Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole hydroxylase activity

Journal of Biological Chemistry

Volumn 271, Issue 21, 1996, Pages 12496-12501

  Ibeanu, Gordon C ^a   Ghanayem, Burhan I ^a   Linko, Patricia ^a   Li, Leiping ^a   Pedersen, Lee G ^a   Goldstein, Joyce A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; OMEPRAZOLE; OXYGENASE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; DRUG HYDROXYLATION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; NONHUMAN; PRIORITY JOURNAL;

ARYL HYDROCARBON HYDROXYLASES; BASE SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES; RECOMBINANT FUSION PROTEINS;

EID: 15844394255     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.21.12496     Document Type: Article

References (46)

1. Nelson, D. R., Kamataki, T., Waxman, D. J., Guengerich, F. P., Estabrook, R. W., Feyereisen, R., Gonzalez, F. J., Coon, M. J., Gunzaalus, I. C., Gotoh, O., Okuda, K., and Nebert, D. (1993) DNA Cell Biol. 12, 1-51
2. Porter, T. D., and Coon, M. J. (1991) J. Biol. Chem. 266, 13469-13472
3. Guengerich, F. P. (1991) J. Biol. Chem. 266, 10019-10022
4. Johnson, E. F. (1992) Trends Phamacol. Sci. 13, 122-126
5. Lindberg, R., and Negishi, M. (1989) Nature 339, 632-634
6. Goldstein, J. A., and de Morais, S. M. F. (1994) Pharmacogenetics 4, 285-299
7. Goldstein, J. A., Faletto, M. B., Romkes-Sparks, M., Sullivan, T., Kitareewan, S., Raucy, J. L., Lasker, J. M., and Ghanayem, B. I. (1994) Biochemistry 33, 1743-1752
8. Hasemann, C. A., Kurumbali, R. G., Boddupalli, S. S., Peterson, J. A., and Diesenhofer, J. (1995) Structure (Lond.) 3, 41-62
9. Laugbton, C. A., Neidle, S., Zvelebil, M. J., and Sternberg, J. M. (1990) Biochem. Biophys. Res. Commun. 171, 1160-1167
10. Laughton, C. A., Zvelebil, M. J., and Neidle, S. (1993) J. Steroid Biochem. Mol. Biol. 44, 399-407
11. Lewis, D. F. V., and Moereels, H. (1992) J. Comput.-Aided. Mol. Design 6, 235-252
12. Zvelebil, M. J., Wolf, J. M., and Sternberg, M. J. E. (1991) Protein Eng. 4, 271-282
13. Gotoh, O. (1992) J. Biol. Chem. 267, 83-90
14. Straub, P., Lloyd, M., Johnson, E. F., and Kemper, B. (1993) J. Biol. Chem. 268, 21997-22003
15. Straub, P., Johnson, E. F., and Kemper, B. (1993) Arch. Biochem. Biophys. 306, 521-527
16. Imai, Y., and Nakamura, M. (1989) Biochem. Biophys. Res. Commun. 158, 717-722
17. Sullivan, T. H., Ghanayem, B. I., Bell, D. A., Zhang, Z. Y., Kaminsky, L. S., Shenfield, G. M., Miners, J. O., Birkett, D. J., and Goldstein, J. A. (1996) Pharmacogenetics, in press
18. Richardson, T. H., and Johnson, E. F. (1994) J. Biol. Chem. 269, 23937-23943
19. Szklar, G. D., He, Y.-a., and Halpert, J. R. (1995) Biochemistry, 34, 14312-14322
20. Juvonen, R. O., Iwasaki, M., and Negishi, M. (1991) J. Biol. Chem. 266, 16431-16435
21. Iwasaki, M., Lindberg, R. L. P., Juvonen, R. D., and Negishi, M. (1993) Biochem. J. 291, 569-573
22. Iwasaki, M., Darden, T. A., Pedersen, L. G., Davis, D. G., Juvonen, R. O., Sueyoshi, T., and Negishi, M. (1993) J. Biol. Chem. 268, 759-762
23. Iwasaki, M., Darden, T. A., Pedersen, L. G., and Negishi, M. (1995) Biochemistry 3, 5054-5059
24. Aoyama, T., Korzekwa, K., Nagata, K., Adesnik, M., Reiss, A., Lapenson, D. P., Gillette, J., Gelboin, H. V., Waxman, D. J., and Gonzalez, F. J. (1989) J. Biol. Chem. 264, 21327-21333
25. Kedzie, K. M., Balfour, C. A., Escobar, G. Y., Grimm, S. W., He, Y., Pepperil, D. J., Regan, J. W., Stevens, J. C., and Halpert, J. R. (1991) J. Biol. Chem. 266, 22515-22521
26. He, Y-a., Luo, Z., Klekotka, P. A., Burnett, V. L., and Halpert, J. R. (1994) Biochemistry 33, 4419-4424
27. Halpert, J. R., and He, Y. (1993) J. Biol. Chem. 268, 4453-4457
28. Hasler, J. A., Harlow, G. R., Szklar, G. D., John, G. H., Kedzie, K. M., Burnett, V. L., Kaminsky, L. S., and Halpert, J. R. (1994) Mol. Pharmacol. 46, 338-345
29. Matsunaga, E., Zeugin, T., Zanger, U. M., Aoyama, T., Meyer, U. A., and Gonzalez, F. J. (1990) J. Biol. Chem. 265, 17197-17201
30. Faletto, M. B., Linko, P., and Goldstein, J. A. (1992) J. Biol. Chem. 267, 2032-2037
31. Deng, W. P., and Nickoloff, J. A. (1992) Anal. Biochem. 200, 81-88
32. Rose, M. D., Winson, P., and Hieter, P. (1990) in Methods in Yeast Genetics (Rose, M. D., Winson, F., and Hieter, P., eds) pp. 180-187, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
33. Oeda, K., Sakaki, T., and Ohkawa, H. (1985) DNA (N. Y.) 4, 203-210
34. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
35. Omura, T., and Sato, R. (1964) J. Biol. Chem. 239, 2370-2378
36. Poulos, T. L., Finzel, B. C., and Howard, A. J. (1987) J. Mol. Biol. 195, 687-700
37. Atkins, W. M., and Sugar, S. G. (1988) J. Biol. Chem. 263, 18842-18849
38. Nelson, D. R., and Strobel, H. W. (1989) Biochemistry 28, 656-660
39. Lin, D., Black, S. M., Nagahama, Y., and Miller, W. M. (1993) Endocrinology 132, 2498-2506
40. Kronbach, T., Larabee, T. M., and Johnson, E. F. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 8262-8265
41. Kronbach, T., Kemper, B., and Johnson, E. F. (1991) Biochemistry 30, 6097-6102
42. Uno, T., and Imai, Y. (1992) J. Biochem. (Tokyo) 112, 155-162
43. Johnson, E. F., Kronbach, T., and Hsu, M.-h. (1992) FASEB J. 6, 700-705
44. Uno, T., and Imai, Y. (1989) J. Biochem. (Tokyo) 106, 569-574
45. Luo, Z., He, Y.-a., and Halpert, J. R. (1994) Arch. Biochem. Biophys. 309, 52-57
46. Ghanayem, B. I., Karam, W. G., and Goldstein, J. A. (1994) Sixth North American International Society for the Study of Xenobiotics Meeting, October 23-27, 1994, Raleigh, NC, (abstr.), p. 50