Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives

Journal of Medicinal Chemistry

Volumn 49, Issue 18, 2006, Pages 5414-5423

  Andersen, Trine F ^a   Tikhonov, Denis B ^b   Bølcho, Ulrik ^c   Bolshakov, Konstantin ^b,d   Nelson, Jared K ^a   Pluteanu, Florentina ^d   Mellor, Ian R ^d   Egebjerg, Jan ^c,e   Strømgaard, Kristian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^c AARHUS UNIVERSITY   (Denmark)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^e H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; AMPA RECEPTOR; CALCIUM ION; ION CHANNEL; PHILANTHOTOXIN; POLYAMINE DERIVATIVE; TOXIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BIOLOGICAL ACTIVITY; CHANNEL GATING; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; FEMALE; MOLECULAR CLONING; MOLECULAR LIBRARY; NONHUMAN; SEQUENCE HOMOLOGY; SOLID;

ANIMALS; BACTERIAL PROTEINS; BINDING SITES; CALCIUM; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OOCYTES; PATCH-CLAMP TECHNIQUES; POLYAMINES; POTASSIUM CHANNELS; RATS; RECEPTORS, AMPA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOXINS, BIOLOGICAL; TYROSINE; WASP VENOMS; XENOPUS LAEVIS;

EID: 33748612728     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060606j     Document Type: Article

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