-
2
-
-
3042781677
-
The oldest fungicide and newest phytoalexin - a reappraisal of the fungitoxicity of elemental sulphur
-
Williams J.S., and Cooper R.M. The oldest fungicide and newest phytoalexin - a reappraisal of the fungitoxicity of elemental sulphur. Plant Pathol. 53 (2004) 263-279
-
(2004)
Plant Pathol.
, vol.53
, pp. 263-279
-
-
Williams, J.S.1
Cooper, R.M.2
-
3
-
-
31344463509
-
Reviewing some origins of pesticide perceptions
-
Krieger R.I. Reviewing some origins of pesticide perceptions. Outlooks on Pest Management 16 (2005) 244-248
-
(2005)
Outlooks on Pest Management
, vol.16
, pp. 244-248
-
-
Krieger, R.I.1
-
4
-
-
33747810189
-
-
Strang, H. (2005) Changes and challenges facing modern crop protection. New Discoveries in Agrochemicals. American Chemical Society Symposium Series, ACS, Wash. D.C., pp. 2-16
-
-
-
-
5
-
-
0011425677
-
Nonlethal parameters as indicies of acute toxicity: inadequacy of the acute LD50
-
Shapiro R.E., and Blumenthal H. (Eds), John Wiley and Sons, NY
-
Sperling F. Nonlethal parameters as indicies of acute toxicity: inadequacy of the acute LD50. In: Shapiro R.E., and Blumenthal H. (Eds). Advances in modern toxicology: new concepts of safety evaluation Vol. 1 (1976), John Wiley and Sons, NY 177
-
(1976)
Advances in modern toxicology: new concepts of safety evaluation
, vol.1
, pp. 177
-
-
Sperling, F.1
-
6
-
-
33747789994
-
-
Basarab, G.S. et al. (1995) Bioassays in the discovery process of agrochemicals. Synthesis and Chemistry of Agrochemicals IV. American Chemical Society Symposium Series, ACS, Wash. D.C., pp. 2
-
-
-
-
7
-
-
0021195869
-
The sulfonylurea herbicide sulfometuron methyl is an extremely potent and selective inhibitor of acetolactate synthase in Salmonella typhimurium
-
LaRossa R.A., and Schloss J.V. The sulfonylurea herbicide sulfometuron methyl is an extremely potent and selective inhibitor of acetolactate synthase in Salmonella typhimurium. J. Biol. Chem. 259 (1984) 8753-8757
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 8753-8757
-
-
LaRossa, R.A.1
Schloss, J.V.2
-
8
-
-
0035146544
-
Mesotrione: a new selective herbicide for use in maize
-
Mitchell G., et al. Mesotrione: a new selective herbicide for use in maize. Pest Manag. Sci. 57 (2001) 120-128
-
(2001)
Pest Manag. Sci.
, vol.57
, pp. 120-128
-
-
Mitchell, G.1
-
10
-
-
0035438391
-
Is there a difference between leads and drugs? A historical perspective
-
Oprea T.I., et al. Is there a difference between leads and drugs? A historical perspective. J. Chem. Inf. Comput. Sci. 41 (2001) 1308-1315
-
(2001)
J. Chem. Inf. Comput. Sci.
, vol.41
, pp. 1308-1315
-
-
Oprea, T.I.1
-
11
-
-
85088886793
-
Life sciences
-
Thayer A.M. Life sciences. Chem. Eng. News 79 (2001) 26-36
-
(2001)
Chem. Eng. News
, vol.79
, pp. 26-36
-
-
Thayer, A.M.1
-
12
-
-
27144554238
-
High throughput screening in agrochemical research
-
Tietjen K., et al. High throughput screening in agrochemical research. Comb. Chem. High Throughput Screen. 8 (2005) 589-594
-
(2005)
Comb. Chem. High Throughput Screen.
, vol.8
, pp. 589-594
-
-
Tietjen, K.1
-
13
-
-
33747749233
-
-
Hunt, D.A. et al. (1998) Synthesis of agrochemicals and agricultural biotechnology entering the 21st century. Synthesis and Chemistry of Agrochemicals V. American Chemical Society Symposium Series, ACS, Wash. D.C., pp. 1
-
-
-
-
14
-
-
33746033147
-
Filtering in drug discovery
-
Spellmeyer D.C. (Ed), Elsevier
-
Lipinski C.A. Filtering in drug discovery. In: Spellmeyer D.C. (Ed). Annual reports in computational chemistry Vol. 1 (2005), Elsevier 155-168
-
(2005)
Annual reports in computational chemistry
, vol.1
, pp. 155-168
-
-
Lipinski, C.A.1
-
15
-
-
0033576605
-
Properties of known drugs. 2. Side chains
-
Bemis G.W., and Murcko M.A. Properties of known drugs. 2. Side chains. J. Med. Chem. 42 (1999) 5095-5099
-
(1999)
J. Med. Chem.
, vol.42
, pp. 5095-5099
-
-
Bemis, G.W.1
Murcko, M.A.2
-
16
-
-
0141994392
-
Drugs and nondrugs: An effective discrimination with topological methods and artificial neural networks
-
Murcia-Soler M. Drugs and nondrugs: An effective discrimination with topological methods and artificial neural networks. J. Chem. Inf. Comput. Sci. 43 (2003) 1688-1702
-
(2003)
J. Chem. Inf. Comput. Sci.
, vol.43
, pp. 1688-1702
-
-
Murcia-Soler, M.1
-
17
-
-
0032572819
-
Can we learn to distinguish between 'drug-like' and 'nondrug-like' molecules
-
Ajay A., et al. Can we learn to distinguish between 'drug-like' and 'nondrug-like' molecules. J. Med. Chem. 41 (1998) 3314-3324
-
(1998)
J. Med. Chem.
, vol.41
, pp. 3314-3324
-
-
Ajay, A.1
-
18
-
-
0032572816
-
A scoring scheme for discriminating between drugs and nondrugs
-
Sadowski J., and Kubinyi H. A scoring scheme for discriminating between drugs and nondrugs. J. Med. Chem. 41 (1998) 3325-3329
-
(1998)
J. Med. Chem.
, vol.41
, pp. 3325-3329
-
-
Sadowski, J.1
Kubinyi, H.2
-
19
-
-
0001376170
-
Potential drugs and nondrugs: Prediction and identification of important structural features
-
Wagener M., and van Geerstein V.J. Potential drugs and nondrugs: Prediction and identification of important structural features. J. Chem. Inf. Comput. Sci. 40 (2000) 280-292
-
(2000)
J. Chem. Inf. Comput. Sci.
, vol.40
, pp. 280-292
-
-
Wagener, M.1
van Geerstein, V.J.2
-
20
-
-
0036589312
-
An overview of the diversity represented in commercially-available databases
-
Bradley M.P. An overview of the diversity represented in commercially-available databases. J. Comput. Aided Mol. Des. 16 (2002) 301-309
-
(2002)
J. Comput. Aided Mol. Des.
, vol.16
, pp. 301-309
-
-
Bradley, M.P.1
-
21
-
-
11144253884
-
Aqueous solubility in discovery, chemistry, and assay changes
-
Lipinski C.A. Aqueous solubility in discovery, chemistry, and assay changes. Methods and Principles in Medicinal Chemistry 18 (2003) 215-231
-
(2003)
Methods and Principles in Medicinal Chemistry
, vol.18
, pp. 215-231
-
-
Lipinski, C.A.1
-
22
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski C.A., et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23 (1997) 3-25
-
(1997)
Adv. Drug Deliv. Rev.
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
-
23
-
-
0035132705
-
Selecting the right compounds for screening: does Lipinski's rule of 5 for pharmaceuticals apply to agrochemicals?
-
Tice C.M. Selecting the right compounds for screening: does Lipinski's rule of 5 for pharmaceuticals apply to agrochemicals?. Pest Manag. Sci. 57 (2001) 3-16
-
(2001)
Pest Manag. Sci.
, vol.57
, pp. 3-16
-
-
Tice, C.M.1
-
24
-
-
33747786463
-
Physical and molecular properties of agrochemicals: insights from an analysis of screen inputs, hits, leads and products
-
Ford M., et al. (Ed), Blackwell Publishing, New York
-
Clarke E.D., and Delaney J.S. Physical and molecular properties of agrochemicals: insights from an analysis of screen inputs, hits, leads and products. In: Ford M., et al. (Ed). EuroQSAR 2002-Designing Drugs and Crop Protectants: Processes, problems and solutions (2003), Blackwell Publishing, New York 51-54
-
(2003)
EuroQSAR 2002-Designing Drugs and Crop Protectants: Processes, problems and solutions
, pp. 51-54
-
-
Clarke, E.D.1
Delaney, J.S.2
-
25
-
-
18244370266
-
A bioavailability score
-
Martin Y.C. A bioavailability score. J. Med. Chem. 48 (2005) 3164-3170
-
(2005)
J. Med. Chem.
, vol.48
, pp. 3164-3170
-
-
Martin, Y.C.1
-
27
-
-
33747749963
-
-
Worthington, P.A. (1983) 1,3-Bis(azolyl)propanols as fungicides and plant growth regulators. US 4416682
-
-
-
-
28
-
-
34347256036
-
Rationale and prospects for drugs that target nicotinic acetylcholine receptors
-
Buccafusco J.J. (Ed), Birkhauser Verlag
-
Wevers A., and Woodruff-Pak D.S. Rationale and prospects for drugs that target nicotinic acetylcholine receptors. In: Buccafusco J.J. (Ed). Cognitive Enhancing Drugs (2004), Birkhauser Verlag 49-68
-
(2004)
Cognitive Enhancing Drugs
, pp. 49-68
-
-
Wevers, A.1
Woodruff-Pak, D.S.2
-
29
-
-
0002400644
-
Structure-activity relationships of acyclic nicotinoids and neonicotinoids for insect nicotinic acetylcholine receptor/ion channel complex
-
Matsuo H., et al. Structure-activity relationships of acyclic nicotinoids and neonicotinoids for insect nicotinic acetylcholine receptor/ion channel complex. Arch. Insect Biochem. Physiol. 37 (1998) 17-23
-
(1998)
Arch. Insect Biochem. Physiol.
, vol.37
, pp. 17-23
-
-
Matsuo, H.1
-
30
-
-
1342323398
-
Mammalian voltage-gated calcium channels are potently blocked by the pyrethroid insecticide allethrin
-
Hildebrand M.E., et al. Mammalian voltage-gated calcium channels are potently blocked by the pyrethroid insecticide allethrin. J. Pharmacol. Exp. Ther. 308 (2004) 805-813
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.308
, pp. 805-813
-
-
Hildebrand, M.E.1
-
31
-
-
0030980167
-
Effect of phenylpyrroles on glycerol accumulation and protein kinase activity of Neurospora crassa
-
Pillonel C., and Meyer T. Effect of phenylpyrroles on glycerol accumulation and protein kinase activity of Neurospora crassa. Pestic. Sci. 49 (1997) 229-236
-
(1997)
Pestic. Sci.
, vol.49
, pp. 229-236
-
-
Pillonel, C.1
Meyer, T.2
-
32
-
-
14844338576
-
Much anticipated - The bioactive conformation of epothilone and its binding to tubulin
-
Heinz D.W., et al. Much anticipated - The bioactive conformation of epothilone and its binding to tubulin. Angew. Chem. Int. Ed Engl. 44 (2005) 1298-1301
-
(2005)
Angew. Chem. Int. Ed Engl.
, vol.44
, pp. 1298-1301
-
-
Heinz, D.W.1
-
33
-
-
7344229198
-
From toxicological problem to therapeutic use: The discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug
-
Lock E.A., et al. From toxicological problem to therapeutic use: The discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug. J. Inherit. Metab. Dis. 21 (1998) 498-506
-
(1998)
J. Inherit. Metab. Dis.
, vol.21
, pp. 498-506
-
-
Lock, E.A.1
-
34
-
-
21144458162
-
Use of nitisinone in patients with alkaptonuria
-
Suwannarat P., et al. Use of nitisinone in patients with alkaptonuria. Metabolism 54 (2005) 719-728
-
(2005)
Metabolism
, vol.54
, pp. 719-728
-
-
Suwannarat, P.1
-
35
-
-
0038121700
-
A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents
-
Kotsikorou E., and Oldfield E. A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents. J. Med. Chem. 46 (2003) 2932-2944
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2932-2944
-
-
Kotsikorou, E.1
Oldfield, E.2
-
36
-
-
0029896933
-
Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists
-
Riechers H., et al. Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists. J. Med. Chem. 39 (1996) 2123-2128
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2123-2128
-
-
Riechers, H.1
-
37
-
-
0346726282
-
Herbicide safety relative to common targets in plants and mammals
-
Shaner D.L. Herbicide safety relative to common targets in plants and mammals. Pest Manag. Sci. 60 (2004) 17-24
-
(2004)
Pest Manag. Sci.
, vol.60
, pp. 17-24
-
-
Shaner, D.L.1
-
38
-
-
1542268206
-
Selective optimization of side activites: another way for drug discovery
-
Wermuth C.G. Selective optimization of side activites: another way for drug discovery. J. Med. Chem. 47 (2004) 1303-1314
-
(2004)
J. Med. Chem.
, vol.47
, pp. 1303-1314
-
-
Wermuth, C.G.1
-
39
-
-
0037439447
-
Nonleadlikeness and leadlikeness in biochemical screening
-
Rishton G.M. Nonleadlikeness and leadlikeness in biochemical screening. Drug Discov. Today 8 (2003) 86-96
-
(2003)
Drug Discov. Today
, vol.8
, pp. 86-96
-
-
Rishton, G.M.1
-
40
-
-
2942564021
-
Pursuing the leadlikeness concept in pharmaceutical research
-
Hann M.M., and Oprea T.I. Pursuing the leadlikeness concept in pharmaceutical research. Curr. Opin. Chem. Biol. 8 (2004) 255-263
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 255-263
-
-
Hann, M.M.1
Oprea, T.I.2
-
41
-
-
0033576601
-
The design of leadlike combinatorial libraries
-
Teague S.J., et al. The design of leadlike combinatorial libraries. Angew. Chem. Int. Ed. Engl. 38 (1999) 3743-3748
-
(1999)
Angew. Chem. Int. Ed. Engl.
, vol.38
, pp. 3743-3748
-
-
Teague, S.J.1
-
42
-
-
0345732338
-
Physical and molecular properties of agrochemicals: An analysis of screen inputs, hits, leads and products
-
Clarke E.D., and Delaney J.S. Physical and molecular properties of agrochemicals: An analysis of screen inputs, hits, leads and products. Chimia 57 (2003) 731-734
-
(2003)
Chimia
, vol.57
, pp. 731-734
-
-
Clarke, E.D.1
Delaney, J.S.2
-
43
-
-
33747800440
-
-
Dorn, F., Exchange of compound libraries between agrochemical and pharmaceutical companies [abstract] Pacifichem 2005. Honolulu, Hawaii, USA. 2005. 330
-
-
-
-
44
-
-
0038387389
-
Hit and lead generation: beyond high-throughput screening
-
Bleicher K.H., et al. Hit and lead generation: beyond high-throughput screening. Nat. Rev. Drug Discov. 2 (2003) 369-378
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 369-378
-
-
Bleicher, K.H.1
-
45
-
-
0036955427
-
Current trends in lead discovery: Are we looking for the appropriate properties?
-
Oprea T.I. Current trends in lead discovery: Are we looking for the appropriate properties?. Mol. Divers. 5 (2002) 199-208
-
(2002)
Mol. Divers.
, vol.5
, pp. 199-208
-
-
Oprea, T.I.1
-
46
-
-
0037124196
-
Drugs, leads and drug-likeness: An analysis of some recently launched drugs
-
Proudfoot J.R. Drugs, leads and drug-likeness: An analysis of some recently launched drugs. Bioorg. Med. Chem. Lett. 12 (2002) 1647-1650
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 1647-1650
-
-
Proudfoot, J.R.1
-
48
-
-
0029776766
-
Antibiotics from gliding bacteria. 77. Epothilone A and B - novel 16-membered macrolides with cytotoxic activity: isolation, crystal structure and conformation in solution
-
Hofle G., et al. Antibiotics from gliding bacteria. 77. Epothilone A and B - novel 16-membered macrolides with cytotoxic activity: isolation, crystal structure and conformation in solution. Angew. Chem. Int. Ed. Engl. 35 (1996) 1567
-
(1996)
Angew. Chem. Int. Ed. Engl.
, vol.35
, pp. 1567
-
-
Hofle, G.1
-
49
-
-
33747781532
-
-
Eicken, K. et al. (1983) 7-Aminoazolo[1,5-a]pyrimidines and fungicides containing them. DE 3130633
-
-
-
-
50
-
-
33747751994
-
-
Himmele, W. et al. (1979) Antimycotic composition. DE 2822326
-
-
-
-
51
-
-
0002846339
-
Anisomycin and related antibiotics
-
Hahn F.E. (Ed), Springer-Verlag, New York (Vol. 5, part 2)
-
Jimènez A., and Vázquez D. Anisomycin and related antibiotics. In: Hahn F.E. (Ed). Antibiotics (1979), Springer-Verlag, New York 1-19 (Vol. 5, part 2)
-
(1979)
Antibiotics
, pp. 1-19
-
-
Jimènez, A.1
Vázquez, D.2
-
52
-
-
0032565968
-
Evidence for the shikimate pathway in apicomplexan parasites
-
Roberts F., et al. Evidence for the shikimate pathway in apicomplexan parasites. Nature 393 (1998) 801-805
-
(1998)
Nature
, vol.393
, pp. 801-805
-
-
Roberts, F.1
-
53
-
-
0026661016
-
Sulphonylureas: a new class of cancer chemotherapeutic agents
-
Mohamadi F., et al. Sulphonylureas: a new class of cancer chemotherapeutic agents. J. Med. Chem. 35 (1992) 3012-3016
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3012-3016
-
-
Mohamadi, F.1
-
54
-
-
0026027578
-
Differential inhibition of chitin synthetases 1 and 2 from Saccharomyces cerevisiae by polyoxin D and nikkomycins
-
Cabib E. Differential inhibition of chitin synthetases 1 and 2 from Saccharomyces cerevisiae by polyoxin D and nikkomycins. Antimicrob. Agents Chemother. 35 (1991) 170-173
-
(1991)
Antimicrob. Agents Chemother.
, vol.35
, pp. 170-173
-
-
Cabib, E.1
-
55
-
-
0033566983
-
The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients
-
Thavasu P., et al. The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients. Cancer Res. 59 (1999) 3980-3984
-
(1999)
Cancer Res.
, vol.59
, pp. 3980-3984
-
-
Thavasu, P.1
-
56
-
-
0035282626
-
Perspectives in animal health: old targets and new opportunities
-
Meinke P.T. Perspectives in animal health: old targets and new opportunities. J. Med. Chem. 44 (2001) 641-659
-
(2001)
J. Med. Chem.
, vol.44
, pp. 641-659
-
-
Meinke, P.T.1
-
57
-
-
0037161585
-
2-(anilinomethyl)imidazolines as alpha 1 adrenergic receptor agonists: The discovery of alpha 1a subtype selective 2′-alkylsulphonyl-substituted analogues
-
Hodson S.J., et al. 2-(anilinomethyl)imidazolines as alpha 1 adrenergic receptor agonists: The discovery of alpha 1a subtype selective 2′-alkylsulphonyl-substituted analogues. J. Med. Chem. 45 (2002) 2229-2239
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2229-2239
-
-
Hodson, S.J.1
|