Single translation-dual destination: Mechanisms of dual protein targeting in eukaryotes

EMBO Reports

Volumn 6, Issue 5, 2005, Pages 420-425

  Karniely, Sharon ^a   Pines, Ophry ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

Dual targeting; Isoenzymes; Membrane translocation; Signal peptides; Subcellular distribution

Indexed keywords

CATALASE; CYTOCHROME P450 2B1; DIHYDROFOLATE REDUCTASE; GLUTATHIONE REDUCTASE;

CELL ORGANELLE; CELLULAR DISTRIBUTION; ENDOPLASMIC RETICULUM; EUKARYOTE; GENETIC TRANSCRIPTION; IN VITRO STUDY; MITOCHONDRION; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN TARGETING; PROTEIN TRANSPORT; REVIEW; RNA SPLICING; RNA TRANSLATION; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE;

EUKARYOTA;

EID: 20044387943     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.7400394     Document Type: Review

References (29)

1. Addya S, Anandatheerthavarada HK, Biswas G, Bhagwat SV, Mullick J, Avadhani NG (1997) Targeting of NH2-terminal-processed microsomal protein to mitochondria: a novel pathway for the biogenesis of hepatic mitochondrial P450MT2. J Cell Biol 139: 589-599
2. Alberts B, Johnson AJ, Lewis J, Raff M, Roberts K, Walter P (2002) Molecular Biology of the Cell. New York, NY, USA: Garland Science
3. Amutha B, Pain D (2003) Nucleoside diphosphate kinase of Saccharomyces cerevisiae, Ynk1p: localization to the mitochondrial intermembrane space. Biochem J 370: 805-815
4. Anandatheerthavarada HK, Biswas G, Mullick J, Sepuri NB, Otvos L, Pain D, Avadhani NG (1999) Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at ser128. EMBO J 18: 5494-5504
5. Anandatheerthavarada HK, Biswas G, Robin MA, Avadhani NG (2003) Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol 161: 41-54
6. Angermayr M, Strobel G, Zollner A, Korber D, Bandlow W (2001) Two parameters improve efficiency of mitochondrial uptake of adenylate kinase: decreased folding velocity and increased propensity of N-terminal alpha-helix formation. FEBS Lett 508: 427-432
7. Bandlow W, Strobel G, Schricker R (1998) Influence of N-terminal sequence variation on the sorting of major adenylate kinase to the mitochondrial intermembrane space in yeast. Biochem J 329: 359-367
8. Chew O, Rudhe C, Glaser E, Whelan J (2003) Characterization of the targeting signal of dual-targeted pea glutathione reductase. Plant Mol Biol 53: 341-356
9. Colombo S, Longhi R, Alcaro S, Ortuso F, Sprocati T, Flora A, Borgese N (2005) N-myristoylation determines dual targeting of mammalian NADH-cytochrome b5 reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning. J Cell Biol 168: 735-745
10. Danpure CJ (1995) How can the products of a single gene be localized to more than one intracellular compartment? Trends Cell Biol 5: 230-238
11. Egner U, Tomasselli AG, Schulz GE (1987) Structure of the complex of yeast adenylate kinase with the inhibitor P1,P5-di(adenosine-5′-) pentaphosphate at 2.6 Å resolution. J Mol Biol 195: 649-658
12. Field LS, Furukawa Y, O'Halloran TV, Culotta VC (2003) Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria. J Biol Chem 278: 28052-28059
13. Hahne K, Haucke V, Ramage L, Schatz G (1994) Incomplete arrest in the outer membrane sorts NADH-cytochrome b5 reductase to two different submitochondrial compartments. Cell 79: 829-839
14. Herlan M, Bornhovd C, Hell K, Neupert W, Reichert AS (2004) Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor. J Cell Biol 165: 167-173
15. Knox C, Sass E, Neupert W, Pines O (1998) Import into mitochondria, folding and retrograde movement of fumarase in yeast. J Biol Chem 273: 25587-25593
16. Muhlenhoff U, Balk J, Richhardt N, Kaiser JT, Sipos K, Kispal G, Lill R (2004) Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae. J Biol Chem 279: 36906-36915
17. Nakai Y, Nakai M, Hayashi H, Kagamiyama H (2001) Nuclear localization of yeast Nfs1p is required for cell survival. J Biol Chem 276: 8314-8320
18. Peeters N, Small I (2001) Dual targeting to mitochondria and chloroplasts. Biochim Biophys Acta 1541: 54-63
19. Petrova VY, Drescher D, Kujumdzieva AV, Schmitt MJ (2004) Dual targeting of yeast catalase A to peroxisomes and mitochondria. Biochem J 380: 393-400
20. Robin MA, Anandatheerthavarada HK, Fang JK, Cudic M, Otvos L, Avadhani NG (2001) Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity. J Biol Chem 276: 24680-24689
21. Robin MA, Anandatheerthavarada HK, Biswas G, Sepuri NB, Gordon DM, Pain D, Avadhani NG (2002) Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation. J Biol Chem 277: 40583-40593
22. Robin MA, Prabu SK, Raza H, Anandatheerthavarada HK, Avadhani NG (2003) Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70. J Biol Chem 278: 18960-18970
23. Sass E, Blachinsky E, Karniely S, Pines O (2001) Mitochondrial and cytosolic isoforms of yeast fumarase are derivatives of a single translation product and have identical amino termini. J Biol Chem 276: 46111-46117
24. Sass E, Karniely S, Pines O (2003) Folding of fumarase during mitochondrial import determines its dual targeting in yeast. J Biol Chem 278: 45109-45116
25. Silva-Filho MC (2003) One ticket for multiple destinations: dual targeting of proteins to distinct subcellular locations. Curr Opin Plant Biol 6: 589-595
26. Small I, Wintz H, Akashi K, Mireau H (1998) Two birds with one stone: genes that encode products targeted to two or more compartments. Plant Mol Biol 38: 265-277
27. Stein I, Peleg Y, Even-Ram S, Pines O (1994) The single translation product of the FUM1 gene (fumarase) is processed in mitochondria before being distributed between the cytosol and mitochondria in Saccharomyces cerevisiae. Mol Cell Biol 14: 4770-4778
28. Strobel G, Zollner A, Angermayr M, Bandlow W (2002) Competition of spontaneous protein folding and mitochondrial import causes dual subcellular location of major adenylate kinase. Mol Biol Cell 13: 1439-1448
29. Vongsamphanh R, Fortier PK, Ramotar D (2001) Pir1p mediates translocation of the yeast Apn1p endonuclease into the mitochondria to maintain genomic stability. Mol Cell Biol 21: 1647-1655