Intact anthocyanins and metabolites in rat urine and plasma after 3 months of anthocyanin supplementation

Nutrition and Cancer

Volumn 54, Issue 1, 2006, Pages 3-12

  He, Jian ^a   Magnuson, Bernadene A ^b   Lala, Geeta ^b   Tian, Qingguo ^a   Schwartz, Steven J ^a   Giusti, M Monica ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHOCYANIN; ANTHOCYANIN RICH EXTRACT; BILBERRY EXTRACT; CHOKEBERRY EXTRACT; COLORING AGENT; GRAPE EXTRACT; PLANT EXTRACT; POLYPHENOL; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; BERRY; BILBERRY; BIOAVAILABILITY; BLOOD ANALYSIS; BLOOD LEVEL; CHEMICAL STRUCTURE; CHOKEBERRY; CONFERENCE PAPER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIODE; GLYCOSYLATION; GRAPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; METHYLATION; NONHUMAN; PHOTODIODE ARRAY; RAT; STOMACH ABSORPTION; STRUCTURE ANALYSIS; URINALYSIS; URINE LEVEL;

ABSORPTION; ACYLATION; ANIMALS; ANTHOCYANINS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY SUPPLEMENTS; GLYCOSYLATION; MALE; MASS SPECTROMETRY; PLANT EXTRACTS; RATS; RATS, INBRED F344; ROSACEAE; SPECIFIC PATHOGEN-FREE ORGANISMS; TIME FACTORS; VACCINIUM MYRTILLUS; VITIS;

PHOTINIA; VACCINIUM MYRTILLUS; VITIS SP.;

EID: 33746496668     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/s15327914nc5401_2     Document Type: Conference Paper

References (38)

1. Hertog MG, Hollman PC, Katan MB, and Kromhout D: Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer 20, 21-29, 1993.
2. Prior RL: Absorption and metabolism of anthocyanins: potential health effects. In Phytochemicals: Mechanism of Action, Meskin MS, Bidlack WR, Davies AJ, Lewis DS, and Randolph RK (eds). Boca Raton, FL: CRC Press, 2004, pp 1-19.
3. Francis FJ: Food colorants: anthocyanins. Crit Rev Food Sci Nutr 28, 273-314, 1989.
4. Giusti MM and Wrolstad RE: Acylated anthocyanins from edible sources and their applications in food systems. Biochem Eng J 14, 217-225, 2003.
5. Kong JM, Chia LS, Goh NK, Chia TF, and Brouillard R: Analysis and biological activities of anthocyanins. Phytochemistry 64, 923-933, 2003.
6. Koide T, Hashimoto Y, Kamei H, Kojima T, Hasegawa M, et al.: Antitumor effect of anthocyanin fractions extracted from red soybeans and red beans in vitro and in vivo. Cancer Biother Radiopharm 12, 277-280, 1997.
7. Kamei H, Hashimoto Y, Koide T, Kojima T, and Hasegawa M: Anti-tumor effect of methanol extracts from red and white wines. Cancer Biother Radiopharm 13, 447-452, 1998.
8. Hagiwara A, Miyashita K, Nakanishi T, Sano M, Tamano S, et al.: Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhlP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine. Cancer Lett 171, 17-25, 2001.
9. Harris GK, Gupta A, Nines RG, Kresty LA, Habib SG, et al.: Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2′-deoxyguanosine levels in the Fischer 344 rat. Nutr Cancer 40, 125-133, 2001.
10. Malik M, Zhao C, Schoene N, Guisti MM, Moyer MP, et al.: Anthocyanin-rich extract from Aronia meloncarpa E induces a cell cycle block in colon cancer but not normal colonic cells. Nutr Cancer 46, 186-196, 2003.
11. Singletary KW, Stansbury MJ, Giusti M, Van Breemen RB, Wallig M, et al.: Inhibition of rat mammary tumorigenesis by concord grape juice constituents. J Agric Food Chem 51, 7280-7286, 2003.
12. Kresty LA, Morse MA, Morgan C, Carlton PS, Lu J, et al.: Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res 61, 6112-6119, 2001.
13. Casto BC, Kresty LA, Kraly CL, Pearl DK, Knobloch TJ, et al.: Chemoprevention of oral cancer by black raspberries. Anticancer Res 22, 4005-4015, 2002.
14. Matsumoto H, Inaba H, Kishi M, Tominaga S, Hirayama M, et al.: Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. J Agric Food Chem 49, 1546-1551, 2001.
15. Cao G and Prior RL: Anthocyanins are detected in human plasma after oral administration of an elderberry extract. Clin Chem 45, 574-576, 1999.
16. Wu X, Cao G, and Prior RL: Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry. J Nutr 132, 1865-1871, 2002.
17. Felgines C, Texier O, Besson C, Fraisse D, Lamaison JL, et al.: Blackberry anthocyanins are slightly bioavailable in rats. J Nutr 132, 1249-1253, 2002.
18. Mazza G, Kay CD, Cottrell T, and Holub BJ: Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50, 7731-7737, 2002.
19. Tsuda T, Horio F, and Osawa T: Absorption and metabolism of cyanidin 3-O-beta-D-glucoside in rats. FEBS Lett 449, 179-182, 1999.
20. Camire ME: Phytochemicals in the vaccinium family: bilberries, blueberries, and cranberries. In Phytochemicals in Nutrition and Health, Meskin MS, Bidlack WR, Davies AJ, Lewis DS, and Randolph RK (eds). Boca Raton, FL: CRC Press, 2004, pp 19-40.
21. Skrede G and Wrolstad RE: Flavonoids from berries and grapes. In Functional Foods: Biochemical and Processing Aspects, Shi J, Mazza G, and Maguer ML (eds). Boca Raton, FL: CRC Press, 2002, vol 2, pp 71-133.
22. Mazza G and Miniati E: Anthocyanins in Fruits, Vegetables and Grains. London: CRC Press, 1993.
23. Zhao C, Giusti MM, Malik M, Moyer MP, and Magnuson BA: Effects of commercial anthocyanin-rich extracts on colonic cancer and non-tumorigenic colonic cell growth. J Agric Food Chem 52, 6122-6128, 2004.
24. Lala G, Malik M, Zhao C, Kwan Y, He J, et al.: Anthocyanin-rich extracts inhibit multiple biomarkers of colonic cancer in rats. Nutr Cancer 54, 84-93, 2006.
25. Miyazawa T, Nakagawa K, Kudo M, Muraishi K, and Someya K: Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans. J Agric Food Chem 47, 1083-1091, 1999.
26. Cao G, Muccitelli HU, Sanchez-Moreno C, and Prior RL: Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study. Am J Clin Nutr 73, 920-926, 2001.
27. Shahidi F and Naczk M: Contribution of phenolic compounds to flavor and color characteristics of foods. In Phenolics in Food and Nutraceuticals. Boca Raton, FL: CRC Press, 2004, pp 443-461.
28. Tian Q, Giusti MM, Stoner GD, and Schwartz SJ: Screening for anthocyanins using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry with precursor-ion analysis, product-ion analysis, common-neutral-loss analysis, and selected reaction monitoring. J Chromatog A, 1091, 72-82, 2005.
29. He J, Magnuson BA, and Giusti MM: Analysis of anthocyanins in rat intestinal contents - impact of anthocyanin chemical structure on fecal excretion. J Agric Food Chem 53, 2859-2866, 2005.
30. Kay CD, Mazza G, Holub BJ, and Wang J: Anthocyanin metabolites in human urine and serum. Br J Nutr 91, 933-942, 2004.
31. Felgines C, Talavera S, Gonthier MP, Texier O, Scalbert A, et al.: Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans. J Nutr 133, 1296-1301, 2003.
32. Bitsch R, Netzel M, Sonntag S, Strass G, Frank T, et al.: Urinary excretion of cyanidin glucosides and glucuronides in healthy humans after elderberry juice ingestion. J Biomed Biotechnol 2004(5), 343-345, 2004.
33. Ichiyanagi T, Rahman MM, Kashiwada Y, Ikeshiro Y, Shida Y, et al.: Absorption and metabolism of delphinidin 3-O-beta-D-glucopyranoside in rats. Free Radic Biol Med 36, 930-937, 2004.
34. Ichiyanagi T, Shida Y, Rahman MM, Hatano Y, Matsumoto H, et al.: Metabolic pathway of cyanidin 3-O-beta-D-glucopyranoside in rats. J Agric Food Chem 53, 145-150, 2005.
35. Ichiyanagi T, Rahman MM, Kashiwada Y, Ikeshiro Y, Shida Y, et al.: Absorption and metabolism of delphinidin 3-O-beta-D-glucoside in rats. Biofactors 21, 411-413, 2004.
36. Tsuda T, Horio F, Kitoh J, and Osawa T: Protective effects of dietary cyanidin 3-O-beta-D-glucoside on liver ischemia-reperfusion injury in rats. Arch Biochem Biophys 368, 361-366, 1999.
37. Tsuda T, Horio F, and Osawa T: The role of anthocyanins as an antioxidant under oxidative stress in rats. Biofactors 13, 133-139, 2000.
38. Seeram NP, Bourquin LD, and Nair MG: Degradation products of cyanidin glycosides from tart cherries and their bioactivities. J Agric Food Chem 49, 4924-4929, 2001.