Neurosteroid modulation of δ subunit-containing GABAA receptor channels

Neurosteroid Effects in the Central Nervous System: The Role of the GABA-A Receptor

Volumn , Issue , 2003, Pages 77-94

  Bianchi, Matt T ^a   Macdonald, Robert L ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33746999896     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (84)

1. A receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential. J. Biol. Chem., 276, 38934-38939.
2. Akk, G. and Steinbach, J.H. (2003). Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function. J. Physiol., 546, 641-646.
3. A receptor subunits: α1β 1 and α1β 1γ2S subunits produce unique ion channels with dissimilar single-channel properties. J. Neurosci., 13, 1429-1440.
4. Araujo, F., Ruano, D., and Vitorica, J. (1998). Absence of association between delta and gamma2 subunits in native GABA(A) receptors from rat brain. Eur. J. Pharmacol., 347, 347-353.
5. Attwell, D., Barbour, B., and Szatkowski, M. (1993). Nonvesicular release of neurotransmitter. Neuron, 11, 401-407.
6. Bach-y-Rita, P. (2001). Nonsynaptic diffusion neurotransmission in the brain: functional considerations. Neurochem. Res., 26, 871-873.
7. Bai, D., Zhu, G., Pennefather, P., Jackson, M.F., MacDonald, J.F., and Orser, B.A. (2001). Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons. Mol. Pharmacol., 59, 814-824.
8. Baulieu, E.-E. and Robel, P. (1990). Neurosteroids: a new brain function? J. Steroid Biochem. Mol. Biol., 37, 395-403.
9. A receptor subtypes containing the δ subunit in rat brain, FEBS Lett., 283, 145-149.
10. A receptors. J. Neurosci., 21, 1127-1136.
11. Bianchi, M.T., Haas, K.F., and Macdonald, R.L. (2002). Alpha1 and alpha6 subunits specify distinct desensitization, deactivation and neurosteroid modulation of GABA(A) receptors containing the delta subunit. Neuropharmacology, 43, 492-502.
12. A receptors. J. Physiol., 497 (Pt. 3), 753-759.
13. Brickley, S.G., Revilla, V., Cull-Candy, S.G., Wisden, W., and Farrant, M. (2001). Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature, 409, 88-92.
14. Brown, N., Kerby, J., Bonnert, T.P., Whiting, P.J., and Wafford, K.A. (2002). Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. Br. J. Pharmacol., 136, 965-974.
15. A receptor. J. Neurosci., 16, 5415-5424.
16. Clements, J.D. (1996). Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends Neurosci., 19, 163-171.
17. A IPSCs during development in rat hippocampal or cerebellar slices. J. Physiol., 521, 437-449.
18. Fancsik, A., Linn, D.M., and Tasker, J.G. (2000). Neurosteroid modulation of GABA IPSCs is phosphorylation dependent. J. Neurosci., 20, 3067-3075.
19. Feng, H.-J., Bianchi, M.T., and Macdonald, R.L. (2002). Pentobarbital exerts distinct modulation of desensitization and channel gating in gamma and delta subunit-containing GABA-A receptors. Society for Neuroscience Abstract, 41.12.
20. A receptors containing γ2 or δ subtypes expressed with α1 and β 3 subtypes in L929 cells. J. Physiol., 505, 283-297.
21. A receptor complexes in rat cortex and spinal cord show differential responses to steroid modulation. Mol. Pharmacol., 40, 995-999.
22. Gee, K.W., Bolger, M.B., Brinton, R.E., Coirini, H., and McEwen, B.S. (1988). Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J. Pharmacol. Exp. Ther., 246, 803-812.
23. A receptor currents in mouse fibroblasts. J. Physiol., 514, 27-45.
24. Hamann, M., Rossi, D.J., and Attwell, D. (2002). Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex. Neuron, 33, 625-633.
25. Harrison, N.L., Vicini, S., and Barker, J.L. (1987). A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons. J. Neurosci., 7, 604-609.
26. Isaacson, J.S. (2000). Spillover in the spotlight. Curr. Biol., 10, R475-R477.
27. A receptors containing alpha6 subunits. J. Neurosci., 18, 2449-2457.
28. Areceptor alpha6 subunit gene inactivation inhibits delta subunit expression. J. Neurosci., 17, 1350-1362.
29. A channel responses to brief agonist pulses. Neuron, 15, 181-191.
30. Koksma, J.J., van Kesteren, R.E., Rosahl, T.W., Zwart, R., Smit, A.B., Luddens, H., and Brussaard, A.B. (2003). Oxytocin regulates neurosteroid modulation of GABA(A) receptors in supraoptic nucleus around parturition. J. Neurosci., 23, 788-797.
31. Korpi, E.R., Mihalek, R.M., Sinkkonen, S.T., Hauer, B., Hevers, W., Homanics, G.E., Sieghart, W., and Luddens, H. (2002). Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits. Neuroscience, 109, 733-743.
32. Areceptor function. Trends Pharmacol. Sci., 16, 295-303.
33. Lambert, J.J., Belelli, D., Harney, S.C., Peters, J.A., and Frenguelli, B.G. (2001). Modulation of native and recombinant GABA(A) receptors by endogenous and synthetic neuroactive steroids. Brain Res. Brain Res. Rev., 37, 68-80.
34. Areceptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J. Neurosci., 12, 4151-4172.
35. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J. Neurosci., 12, 1063-1076.
36. Leao, R.M., Mellor, J.R., and Randall, A.D. (2000). Tonic benzodiazepine-sensitive GABAergic inhibition in cultured rodent cerebellar granule cells. Neuropharmacology, 39, 990-1003.
37. Lees, G. and Edwards, M.D. (1998). Modulation of recombination human gamma-aminobutyric acidA receptors by isoflurane: influence of the delta subunit. Anesthesiology, 88, 206-217.
38. Leidenheimer, N.J. and Chapell, R. (1997). Effects of PKC activation and receptor desensitization on neurosteroid modulation of GABA(A) receptors. Brain Res. Mol. Brain Res., 52, 173-181.
39. Lerma, J., Herranz, A.S., Herreras, O., Abraira, V., and Martin del Rio, R. (1986). In vivo determination of extracellular concentration of amino acids in the rat hippocampus: a method based on brain dialysis and computerized analysis. Brain Res., 384, 145-155.
40. Liu, Q.Y., Schaffner, A.E., Chang, Y.H., Maric, D., and Barker, J.L. (2000). Persistent activation of GABA(A) receptor/Cl(-) channels by astrocyte-derived GABA in cultured embryonic rat hippocampal neurons. J. Neurophysiol., 84, 1392-1403.
41. Areceptor main conductance state of mouse spinal cord neurones in culture. J. Physiol., 410, 479-499.
42. Majewska, M.D., Harrison, N.L., Schwartz, R.D., Barker, J.L., and Paul, S.M. (1986). Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science, 232, 1004-1007.
43. A-receptor subtypes really occur in the brain? Trends Neurosci., 19, 139-143.
44. Mihalek, R.M., Banerjee, P.K., Korpi, E.R., Quinlan, J.J., Firestone, L.L., Mi, Z.P., Lagenaur, C., Tretter, V., Sieghart, W., Anagnostaras, S.G., Sage, J.R., Fanselow, M.S., Guidotti, A., Spigelman, I., Li, Z., DeLorey, T.M., Olsen, R.W., and Homanics, G.E. (1999). Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice. Proc. Natl. Acad. Sci. U.S.A., 96, 12905-12910.
45. Mihalek, R.M., Bowers, B.J., Wehner, J.M., Kralic, J.E., VanDoren, M.J., Morrow, A.L., and Homanics, G.E. (2001). GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol. Alcohol. Clin. Exp. Res., 25, 1708-1718.
46. Mistry, D.K. and Cottrell, G.A. (1990). Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture. Exp. Physiology, 75, 199-209.
47. Morrow, A.L., VanDoren, M.J., Penland, S.N., Matthews, D.B. (2001). The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brain Res. Brain Res. Rev., 37, 98-109.
48. A receptors on cerebellar granule cells as determined by a quantitative immunogold method. J. Neurosci., 15, 2948-2960.
49. A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J. Neurosci., 18, 1693-1703.
50. Nusser, Z. and Mody, I. (2002). Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. J. Neurophysiol., 87, 2624-2628.
51. Overstreet, L.S. and Westbrook, G.L. (2001). Paradoxical reduction of synaptic inhibition by vigabatrin. J. Neurophysiol., 86, 596-603.
52. A receptor function through distinct sites. Brain Res., 830, 72-87.
53. Paul, S.M. and Purdy, R.H. (1992). Neuroactive steroids. FASEB J., 6, 2311-2322.
54. Peng, Z., Hauer, B., Mihalek, R.M., Homanics, G.E., Sieghart, W., Olsen, R.W., and Houser, C.R. (2002). GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain. J. Comp. Neurol., 446, 179-197.
55. Pirker, S., Schwarzer, C., Wieselthaler, A., Sieghart, W., and Sperk, G. (2000). GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience, 101, 815-850.
56. A receptor. Neuron, 4, 759-765.
57. A receptors from rat brain. Eur. J. Pharmacol., 290, 175-181.
58. Rossi, D.J. and Hamann, M. (1998). Spillover-mediated transmission at inhibitory synapses promoted by high affinity alpha6 subunit GABA(A) receptors and glomerular geometry. Neuron, 20, 783-795.
59. Rossi, D., Hamann, M., and Attwell, D. (2003). Multiple modes of GABAergic inhibition of rat cerebellar granule cells. J Physiol. (Lond.), epub ahead of print.
60. A receptor subunits: role of the delta subunit. J. Neurosci., 14, 7077-7086.
61. A receptor isoforms. Mol. Pharmacol., 49, 567-579.
62. Scotti, A.L. and Reuter, H. (2001). Synaptic and extrasynaptic gamma-aminobutyric acid type A receptor clusters in rat hippocampal cultures during development. Proc. Natl. Acad. Sci. U.S.A., 98, 3489-3494.
63. Sieghart, W., Fuchs, K., Tretter, V., Ebert, V., Jechlinger, M., Hoger, H., and Adamiker, D. (1999). Structure and subunit composition of GABA(A) receptors. Neurochem. Int., 34, 379-385.
64. A receptors. Trends Pharmacol. Sci., 18, 425-429.
65. A-receptor delta subunit. Epilepsia, 43 (Suppl. 5), 3-8.
66. Stell, B.M. and Mody, I. (2002). Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons. J. Neurosci., 22, RC223.
67. Sundstrom-Poromaa, I., Smith, D.H., Gong, Q.H., Sabado, T.N., Li, X., Light, A., Wiedmann, M., Williams, K., and Smith, S.S. (2002). Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol. Nat. Neurosci., 5, 721-722.
68. Sur, C., Farrar, S.J., Kerby, J., Whiting, P.J., Atack, J.R., and McKernan, R.M. (1999). Preferential coassembly of alpha4 and delta subunits of the gamma-aminobutyric acidA receptor in rat thalamus. Mol. Pharmacol., 56, 110-115.
69. Thompson, S.A., Wingrove, P.B., Connelly, L., Whiting, P.J., and Wafford, K.A. (2002). Tracazolate reveals a novel type of allosteric interaction with recombinant gammaaminobutyric acid(A) receptors. Mol. Pharmacol., 61, 861-869.
70. A receptor subtype. J. Neurosci., 17, 2728-2737.
71. Tretter, V., Hauer, B., Nusser, Z., Mihalek, R.M., Hoger, H., Homanics, G.E., Somogyi, P., and Sieghart, W. (2001). Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells. J. Biol. Chem., 276, 10532-10538.
72. Turner, D.M., Ransom, R.W., Yang, J.S.-J., and Olsen, E.W. (1989). Steroid anesthetics and naturally occurring analogs modulate the γ-aminobutyric acid receptor complex at a site distinct from barbiturates. J. Pharmacol. Exp. Ther., 248, 960-966.
73. A receptor channels. Neurosci. Lett., 96, 89-95.
74. Twyman, R.E., Rogers, C.J., and Macdonald, R.L. (1989b). Differential regulation of gammaaminobutyric acid receptor channels by diazepam and phenobarbital. Ann. Neurol., 25, 213-220.
75. A receptor single-channel kinetic properties of mouse spinal cord neurons in culture. J. Physiol., 456, 215-245.
76. VanDoren, M.J., Matthews, D.B., Janis, G.C., Grobin, A.C., Devaud, L.L., and Morrow, A.L. (2000). Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. J. Neurosci., 20, 1982-1989.
77. Vicini, S., Losi, G., and Homanics, G.E. (2002). GABA(A) receptor delta subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons. Neuropharmacology, 43, 646-650.
78. A receptor-mediated currents in granule cells of postnatal rat cerebellum. Eur. J. Neurosci., 9, 533-548.
79. Areceptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J. Neurosci., 12, 1040-1062.
80. A receptors containing the delta subunit. J. Neurosci., 22, 1541-1549.
81. A receptors in hippocampal neurons are high-affinity, lowconductance sensors for extracellular GABA. Mol. Pharmacol., 63, 2-8.
82. A receptors. J. Neurosci., 16, 6648-6656.
83. Zoli, M., Jansson, A., Sykova, E., Agnati, L.F., and Fuxe, K. (1999). Volume transmission in the CNS and its relevance for neuropsychopharmacology. Trends Pharmacol. Sci., 20, 142-150.
84. Zorumski, C.F., Mennerick, S., and Covey, D.F. (1998). Enantioselective modulation of GABAergic synaptic transmission by steroids and benz[e]indenes in hippocampal microcultures. Synapse, 29, 162-171.