Characterization of porin isoforms expressed in tumor cells

European Journal of Biochemistry

Volumn 267, Issue 19, 2000, Pages 6067-6073

  Shinohara, Yasuo ^a,b   Ishida, Taro ^a   Hino, Mami ^a   Yamazaki, Naoshi ^a   Baba, Yoshinobu ^a,b   Terada, Hiroshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

cDNA cloning; Hexokinase; Mitochondria; Porin; Voltage dependent anion channel (VDAC)

Indexed keywords

HEXOKINASE; ISOPROTEIN; PORIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CLONING; ENZYME BINDING; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; TUMOR CELL;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; DNA, COMPLEMENTARY; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HEXOKINASE; HUMANS; LIVER NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; MITOCHONDRIA, LIVER; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PORINS; PROTEIN ISOFORMS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; VOLTAGE-DEPENDENT ANION CHANNEL 1; VOLTAGE-DEPENDENT ANION CHANNEL 2; VOLTAGE-DEPENDENT ANION CHANNELS;

ANIMALIA;

EID: 0033798036     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01687.x     Document Type: Article

References (34)

1. Tumor mitochondria and the bioenergetics of cancer cells
2. Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line
3. Hexokinases
4. Hexokinase isozyme patterns of experimental hepatomas of rats
5. Transport and phosphorylation of hexoses in normal and Rous sarcoma virus-transformed chick embryo fibroblasts
6. Determination and characterization of hexokinase in thyroid cancer and benign neoplasms
7. Hexokinase isoenzymes from the Novikoff hepatoma. Purification, kinetic and structural characterization, with emphasis on hexokinase C
8. Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130
9. Quantitative determinations of the steady state transcript levels of hexokinase isozymes and glucose transporter isoforms in normal rat tissues and the malignant tumor cell line AH130
10. Glucose catabolism in cancer cells. Isolation, sequence and activity of the promoter for type II hexokinase
11. Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP
12. The kinetic consequences of binding of hexokinase-I to the mitochondrial outer membrane
13. Mitochondrial hexokinase. Release, rebinding and location
14. Study on ATP-generating system and related hexokinase activity in mitochondria isolated from undifferentiated or differentiated HT29 adenocarcinoma cells
15. Source of ATP for hexokinase-catalyzed glucose phosphorylation in tumor cells: Dependence on the rate of oxidative phosphorylation relative to that of extramitochondrial ATP generation
16. Purification of a hexokinase-binding protein from the outer mitochondrial membrane
17. An intact hydrophobic N-terminal sequence is critical for binding of rat brain hexokinase to mitochondria
18. Targeting of hexokinase 1 to liver and hepatoma mitochondria
19. Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel
20. A mitochondrial porin cDNA predicts the existence of multiple human porins
21. Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: Mapping and identification of two new isoforms
22. Isolation, characterization and mapping of two mouse mitochondrial voltage-dependent anion channel isoforms
23. A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8
24. The murine voltage-dependent anion channel gene family. Conserved structure and function
25. A novel isoform of the mitochondrial outer membrane protein VDAC3 via alternative splicing of a 3-base exon. Functional characteristics and subcellular localization
26. Characterization of rat porin isoforms: Cloning of a cardiac type-3 variant encoding an additional methionine at its putative N-terminal region
27. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
28. Evolution of the type II hexokinase gene by duplication and fusion of the glucokinase gene with conservation of its organization
29. Thromboplastic and fibrinolytic activities of ascites tumor cells of rats, with reference to their role in metastasis formation
30. Isolation and cloning of a voltage-dependent anion channel-like Mr 36,000 polypeptide from mammalian brain
31. Hexokinase receptors: Preferential enzyme binding in normal cells to nonmitochondrial sites and in transformed cells to mitochondrial sites
32. Microcompartmentation of energy metabolism at the outer mitochondrial membrane: Role in diabetes mellitus and other diseases
33. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC