Mutation hotspots and DNA methylation

Current Topics in Microbiology and Immunology

Volumn 249, Issue , 2000, Pages 1-19

  Pfeifer, G P ^a   Tang, M S ^b   Denissenko, M F ^c  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c BD Technologies   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; PROTEIN P53;

DEAMINATION; DNA DAMAGE; DNA METHYLATION; ENZYME ACTIVITY; LUNG CANCER; MAMMAL; MUTATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SKIN CANCER;

MAMMALIA;

EID: 0034012880     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-59696-4_1     Document Type: Review

References (14)

1. Aguilar F, Hussain SP, Cerutti P (1993) Aflatoxin B1 induces the transversion of G → T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci USA 90:8586-8590
2. Ambs S, Bennett WP, Merriam WG, Ogunfusika MO, Oser SM, Harrington AM, Shields PG, Felley-Bosco E, Hussain SP, Harris CC (1999) Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. J Natl Cancer Inst 91:86-88
3. Bentivegna SS, Bresnick E (1994) Inhibition of human O6-methylguanine-DNA methyltransferase by 5-methylcytosine. Cancer Res 54:327-329
4. Bill CA, Duran WA, Miselis NR, Nickoloff JA (1998) Efficient repair of all types of single-base mismatches in recombination intermediates in Chinese hamster ovary cells: competition between long-patch and G-T glycosylase-mediated repair of G-T mismatches. Genetics 149:1935-1943
5. Bird AP (1986) CpG-rich islands and the function of DNA methylation. Nature (London) 321:209-213
6. Bird AP (1992) The essentials of DNA methylation. Cell 70:5-8
7. Boehm TLJ, Drahovsky D (1983) Alteration of enzymatic DNA methylation by chemical carcinogens. Recent Results Cancer Res 84:212-225
8. Bottema CD, Ketterling RP, Vielhaber E, Yoon US, Gostout B, Jacobson DP, Shapiro A, Sommer SS (1993) The pattern of spontaneous germ-line mutation: relative rates of mutation at or near CpG dinucleotides in the factor IX gene. Hum Genet 91:496-503
9. Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ, Baden HP, Halperin AJ, Pontén J (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA 88:10124-10128
10. Caron de Fromentel C, Soussi T (1992) TP53 tumor suppressor gene: a model for investigating human mutagenesis. Genes Chromosomes Cancer 4:1-15
11. Chen JX, Zheng Y, West M, Tang M-S (1998) Carcinogens preferentially bind at methylated CpG in the p53 mutational hotspots. Cancer Res 58:2070-2075
12. Chen R-H, Maher VM, McCormick JJ (1990) Effect of excision repair by diploid human fibroblasts on the kinds and locations of mutations induced by ( + )-7b,8a-dihydroxy-9a,10a-epoxy-7,8,9,10-tetra-hydrobenzo[a]pyrene in the coding region of the HPRT gene. Proc Natl Acad Sci USA 87:8680-8684
13. Chen R-H, Maher VM, Brouwer J, Van de Putte P, McCormick JJ (1992) Preferential repair and strand-specific repair of benzo(a)pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts. Proc Natl Acad Sci USA 89:5413-5417
14. Coulondre C, Miller JH, Farabaugh PJ, Gilbert W (1978) Molecular basis of base substitution hotspots in Eschcrichia coli. Nature 274:775-780