The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism

Journal of Medicinal Chemistry

Volumn 48, Issue 1, 2005, Pages 56-70

  Jørgensen, Malene R ^a   Olsen, Christian A ^a   Mellor, Ian R ^b   Usherwood, Peter N R ^b   Witt, Matthias ^c   Franzyk, Henrik ^a   Jaroszewski, Jerzy W ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c BRUKER DALTONIK GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 (3 HYDROXY 5 METHYL 4 ISOXAZOYL)PROPANOIC ACID RECEPTOR; BRAIN RECEPTOR; DEXTROLEVO N [ 3 (( 4 (( 3 AMINOPROPYL)AMINO)BUTYL)AMINO)PROPYL] 1 ( 1 OXOBUTYL) 4 PHENYL PIPERIDINE 4 CARBOXYLAMIDE TRIS(TRIFLUOROACETATE); DEXTROLEVO N [ 3 (( 4 (( 3 AMINOPROPYL)AMINO)BUTYL)AMINO)PROPYL] 1 ( 1 OXOBUTYL)INDOLINE 2 CARBOXYLAMIDE TRIS(TRIFLUOROACETATE); DEXTROLEVO N [ 3 (( 4 (( 3 AMINOPROPYL)AMINO)BUTYL)AMINO)PROPYL] 6 HYDROXY 2 ( 1 OXOBUTYL) 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLAMIDE TRIS(TRIFLUOROACETATE); N [ 3 (( 4 (( 3 AMINOPROPYL)AMINO)BUTYL)AMINO)PROPYL] 4 ( 2 NAPHTHYLOXY) 1 ( 1 OXOBUTYL)PYRROLIDINE 2 CARBOXYLAMIDE TRIS(TRIFLUOROACETATE); N [ 3 (( 4 (( 3 AMINOPROPYL)AMINO)BUTYL)AMINO)PROPYL] 4 PHENYLMETHYL 1 ( 1 OXOBUTYL)PYRROLIDINE 2 CARBOXYLAMIDE TRIS(TRIFLUOROACETATE); N [ 3 (( 4 (( 3 AMINOPROPYL)AMINO)BUTYL)AMINO)PROPYL]ALPHA [( 1 OXOBUTYL)AMINO] 1H INDOLE 3 CARBOXYLAMIDE TRIS(TRIFLUOROACETATE); PENTAFLUOROPHENYL LEVO 2 ( 9H FLUOREN 9 YLMETHOXYCARBONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLATE; PHILANTHOTOXIN 343; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE LIBRARY; HYDROGEN BOND; NONHUMAN; RAT; RECEPTOR BINDING; SOLID PHASE SYNTHESIS; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; TOXIN SYNTHESIS;

ANIMALS; BIOCHEMISTRY; BRAIN; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; INHIBITORY CONCENTRATION 50; OOCYTES; PHENOLS; POLYAMINES; RATS; RECEPTORS, GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 12144255597     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049906w     Document Type: Article

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