Pharmacokinetics of the β-carboline norharman in man

Life Sciences

Volumn 69, Issue 18, 2001, Pages 2113-2121

  Fekkes, Durk ^a   Tuiten, Adriaan ^b   Bom, Isaac ^c   Pepplinkhuizen, Lolke ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

Author keywords

carboline; Norharman; Pharmacokinetics; Sublingual dosing

Indexed keywords

BETA CARBOLINE; CYCLODEXTRIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HALF LIFE; EVALUATION; FEMALE; HUMAN; MALE; NORMAL HUMAN; SEX DIFFERENCE; TIME;

ADMINISTRATION, ORAL; ADULT; CARBOLINES; FEMALE; HARMINE; HUMANS; MALE; MIDDLE AGED; MUTAGENS;

EID: 0035929334     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01293-0     Document Type: Article

References (28)

1. Plasma norharman (β-carboline) levels are elevated in chronic alcoholics
2. Norharman, a normal body constituent
3. Occurrence and partition of the β-carboline norharman in rat organs
4. Harman (1-methyl-β-carboline) is a natural inhibitor of monoamine oxidase type A in rats
5. Endogenously formed norharman (β-carboline) in platelet rich plasma obtained from porphyric rats
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9. The isolation of harmane and norharmane from tobacco and cigarette smoke
10. 3H]-diazepam binding in mouse brain
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12. Benzodiazepine antagonism by harman and other β-carbolines in vitro and in vivo
13. β-Carboline kindling of the benzodiazepine receptor
14. Relationship between occurrence of tremor/convulsion and level of β-carbolines in the brain after administration of β-carbolines into mice
15. The inhibitory effect of norharman on morphine withdrawal syndrome in rats: Comparison with ibogaine
16. The role of beta-carbolines (harman/norharman) in heroin addicts
17. Elevated norharman plasma levels in alcoholic patients and controls resulting from tobacco smoking
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19. Lack of hepatotoxicity or promotion of enzyme altered liver foci developments in rats treated with harman or norharman
20. Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats
21. Genotoxic potential of β-carbolines: A review
22. Effects of harman and norharman on the mutagenicity and binding to DNA of benzo[a]pyrene metabolites in vitro and on aryl hydrocarbon hydroxylase induction in cell culture
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24. The shortened version of the Dutch translation of the Profile of Mood States (POMS)
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27. 3H]Harman binding experiments. II: Reversible and selective radioligand for monoamine oxidase subtype A in the CNS of the rat
28. Comparison of the in vitro binding characteristics of the β-carboline harman and norharman in rat brain and liver and in bovine adrenal medulla