Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-β-carbolines

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 6, 2005, Pages 2263-2283

  Laronze, M ^a   Boisbrun, M ^a,e   Leonce S ^b   Pfeiffer, B ^b   Renard, P ^b   Lozach, O ^c   Meijer, L ^c   Lansiaux, A ^d   Bailly, C ^d   Sapi, J ^a   Laronze, J Y ^a  

^a CNRS   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c STATION BIOLOGIQUE   (France)

^d INSERM   (France)

^e INSTITUT JEAN LAMOUR   (France)

Author keywords

Cytotoxicity; DNA binding; Pyrrolo carbolines; Pyrrolocarbazoles

Indexed keywords

1 DIMETHYLAMINO 5 METHYL 1,2 DIHYDRO 6H PYRROLO[3,4 C]CARBAZOL 3 ONE; 1 DIMETHYLAMINO 6 (2 DIMETHYLAMINOETHYL) 5 METHYL 1,2 DIHYDRO 6H PYRROLO[3,4 C]CARBAZOL 3 ONE; 10 AMINOETHYL 2 BENZYL 4 METHYL 5 (2 TRIMETHYLSILANYLETHOXYMETHYL) 5H PYRROLO[3,4 B]CARBAZOLE 1,3 DIONE; 10 AMINOETHYL 2,4 DIMETHYL 5 (2 TRIMETHYLSILANYLETHOXYMETHYL) 5H PYRROLO[3,4 B]CARBAZOLE 1,3 DIONE; 2 (2 DIMETHYLAMINOETHYL) 1 IMINO 5 METHYL 6 (2 TRIMETHYLSILANYLETHOXYMETHYL) 1,2 DIHYDRO 6H PYRROLO[3,4 C]CARBAZOL 3 ONE; 2 (2 DIMETHYLAMINOETHYL) 5 METHYL 1,2 DIHYDRO 6H 2,4,6 TRIAZACYCLOPENTA[C] FLUOREN 3 ONE; 2 (2 DIMETHYLAMINOETHYL) 5 METHYL 6 (2 TRIMETHYLSILANYLETHOXYMETHYL) 6H PYRROLO[3,4 C]CARBAZOL 3 DIONE; 2 BENZYL 5 PHENYL 1,2 DIHYDRO 6H 2,4,6 TRIAZACYCLOPENTA[C]FLUOREN 3 ONE; 2 DIMETHYLAMINO N (3 OXO 1,2,3,6 TETRAHYDRO 2,4,6 TRIAZACYCLOPENTA[C] FLUOREN 5 YLMETHYL)ACETAMIDE; 2 DIMETHYLAMINO N [2,4 DIMETHYL 1,3 DIOXO 5 (2 TRIMETHYLSILANYLETHOXYMETHYL) 1,2,3,5 TETRAHYDROPYRROLO[3,4 B]CARBAZOL 10 YLMETHYL]ACETAMIDE; 2 PYRROLIDONE DERIVATIVE; 2,4 DIMETHYL 1,3 DIOXO 5 (2 TRIMETHYLSILANYLETHOXYMETHYL) 1,2,3,5 TETRAHYDROPYRROLO[3,4 B]CARBAZOLE 10 CARBONITRILE; 2,4,6 TRIMETHYLAMINO N (3 OXO 1,2,3,6 TETRAHYDRO 2,4,6 TRIAZACYCLOPENTA[C] FLUOREN 5 YLMETHYL)BENZENE SULFONAMIDE; 3 DIMETHYLAMINO N [2,4 DIMETHYL 1,3 DIOXO 5 (2 TRIMETHYLSILANYLETHOXYMETHYL) 1,2,3,5 TETRAHYDROPYRROLO[3,4 B]CARBAZOL 10 YLMETHYL]PROPIONAMIDE; 5 AMINOMETHYL 1,2 DIHYDRO 6H 2,4,6 TRIAZACYCLOPENTA[C]FLUOREN 3 ONE; 5 METHYL 1,2 DIHYDRO 6H 2,4,6 TRIAZACYCLOPENTA[C]FLUOREN 3 ONE; 5 METHYL 1,2 DIHYDRO 6H PYRROLO[3,4 C]CARBAZOL 3 ONE; 5 METHYL 6 (2 TRIMETHYLSILANYLETHOXYMETHYL) 1,2 DIHYDRO 6H PYRROLO[3,4 C]CARBAZOL 3 ONE; 6 (2 DIMETHYLAMINOETHYL) 5 METHYL 1,2 DIHYDRO 6H 2,4,6 TRIAZACYCLOPENTA[C] FLUOREN 3 ONE; 8 CHLORO 2,4 DIMETHYL 1,3 DIOXO 5 (2 TRIMETHYLSILANYLETHOXYMETHYL) 1,2,3,5 TETRAHYDROPYRROLO[3,4 B]CARBAZOLE 10 CARBONITRILE; ANTINEOPLASTIC AGENT; CARBAZOLE DERIVATIVE; CARBOLINE DERIVATIVE; DNA; N [2 BENZYL 4 METHYL 1,3 DIOXO 5 (2 TRIMETHYLSILANYLETHOXYMETHYL) 1,2,3,5 TETRAHYDROPYRROLO[3,4 B]CARBAZOL 10 YLMETHYL] 2 DIMETHYLAMINOACETAMIDE; N [2 BENZYL 4 METHYL 1,3 DIOXO 5 (2 TRIMETHYLSILANYLETHOXYMETHYL) 1,2,3,5 TETRAHYDROPYRROLO[3,4 B]CARBAZOL 10 YLMETHYL] 3 DIMETHYLAMINOPROPIONAMIDE; UNCLASSIFIED DRUG; [2 [(2 BENZYL 4 METHYL 1,3 DIOXO 1,2,3,5 TETRAHYDROPYRROLO[3,4 B]CARBAZOL 10 YLMETHYL)CARBAMOYL]ETHYL]DIMETHYLAMMONIUM CHLORIDE; [2 [(2 DIMETHYL 1,3 DIOXO 1,2,3,5 TETRAHYDROPYRROLO[3,4 B]CARBAZOL 10 YLMETHYL)CARBAMOYL]ETHYL]DIMETHYLAMMONIUM CHLORIDE; [[(2 BENZYL 4 METHYL 1,3 DIOXO 1,2,3,5 TETRAHYDROPYRROLO[3,4 B]CARBAZOL 10 YLMETHYL)CARBAMOYL]METHYL]DIMETHYLAMMONIUM CHLORIDE; [[(2,4 DIMETHYL 1,3 DIOXO 1,2,3,5 TETRAHYDROPYRROLO[3,4 B]CARBAZOL 10 YLMETHYL)CARBAMOYL]METHYL]DIMETHYLAMMONIUM CHLORIDE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG SCREENING; MOUSE; NONHUMAN; PROTEIN INTERACTION;

EID: 13844316072     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.12.045     Document Type: Article

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