Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists

Journal of Medicinal Chemistry

Volumn 39, Issue 11, 1996, Pages 2123-2128

  Riechers, Hartmut ^a   Albrecht, Hans Peter ^a   Amberg, Willi ^a   Baumann, Ernst ^a   Bernard, Harald ^a   Böhm, Hans Joachim ^a   Klinge, Dagmar ^a   Kling, Andreas ^a   Müller, Stefan ^a   Raschack, Manfred ^b   Unger, Liliane ^b   Walker, Nigel ^a   Wernet, Wolfgang ^b  

^a BASF SE   (Germany)

^b Knoll AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(4,6 DIMETHOXYPYRIMIDIN 2 YL)OXY] 3 METHOXY 3,3 DIPHENYLPROPIONIC ACID; ENDOTHELIN A RECEPTOR ANTAGONIST; LU 110896; LU 110897; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG EFFECT; DRUG FORMULATION; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION; VASODILATATION;

ADMINISTRATION, ORAL; ANIMALS; DANSYL COMPOUNDS; DEATH, SUDDEN; DRUG DESIGN; ENDOTHELINS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; RATS; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0029896933     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960274q     Document Type: Article

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