVAL; POLYAMINE METABOLISM; TOXOPLASMA GONDII; TOXOPLASMOSIS; TRYPANOSOMA CRUZI; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CERCOPITHECUS; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; HOST PARASITE INTERACTION; METABOLISM; PARASITOLOGY; PERITONEUM MACROPHAGE; TOXOPLASMA; VERO CELL;

TOXOPLASMA GONDII; TRYPANOSOMA CRUZI;

ANIMALS; CARBOXY-LYASES; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; HOST-PARASITE RELATIONS; MACROPHAGES, PERITONEAL; MALE; MICE; NITRIC OXIDE; ORNITHINE; ORNITHINE DECARBOXYLASE; POLYAMINES; PUTRESCINE; SPERMIDINE; TOXOPLASMA; VERO CELLS;

EID: 3142765893     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.1645/GE-179R     Document Type: Article

References (27)

1. ADAMS, L. B., J. B. HIBBS, R. R. TAINTOR, AND J. L. KRAHENBUHL. 1990. Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine. Journal of Immunology 144: 2725-2729.
2. ASSREUY, J., F. Q. CUNHA, M. EPPERLEIN, A. NORONHA-DUTRA, C. A. O'DONNELL, F. Y. LIEW, AND S. MONCADA. 1994. Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major. European Journal of Immunology 24: 672-676.
3. BALESTIERI, F. M. P., A. R. P. QUEIROZ, C. SCAVONE, V. M. A. COSTA, M. BARRAL-NETTO, AND I. A. ABRAHAMSOHN. 2002. Leishmania (L.) amazonensis-induced inhibition of nitric oxide synthesis in host macrophages. Microbes and Infection 4: 23-29.
4. BAUER, P. M., G. M. BUGA, J. M., FUKUTO, A. E. PEGG, AND L. J. IGNARRO. 2001. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. Journal of Biological Chemistry 276: 34458-34464.
5. COBURN, R. F., D. H. JONES, C. P. MORGAN, C. B. BARON, AND S. COCKCROFT. 2002. Spermine increases phosphatidylinositol 4,5-bisphosphate content in permeabilized and nonpermeabilized HL60 cells. Biochemical and Biophysical Acta 1584: 20-30.
6. DAMATTA, R. A., S. H. SEABRA, D. L. MANHAES, AND W. DE SOUZA. 2000. Nitric oxide is not involved in the killing of Trypanosoma cruzi by chicken macrophages. Parasitology Research 86: 239-243.
7. DE MELLO, F. G., U. BACHRACH, AND M. NIRENBERG. 1976. Ornithine and glutamic acid decarboxylase activities in the developing chick retina. Journal of Neurochemistry 27: 847-851.
8. DE MELLO, M. C. F., R. GUERRA PEIXE, AND F. G. DE MELLO. 1993. Excitatory amino acid receptors mediate the glutamate-induced release of GABA synthesized from putrescine in cultured cells of embryonic avian retina. Neurochemistry International 22: 249-253.
9. FREIRE-DE-LIMA, C. G., D. O. NASCIMENTO, M. B. P. SOARES, P. T. BOZZA, H. C. CASTRO-FARIA-NETO, F. G. DE MELLO, G. A. DOSREIS, AND M. F. LOPES. 2000. Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages. Nature 403: 199-203.
10. GALEA, E., S. REGUNATHAN, V. ELIOPOULOS, D. L. FEINSTEIN, AND D. J. REIS. 1996. Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochemical Journal 316: 247-249.
11. GAZZINELLI, R. T., I. P. OSWALD, S. L. HYENI, S. JAMES, AND A. SHER. 1992. The microbicidal activity of interferon-γ treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-β. European Journal of Immunology 22: 2501-2506.
12. JOHNSON, J. J., C. W. ROBERTS, C. POPE, F. ROBERTS, M. J. KIRISITS, R. ESTES, E. MUI, T. KRIEGER, C. R. BROWN, J. FORMAN, AND R. MCLEOD. 2002. In vitro correlates of Ld-restricted resistance to toxoplasmic encephalitis and their critical dependence on parasite strain. Journal of Immunology 169: 966-973.
13. KAPOOR, P., V. S. RAJ, S. SAXENA, S. BALARAMAN, AND R. MADHUBALA. 2001. Effect of Leishmania donovani lipophosphoglycan on ornithine decarboxylase activity in macrophages. Journal of Parasitology 87: 1071-1076.
14. MARTON, L. J., AND A. E. PEGG. 1995. Polyamines as targets for therapeutic intervention. Annual Review of Pharmacology and Toxicology 35: 55-91.
15. MORDUE, D. G., S. HÅKANSSON, I. NIESMAN, AND L. D. SIBLEY. 1999. Toxoplasma gondii resides in a vacuole that avoids fusion with host cell endocytic and exocytic vesicular trafficking pathways. Experimental Parasitology 92: 87-99.
16. MORISAKI, J. H., J. E. HEUSER, AND L. D. SIBLEY. 1995. Invasion of Toxoplasma gondii occurs by active penetration of the host cell. Journal of Cell Science 108: 2457-2464.
17. MÜLLER, S., G. H. COOMBS, AND R. D. WALTER. 2001. Targeting polyamines of parasitic protozoa in chemotherapy. Trends in Parasitology 17: 242-249.
18. MURRAY, H. W., AND Z. A. COHN. 1979. Macrophage oxygen-dependent antimicrobial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates. Journal of Experimental Medicine 150: 938-949.
19. 2. Immunobiology 184: 93-105.
20. NICHOLS, B. A., AND G. R. O'CONNOR. 1981. Penetration of mouse peritoneal macrophages by the protozoan Toxoplasma gondii. Laboratory Investigation 44: 324-335.
21. PAKIANATHAN, D. R., AND R. E. KUHN. 1994. Trypanosoma cruzi affects nitric oxide production by murine peritoneal macrophages. Journal of Parasitology 80: 432-437.
22. PEGG, A. E., AND P. P. MCCANN. 1982. Polyamine metabolism and function. American Journal of Physiology 243: C212-221.
23. SASTRE, M., E. GALEA, D. FEINSTEIN, D. J. REIS, AND S. REGUNATUAN. 1998. Metabolism of agmatine in macrophages: modulation by lipopolysaccharide and inhibitory cytokines. Biochemical Journal 330: 1405-1409.
24. SEABRA, S. H., W. DE SOUZA, AND R. A. DAMATTA. 2002. Toxoplasma gondii partially inhibits nitric oxide production of activated murine macrophages. Experimental Parasitology 100: 62-70.
25. WILSON, C. B., V. TSAI, AND J. S. REMINGTON. 1980. Failure to trigger the oxidative burst of normal macrophages. Possible mechanism for survival of intracellular pathogens. Journal of Experimental Medicine 151: 328-346.
26. WU, W. H., AND D. R. MORRIS. 1973. Biosynthetic arginine decarboxylase from Escherichia coli. Journal of Biological Chemistry 248: 1687-1695.
27. YAMASAKI, E. N., V. D. BARBOSA, F. G. DE MELLO, AND J. N. HOKOC. 1999. Gabaergic system in the developing mammalian retina. Dual source of GABA at early stages of postnatal development. International Journal of Developmental Neuroscience 17: 203-215.