Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase

Journal of Immunology

Volumn 156, Issue 6, 1996, Pages 2171-2177

  Kwok, William W ^a   Domeier, Mary Ellen ^a   Raymond, Fenella C ^a   Byers, Patricia ^a   Nepom, Gerald T ^a  

^a BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE DECARBOXYLASE; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN;

ALLELISM; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; BINDING SITE; DIABETES MELLITUS; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; PEPTIDE ANALYSIS; PRIORITY JOURNAL;

ALLELES; AMINO ACID SEQUENCE; CELL LINE, TRANSFORMED; DIABETES MELLITUS, TYPE 1; EPITOPES; GLUTAMATE DECARBOXYLASE; HLA-DQ ANTIGENS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYMORPHISM, GENETIC; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 0029979525     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Lampeter, E. F., M. Homberg, K. Quabeck, U. W. Schaefer, P Wernet, J. Bertrams, H. Grosse-Wilde, F. A Gries, and H. Kolb. 1993. Transfer of insulin-dependent diabeies between HLA-identical siblings by bone marrow transplantation. Lancet 341-1243.
2. Vialettes, B , D Maraninchi, M. P. San Marco, F. Birg, A M. Stoppa, C. Matter-Zevaco, C. Thivolet, L. Hermitte, P Vague, and P. Mercier. 1993. Autoimmune polyendocrine failure-type I (insulin-dependent) diabetes mellitus and hypothyroidism after allogeneic bone marrow transplantation. Diabetologia 36:541.
3. 1 mice with bone marrow cells from NOD mice. J Exp Med. 167:1801.
4. 1 mouse mouse bone marrow chimeras. Diabetologia 33:84.
5. Nepom, G. T. and H Erlich. 1991. MHC class II molecules and autoimmunity. Annu. Rev. Immunol. 9:493.
6. Todd, J. A., J. I. Bell, and H. O McDevitt. 1987. HLA-DQb gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329:599.
7. Atkinson, M. A., and N. K. Maclaren 1993. Islet cell autoantigens in insulin-dependent diabetes. J. Clin. Invest. 92:1608.
8. Hagopian, W. A., A. E Karlsen, A. Gottsater, M. Landin-Olsson, C E. Grubin, G. Sundkvist, J. S. Petersen, E. Boel, T. Dyiberg, and Å. Lernmark. 1993. Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type. J. Clin. Invest 91:368.
9. Rowley, M. J., I. R. Mackay, Q.-Y. Chen, W. J. Knowles, and P Z. Zimmet. 1992. Antibodies to glutamic acid discriminate major types of diabetes mellitus. Diabetes 41:548.
10. Serjeantson, S. W., M. R. J. Kohonen-Corish, M. J. Rowley, I. R Mackay, W. J. Knowles, and P Z. Zimmet. 1992. Antibodies to glutamic acid decarboxylase are associated with HLA-DR genotypes in both Australians and Asians with type 1 (insulin-dependent) diabetes mellitus. Diabetologia 35:96
11. Zimmet, P. Z., R. B. Elliott, I. R. Mackay, T. Tuomi, M. J Rowley, C. C Pilcher, and W. J. Knowles 1994. Autoantibodies to glutamic acid decarboxylase and insulin in islet cell antibody positive presymptomatic type 1 diabetes mellitus: frequency and segregation by age and gender. Diabet. Med. 11:866.
12. Zimmet, P. Z., B. J. Shaten, L. H. Kuller, M. J Rowley, W. J. Knowles, and I. R. Mackay. 1994. Antibodies to glutamic acid decarboxylase and diabetes mellitus in the Multiple Risk Factor Intervention Trial. Am. J. Epidemiol. 140-683.
13. Serjeantson, S. W , J Court, I. R Mackay, B, Matheson, M. J. Rowley, T. Tuomi, J. D. Wilson, and P. Zimmet 1993. HLA-DQ genotypes are associated with autoimmunity to glutamic acid decarboxylase in insulin-dependent diabetes mellitus patients. Hum Immunol. 38:97.
14. Rowe, R. E., N. J. Leech, G. T. Nepom, and D. K. McCulloch. 1994. High genetic risk for insulin-dependent diabetes in the Pacific Northwest: first report from the Washington State Diabetes Prediction Study. Diabetes 43:87.
15. Sercarz, E. E., P. V. Lehmann, A. Ametani, G. Benichou, A. Miller, and K. Moudgil. 1993. Dominance and crypticity of T cell antigenic determinants Annu. Rev. Immunol. 11.729.
16. Petersen, J S , A. E. Karlsen, H. Markholst, A. Worsaae, T. Dyrberg, and B. Michelsen. 1994. Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in NOD mice. Diabetes 43:1478.
17. 67) prevents autoimmune diabetes in NOD mice. Diabetes 43:1494.
18. Tisch, R , X. D. Yang, R. S. Liblau, and H O McDevitt. 1994 Administering glutamic acid decarboxylase to NOD mice prevents diabetes. J Autoimmun. 7:845.
19. Kaufman, D. L., M. Clare-Salzler, J Tian, T. Forsthuber, G. S. P. Ting, P. Robinson, M. A. Alkinson, E. E. Sercarz, A. J. Tobin, and P. V. Lehmann. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366:69.
20. King, M L., A Shaik, D. Birdwell, A. Voller, and J. E. Banarvala. 1983. Coxsackie-B-virus-specific IgM responses in children with insulin-dependent (juvenile-onset: type I) diabetes mellitus. Lancet i:1397.
21. D'Alessio, D. J. 1992 A case-control study of group B Coxsackievirus immunoglobulin M antibody prevalence and HLA-DR antigens in newly diagnosed cases of insulin-dependent diabetes mellitus. Am J. Epidemiol. 135:1331.
22. Atkinson, M. A., M. A. Bowman, L Campbell, B. L. Darrow, D. L. Kaufman, and N. K. Maclaren. 1994. Cellular immunity to a determinant common to glutamate decarboxylase and Coxsackievirus in insulin-dependent diabetes. J. Clin. Invest. 94:2125.
23. Tian, J., P. V. Lehmann, and D. L. Kaufman. 1994. T cell cross-reactivity between Coxsaekievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. J. Exp Med 180:1979
24. Falk, K., O. Rötzschke, S Stevanovic, G. Jung, and H.-G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351-290
25. Madden, D. R , J. C. Gorga, J. L. Strommger, and D. C. Wiley. 1992. The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC. Cell 70:1035.
26. O'Sullivan, D., J. Sidney, E. Appella, L. Walker, L. Phillips, S M. Colón, C Miles, R. W. Chesnut, and A. Sette. 1990 Characterization of the specificity of pepude binding to four DR haplotypes. J Immunol. 145:1799.
27. Marshall, K. W., A F. Liu, J. Canales, B. Perahia, B. Jorgensen, R D. Gantzos, B Aguilar, B. Devaux, and J. B. Rothbard. 1994 Role of the polymorphic residues in HLA-DR molecules in allele-specific binding of peptide ligands. J. Immunol 152.4946.
28. Stem, L J , J. H. Brown, T. S. Jardetzky, J. C. Gorga, R G. Urban, J. L Strominger, and D, C. Wiley 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368:215.
29. Chicz, R. M., R. G. Urban, J C. Gorga, D. A. A. Vignali, W. S Lane, and J. L. Strominger 1993. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J Exp. Med 178.27.
30. Madden, D R. 1995. The three-dimensional structure of peptide-MHC complexes. Annu Rev. Immunol. 13:587.
31. Sidney, J , C. Oseroff, M. del Guercio, S. Southwood, J. I Krieger, G. Y Ishioka, K Sakaguchi, E Appella, and A Sette. 1994. Definition of a DQ3.1-specific binding motif J. Immunol. 152:4516.
32. Chicz, R. M , W. S. Lane, R. A. Robinson, M. Trucco, J L. Strominger, and J. C. Gorga. 1994. Seif-peptides bound to the type I diabetes-associated class II MHC molecules HLA-DQ1 and HLA-DQ8. Int. Immunol. 6.1639.
33. Verreck, F. A. W., A. van de Poel, A. Termijtelen, R. Amons, J. Drijfhout, and F. Koning. 1994. Identification of an HLA-DQ2 peptide binding motif and HLA-DPw3-bound self-peptide by pool sequencing Eur. J. Immunol. 24:375
34. Kwok, W. W., G. T. Nepom, and F C Raymond. 1995. HLA-DQ polymorphisms are highly selective for peptide binding interactions. J. Immunol 155: 2468
35. Celis, E., R. W Karr, P. K. Gregersen, and N L. Reinsmoen 1990. Functional analysis of MHC class II-restricted T cells derived from a Caucasian with a DR4, Dw15, DQw8 haplotype. Hum. Immunol. 29.31.
36. Gedde-Dahl, T., III, A. Spurkland, B. Possum, A. Wittinghofer, E Thorsby, and G. Gaudernack. 1994. T cell epitopes encompassing the mutational hot spot position 61 of p21 ras. promiscuity in ras peptide binding to HLA. Eur. J. Immunol. 24:410
37. Kwok, W. W., M. E. Domeier, M. L. Johnson, G. T Nepom, and D M. Koelle. 1996 HLA-DQB1 codon 57 is a critical determinant of peptide binding and recognition J. Exp. Med. In press