Mechanisms of disease: Immunopathogenesis of celiac disease

Nature Clinical Practice Gastroenterology and Hepatology

Volumn 3, Issue 9, 2006, Pages 516-525

  Jabri, Bana ^a   Sollid, Ludvig M ^b,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTEN; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2D; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

AUTOIMMUNE DISEASE; CELIAC DISEASE; DIETARY INTAKE; GENETIC DISORDER; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; INNATE IMMUNITY; INTESTINE CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; STRESS; T CELL LYMPHOMA;

CELIAC DISEASE; CLINICAL TRIALS; CLINICAL TRIALS AS TOPIC; GLIADIN; HLA-DQ ANTIGENS; HUMANS; INTESTINAL MUCOSA; TRANSGLUTAMINASES;

EID: 33748323039     PISSN: 17434378     EISSN: 17434386     Source Type: Journal    
DOI: 10.1038/ncpgasthep0582     Document Type: Review

References (79)

1. Green PH and Jabri B (2003) Coeliac disease. Lancet 362: 383-391
2. MacDonald TT et al. (1999) T cells orchestrate intestinal mucosal shape and integrity. Immunol Today 20: 505-510
3. Ferguson A et al. (1976) Intraepithelial lymphocyte counts in small intestinal biopsies from children with diarrhoea. Acta Paediatr Scand 65: 541-546
4. Marsh MN (1992) Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 102: 330-354
5. Dieterich W et al. (1997) Identification of tissue transglutaminase as the autoantigen of celiac disease. Nature Med 3: 797-801
6. Sollid LM (2002) Coeliac disease: Dissecting a complex inflammatory disorder. Nature Reviews Immunology 2: 647-655
7. Sardy M et al. (2002) Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. J Exp Med 195: 747-757
8. Catassi C et al. (1996) The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school-age subjects. Acta Paediatr Suppl 412: 29-35
9. Green PH and Jabri B (2002) Celiac disease and other precursors to small-bowel malignancy. Gastroenterol Clin North Am 31: 625-639
10. Sollid LM and Jabri B (2005) Is celiac disease an autoimmune disorder? Curr Opin Immunol 17: 595-600
11. Ventura A et al. (1999) Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease. Gastroenterology 117: 297-303
12. Viljamaa M et al. (2005) Coeliac disease, autoimmune diseases and gluten exposure. Scand J Gastroenterol 40: 437-443
13. Sollid LM and Lie BA (2005) Celiac disease genetics: Current concepts and practical applications. Clin Gastroenterol Hepatol 3: 843-851
14. Sollid LM and Thorsby E (1993) HLA susceptibility genes in celiac disease: Genetic mapping and role in pathogenesis. Gastroenterology 105: 910-922
15. Ploski R et al. (1993) On the HLA-DQ(α1*0501, β1*0201)-associated susceptibility in celiac disease: A possible gene dosage effect of DQB1*0201. Tissue Antigens 41: 173-177
16. Vader W et al. (2003) The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses. Proc Natl Acad Sci USA 100: 12390-12395
17. Nistico L et al. (2006) Concordance, disease progression, and heritability of coeliac disease in Italian twins. Gut 55: 803-808
18. Mearin ML et al. (1983) HLA-DR phenotypes in Spanish coeliac children: their contribution to the understanding of the genetics of the disease. Gut 24: 532-537
19. van Heel DA et al. (2005) Genetics in coeliac disease. Best Pract Res Clin Gastroenterol 19: 323-339
20. Babron MC et al. (2003) Meta and pooled analysis of European coeliac disease data. Eur J Hum Genet 11: 828-834
21. van Belzen MJ et al. (2003) A major non-HLA locus in celiac disease maps to chromosome 19. Gastroenterology 125: 1032-1041
22. Monsuur AJ et al. (2005) Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nature Genet 37: 1341-1344
23. Hunt KA et al. (2006) Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. Gut 55: 969-972
24. Amundsen SS et al. (2006) Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort. Hum Immunol 67: 341-345
25. van Elburg RM et al. (1993) Intestinal permeability in patients with coeliac disease and relatives of patients with coeliac disease. Gut 34: 354-357.
26. Wirth JA et al. (1996) Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail. J Cell Sci 109: 653-661
27. Cataldo F et al. (1998) Prevalence and clinical features of selective immunoglobulin A deficiency in coeliac disease: An Italian multicentre study. Italian Society of Paediatric Gastroenterology and Hepatology (SIGEP) and "Club del Tenue" Working Groups on Coeliac Disease. Gut 42: 362-365
28. Castigli E et al. (2005) TACI is mutant in common variable immunodeficiency and IgA deficiency. Nature Genet 37: 829-834
29. Lundin KE et al. (1993) Gliadin-specific, HLA-DQ(α1*0501, β1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 178: 187-196
30. Lundin KE et al. (1994) T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8. Hum Immunol 41: 285-291
31. Johansen BH et al. (1996) Identification of a putative motif for binding of peptides to HLA-DQ2. Int Immunol 8: 177-182
32. van de Wal Y et al. (1996) Peptide binding characteristics of the coeliac disease-associated DQ(α1*0501, β1*0201) molecule. Immunogenetics 44: 246-253
33. Kwok WW et al. (1996) Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase. J Immunol 156: 2171-2177
34. Suri A et al. (2005) Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity. J Clin Invest 115: 2268-2276
35. Molberg O et al. (1998) Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nature Med 4: 713-717
36. van de Wal Y et al. (1998) Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 161: 1585-1588
37. Fleckenstein B et al. (2002) Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process. J Biol Chem 277: 34109-34116
38. Vader LW et al. (2002) Specificity of tissue transglutaminase explains cereal toxicity in celiac disease. J Exp Med 195: 643-649
39. Shan L et al. (2002) Structural basis for gluten intolerance in celiac sprue. Science 297: 2275-2279
40. Shan L et al. (2005) Identification and analysis of multivalent proteolytically resistant peptides from gluten: Implications for celiac sprue. J Proteome Res 4: 1732-1741
41. Arentz-Hansen H et al. (2004) The molecular basis for oat intolerance in patients with celiac disease. PLoS Med 1: E1
42. Qiao SW et al. (2005) Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation. J Immunol 175: 254-261
43. Kim CY et al. (2004) Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proc Natl Acad Sci USA 101: 4175-4179
44. Moustakas AK et al. (2000) Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes. Int Immunol 12: 1157-1166
45. Tollefsen S et al. HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. J Clin Invest 116: 2226-2236
46. Sollid LM et al. (1997) Autoantibodies in coeliac disease: Tissue transglutaminase-guilt by association? Gut 41: 851-852
47. Fleckenstein B et al. (2004) Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides. J Biol Chem 279: 17607-17616
48. + T cell transendothelial migration. J Immunol 171: 3179-3186
49. Maiuri L et al. (2005) Unexpected role of surface transglutaminase type II in celiac disease. Gastroenterology 129: 1400-1413
50. Le Naour F et al. (2001) Profiling changes in gene expression during differentiation and maturation of monocyte-derived dendritic cells using both oligonucleotide microarrays and proteomics. J Biol Chem 276: 17920-17931
51. Akimov SS and Belkin AM (2001) Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin. Blood 98: 1567-1576
52. Marietta E et al. (2004) A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice. J Clin Invest 114: 1090-1097
53. Kaukinen K et al. (2005) Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study. Scand J Gastroenterol 40: 564-572
54. + T cell responses: Identification of a novel gliadin-derived HLA-A2-restricted epitope. J Immunol 170: 2719-2726
55. Hue S et al. (2004) A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 21: 367-377
56. Meresse B et al. (2004) Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21: 357-366
57. Meresse B et al. (2006) Reprogramming of CTL into natural killer-like cells in celiac disease. J Exp Med 203: 1343-1355
58. Roberts AI et al. (2001) NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment. J Immunol 167: 5527-5530
59. Jabri B et al. (2000) Selective expansion of intraepithelial lymphocytes expressing the HLA-Especific natural killer receptor CD94 in celiac disease. Gastroenterology 118: 867-879
60. Mention JJ et al. (2003) Interleukin 15: A key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology 125: 730-745
61. Bauer S et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285: 727-729
62. Braud VM et al. (1998) HLA-E binds to natural killer cell receptors CD94/ NKG2A, B and C. Nature 391: 795-799
63. Lee N et al. (1998) HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc Natl Acad Sci USA 95: 5199-5204
64. Nikulina M et al. (2004) Wheat gluten causes dendritic cell maturation and chemokine secretion. J Immunol 173: 1925-1933
65. Palova-Jelinkova L et al. (2005) Gliadin fragments induce phenotypic and functional maturation of human dendritic cells. J Immunol 175: 7038-7045
66. Ogasawara K et al. (2004) NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity 20: 757-767
67. Turley S et al. (2003) Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med 198: 1527-1537
68. Turley SJ et al. (2005) Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci USA 102: 17729-17733
69. Jabri B et al. (2005) Innate and adaptive immunity: The yin and yang of celiac disease. Immunol Rev 206: 219-231
70. Troncone R et al. (1996) In siblings of celiac children, rectal gluten challenge reveals gluten sensitization not restricted to celiac HLA. Gastroenterology 111: 318-324
71. Maiuri L et al. (2003) Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 362: 30-37
72. Lang KS et al. (2005) Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nature Med 11: 138-145
73. Sollid LM and Vaage JT (2006) Cross-dressing T cells go wild. Nature Med 12: 611-612
74. Lee SK et al. (2003) Duodenal histology in patients with celiac disease after treatment with a gluten-free diet. Gastrointest Endosc 57: 187-191
75. Wahab PJ et al. (2002) Histologic follow-up of people with celiac disease on a gluten-free diet: Slow and incomplete recovery. Am J Clin Pathol 118: 459-463
76. Cellier C et al. (2000) Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet 356: 203-208
77. Isaacson PG (2000) Relation between cryptic intestinal lymphoma and refractory sprue. Lancet 356: 178-179
78. + T cells. J Exp Med 193: 219-231
79. Sollid LM and Khosla C (2005) Future therapeutic options for celiac disease. Nat Clin Pract Gastroenterol Hepatol 2: 140-147