A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat

Bone

Volumn 30, Issue 5, 2002, Pages 746-753

  Lark, M W ^a,b   Stroup, G B ^a   James, I E ^a   Dodds, R A ^a   Hwang, S M ^a   Blake, S M ^a   Lechowska, B A ^a   Hoffman, S J ^a   Smith, B R ^a   Kapadia, R ^a   Liang, X ^a   Erhard, K ^a   Ru, Y ^a   Dong, X ^a   Marquis, R W ^a   Veber, D ^a   Gowen, M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Bone resorption; Cathepsin K; Cathepsins; Cysteine proteases; Osteoclast; Ovariectomized (ovx) rat

Indexed keywords

5 (2 MORPHOLIN 4 YLETHOXY)BENZOFURAN 2 CARBOXYLIC ACID [3 METHYL 1 [3 OXO 1 [2 (3 PYRIDIN 2 YLPHENYL)ETHENOYL]AZEPAN 4 YLCARBANOYL]BUTYL]AMIDE; CATHEPSIN B; CATHEPSIN K; DEOXYPYRIDINOLINE; PARATHYROID HORMONE; PROTEINASE INHIBITOR; SB 331750; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE MATRIX; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; HYPERCALCEMIA; IC 50; MALE; MOLECULAR SIZE; NEWBORN; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY; RAT; TRABECULAR BONE; URINE LEVEL;

ANIMALS; BENZOFURANS; BINDING SITES; BONE RESORPTION; CATHEPSINS; CYSTEINE PROTEINASE INHIBITORS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; OSTEOCLASTS; OVARIECTOMY; PARATHYROIDECTOMY; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; THYROIDECTOMY;

EID: 0036255616     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(02)00675-0     Document Type: Article

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