From toxicological problem to therapeutic use: The discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug

Journal of Inherited Metabolic Disease

Volumn 21, Issue 5, 1998, Pages 498-506

  Lock, E A ^a   Ellis, M K ^a   Gaskin, P ^a   Robinson, M ^a   Auton, T R ^a   Provan, W M ^a   Smith, L L ^a   Prisbylla, M P ^b   Mutter, L C ^b   Lee, D L ^b  

^a ASTRAZENECA   (United Kingdom)

^b Zeneca Ag Products   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 NITRO 4 FLUOROMETHYLBENZOYL) 1,3 CYCLOHEXANEDIONE; 4 HYDROXYPHENYLPYRUVATE DIOXYGENASE; KETONE DERIVATIVE; UNCLASSIFIED DRUG;

CASE REPORT; CONFERENCE PAPER; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; TYROSINEMIA;

4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; AMINO ACID METABOLISM, INBORN ERRORS; ANIMALS; CYCLOHEXANONES; ENZYME INHIBITORS; HERBICIDES; HUMANS; NITROBENZOATES; TYROSINE;

EID: 7344229198     PISSN: 01418955     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005458703363     Document Type: Conference Paper

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