Peptide binding characteristics of the coeliac disease associated DQ(α1(*)0501, β1(*)0201) molecule

Immunogenetics

Volumn 44, Issue 4, 1996, Pages 246-253

  Van De Wal, Yvonne ^a   Kooy, Yvonne M C ^a   Drijfhout, Jan Wouter ^a   Amons, Reinout ^b   Koning, Frits ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLIADIN; GLUTEN; HLA DQ ANTIGEN; LYSINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ALLELE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGEN PRESENTATION; ARTICLE; CELIAC DISEASE; CONTROLLED STUDY; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; T LYMPHOCYTE;

EID: 0029815574     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02602553     Document Type: Article

References (41)

1. Bijlmakers, M. J., Benaroch, P., and Ploegh, H. L. Mapping functional regions in the lumenal domain of the class II-associated invariant chain. J Exp Med 180: 623-629, 1994
2. Chicz, R. M., Urban, R. G., Lane, W. S., Gorga, J. C., Stern, L. J., Vignali, D. A. A., and Strominger, J. L. Predominantly naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size. Nature 358: 764-771, 1992
3. Chicz, R. M., Urban, R. G., Gorga, J. C., Vignali, D. A., Lane, W. S., and Strominger, J. L. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J Exp Med 178: 27-47, 1993
4. Chicz, R. M., Lane, W. S., Robinson, R. A., Trucco, M., Strominger, J. L., and Gorga, J. C. Self-peptides bound to the type I diabetes associated class II MHC molecules HLA-DQ1 and HLA-DQ8. Int Immunol 6: 1639-1649, 1994
5. Falk, K., Rotzschke, O., Stevanović, S., Jung, G., and Rammensee, H. G. Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules. Immunogenetics 39: 230-242, 1994
6. Geluk, A., Van Meijgaarden, K. E., Drijfhout, J. W., and Ottenhoff, T. H. M. CLIP binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs. Mol Immunol 32: 975-981, 1995
7. Ghosh, P., Amaya, M., Mellins, E., and Wiley, D. C. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378: 457-462, 1995
8. Gorga, J. C., Horejsi, V., Johnson, D. R., Raghupathy, R., and Strominger, J. L. Purification and characterization of class II histocompatibility antigens from a homozygous B cell line. J Biol Chem 262: 16087-16094, 1987
9. Greenwood, F. C., Hunter, W. H., and Glover, J. S. The preparation of 131I-labelled human growth hormone of high specific radioactivity. Biochem J 89: 114-120, 1963
10. Gregersen, P. K., Silver, J., and Winchester, R. J. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30: 1205-1213, 1987
11. Hammer, J., Takacs, B., and Sinigaglia, F. Identification of a motif for HLA-DR1 binding peptides using M13 display libraries. J Exp Med 176: 1007-1013, 1992
12. Hillarby, M. C., Clarkson, R., Grennan, D. M., Bate, A. S., Ollier, W., Sanders, P. A., Chattophadhyay, C., Davis, M., O'Sullivan, M. M., and Williams, B. Immunogenetic heterogeneity in rheumatoid disease as illustrated by different MHC associations (DQ, Dw and C4) in articular and extra-articular subsets. Br J Rheumatol 30: 5-9, 1991
13. Johansen, B. H., Buus, S., Vartdal, F., Viken, H., Eriksen, J. A., Thorsby, E., and Sollid, L. M. Binding of peptides to HLA-DQ molecules: peptide binding properties of the disease-associated HLA-DQ (alpha 1*0501, beta 1*0201) molecule. Int Immunol 6: 453-461, 1994
14. Khalil, I., d'Auriol, L., Gobet, M., Morin, L., Lepage, V., Deschamps, L., Park, MS, Degos, L., Galibert, F., and Hors, J. A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus. J Clin Invest 85: 1315-1319, 1990
15. Kropshofer, M., Max, H., Halder, T., Kalbus, M., Muller, C. A., and Kalbacher, H. Self-peptides from four HLA-DR alleles share hydrophobic anchor residues near the NH2-terminal including proline as a stop signal for trimming. J Immunol 151: 4732-4742, 1993
16. Lanchbury, J. S., Sakkas, L. I., Marsh, S. G., Bodmer, J. G., Welsh, K. I., and Panayi, G. S. HLA-DQ beta 3.1 allele is a determinant of susceptibility to DR4-associated rheumatoid arthritis. Hum Immunol 26: 59-71, 1989
17. Lundin, K. E., Scott, H., Hansen, T., Paulsen, G., Halstensen, T. S., Fausa, O., Thorsby, E., and Sollid, L. M. Gliadin-specific, HLA-DQ(alpha 1*0501, beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 178: 187-196, 1993
18. Malcherek, G., Gnau, V., Jung, G., Rammensee, H. G., and Melms, A. Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules. J Exp Med 181: 527-536, 1995
19. O'Sullivan, D., Sidney, J., del Guercio, M. F., Colon, S. M., and Sette, A. Truncation analysis of several DR binding epitopes. J Immunol 146: 1240-1246, 1991
20. Olerup, O., Hillert, J., Fredrikson, S., Olsson, T., Kam-Hansen, S., Moller, E., Carlsson, B., and Walling, J. Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities. Proc Natl Acad Sci USA 86: 7113-7117, 1989
21. Rammensee, H. G., Friede, T., and Stevanović S. MHC ligands and peptide motifs: first listing. Immunogenetics 41: 178-228, 1995
22. Riberdy, J. M., Newcomb, J. R., Surman, M. J., Barbosa, J. A., and Cresswell, P. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature 360: 474-477, 1992
23. Roche, P. A. and Cresswell, P. Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding. Nature 345: 615-618, 1990
24. Romagnoli, P. and Germain, R. N. The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy. J Exp Med 180: 1107-1113, 1994
25. Routsias, J. and Papadopoulos, G. K. Polymorphic structural features of modelled HLA-DQ molecules segregate according to susceptibility or resistance to IDDM. Diabetologia 38: 1251-1261, 1995
26. Sansom, D. M., Bidwell, J. L., Maddison, P. J., Campion, G., Klouda, P. T., and Bradley, B. A. HLA DQ alpha and DQ beta restriction fragment length polymorphisms associated with Felty's syndrome and DR4-positive rheumatoid arthritis. Hum Immunol 19: 269-278, 1987
27. Sette, A., Ceman, S., Kubo, R. T., Sakaguchi, K., Appella, E., Hunt, D. F., Davis, T. A., Michel, H., Shabanowitz, J., Rubersdorf, R., Grey, H. M., and DeMars, R. Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. Science 258: 1801-1804, 1992
28. Sidney, J., Oseroff, C., Southwood, S., Wall, M., Ishioka, G., Koning, F., and Sette, A. DRBA*0301 molecules recognize a structural motif distinct from the one recognized by most DR beta 1 alleles. J Immunol 149: 2634-2640, 1992
29. Sidney, J., Oseroff, C., del Guercio, M. F., Southwood, S., Krieger, J. I., Ishioka, G. Y., Sakaguchi, K., Appella, E., and Sette, A. Definition of a DQ3.1-specific binding motif. J Immunol 152: 4516-4525, 1994
30. Sollid, L. M., Markussen, G., and Ek, J. Evidence for a primary association of coeliac disease to a particular HLA-DQ alpha/beta heterodimer. J Exp Med 169: 345-350, 1989
31. Spits, H., Borst, J., Giphart, M. J., Coligan, J., Terhorst, C., and De Vries, J. HLA-DQ antigens can serve as recognition elements for human cytotoxic T lymphocytes. Eur J Immunol 14: 299-304, 1984
32. Spurkland, A., Ronningen, K. S., Vandvik, B., Thorsby, E., and Vartdal, F. HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis. Hum Immunol 30: 69-75, 1991
33. Stern, L. J., Brown, J. H., Jardetzky, T. S., Gorga, J. C., Urban, R. G., Strominger, J. L., and Wiley, D. C. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368: 215-221, 1994
34. Tighe, M. R., Hall, M. A., and Barbado, M. HLA class II alleles associated with celiac disease susceptibility in a southern European population. Tissue Antigens 40: 90-97, 1992
35. Tighe, M. R. and Ciclitira, P. J. The gluten-host interaction. Cl Gastroenterol 9: 215-230, 1995
36. Todd, J. A., Bell, J. I., and McDevitt, H. O. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329: 599-604, 1987
37. Todd, J. A. Genetic control of autoimmunity in type 1 diabetes. Immunol Today 11: 122-129, 1990
38. Vartdal, F., Sollid, L. M., Vandvik, B., Markussen, G., and Thorsby, E. Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic amino acid sequences. Hum Immunol 25: 103-110, 1989
39. Verreck, F. A. W., Van de Poel, A., Termijtelen, A., Amons, R., Drijfhout, J. W., and Koning, F. Identification of an HLA-DQ2 peptide binding motif and HLA-DPw3-bound self-peptide by pool sequencing. Eur J Immunol 24: 375-379, 1994
40. Verreck, F. A. W., Vermeulen, C., Van de Poel, A., Jorritsma, P., Amons, R., Coligan, J. E., Drijfhout, J. W., and Koning, F. The generation of SDS-stable HLA DR dimers is independent of efficient peptide binding. Int Immunol. in press
41. Wucherpfennig, K. W. and Strominger, J. L. Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases. J Exp Med 181: 1597-1601, 1995