Different arrangement of hydrophobic and nucleophilic components of channel binding sites in N-methyl-D-aspartate and AMPA receptors of rat brain is revealed by channel blockade

Neuroscience Letters

Volumn 291, Issue 2, 2000, Pages 101-104

  Bolshakov, K V ^a   Tikhonov, D B ^a   Gmiro, V E ^b   Magazanik, L G ^a  

^a SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

AMPA receptor; Channel block; Channel structure; N methyl D aspartate receptor; Structure activity relationships

Indexed keywords

AMANTADINE; AMMONIUM DERIVATIVE; AMPA RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CHANNEL GATING; CHEMICAL STRUCTURE; CONTROLLED STUDY; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TOPOGRAPHY;

ANIMALS; BINDING SITES; BRAIN CHEMISTRY; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; HIPPOCAMPUS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034666001     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01386-0     Document Type: Article

References (20)

1. Antonov S.M., Johnson J.W., Lukomskaya N., Ya ., Potapyeva N.N., Gmiro V.E., Magazanik L.G. Novel adamantane derivatives act as blockers of open ligand-gated channels and as anticonvulsants. Mol. Pharmacol. 47:1995;558-567.
2. Brackley P.T., Bell D.R., Choi S.K., Nakanishi K., Usherwood P.N. Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins. J. Pharmacol. Exp. Ther. 266:1993;1573-1580.
3. Dingledine R., Hume R.I., Heinemann S. Structural determinants of barium permeation and rectification in non-NMDA glutamate receptor channels. J. Neurosci. 12:1992;4080-4087.
4. Dingledine R., Borges K., Bowie D., Traynelis S.F. The glutamate receptor ion channels. Pharmacol. Rev. 51:1999;8-61.
5. Frankiewicz T., Potier B., Bashir Z.I., Collingridge G.L., Parsons C.G. Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices. Br. J. Pharmacol. 117:1996;689-697.
6. Herlitze S., Raditsch M., Ruppersberg J.P., Jahn W., Monyer H., Schoepfer R., Witzemann V. Argiotoxin detects molecular differences in AMPA receptor channels. Neuron. 10:1993;1131-1140.
7. Isa T., Iino M., Ozawa S. Spermine blocks synaptic transmission mediated by Ca(2+)-permeable AMPA receptors. NeuroReport. 7:1996;689-692.
8. Kashiwagi K., Pahk A.J., Masuko T., Igarashi K., Williams K. Block and modulation of N-methyl-D-aspartate receptors by polyamines and protons: role of amino acid residues in the transmembrane and pore-forming regions of NR1 and NR2 subunits. Mol. Pharmacol. 52:1997;701-713.
9. MacDonald J.F., Bartlett M.C., Mody I., Pahapill P., Reynolds J.N., Salter M.W., Schneiderman J.H., Pennefather P.S. Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones. J. Physiol. 432:1991;483-508.
10. Magazanik L.G., Buldakova S.L., Samoilova M.V., Gmiro V.E., Mellor I.R., Usherwood P.N.R. Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J. Physiol. 505:1997;655-663.
11. O'Dell T.J., Christensen B.N. Mecamylamine is a selective non-competitive antagonist of N-methyl-D-aspartate- and aspartate-induced currents in horizontal cells dissociated from the catfish retina. Neurosci. Lett. 94:1988;93-98.
12. Panchenko V.A., Glasser C.R., Partin K.M., Mayer M.L. Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines. J. Physiol. 520:1999;337-357.
13. Parsons C.G., Panchenko V.A., Pinchenko V.O., Tsyndrenko A.Y., Krishtal O.A. Comparative patch-clamp studies with freshly dissociated rat hippocampal and striatal neurons on the NMDA receptor antagonistic effects of amantadine and memantine. Eur. J. Neurosci. 8:1996;446-454.
14. Parsons C.G., Danysz W., Quack G. Glutamate in CNS disorders as a target for drug development: an update. Drug News Perspect. 11:1998;523-569.
15. Samoilova M.V., Buldakova S.L., Vorobjev V.S., Sharonova I.N., Magazanik L.G. The open channel blocking drug. IEM-1460, reveals functionally distinct α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors in rat brain neurons, Neuroscience. 94:1999;261-268.
16. Tikhonov D.B., Zhorov B.S., Magazanik L.G. Intersegment hydrogen bonds as possible structural determinants of the N/Q/R site in glutamate receptors. Biophys. J. 77:1999;1914-1926.
17. Tikhonov D.B., Samoilova M.V., Buldakova S.L., Gmiro V.E., Magazanik L.G. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br. J. Pharmacol. 129:2000;265-274.
18. Vorobjev V.S. Vibrodissociation of sliced mammalian nervous tissue. J. Neurosci. Methods. 38:1991;145-150.
19. Vorobjev V.S., Sharonova I.N., Haas H.L. A simple perfusion system for patch-clamp studies. J. Neurosci. Methods. 68:1996;303-307.
20. Washburn M.S., Numberger M., Zhang S., Dingledine R. Differential dependence on GluR2 expression of three characteristic features of AMPA receptors. J. Neurosci. 17:1997;9393-9406.