2-(Anilinomethyl)imidazolines as α1 adrenergic receptor agonists: The discovery of α10 subtype selective 2′-alkylsulfonyl-substituted analogues

Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2002, Pages 2229-2239

  Hodson, Stephen J ^a   Bishop, Michael J ^a,b   Speake, Jason D ^a,b   Navas III, Frank ^a,b   Garrison, Deanna T ^a,b   Bigham, Eric C ^a,b   Saussy Jr , David L ^a,c   Liacos, James A ^a,c   Irving, Paul E ^a,c   Jeffrey Gobel, M ^a,c   Sherman, Bryan W ^a,c  

^a GLAXOSMITHKLINE   (United States)

^b Medicinal Chemistry Department   (United States)

^c Receptor Biochemistry Department   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (ANILINOMETHYL)IMIDAZOLINE DERIVATIVE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; PHENYL GROUP; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; LIGAND BINDING; OXIDATION; REACTION ANALYSIS; RECEPTOR BINDING;

ADRENERGIC ALPHA-AGONISTS; CALCIUM; CELL LINE; CYCLIC AMP; FIBROBLASTS; HUMANS; IMIDAZOLES; RECEPTORS, ADRENERGIC, ALPHA-1; SULFONES;

EID: 0037161585     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000542r     Document Type: Article

References (39)

1. Catecholamines, sympatomimetic drugs, and adrenergic receptor antagonists
2. Treatment of female stress urinary incontinence: Preliminary report
3. The effects of α-adrenergic stimulation in stress incontinence
4. The importance of the adrenergic nervous system in urology
5. NS-49, an α 1A-adrenoceptor agonist, selectively increases intraurethral pressure in dogs
6. Identification of α 1A-adrenoceptor subtypes in the human prostatic urethra
7. Adrenergic activities of some substituted 2-(aminomethyl)imidazolines
8. Synthesis of sulfoxides. A review
9. Peracid and peroxide oxidations
10. Synthesis of open-chain sulfones
11. Synthetic entries to 6-fluoro-7-substituted indole derivatives
12. Synthesis of 2-amino-3-fluorobenzenethiol and its conversion into different heterocycles
13. Antirheumatic agents: Novel methotrexate derivatives bearing a benzoxazine or benzothiazine moiety
14. A-aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase
15. Development of scintillationproximity assays for alpha adrenoceptors
16. Increased voltage-dependent calcium influx produced by alpha 1B-adrenergic receptor activation in rat medullary thyroid carcinoma 6-23 cells
17. 1badrenergic receptor is initiated by disruption of an interhelical salt bridge constraint
18. Oxidation of α,β-enones and alkenes with oxone and sodium halides: A convenient laboratory preparation of chlorine and bromine
19. Oxazepines and thiazepines XVII, new procedures for the preparation of 2,3-dihydro-1,5-benzothiazepin-4(5h)-ones substituted in position 2
20. Synthesis and biological evaluation of alkyl-, alkoxy-, alkylthio-, or amino-substituted 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones
21. Synthesis and some properties of vinyl 2-amino-phenyl sulfide
22. Reactions of phenylnitrenium ion with sulfides. Novel synthetic methods for aminophenyl sulfide derivatives