The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts

Journal of Bone and Joint Surgery

Volumn 83, Issue 2, 2001, Pages 201-211

  Vermes, C ^a   Chandrasekaran, R ^a   Jacobs, J J ^a   Galante, J O ^a   Roebuck, K A ^a   Glant, T T ^a  

^a RUSH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BREFELDIN A; CELL PROTEIN; CHEMOKINE; CHROMIUM DERIVATIVE; CHROMIUM ORTHOPHOSPAHTE; CYTOKINE; DACTINOMYCIN; FLUORESCEIN DIACETATE; GROWTH FACTOR; HYDROGEN; ICOSANOID; INTERLEUKIN 6; OSTEOCALCIN; OSTEONECTIN; PHOSPHATE; POLYETHYLENE; POLYSTYRENE; PROCOLLAGEN; PROCOLLAGEN ALPHA1; PROSTAGLANDIN E2; SOMATOMEDIN C; THYMIDINE DERIVATIVE; TITANIUM; TRANSFORMING GROWTH FACTOR BETA1; TRYPAN BLUE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL KINETICS; CELL PROLIFERATION; CELL VIABILITY; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; NORTHERN BLOTTING; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROSTHESIS; PROTEIN SYNTHESIS; PROTEIN TRANSPORT;

EID: 0035110245     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: 10.2106/00004623-200102000-00007     Document Type: Article

References (50)

1. Management of bone loss in revision total hip arthroplasty using custom cementless femoral components
2. The problem in total joint arthroplasty: Aseptic loosening
3. Femoral lysis after cemented hip arthroplasty
4. Revision, without cement, of aseptically loose, cemented total hip prostheses. Quantitative comparison of the effects of four types of medullary treatment on bone ingrowth in a canine model
5. The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis
6. Production of cytokines around loosened cemented acetabular components. Analysis with immunohistochemical techniques and in situ hybridization
7. Aseptic loosening of hip prostheses. A histologic and enzyme histochemical study
8. Aggressive granulomatous lesions associated with hip arthroplasty. Immunopathological studies
9. Particle debris
10. Identification of orthopaedic wear debris
11. Particulate-induced, prostaglandin- And cytokine-mediated bone resorption in an experimental system and in failed joint replacements
12. Wear debris in total joint replacements
13. Isolation and characterization of debris in membranes around total joint prostheses
14. Composition and morphology of wear debris in failed uncemented total hip replacement arthreplasty
15. Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles
16. Biomaterial particle phagocytosis by bone-resorbing osteoclasts
17. Suppression of osteoblast function by titanium particles
18. The potential role of fibroblasts in periprosthetic osteolysis: Fibroblast response to titanium particles
19. Mechanisms of phagocytosis
20. Two distinct regions of FC gamma RI initiate separate signalling pathways involved in endocytosis and phagocytosis
21. Functional separation of pseudopod extension and particle internalization during Fc gamma receptor-mediated phagocytosis
22. Modulation of the production of cytokines in titanium-stimulated human peripheral blood monocytes by pharmacological agents. The role of cAMP-mediated signaling mechanisms
23. Signal transduction of phagocytosis
24. Signaling pathways for tumor necrosis factor-alpha and interleukin-6 expression in human macrophages exposed to titanium-alloy particulate debris in vitro
25. Particulate wear debris activates protein tyrosine kinases and nuclear factorkappaB, which down-regulates type I collagen synthesis in human osteoblasts
26. Bone resorption activity of particulate-stimulated macrophages
27. Effect of size, concentration, surface area, and volume of polymethylmethacrylate particles on human macrophages in vitro
28. Human monocyte/macrophage response to cobalt-chromium corrosion products and titanium particles in patients with total joint replacements
29. Human monocyte response to particulate biomaterials generated in vivo and in vitro
30. Cellular mediators secreted by interfacial membranes obtained at revision total hip arthroplasty
31. The effect of ultra-high molecular weight polyethylene wear debris on MG63 osteosarcoma cells in vitro
32. NFkappaB inhibits expression of the alpha1(I) collagen gene
33. Arginine increases insulin-like growth factor-I production and collagen synthesis in osteoblast-like cells
34. Functional analysis of human alpha 1(I) procollagen gene promoter. Differential activity in collagen-producing and -nonproducing cells and response to transforming growth factor beta 1
35. Inhibition of collagen synthesis by prostaglandins in the immortalized rat osteoblastic cell line Py1a: Structure-activity relations and signal transduction mechanisms
36. Membrane trafficking along the phagocytic pathway
37. Contribution of mannose receptor to signal transduction in Fc gamma receptor-mediated phagocytosis of mouse peritoneal macrophages induced by liposomes
38. Regulation of osteoclast activity
39. Increased osteoclast development after estrogen loss: Mediation by interleukin-6
40. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
41. The role of IL-6 type of cytokines and their receptors in bone
42. Bone and cytokines: Beyond IL-1, IL-6 and TNF-alpha [editorial]
43. Prostaglandin E2, interleukin 1alpha, and tumor necrosis factor-alpha increase human osteoclast formation and bone resorption in vitro
44. Osteoclasts are capable of particle phagocytosis and bone resorption
45. Transcriptional mechanisms of type I collagen gene expression are differentially regulated by interleukin-1 beta, tumor necrosis factor alpha, and transforming growth factor beta in Ito cells
46. Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts
47. Detection of receptors for interleukin-6, interleukin-11, leukemia inhibiting factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells
48. Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts
49. Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells
50. IL-6 receptor and mechanism of signal transduction