The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine

Cancer Research

Volumn 66, Issue 15, 2006, Pages 7686-7693

  Turner, David P ^a,c   Cortellino, Salvatore ^a   Schupp, Jane E ^b   Caretti, Elena ^a   Loh, Tamalette ^b   Kinsella, Timothy J ^b   Bellacosa, Alfonso ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; DNA N GLYCOSYLASE ENZYME; FLUOROURACIL; HALOGEN; IDOXURIDINE; MED 1 PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PYRIMIDINE DERIVATIVE; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG; URACIL;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; COLONY FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA METHYLATION; FIBROBLAST; GENE INACTIVATION; GENE TARGETING; GENOTYPE; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MISMATCH REPAIR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS;

ANIMALS; BASE PAIR MISMATCH; CELL LINE; CPG ISLANDS; EMBRYO; ENDODEOXYRIBONUCLEASES; GENE SILENCING; HUMANS; IDOXURIDINE; MICE; PYRIMIDINES; SUBSTRATE SPECIFICITY;

EID: 33747890207     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-4488     Document Type: Article

References (57)

1. Ito Y, Jones PA, Vogt PK, et al., editors. DNA methylation and cancer. Vol. 249. New York: Springer-Verlag, 2000.
2. El-Osta A. DNMT cooperativity-the developing links between methylation, chromatin structure and cancer. Bioessays 2003;25:1071-84.
3. Kleihues P, Schauble B, zur Hausen A, Esteve J, Ohgaki H. Tumors associated with p53 germline mutations: a synopsis of 91 families. Am J Pathol 1997;150:1-13.
4. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994;54:4855-78.
5. Pfeifer GP, Tang M-S, Denissenko MF. Mutation hotspots and DNA methylation. In: Ito Y, Jones PA, Vogt PK et al., editors. DNA methylation and cancer. New York: Springer-Verlag; 2000. p. 1-19.
6. Zingg JM, Jones PA, Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis 1997;18:869-82.
7. 4-ethenocytosine from DNA. J Biol Chem 1999;274:31034-8.
8. Duncan BK, Miller JH. Mutagenic deamination of cytosine residues in DNA. Nature 1980;287:560-1.
9. Wallace SS. Biological consequences of free radical-damaged DNA bases. Free Radic Biol Med 2002;33:1-14.
10. Neddermann P, Jiricny J. The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells. J Biol Chem 1993;268:21218-24.
11. Neddermann P, Jiricny J. Efficient removal of uracil from G·U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells. Proc Natl Acad Sci U S A 1994;91:1642-6.
12. Hendrich B, Hardeland U, Ng HH, Jiricny J, Bird A. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature 1999;401:301-4.
13. Petronzelli F, Riccio A, Markham GD, et al. Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase. J Biol Chem 2000;275:32422-9.
14. Petronzelli F, Riccio A, Markham GD, et al. Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): Fundamental role of the catalytic domain. J Cell Physiol 2000;185:473-80.
15. Neddermann P, Gallinari P, Lettieri T, et al. Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. J Biol Chem 1996;271:12767-74.
16. Schärer OD, Jiricny J. Recent progress in the biology, chemistry and structural biology of DNA glycosylases. Bioessays 2001;23:270-81.
17. David SS, Williams SD. Chemistry of glycosylases and endonucleases involved in base-excision reair. Chem Rev 1998;98:1221-61.
18. Hickson ID. General introduction to DNA base excision repair. In: Hickson ID, editor. Base excision repair of DNA damage. Austin (TX): Landes Bioscience (Springer-Verlag); 1997. p. 1-5.
19. Krokan HE, Nilsen H, Skorpen F, Otterlei M, Slupphaug G. Base excision repair of DNA in mammalian cells. FEBS Lett 2000;476:73-7.
20. Wallace SS. DNA damages processed by base excision repair: biological consequences. Int J Radiat Biol 1994;66:579-89.
21. Bellacosa A. Role of MED1 (MBD4) Gene in DNA repair and human cancer. J Cell Physiol 2001;187:137-44.
22. Bellacosa A, Cicchlllitti L, Schepis F, et al. MED1, a novel human methyl-CpG-binding endonuclease, interacts with the DNA mismatch repair protein MLH1. Proc Natl Acad Sci U S A 1999;96:3969-74.
23. Yoon JH, Iwai S, O'Connor TR, Pfeifer GP. Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair. Nucleic Acids Res 2003;31:5399-404.
24. Valinluck V, Liu P, Kang JI, Jr., Burdzy A, Sowers LC. 5-halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2). Nucleic Acids Res 2005;33:3057-64.
25. Spratt TE, Levy DE. Structure of the hydrogen bonding complex of O6-methylguanine with cytosine and thymine during DNA replication. Nucleic Acids Res 1997;25:3354-61.
26. Grover PL. Chemical carcinogens and DNA. Vol. 1. Boca Raton (FL): CRC Press; 1979. p. 112-59.
27. Karran P, Bignami M. Mismatch repair and cancer. In: Smith PJ, Jones CJ, editors. DNA recombination and repair. New York: Oxford Univ. Press; 1999. p. 66-159.
28. Bellacosa A. Functional interactions and signaling properties of mammalian DNA mismatch repair proteins. Cell Death Differ 2001;8:1076-92.
29. 2-M arrest in MMR-proficient RKO cells. Clin Cancer Res 2003;9:2327-34.
30. Yan T, Desai AB, Jacobberger JW, Sramkoski RM, Loh T, Kinsella TJ. CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. Mol Cancer Ther 2004;3:1147-57.
31. Cortellino S, Turner D, Masciullo V, et al. The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. Proc Natl Acad Sci U S A 2003;100:15071-6.
32. Millar CB, Guy J, Sansom OJ, et al. Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science 2002;297:403-5.
33. Wong E, Yang K, Kuraguchi M, et al. Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation. Proc Natl Acad Sci U S A 2002;99:14937-42.
34. Stoscheck CM. Quantitation of protein. Methods Enzymol 1990;182:50-68.
35. Ho SN, Hunt HD, Horton RM, Pullen JK, Pease LR. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 1989;77:51-9.
36. Oleykowski CA, Bronson Mullins CR, Godwin AK, Yeung AT. Mutation detection using a novel plant endonuclease. Nucleic Acids Res 1998;26:4597-602.
37. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1989.
38. Connolly BA, Liu HH, Parry D, Engler LE, Kurpiewski MR, Jen-Jacobson L. Assay of restriction endonucleases using oligonucleotides. Methods Mol Biol 2001;148:465-90.
39. Hansen MB, Nielsen SE, Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 1989;119:203-10.
40. Taverna P, Hwang HS, Schupp JE, et al. Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization. Cancer Res 2003;63:838-46.
41. Seo Y, Yan T, Schupp JE, Colussi V, Taylor KL, Kinsella TJ. Differential radiosensitization in DNA mismatch repair-proficient and -deficient human colon cancer xenografts with 5-iodo-2-pyrimidinone-2′-deoxyribose. Clin Cancer Res 2004;10:7520-8.
42. Schulz CA, Mehta MP, Badie B, et al. Continuous 28-day iododeoxyuridine infusion and hyperfractionated accelerated radiotherapy for malignant glioma: a phase I clinical study. Int J Radiat Oncol Biol Phys 2004;59:1107-15.
43. Kinsella TJ. An approach to the radiosensitization of human tumors. Cancer J Sci Am 1996;2:184.
44. Miller EM, Fowler JF, Kinsella TJ. Linear-quadratic analysis of radiosensitization by halogenated pyrimidines. II. Radiosensitization of human colon cancer cells by bromodeoxyuridine. Radiat Res 1992;131:90-7.
45. Hutchinson F, Stein J. Mutagenesis of lambda phage: 5-bromouracil and hydroxylamine. Mol Gen Genet 1977;152:29-36.
46. Rydberg B. Bromouracil mutagenesis in Escherichia coli evidence for involvement of mismatch repair. Mol Gen Genet 1977;152:19-28.
47. Berry SE, Loh T, Yan T, Kinsella TJ. Role of MutSα in the recognition of iododeoxyuridine in DNA Cancer Res 2003;63:5490-5.
48. Sansom OJ, Zabkiewicz J, Bishop SM, Guy J, Bird A, Clarke AR. MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene 2003;22:7130-6.
49. Parsons BL. MED1: a central molecule for maintenance of genome integrity and response to DNA damage. Proc Natl Acad Sci U S A 2003;100:14601-2.
50. Xia L, Zheng L, Lee HW, et al. Human 3-methyl-adenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease. J Mol Biol 2005;346:1259-74.
51. Turner DP, Connolly BA. Interaction of the E. coli DNA G:T-mismatch endonuclease (vsr protein) with oligonucleotides containing its target sequence. J Mol Biol 2000;304:765-78.
52. Wu P, Qiu C, Sohail A, Zhang X, Bhagwat AS, Cheng X. Mismatch repair in methylated DNA. Structure and activity of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4. J Biol Chem 2003;278:5285-91.
53. Stivers JT, Jiang YL. A mechanistic perspective on the chemistry of DNA repair glycosylases. Chem Rev 2003;103:2729-59.
54. Coll M, Saal D, Frederick CA, Aymami J, Rich A, Wang AH. Effects of 5-fluorouracil/guanine wobble base pairs in Z-DNA: molecular and crystal structure of d(CGCGFG). Nucleic Acids Res 1989;17:911-23.
55. Berry SE, Kinsella TJ. Targeting DNA mismatch repair for radiosensitization. Semin Radiat Oncol 2001;11:300-15.
56. Bader S, Walker M, Hendrich B, et al. Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency. Oncogene 1999;18:8044-7.
57. Riccio A, Aaltonen LA, Godwin AK, et al. The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. Nat Genet 1999;23:266-8.