메뉴 건너뛰기




Volumn 7, Issue 2, 2006, Pages 177-185

Roles and causes of abnormal DNA methylation in gastrointestinal cancers

Author keywords

Aging; Cimp; DNA methylation; Folate; Gastrointestinal cancer; Inflammation; Mthfr; Polymorphism; Tumor suppressor

Indexed keywords

FOLIC ACID;

EID: 33748454508     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (22)

References (75)
  • 1
    • 0032401808 scopus 로고    scopus 로고
    • Aging and DNA methylation in colorectal mucosa and cancer
    • Ahuja N, Li Q, Mohan AL, Baylin SB, Issa JP (1998). Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res, 58, 5489-94.
    • (1998) Cancer Res , vol.58 , pp. 5489-5494
    • Ahuja, N.1    Li, Q.2    Mohan, A.L.3    Baylin, S.B.4    Issa, J.P.5
  • 2
    • 22344435817 scopus 로고    scopus 로고
    • The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer
    • Akino K, Toyota M, Suzuki H et al (2005). The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. Gastroenterology, 129, 156-69.
    • (2005) Gastroenterology , vol.129 , pp. 156-169
    • Akino, K.1    Toyota, M.2    Suzuki, H.3
  • 3
    • 0032573077 scopus 로고    scopus 로고
    • A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells
    • Bagley P, Selhub J (1998). A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA, 95, 13217-20.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13217-13220
    • Bagley, P.1    Selhub, J.2
  • 4
    • 0025768493 scopus 로고
    • Nutritional factors in colorectal cancer risk: a case-control study in Majorca
    • Benito E, Stiggelbout A, Bosch FX et al (1991). Nutritional factors in colorectal cancer risk: a case-control study in Majorca. Int J Cancer, 49, 161-7.
    • (1991) Int J Cancer , vol.49 , pp. 161-167
    • Benito, E.1    Stiggelbout, A.2    Bosch, F.X.3
  • 6
    • 0033601073 scopus 로고    scopus 로고
    • Methylation-induced repression-belts, braces, and chromatin
    • Bird AP, Wolffe AP (1999). Methylation-induced repression-belts, braces, and chromatin. Cell, 99, 451-4.
    • (1999) Cell , vol.99 , pp. 451-454
    • Bird, A.P.1    Wolffe, A.P.2
  • 7
    • 0034190659 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review
    • Botto LD, Yang Q (2000). 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol, 151, 862-77.
    • (2000) Am J Epidemiol , vol.151 , pp. 862-877
    • Botto, L.D.1    Yang, Q.2
  • 8
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB (1999). Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet, 21, 103-7.
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 9
    • 0029855024 scopus 로고    scopus 로고
    • A methylenetetrahydro-folate reductase polymorphism and the risk of colorectal cancer
    • Chen J, Giovannucci E, Kelsy K et al (1996). A methylenetetrahydro-folate reductase polymorphism and the risk of colorectal cancer. Cancer Res, 56, 4862-4.
    • (1996) Cancer Res , vol.56 , pp. 4862-4864
    • Chen, J.1    Giovannucci, E.2    Kelsy, K.3
  • 11
    • 0037275750 scopus 로고    scopus 로고
    • Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer
    • Corn PG, Summers MK, Fogt F et al (2003). Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. Carcinogenesis, 24, 47-51.
    • (2003) Carcinogenesis , vol.24 , pp. 47-51
    • Corn, P.G.1    Summers, M.K.2    Fogt, F.3
  • 12
    • 0033918563 scopus 로고    scopus 로고
    • Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21
    • Dammann R, Li C, Yoon JH et al (2000). Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet, 25, 315-9.
    • (2000) 3. Nat Genet , vol.25 , pp. 315-319
    • Dammann, R.1    Li, C.2    Yoon, J.H.3
  • 13
    • 17644383316 scopus 로고    scopus 로고
    • Folate DNA stability and colo-rectal neoplasia
    • Duthie SJ, Narayanan S, Sharp L et al (2004). Folate, DNA stability and colo-rectal neoplasia. Proc Nutr Soc, 63, 571-8.
    • (2004) Proc Nutr Soc , vol.63 , pp. 571-578
    • Duthie, S.J.1    Narayanan, S.2    Sharp, L.3
  • 14
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • Eden A, Gaudet F, Waghmare A, Jaenisch R (2003). Chromosomal instability and tumors promoted by DNA hypomethylation. Science, 300, 455.
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3    Jaenisch, R.4
  • 15
    • 28644450906 scopus 로고    scopus 로고
    • RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer
    • Endoh M, Tamura G, Honda T et al (2005). RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer. Br J Cancer, 93, 1395-9.
    • (2005) Br J Cancer , vol.93 , pp. 1395-1399
    • Endoh, M.1    Tamura, G.2    Honda, T.3
  • 16
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg AP, Tycko B (2004). The history of cancer epigenetics. Nat Rev Cancer, 4, 143-53.
    • (2004) Nat Rev Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 17
    • 0031903189 scopus 로고    scopus 로고
    • Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults
    • Fenech M, Aitken C, Rinaldi J (1998). Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis, 19, 1163-1171.
    • (1998) Carcinogenesis , vol.19 , pp. 1163-1171
    • Fenech, M.1    Aitken, C.2    Rinaldi, J.3
  • 18
    • 0037117501 scopus 로고    scopus 로고
    • A commonmutation in the 5 10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation status through an interaction with folate status
    • Friso S, Choi SW, Girelli D et al (2002). A commonmutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation status through an interaction with folate status. Proc Natl Acad Sci USA, 99, 5606-11.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5606-5611
    • Friso, S.1    Choi, S.W.2    Girelli, D.3
  • 19
    • 0029049553 scopus 로고
    • Candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R et al (1995). Candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet, 10, 111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 20
    • 0028921519 scopus 로고
    • Alcohol, lowmethionine - low-folatediets, and risk of colon cancer in men
    • Giovannucci E, Rimm EB, Ascherio A et al (1995). Alcohol, lowmethionine - low-folatediets, and risk of colon cancer in men. J Natl Cancer Inst, 87, 265-73.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 265-273
    • Giovannucci, E.1    Rimm, E.B.2    Ascherio, A.3
  • 21
    • 0027286578 scopus 로고
    • Folate, methionine, and alcohol intake and risk of colorectal adenoma
    • Giovannucci E, Stampfer MJ, Colditz GA et al (1993). Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst, 85, 875-84.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 875-884
    • Giovannucci, E.1    Stampfer, M.J.2    Colditz, G.A.3
  • 22
    • 0032190337 scopus 로고    scopus 로고
    • Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study
    • Giovannucci E, Stampfer MJ, Colditz GA et al (1998). Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann Intern Med, 129, 517-24.
    • (1998) Ann Intern Med , vol.129 , pp. 517-524
    • Giovannucci, E.1    Stampfer, M.J.2    Colditz, G.A.3
  • 23
    • 0028487161 scopus 로고
    • Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification
    • Goyette P, Sumner JS, Milos R et al (1994). Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet, 7, 195-200.
    • (1994) Nat Genet , vol.7 , pp. 195-200
    • Goyette, P.1    Sumner, J.S.2    Milos, R.3
  • 24
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB (2003). Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med, 349, 2042-54.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 25
    • 20544445183 scopus 로고    scopus 로고
    • CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations
    • Hesson LB, Wilson R, Morton D et al (2005). CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations. Oncogene, 24, 3987-94.
    • (2005) Oncogene , vol.24 , pp. 3987-3994
    • Hesson, L.B.1    Wilson, R.2    Morton, D.3
  • 26
    • 0035328527 scopus 로고    scopus 로고
    • Accelerated age-related CpG island methylation in ulcerative colitis
    • Issa JP, Ahuja N, Toyota M, Bronner MP, Brentnall TA (2001). Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res, 61, 3573-7.
    • (2001) Cancer Res , vol.61 , pp. 3573-3577
    • Issa, J.P.1    Ahuja, N.2    Toyota, M.3    Bronner, M.P.4    Brentnall, T.A.5
  • 27
    • 0034597517 scopus 로고    scopus 로고
    • Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma
    • Iwata N, Yamamoto H, Sasaki S et al (2000). Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma. Oncogene, 19, 5298-302.
    • (2000) Oncogene , vol.19 , pp. 5298-5302
    • Iwata, N.1    Yamamoto, H.2    Sasaki, S.3
  • 28
    • 0031816123 scopus 로고    scopus 로고
    • Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylationin postmenopausal women
    • Jacob RA, Gretz DM, Taylor PC et al (1998). Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylationin postmenopausal women. J Nutr, 128, 1204-1212.
    • (1998) J Nutr , vol.128 , pp. 1204-1212
    • Jacob, R.A.1    Gretz, D.M.2    Taylor, P.C.3
  • 29
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
    • Jacques PF, Bostom AG, Williams RR et al (1996). Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation, 93, 7-9.
    • (1996) Circulation , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3
  • 30
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB (2002). The fundamental role of epigenetic events in cancer. Nat Rev Genet, 3, 415-28.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 31
    • 0035056507 scopus 로고    scopus 로고
    • Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus
    • Kaneto H, Sasaki S, Yamamoto H et al (2001). Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus. Gut, 48, 372-7.
    • (2001) Gut , vol.48 , pp. 372-377
    • Kaneto, H.1    Sasaki, S.2    Yamamoto, H.3
  • 32
    • 0036907435 scopus 로고    scopus 로고
    • 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites
    • Keku T, Millikan R, Worley K et al (2002). 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites. Cancer Epidemiol Biomarkers Prev, 11, 1611-21.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 1611-1621
    • Keku, T.1    Millikan, R.2    Worley, K.3
  • 33
    • 0031949104 scopus 로고    scopus 로고
    • The effect of ethanol and its metabolites upon methionine synthase activity in vitro
    • Kenyon SH, Nicolaou A, Gibbons WA (1998). The effect of ethanol and its metabolites upon methionine synthase activity in vitro. Alcohol, 15, 305-9.
    • (1998) Alcohol , vol.15 , pp. 305-309
    • Kenyon, S.H.1    Nicolaou, A.2    Gibbons, W.A.3
  • 34
    • 0033007272 scopus 로고    scopus 로고
    • Folate and carcinogenesis: evidence, mechanisms, and implications
    • Kim YI (1999). Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem, 10, 66-88.
    • (1999) J Nutr Biochem , vol.10 , pp. 66-88
    • Kim, Y.I.1
  • 35
    • 0033869675 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of genenutrient interactions in carcinogenesis
    • Kim YI (2000). Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of genenutrient interactions in carcinogenesis. Nutr Rev, 58, 205-9.
    • (2000) Nutr Rev , vol.58 , pp. 205-209
    • Kim, Y.I.1
  • 36
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW, Vogelstein B (1996). Lessons from hereditary colorectal cancer. Cell, 87, 159-70.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 37
    • 2442577021 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation
    • Kondo Y, Shen L, Yan PS, Huang TH, Issa JP (2004). Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation. Proc Natl Acad Sci USA, 101, 7398-403.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7398-7403
    • Kondo, Y.1    Shen, L.2    Yan, P.S.3    Huang, T.H.4    Issa, J.P.5
  • 38
    • 0036784440 scopus 로고    scopus 로고
    • Intake of dietary folate vitamers and risk of colorectal carcinoma; results from the Netherlands cohort study
    • Konings EJ, Goldbohm RA, Brants HA, Saris WH, van den Brandt PA (2002). Intake of dietary folate vitamers and risk of colorectal carcinoma; results from the Netherlands cohort study. Cancer, 95, 1421-33.
    • (2002) Cancer , vol.95 , pp. 1421-1433
    • Konings, E.J.1    Goldbohm, R.A.2    Brants, H.A.3    Saris, W.H.4    van den Brandt, P.A.5
  • 39
    • 33645801603 scopus 로고    scopus 로고
    • Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus
    • Kusano M, Toyota M, Suzuki H et al (2006). Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus. Cancer, 106, 1467-79.
    • (2006) Cancer , vol.106 , pp. 1467-1479
    • Kusano, M.1    Toyota, M.2    Suzuki, H.3
  • 40
    • 0031025741 scopus 로고    scopus 로고
    • The effect of folic acid supplementation on the risk for cancer or dysplasia in ulcerative colitis
    • Lashner BA, Provencher KS, Seidner DL, Knesebeck A, Brzezinski A (1997). The effect of folic acid supplementation on the risk for cancer or dysplasia in ulcerative colitis. Gastroenterology, 112, 29-32.
    • (1997) Gastroenterology , vol.112 , pp. 29-32
    • Lashner, B.A.1    Provencher, K.S.2    Seidner, D.L.3    Knesebeck, A.4    Brzezinski, A.5
  • 41
    • 0036230697 scopus 로고    scopus 로고
    • B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
    • Le Marchand L, Donlon T, Hankin JH et al (2002). B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). Cancer Causes Control, 13, 239-48.
    • (2002) Cancer Causes Control , vol.13 , pp. 239-248
    • Le Marchand, L.1    Donlon, T.2    Hankin, J.H.3
  • 42
    • 0030615085 scopus 로고    scopus 로고
    • Methylenetetrahydro-folate reductase polymorphism, dietary interactions and risk of colorectal cancer
    • Ma J, Stampfer MJ, Giovannucci E et al (1997). Methylenetetrahydro-folate reductase polymorphism, dietary interactions and risk of colorectal cancer. Cancer Res, 57, 1098-102.
    • (1997) Cancer Res , vol.57 , pp. 1098-1102
    • Ma, J.1    Stampfer, M.J.2    Giovannucci, E.3
  • 43
    • 0032878590 scopus 로고    scopus 로고
    • A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk
    • Ma J, Stampfer MJ, Christensen B et al (1999). A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev, 8, 825-9.
    • (1999) Cancer Epidemiol Biomarkers Prev , vol.8 , pp. 825-829
    • Ma, J.1    Stampfer, M.J.2    Christensen, B.3
  • 44
    • 0030615085 scopus 로고    scopus 로고
    • Methylenetetrahydro-folate reductase polymorphism, dietary interactions and risk of colorectal cancer
    • Ma J, Stampfer MJ, Giovannucci E et al (1997). Methylenetetrahydro-folate reductase polymorphism, dietary interactions and risk of colorectal cancer. Cancer Res, 57, 1098-1102.
    • (1997) Cancer Res , vol.57 , pp. 1098-1102
    • Ma, J.1    Stampfer, M.J.2    Giovannucci, E.3
  • 45
    • 0035942170 scopus 로고    scopus 로고
    • Selective association of the methyl CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia
    • Magdinier F, Wolffe AP (2001). Selective association of the methyl CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. Proc Natl Acad Sci USA, 98, 4990-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4990-4995
    • Magdinier, F.1    Wolffe, A.P.2
  • 46
    • 0030955502 scopus 로고    scopus 로고
    • Thermolabile variant of 5 10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations
    • Molloy AM, Daly S, Mills JL et al (1997). Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet, 349, 1591-3.
    • (1997) Lancet , vol.349 , pp. 1591-1593
    • Molloy, A.M.1    Daly, S.2    Mills, J.L.3
  • 47
    • 19944433480 scopus 로고    scopus 로고
    • Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer
    • Murai M, Toyota M, Suzuki H et al (2005). Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. Clin Cancer Res, 11, 1021-7.
    • (2005) Clin Cancer Res , vol.11 , pp. 1021-1027
    • Murai, M.1    Toyota, M.2    Suzuki, H.3
  • 48
    • 4444363632 scopus 로고    scopus 로고
    • Interactions between two common variants C677T and A1298C in the methylene-tetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strandbreaks, misincorporated uraciland DNA methylation status)
    • Narayanan S, McConnell J, Little J et al (2004). Interactions between two common variants C677T and A1298C in the methylene-tetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strandbreaks, misincorporated uraciland DNA methylation status). Cancer Epidemiol Biomarkers Prev, 13, 1-8.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 1-8
    • Narayanan, S.1    McConnell, J.2    Little, J.3
  • 49
    • 0346333257 scopus 로고    scopus 로고
    • Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer
    • Obata T, Toyota M, Satoh A et al (2003). Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. Clin Cancer Res, 9, 6410-8.
    • (2003) Clin Cancer Res , vol.9 , pp. 6410-6418
    • Obata, T.1    Toyota, M.2    Satoh, A.3
  • 50
    • 2442539281 scopus 로고    scopus 로고
    • The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer
    • Oyama K, Kawakami K, Maeda K, Ishiguro K, Watanabe G (2004). The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer. Anticancer Res, 24, 649-54.
    • (2004) Anticancer Res , vol.24 , pp. 649-654
    • Oyama, K.1    Kawakami, K.2    Maeda, K.3    Ishiguro, K.4    Watanabe, G.5
  • 51
    • 0032799527 scopus 로고    scopus 로고
    • The 677>T mutation in 5 10-methylenetetrahydrofolate reductase and colorectal cancer risk
    • Park KS, Mok JW, Kim JC (1999). The 677>T mutation in 5,10-methylenetetrahydrofolate reductase and colorectal cancer risk. Genet Test, 3, 233-6.
    • (1999) Genet Test , vol.3 , pp. 233-236
    • Park, K.S.1    Mok, J.W.2    Kim, J.C.3
  • 52
    • 0036682379 scopus 로고    scopus 로고
    • Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumours
    • Paz MF, Avila S, Fraga MF et al (2002). Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumours. Cancer Res, 62, 4519-24.
    • (2002) Cancer Res , vol.62 , pp. 4519-4524
    • Paz, M.F.1    Avila, S.2    Fraga, M.F.3
  • 53
    • 0029739419 scopus 로고    scopus 로고
    • Levels of folic acid in plasma and in red blood cells of colorectal cancer patients
    • Porcelli B, Frost B, Rosi F et al (1996). Levels of folic acid in plasma and in red blood cells of colorectal cancer patients. Biomedical Pharmacotherapy, 50, 303-5.
    • (1996) Biomedical Pharmacotherapy , vol.50 , pp. 303-305
    • Porcelli, B.1    Frost, B.2    Rosi, F.3
  • 54
    • 0038523843 scopus 로고    scopus 로고
    • Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study
    • Pufulete M, Al-Ghnaniem R, Leather AJ et al (2003a). Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology, 124, 1240-1248.
    • (2003) Gastroenterology , vol.124 , pp. 1240-1248
    • Pufulete, M.1    Al-Ghnaniem, R.2    Leather, A.J.3
  • 55
    • 0038605227 scopus 로고    scopus 로고
    • Folate DNA methylation and colorectal cancer
    • Pufulete M, Emery PW, Sanders TA (2003b). Folate, DNA methylation and colorectal cancer. Proc Nutr Soc, 62, 437-45.
    • (2003) Proc Nutr Soc , vol.62 , pp. 437-445
    • Pufulete, M.1    Emery, P.W.2    Sanders, T.A.3
  • 56
    • 0033805888 scopus 로고    scopus 로고
    • Genomic DNA methylation decreases in response to moderate folate depletionin elderly women
    • Rampersaud GC, Kauwell GP, Hutson AD, Cerda JJ, Bailey LB (2000). Genomic DNA methylation decreases in response to moderate folate depletionin elderly women. Am J Clin Nutr, 72, 998-1003.
    • (2000) Am J Clin Nutr , vol.72 , pp. 998-1003
    • Rampersaud, G.C.1    Kauwell, G.P.2    Hutson, A.D.3    Cerda, J.J.4    Bailey, L.B.5
  • 57
    • 7644228433 scopus 로고    scopus 로고
    • CpG island methylation in gastroenterologic neoplasia: a maturing field
    • Rashid A, Issa JP (2004). CpG island methylation in gastroenterologic neoplasia: a maturing field. Gastroenterology, 127, 1578-88.
    • (2004) Gastroenterology , vol.127 , pp. 1578-1588
    • Rashid, A.1    Issa, J.P.2
  • 58
    • 24144449572 scopus 로고    scopus 로고
    • Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer
    • Samowitz WS, Albertsen H, Herrick J et al (2005). Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology, 129, 837-45.
    • (2005) Gastroenterology , vol.129 , pp. 837-845
    • Samowitz, W.S.1    Albertsen, H.2    Herrick, J.3
  • 59
    • 18444375277 scopus 로고    scopus 로고
    • DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers
    • Satoh A, Toyota M, Itoh F et al (2002). DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers. Br J Cancer, 86, 1817-23.
    • (2002) Br J Cancer , vol.86 , pp. 1817-1823
    • Satoh, A.1    Toyota, M.2    Itoh, F.3
  • 60
    • 1442300286 scopus 로고    scopus 로고
    • Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
    • Sharp L, Little J (2004). Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol, 159, 423-43.
    • (2004) Am J Epidemiol , vol.159 , pp. 423-443
    • Sharp, L.1    Little, J.2
  • 62
    • 0033846460 scopus 로고    scopus 로고
    • Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene
    • Stern LL, Mason JB, Selhub J, ChoiSW (2000). Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev, 9, 849-853.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 849-853
    • Stern, L.L.1    Mason, J.B.2    Selhub, J.3    Choi, S.W.4
  • 63
    • 0032848687 scopus 로고    scopus 로고
    • Distinct methylation pattern and microsatellite instability in sporadic gastric cancer
    • Suzuki H, Itoh F, Toyota M et al (1999). Distinct methylation pattern and microsatellite instability in sporadic gastric cancer. Int J Cancer, 83, 309-13.
    • (1999) Int J Cancer , vol.83 , pp. 309-313
    • Suzuki, H.1    Itoh, F.2    Toyota, M.3
  • 64
    • 0034662605 scopus 로고    scopus 로고
    • Inactivation of the 14-3-3 sigma gene is associated with 5' CpG island hypermethylation in human cancers
    • Suzuki H, Itoh F, Toyota M et al (2000). Inactivation of the 14-3-3 sigma gene is associated with 5' CpG island hypermethylation in human cancers. Cancer Res, 60, 4353-7.
    • (2000) Cancer Res , vol.60 , pp. 4353-4357
    • Suzuki, H.1    Itoh, F.2    Toyota, M.3
  • 65
    • 0036613250 scopus 로고    scopus 로고
    • A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer
    • Suzuki H, Gabrielson E, Chen W et al (2002). A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet, 31, 141-9.
    • (2002) Nat Genet , vol.31 , pp. 141-149
    • Suzuki, H.1    Gabrielson, E.2    Chen, W.3
  • 66
    • 0037133565 scopus 로고    scopus 로고
    • Comprehensive analysis of CpG islands in human chromosomes 21 and 22
    • Takai D, Jones PA (2002). Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci USA, 99, 3740-45.
    • (2002) roc Natl Acad Sci USA , vol.99 , pp. 3740-3745
    • Takai, D.1    Jones, P.A.2
  • 67
    • 0033587747 scopus 로고    scopus 로고
    • CpG island methylator phenotype in colorectal cancer
    • Toyota M, Ahuja N, Ohe-Toyota M et al (1999a). CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA, 96, 8681-86.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8681-8686
    • Toyota, M.1    Ahuja, N.2    Ohe-Toyota, M.3
  • 68
    • 0037934421 scopus 로고    scopus 로고
    • Epigenetic inactivation of CHFR in human tumors
    • Toyota M, Sasaki Y, Satoh A et al (2003). Epigenetic inactivation of CHFR in human tumors. Proc Natl Acad Sci USA, 100, 7818-23.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7818-7823
    • Toyota, M.1    Sasaki, Y.2    Satoh, A.3
  • 69
    • 0033229890 scopus 로고    scopus 로고
    • Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
    • Toyota M, Ahuja N, Suzuki H et al (1999b). Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res, 59, 5438-42.
    • (1999) Cancer Res , vol.59 , pp. 5438-5442
    • Toyota, M.1    Ahuja, N.2    Suzuki, H.3
  • 70
    • 0034681117 scopus 로고    scopus 로고
    • Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype
    • Toyota M, Ohe-Toyota M, Ahuja N, Issa JP (2000). Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci USA, 97, 710-5.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 710-715
    • Toyota, M.1    Ohe-Toyota, M.2    Ahuja, N.3    Issa, J.P.4
  • 72
    • 0037731713 scopus 로고    scopus 로고
    • Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer
    • van Engeland M, Weijenberg MP, Roemen GM et al (2003). Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. Cancer Res, 63, 3133-7.
    • (2003) Cancer Res , vol.63 , pp. 3133-3137
    • van Engeland, M.1    Weijenberg, M.P.2    Roemen, G.M.3
  • 73
    • 0036895068 scopus 로고    scopus 로고
    • Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands
    • van Rijnsoever M, Grieu F, Elsaleh H, Joseph D, Iacopetta B (2002). Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut, 51, 797-802.
    • (2002) Gut , vol.51 , pp. 797-802
    • van Rijnsoever, M.1    Grieu, F.2    Elsaleh, H.3    Joseph, D.4    Iacopetta, B.5
  • 74
    • 0034703084 scopus 로고    scopus 로고
    • Increase in plasma homocysteine associated with parallel increases in plasma Sadenosylhomocysteine and lymphocyte DNA hypomethylation
    • Yi P, Melnyk S, Pogribna M et al (2000). Increase in plasma homocysteine associated with parallel increases in plasma Sadenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem, 275, 29318-23.
    • (2000) J Biol Chem , vol.275 , pp. 29318-29323
    • Yi, P.1    Melnyk, S.2    Pogribna, M.3
  • 75
    • 0344827254 scopus 로고    scopus 로고
    • Methylation of ASC/ TMS1, a proapoptotic gene responsible for activating procaspase-1, in human colorectal cancer
    • Yokoyama T, Sagara J, Guan X et al (2003). Methylation of ASC/ TMS1, a proapoptotic gene responsible for activating procaspase-1, in human colorectal cancer. Cancer Lett, 202, 101-8.
    • (2003) Cancer Lett , vol.202 , pp. 101-108
    • Yokoyama, T.1    Sagara, J.2    Guan, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.