Protein kinase C activity and protein levels in Alzheimer's disease

Brain Research

Volumn 764, Issue 1-2, 1997, Pages 75-80

  Lanius, R A ^a   Wagey, R ^a   Sahl, B ^b   Beattie, B L ^a   Feldman, H ^a   Pelech, S L ^b   Krieger, C ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Kinetek Pharmaceuticals Inc   (Canada)

Author keywords

Alzheimer's disease; Brain; Calcium; Leukocyte; Platelet; Protein kinase C

Indexed keywords

HISTONE H1; PHOSPHOTRANSFERASE; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE;

ALZHEIMER DISEASE; ARTICLE; CELL DEATH; CYTOSOL; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AGED; ALZHEIMER DISEASE; BLOOD PLATELETS; BRAIN; CYTOSOL; FEMALE; HISTONES; HUMANS; ISOENZYMES; LEUKOCYTES; MALE; NERVE TISSUE PROTEINS; PROTEIN KINASE C;

EID: 0030768286     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00422-8     Document Type: Article

References (24)

1. N.L. Baenziger, P.W. Majerus, Isolation of human platelets and platelet surface membranes, Methods Enzymol. 31 (1974) 149-155.
2. G.J. Bosman, J.H. Schuurmans Stekhoven, J.J. Melenhorst, A.J. Van Zuylen, I.G.P. Bartholomeus, P.J.C. Van Kalmthout, W.J. De Grip, Are thrombocyte membranes altered in Alzheimer's disease? A morphometric and biochemical study, Neurobiol. Aging 13 (1992) 711-716.
3. A. Bruel, G. Cherqui, S. Columelli, D. Margelin, M. Roudier, P.-M. Sinet, M. Prieur, J.-L. Perignon, J. Delabar, Reduced protein kinase C activity in sporadic Alzheimer's disease fibroblasts, Neurosci. Lett. 133 (1991) 89-92.
4. E.A. Clark, K.L. Leach, J.Q. Trojanowski, V.M. Lee, Characterization and differential distribution of the three major human protein kinase C isozymes of the central nervous system in normal and Alzheimer's disease brains, Lab. Invest. 64 (1991) 35-44.
5. G. Cole, K.R. Dobkins, L.A. Hansen, R.D. Terry, T. Saitoh, Decreased levels of protein kinase C in Alzheimer brain, Brain Res. 452 (1988) 165-174.
6. M.F. Folstein, S. Folstein, P.R. McHugh, Mini-mental state: a practical method for grading the cognitive state of patients for the clinician, J. Psychiatry Res. 12 (1975) 189-198.
7. S. Govoni, S. Bergamaschi, M. Racchi, F. Battaini, G. Binetti, A. Bianchetti, M. Trabucchi, Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients, Neurology 43 (1993) 2581-2586.
8. I. Grundke-Iqbal, K. Iqbal, Y.-C. Tung, M. Quinlan, H.M. Wisniewski, L.I. Binder, Abnormal phosphorylation of the microtubule-associated protein τ (tau) in Alzheimer cytoskeletal pathology, Proc. Natl. Acad. Sci. USA 83 (1986) 4913-4917.
9. 3H]phorbol 12,13-dibutyrate binding to protein kinase C in Alzheimer's disease, J. Neurochem. 56 (1991) 1121-1129.
10. T.V. Huynh, G. Cole, R. Katzman, K.-P. Huang, T. Saitoh, Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts, Arch. Neurol. 46 (1989) 1195-1199.
11. A. Kishimoto, K. Mikawa, K. Hashimoto, I. Yasuda, S.-I. Tanaka, M. Tominaga, T. Kuroda, Y. Nishizuka, Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain), J. Biol. Chem. 264 (1989) 4088-4092.
12. U.K. Laemmli, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227 (1970) 680-685.
13. R.A. Lanius, H.B. Paddon, M. Mezei, R. Wagey, C. Krieger, S.L. Pelech, C.A. Shaw, A role for amplified protein kinase C activity in the pathogenesis of amyotrophic lateral sclerosis, J. Neurochem. 65 (1995) 927-930.
14. V.M.-Y. Lee, B.J. Balin, L. Otvos Jr., J.Q. Trojanowski, A68: a major subunit of paired helical filaments and derivatized forms of normal tau, Science 251 (1991) 675-678.
15. E. Masliah, G. Cole, S. Shimohama, L. Hansen, R. De Teresa, R.D. Terry, T. Saitoh, Differential involvement of protein kinase C isozymes in Alzheimer's disease, J. Neurosci. 10 (1990) 2113-2124.
16. 2+-independent protein kinase C changes in the brains of patients with Alzheimer's disease, J. Neurochem. 67 (1996) 317-323.
17. H. Matsushima, S. Shimohama, S. Tanaka, T. Taniguchi, M. Hagiwara, H. Hidaka, J. Kimura, Platelet protein kinase C levels in Alzheimer's disease, Neurobiol. Aging 15 (1994) 671-674.
18. S.E. Molchan, H. Manji, G. Chen, L. Dou, J. Little, W.Z. Potter, T. Sunderland, Effect of chronic lithium treatment on platelet PKC isozymes in Alzheimer's and elderly control subjects, Neurosci. Lett. 162 (1993) 187-191.
19. G. McKhann, D.A. Drachman, M. Folstein, R. Katzman, D.L. Price, E.M. Stadlan, Clinical diagnosis of Alzheimer's disease, Neurology 34 (1984) 939-944.
20. S.L. Pelech, M. Samiei, D.L. Charest, S. Howard, H. Salari, Characterization of calcium independent forms of protein kinase C in phorbol ester treated rabbit platelets, J. Biol. Chem. 266 (1991) 8696-8705.
21. T. Saitoh, E. Masliah, L.-W. Jin, G.M. Cole, T. Wieloch, I.P. Shapiro, Protein kinases and phosphorylation in neurological disorders and cell death, Lab. Invest. 64 (1991) 596-616.
22. S. Shimohama, M. Narita, H. Matsushima, J. Kimura, M. Kameyama, M. Hagiwara, H. Hidaka, T. Taniguchi, Assessment of protein kinase C isozymes by two-site immunoassay in human brains and changes in Alzheimer's disease, Neurology 43 (1993) 1407-1413.
23. C. Tanaka, Y. Nishizuka, The protein kinase C family for neuronal signaling, Annu. Rev. Neurosci. 17 (1994) 551-567.
24. H.-Y. Wang, M.R. Pisano, E. Friedman, Attenuated protein kinase C activity and translocation in Alzheimer's disease brain, Neurobiol. Aging 15 (1994) 293-298.