The central role of wear debris in periprosthetic osteolysis

HSS Journal

Volumn 2, Issue 2, 2006, Pages 102-113

  Purdue, P Edward ^a   Koulouvaris, Panagiotis ^a   Nestor, Bryan J ^a   Sculco, Thomas P ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

Aseptic loosening; Periprosthetic osteolysis; Wear debris

Indexed keywords

EID: 33748291470     PISSN: 15563316     EISSN: 15563324     Source Type: Journal    
DOI: 10.1007/s11420-006-9003-6     Document Type: Article

References (152)

1. Harris WH (2001) Wear and periprosthetic osteolysis: the problem. Clin Orthop Relat Res 66-70
2. Dumbleton JH, Manley MT, Edidin AA (2002) A literature review of the association between wear rate and osteolysis in total hip arthroplasty. J Arthroplasty 17:649-661
3. Schmalzried TP, Jasty M, Harris WH (1992) Periprosthetic bone loss in total hip arthroplasty. Polyethylene wear debris and the concept of the effective joint space. J Bone Jt Surg Am 74:849-863
4. Hirakawa K, Bauer TW, Stulberg BN et al. (1996) Comparison and quantitation of wear debris of failed total hip and total knee arthroplasty. J Biomed Mater Res 31:257-263
5. Margevicius KJ, Bauer TW, McMahon JT et al (1994) Isolation and characterization of debris in membranes around total joint prostheses. J Bone Jt Surg Am 76:1664-1675
6. Schwarz EM, Benz EB, Lu AP et al (2000) Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis. J Orthop Res 18:849-855
7. Millett PJ, Allen MJ, Bostrom MP (2002) Effects of alendronate on particle-induced osteolysis in a rat model. J Bone Jt Surg Am 84-A:236-249
8. Merkel KD, Erdmann JM, McHugh KP et al (1999) Tumor necrosis factor-alpha mediates orthopedic implant osteolysis. Am J Pathol 154:203-210
9. Shanbhag AS, Hasselman CT, Rubash HE (1997) The John Charnley Award. Inhibition of wear debris mediated osteolysis in a canine total hip arthroplasty model. Clin Orthop Relat Res: 33-43
10. Wooley PH, Morren R, Andary J et al (2002) Inflammatory responses to orthopaedic biomaterials in the murine air pouch. Biomaterials 23:517-526
11. Warme BA, Epstein NJ, Trindade MC et al (2004) Proinflammatory mediator expression in a novel murine model of titanium-particle-induced intramedullary inflammation. J Biomed Mater Res B Appl Biomater 71:360-366
12. Yang SY, Wu B, Mayton L et al (2004) Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis. Gene Ther 11:483-491
13. Blaine TA, Rosier RN, Puzas JE et al (1996) Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles. J Bone Jt Surg Am 78:1181-1192
14. Nakashima Y, Sun DH, Trindade MC et al (1999) Signaling pathways for tumor necrosis factor-alpha and interleukin-6 expression in human macrophages exposed to titanium-alloy particulate debris in vitro. J Bone Jt Surg Am 81:603-615
15. Wimhurst JA, Brooks RA, Rushton N (2001) Inflammatory responses of human primary macrophages to particulate bone cements in vitro. J Bone Jt Surg Br 83:278-282
16. Ingham E, Green TR, Stone MH et al. (2000) Production of TNF-alpha and bone resorbing activity by macrophages in response to different types of bone cement particles. Biomaterials 21:1005-1013
17. Maloney WJ, James RE, Smith RL (1996) Human macrophage response to retrieved titanium alloy particles in vitro. Clin Orthop Relat Res: 268-278
18. Skripitz R, Aspenberg P (2000) Pressure-induced periprosthetic osteolysis: a rat model. J Orthop Res 18:481-484
19. Greenfield EM, Bi Y, Ragab AA et al (2005) Does endptoxin contribute to aseptic loosening of orthopedic implants? J Biomed Mater Res B Appl Biomater 72:179-185
20. Saleh KJ, Thongtrangan I, Schwarz EM (2004) Osteolysis: medical and surgical approaches. Clin Orthop Relat Res: 138-147
21. Yagil-Kelmer E, Kazmier P, Rahaman MN et al (2004) Comparison of the response of primary human blood monocytes and the U937 human monocytic cell line to two different sizes of alumina ceramic particles. J Orthop Res 22:832-838
22. Xing S, Waddell JE, Boynton EL (2002) Changes in macro-phage morphology and prolonged cell viability following exposure to polyethylene particulate in vitro. Microsc Res Tech 57:523-529
23. Chiba J, Rubash HE, Kim KJ et al (1994) The characterization of cytokines in the interface tissue obtained from failed cementless total hip arthroplasty with and without femoral osteolysis. Clin Orthop Relat Res:304-312
24. Stea S, Visentin M, Granchi D et al (2000) Cytokines and osteolysis around total hip prostheses. Cytokine 12:1575-1579
25. Goodman SB, Huie P, Song Y et al. (1998) Cellular profile and cytokine production at prosthetic interfaces. Study of tissues retrieved from revised hip and knee replacements. J Bone Jt Surg Br 80:531-539
26. Sabokbar A, Rushton N (1995) Role of inflammatory mediators and adhesion molecules in the pathogenesis of aseptic loosening in total hip arthroplasties. J Arthroplasty 10:810-816
27. Fiorito S, Magrini L, Goalard C (2003) Pro-inflammatory and anti-inflammatory circulating cytokines and periprosthetic osteolysis. J Bone Jt Surg Br 85:1202-1206
28. Granchi D, Verri E, Ciapetti G et al (1998) Bone-resorbing cytokines in serum of patients with aseptic loosening of hip prostheses. J Bone Jt Surg Br 80:912-917
29. Hernigou P, Intrator L, Bahrami T et al (1999) Interleukin-6 in the blood of patients with total hip arthroplasty without loosening. Clin Orthop Relat Res:147-154
30. Nakashima Y, Sun DH, Maloney WJ et al (1998) Induction of matrix metalloproteinase expression in human macrophages by orthopaedic particulate debris in vitro. J Bone Jt Surg Br 80:694-700
31. Kido A, Pap G, Nagler DK et al (2004) Protease expression in interface tissues around loose arthroplasties. Clin Orthop Relat Res:230-236
32. Takei I, Takagi M, Santavirta S et al (2000) Messenger ribonucleic acid expression of 16 matrix metalloproteinases in boneimplant interface tissues of loose artificial hip joints. J Biomed Mater Res 52:613-620
33. Sethi RK, Neavyn MJ, Rubash HE et al (2003) Macrophage response to cross-linked and conventional UHMWPE. Biomaterials 24:2561-2573
34. Haynes DR, Boyle SJ, Rogers SD et al (1998) Variation in cytokines induced by particles from different prosthetic materials. Clin Orthop Relat Res:223-230
35. Green TR, Fisher J, Stone M et al (1998) Polyethylene particles of a 'critical size' are necessary for the induction of cytokines by macrophages in vitro. Biomaterials 19:2297-2302
36. Yang SY, Ren W, Park Y et al (2002) Diverse cellular and apoptotic responses to variant shapes of UHMWPE particles in a murine model of inflammation. Biomaterials 23:3535-3543
37. Shanbhag AS, Jacobs JJ, Black J et al (1994) Macrophage/particle interactions: effect of size, composition and surface area. J Biomed Mater Res 28:81-90
38. Brooks RA, Wimhurst JA, Rushton N (2002) Endotoxin contamination of particles produces misleading inflammatory cytokine responses from macrophages in vitro. J Bone Jt Surg Br 84:295-299
39. Bi Y, Van De Motter RR, Ragab AA et al (2001) Titanium particles stimulate bone resorption by inducing differentiation of murine osteoclasts. J Bone Jt Surg Am 83-A:501-508
40. Skoglund B, Aspenberg P (2003) PMMA particles and pressure - a study of the osteolytic properties of two agents proposed to cause prosthetic loosening. J Orthop Res 21:196-201
41. McEvoy A, Jeyam M, Ferrier G et al (2002) Synergistic effect of particles and cyclic pressure on cytokine production in human monocyte/macrophages: proposed role in periprosthetic osteolysis. Bone 30:171-177
42. Fujishiro T, Nishikawa T, Shibanuma N et al (2004) Effect of cyclic mechanical stretch and titanium particles on prostaglandin E2 production by human macrophages in vitro. J Biomed Mater Res A 68:531-536
43. Goodman SB, Fornasier VL, Lee J et al (1990) The histological effects of the implantation of different sizes of polyethylene particles in the rabbit tibia. J Biomed Mater Res 24:517-524
44. Goodman SB, Chin RC, Magee FP (1992) Prostaglandin E2 production by the membrane surrounding loose and fixated cemented tibial hemiarthroplasties in the rabbit knee. Clin Orthop Relat Res:283-287
45. Spector M, Shortkroff S, Hsu HP et al (1990) Tissue changes around loose prostheses. A canine model to investigate the effects of an antiinflammatory agent. Clin Orthop Relat Res: 140-152
46. Gelb H, Schumacher HR, Cuckler J et al (1994) In vivo inflammatory response to polymethylmethacrylate particulate debris: effect of size, morphology, and surface area. J Orthop Res 12:83-92
47. Nagase M, Udagawa E, Schumacher HR et al (1990) Prolonged inflammatory reactions induced by ceramic powders in the rat air pouch model. Nippon Seikeigeka Gakkai Zasshi 64:602-611
48. Yang S, Wu B, Mayton L et al (2002) IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model. Inflamm Res 51:342-350
49. Schwarz EM, Lu AP, Goater JJ et al (2000) Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis. J Orthop Res 18:472-480
50. Childs LM, Goater JJ, O'Keefe RJ et al (2001) Efficacy of etanercept for wear debris-induced osteolysis. J Bone Miner Res 16:338-347
51. Carmody EE, Schwarz EM, Puzas JE et al (2002) Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles. Arthritis Rheum 46:1298-1308
52. Zhang X, Morham SG, Langenbach R et al (2001) Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis. J Bone Miner Res 16:660-670
53. Epstein NJ, Warme BA, Spanogle J et al (2005) Interleukin-1 modulates periprosthetic tissue formation in an intramedullary model of particle-induced inflammation. J Orthop Res 23:501-510
54. Hsu H, Lacey DL, Dunstan CR et al (1999) Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 96:3540-3545
55. Nicholson GC, Malakellis M, Collier FM et al (2000) Induction of osteoclasts from CD14-positive human peripheral blood mononuclear cells by receptor activator of nuclear factor kappaB ligand (RANKL). Clin Sci (Lond) 99:133-140
56. Quinn JM, Elliott J, Gillespie MT et al (1998) A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro. Endocrinology 139:4424-4427
57. Simonet WS, Lacey DL, Dunstan CR et al (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density, Cell 89:309-319
58. Hofbauer LC, Schoppet M (2004) Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. JAMA 292:490-495
59. Ulrich-Vinther M, Carmody EE, Goater JJ et al (2002) Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis. J Bone Jt Surg Am 84-A: 1405-1412
60. Goater JJ, O'Keefe RJ, Rosier RN et al (2002) Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis, J Orthop Res 20:169-173
61. Childs LM, Paschalis EP, Xing L et al (2002) In vivo RANK signaling blockade using the receptor activator of NF-kappaB: Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis, J Bone Miner Res 17:192-199
62. Masui T, Sakano S, Hasegawa Y et al (2005) Expression of inflammatory cytokines, RANKL and OPG induced by titanium, cobalt-chromium and polyethylene particles. Biomaterials 26:1695-1702
63. Mandel in J, Li TF, Liljestrom M et al (2003) Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement. J Bone Jt Surg Br 85:1196-1201
64. Gehrke T, Sers C, Morawietz L et al (2003) Receptor activator of nuclear factor kappaB ligand is expressed in resident and inflammatory cells in aseptic and septic prosthesis loosening. Scand J Rheumatol 32:287-294
65. Haynes DR, Crotti TN, Potter AE et al (2001) The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis. J Bone Jt Surg Br 83:902-911
66. Horiki M, Nakase T, Myoui A et al (2004) Localization of RANKL in osteolytic tissue around a loosened joint prosthesis. J Bone Miner Metab 22:346-351
67. Takayanagi H, Ogasawara K, Hida S et al (2000) T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 408:600-605
68. Rakshit DS, Ly K, Sengupta TK et al (2006) Wear debris inhibition of anti-osteoclastogenic signaling By IL6 and IFN-gamma: mechanistic insights and implications for periprosthetic osteolysis. J Bone Jt Surg Am 88:788-799
69. Sabokbar A, Fujikawa Y, Neale S et al (1997) Human arthroplasty derived macrophages differentiate into osteoclastic bone resorbing cells, Ann Rheum Dis 56:414-420
70. Nakashima Y, Sun DH, Trindade MC et al (1999) Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles. J Bone Jt Surg Br 81:155-162
71. Haynes DR, Crotti TN, Zreiqat H (2004) Regulation of osteoclast activity in peri-implant tissues. Biomaterials 25:4877-4885
72. Yu X, Huang Y, Collin-Osdoby P et al. (2004) CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts. J Bone Miner Res 19: 2065-2077
73. Ishiguro N, Kojima T, Ito T et al (1997) Macrophage activation and migration in interface tissue around loosening total hip arthroplasty components. J Biomed Mater Res 35: 399-406
74. Lassus J, Waris V, Xu JW et al (2000) Increased interleukin-8 (IL-8) expression is related to aseptic loosening of total hip replacement. Arch Orthop Trauma Surg 120:328-332
75. Shanbhag AS, Jacobs JJ, Black J et al (1995) Cellular mediators secreted by interfacial membranes obtained at revision total hip arthroplasty. J Arthroplasty 10:498-506
76. Vermes C, Chandrasekaran R, Jacobs JJ et al (2001) The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J Bone Jt Surg Am 83-A:201-211
77. Yao J, Cs-Szabo G, Jacobs JJ et al (1997) Suppression of osteoblast function by titanium particles. J Bone Jt Surg Am 79:107-112
78. Vermes C, Roebuck KA, Chandrasekaran R et al (2000) Particulate wear debris activates protein tyrosine kinases and nuclear factor kappaB, which down-regulates type I collagen synthesis in human osteoblasts. J Bone Miner Res 15:1756-1765
79. Pioletti DP, Leoni L, Genini D et al (2002) Gene expression analysis of osteoblastic cells contacted by orthopedic implant particles. J Biomed Mater Res 61:408-420
80. Zambonin G, Colucci S, Cantatore F et al. (1998) Response of human osteoblasts to polymethylmetacrylate in vitro. Calcif Tissue Int 62:362-365
81. Wang ML, Nesti LJ, Tuli R et al (2002) Titanium particles suppress expression of osteoblastic phenotype in human mesenchymal stem cells. J Orthop Res 20:1175-1184
82. Wang ML, Tuli R, Manner PA et al (2003) Direct and indirect induction of apoptosis in human mesenchymal stem cells in response to titanium particles. J Orthop Res 21:697-707
83. Pioletti DP, Kottelat A (2004) The influence of wear particles in the expression of osteoclastogenesis factors by osteoblasts. Biomaterials 25:5803-5808
84. Quinn JM, Horwood NJ, Elliott J et al. (2000) Fibroblastic stromal cells express receptor activator of NF-kappa B ligand and support osteoclast differentiation. J Bone Miner Res 15:1459-1466
85. Wei X, Zhang X, Zuscik MJ et al (2005) Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles. J Bone Miner Res 20:1136-1148
86. Sabokbar A, Itonaga I, Sun SO et al (2005) Arthroplasty membrane-derived fibroblasts directly induce osteoclast formation and osteolysis in aseptic loosening. J Orthop Res 23:511-519
87. Yao J, Giant TT, Lark MW et al (1995) The potential role of fibroblasts in periprosthetic osteolysis: fibroblast response to titanium particles. J Bone Miner Res 10:1417-1427
88. Manlapaz M, Maloney WJ, Smith RL (1996) In vitro activation of human fibroblasts by retrieved titanium alloy wear debris. J Orthop Res 14:465-472
89. Yaszay B, Trindade MC, Lind M et al (2001) Fibroblast expression of C-C chemokines in response to orthopaedic biomaterial particle challenge in vitro. J Orthop Res 19:970-976
90. Kotake S, Udagawa N, Hakoda M et al (2001) Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients. Arthritis Rheum 44:1003-1012
91. Gravallese EM, Manning C, Tsay A et al (2000) Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum 43:250-258
92. Kong YY, Feige U, Sarosi I et al (1999) Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402:304-309
93. Farber A, Chin R, Song Y et al (2001) Chronic antigen-specific immune-system activation may potentially be involved in the loosening of cemented acetabular components. J Biomed Mater Res 55:433-441
94. Arora A, Song Y, Chun L et al. (2003) The role of the TH1 and TH2 immune responses in loosening and osteolysis of cemented total hip replacements. J Biomed Mater Res A 64:693-697
95. Baldwin L, Flanagan BF, McLaughlin PJ et al. (2002) A study of tissue interface membranes from revision accord knee arthroplasty: the role of T lymphocytes. Biomaterials 23:3007-3014
96. Li TF, Santavirta S, Waris V et al (2001) No lymphokines in T-cells around loosened hip prostheses. Acta Orthop Scand 72:241-247
97. Jiranek W, Jasty M, Wang JT et al (1995) Tissue response to particulate polymethylmethacrylate in mice with various immune deficiencies. J Bone Jt Surg Am 77:1650-1661
98. Goodman S, Wang JS, Regula D et al (1994) T-lymphocytes are not necessary for particulate polyethylene-induced macrophage recruitment. Histologic studies of the rat tibia. Acta Orthop Scand 65:157-160
99. Taki N, Tatro JM, Nalepka JL et al (2005) Polyethylene and titanium particles induce osteolysis by similar, lymphocyte-independent, mechanisms. J Orthop Res 23:376-383
100. Sandhu J, Waddell JE, Henry M et al (1998) The role of T cells in polyethylene participate induced inflammation. J Rheumatol 25:1794-1799
101. Childs LM, Goater JJ, O'Keefe RJ et al (2001) Effect of antitumor necrosis factor-alpha gene therapy on wear debrisinduced osteolysis. J Bone Jt Surg Am 83-A: 1789-1797
102. Hallab NJ, Anderson S, Stafford T et al (2005) Lymphocyte responses in patients with total hip arthroplasty. J Orthop Res 23:384-391
103. Davies AP, Willert HG, Campbell PA et al (2005) An unusual lymphocytic perivascular infiltration in tissues around contemporary metal-on-metal joint replacements. J Bone Jt Surg Am 87:18-27
104. DeHeer DH, Engels JA, DeVries AS et al (2001) In situ complement activation by polyethylene wear debris. J Biomed Mater Res 54:12-19
105. Santavirta S, Hoikka V, Eskola A et al (1990) Aggressive granulomatous lesions in cementless total hip arthroplasty. J Bone Jt Surg Br 72:980-984
106. Palecanda A, Paulauskis J, Al-Mutairi E et al (1999) Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles. J Exp Med 189:1497-1506
107. Palmbos PL, Sytsma MJ, DeHeer DH et al (2002) Macrophage exposure to particulate titanium induces phosphorylation of the protein tyrosine kinase lyn and the phospholipases Cgamma-1 and Cgamma-2. J Orthop Res 20:483-489
108. Maloney WJ, Sun DH, Nakashima Y et al (1998) Effects of serum protein opsonization on cytokine release by titanium-alloy particles, J Biomed Mater Res 41:371-376
109. Sun DH, Trindade MC, Nakashima Y et al (2003) Human serum opsonization of orthopedic biomaterial particles: protein-binding and monocyte/macrophage activation in vitro. J Biomed Mater Res A 65:290-298
110. Rezzonico R, Chicheportiche R, Imbert V et al (2000) Engagement of GD11b and GD11c beta2 integrin by antibodies or soluble CD23 induces TL-1beta production on primary human monocytes through mitogen-activated protein kinase-dependent pathways. Blood 95:3868-3877
111. Rezzonico R, Imbert V, Chicheportiche R et al (2001) Ligation of GD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1 alpha (MIP-1 alpha) and MIP-1 beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB. Blood 97:2932-2940
112. Abbas S, Clohisy JC, Abu-Amer Y (2003) Mitogen-activated protein (MAP) kinases mediate PMMA-induction of osteoclasts. J Orthop Res 21:1041-1048
113. Boyle WJ, Simonet WS, Lacey DL (2003) Osteoclast differentiation and activation. Nature 423:337-342
114. Iotsova V, Caamano J, Loy J et al (1997) Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 3:1285-1289
115. Franzoso G, Carlson L, Xing L et al (1997) Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev 11:3482-3496
116. Clohisy JC, Hirayama T, Frazier E et al (2004) NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis. J Orthop Res 22:13-20
117. Ren W, Li XH, Chen BD et al (2004) Erythromycin inhibits wear debris-induced osteoclastogenesis by modulation of murine macrophage NF-kappaB activity. J Orthop Res 22:21-29
118. Miyanishi K, Trindade MC, Ma T et al (2003) Periprosthetic osteolysis: induction of vascular endothelial growth factor from human monocyte/macrophages by orthopaedic biomaterial particles. J Bone Miner Res 18:1573-1583
119. Shuai K, Liu B (2003) Regulation of JAK-STAT signalling in the immune system, Nat Rev Immunol 3:900-911
120. Sengupta TK, Talbot ES, Scherle PA et al (1998) Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases. Proc Natl Acad Sci USA 95:11107-11112
121. Ahmed ST, Ivashkiv LB (2000) Inhibition of IL-6 and 1L-10 signaling and Stat activation by inflammatory and stress pathways. J Immunol 165:5227-5237
122. Kubo M, Hanada T, Yoshimura A (2003) Suppressors of cytokine signaling and immunity. Nat Immunol 4:1169-1176
123. Sochart DH (1999) Relationship of acetabular wear to osteolysis and loosening in total hip arthroplasty. Clin Orthop Relat Res: 135-150
124. Ilchmann T, Markovic L, Joshi A et al (1998) Migration and wear of long-term successful Charnley total hip replacements. J Bone Jt Surg Br 80:377-381
125. Muratoglu OK, Bragdon CR, O'Connor DO et al (2001) A novel method of cross-linking ultra-high-molecular-weight polyethylene to improve wear, reduce oxidation, and retain mechanical properties. Recipient of the 1999 HAP Paul Award. J Arthroplasty 16:149-160
126. Muratoglu OK, Bragdon CR, O'Connor D et al (2001) Larger diameter femoral heads used in conjunction with a highly cross-linked ultra-high molecular weight polyethylene: a new concept. J Arthroplasty 16:24-30
127. Heisel C, Silva M, dela Rosa MA et al (2004) Short-term in vivo wear of cross-linked polyethylene. J Bone Jt Surg Am 86-A:748-751
128. Digas G, Karrholm J, Thanner J et al (2003) Highly cross-linked polyethylene in cemented THA: randomized study of 61 hips. Clin Orthop Relat Res: 126-138
129. D'Antonio JA, Manley MT, Capello WN et al (2005) Five-year experience with Crossfire highly cross-linked polyethylene. Clin Orthop Relat Res 441:143-150
130. Engh CA, Sychterz CJ, Engh CA, Jr (2005) Conventional ultra-high molecular weight polyethylene: a gold standard of sorts. Instr Course Lect 54:183-187
131. Barrack RL, Burak C, Skinner HB (2004) Concerns about ceramics in THA. Clin Orthop Relat Res:73-79
132. Capello WN, Dantonio JA, Feinberg JR et al (2005) Alternative bearing surfaces: alumina ceramic bearings for total hip arthroplasty. Instr Course Lect 54:171-176
133. Jazrawi LM, Kummer FJ, DiCesare PE (1998) Alternative bearing surfaces for total joint arthroplasty. J Am Acad Orthop Surg 6:198-203
134. Bourne RB, Barrack R, Rorabeck CH et al (2005) Arthroplasty options for the young patient: Oxinium on cross-linked polyethylene. Clin Orthop Relat Res 441:159-167
135. MacDonald SJ (2004) Metal-on-metal total hip arthroplasty: the concerns. Clin Orthop Relat Res:86-93
136. Cuckler JM (2005) The rationale for metal-on-metal total hip arthroplasty. Clin Orthop Relat Res 441:132-136
137. Pollice PF, Rosier RN, Looney RJ et al (2001) Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes: a potential treatment for aseptic loosening of total joint components. J Bone Jt Surg Am 83-A:1057-1061
138. Schwarz EM, Campbell D, Totterman S et al (2003) Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of periprosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo. J Orthop Res 21:1049-1055
139. von Knoch M, Wedemeyer C, Pingsmann A (2005) The decrease of particle-induced osteolysis after a single dose of bisphosphonate. Biomaterials 26:1803-1808
140. von Knoch F, Heckelei A, Wedemeyer C (2005) The effect of simvastatin on polyethylene particle-induced osteolysis. Biomaterials 26:3549-3555
141. Bekker PJ, Holloway DL, Rasmussen AS et al. (2005) A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. 2004. J Bone Miner Res 20:2275-2282
142. Takahashi N, Ozawa H (2005) A new treatment for osteoporosis using fully human monoclonal antibody to RANKL, AMG 162. Clin Calcium 15:43-48
143. Zwerina J, Hayer S, Tohidast-Akrad M et al (2004) Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction. Arthritis Rheum 50:277-290
144. Dai S, Hirayama T, Abbas S et al (2004) The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. J Biol Chem 279:37219-37222
145. Bossard MJ, Tomaszek TA, Levy MA et al (1999) Mechanism of inhibition of cathepsin K by potent, selective 1,5-diacylcarbohydrazides: a new class of mechanism-based inhibitors of thiol proteases. Biochemistry 38:15893-15902
146. Lark MW, Stroup GB, James IE et al (2002) A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat. Bone 30:746-753
147. Visentin L, Dodds RA, Valente M et al (2000) A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats. J Clin Invest 106:309-318
148. Lark MW, Stroup GB, Dodds RA et al (2001) Antagonism of the osteoclast vitronectin receptor with an orally active non-peptide inhibitor prevents cancellous bone loss in the ovariectomized rat. J Bone Miner Res 16:319-327
149. Shakespeare WC, Metcalf CA, 3rd, Wang Y et al (2003) Novel bone-targeted Src tyrosine kinase inhibitor drug discovery. Curr Opin Drug Discov Dev 6:729-741
150. Potter HG, Nestor BJ, Sofka CM et al (2004) Magnetic resonance imaging after total hip arthroplasty: evaluation of periprosthetic soft tissue. J Bone Jt Surg Am 86-A:1947-1954
151. Looney RJ, Boyd A, Totterman S et al (2002) Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear. Arthritis Res 4:59-63
152. Puri L, Wixson RL, Stern SH et al (2002) Use of helical computed tomography for the assessment of acetabular osteolysis after total hip arthroplasty. J Bone Jt Surg Am 84-A:609-614