High-level expression of B7-H1 molecules by dendritic cells suppresses the function of activated T cells and desensitizes allergen-primed animals

Journal of Leukocyte Biology

Volumn 79, Issue 4, 2006, Pages 686-695

  Hee, Kyung Kim ^a   Guan, Hongbing ^a   Zu, Guorui ^a   Li, Hui ^a   Wu, Lizhi ^b   Feng, Xu ^b   Elmets, Craig ^a   Fu, Yangxin ^c   Xu, Hui ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Contact hypersensitivity; Cytokines; Immunology; PD 1

Indexed keywords

B7 ANTIGEN; B7 DC ANTIGEN; B7 H1 ANTIGEN; HAPTEN; IMMUNOGLOBULIN G; ALLERGEN; CYTOKINE; LIGAND; MEMBRANE PROTEIN; PDCD1LG1 PROTEIN, MOUSE; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CELL SPECIFICITY; CELL STIMULATION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DENDRITIC CELL; DESENSITIZATION; DRUG INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; A J MOUSE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; COMPARATIVE STUDY; DRUG EFFECT; GENETIC TRANSFECTION; IMMUNOLOGY; METHODOLOGY; RAT; T LYMPHOCYTE; TIME;

ANIMALIA;

ALLERGENS; ANIMALS; ANTIGENS, CD80; CELL LINE; CELL PROLIFERATION; CYTOKINES; DENDRITIC CELLS; DESENSITIZATION, IMMUNOLOGIC; HAPTENS; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED A; MICE, INBRED C57BL; PEPTIDES; RATS; T-LYMPHOCYTES; TIME FACTORS; TRANSFECTION;

EID: 33746416742     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0805436     Document Type: Article

References (54)

1. Van Parijs, L., Ibraghimov, A., Abbas, A. K. (1996) The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity 4, 321-328.
2. Khoury, S. J., Sayegh, M. H. (2004) The roles of the new negative T cell costimulatory pathways in regulating autoimmunity. Immunity 20, 529-538.
3. Liu, Y. (1997) Is CTLA-4 a negative regulator for T-cell activation? Immunol. Today 18, 569-572.
4. Walker, L. S., Abbas, A. K. (2002) The enemy within: keeping self-reactive T cells at bay in the periphery. Nat. Rev. Immunol. 2, 11-19.
5. Maher, S., Toomey, D., Condron, C., Bouchier-Hayes, D. (2002) Activation-induced cell death: the controversial role of Fas and Fas ligand in immune privilege and tumor counterattack. Immunol. Cell Biol. 80, 131-137.
6. Hamad, A. R., Schneck, J. P. (2001) Antigen-induced T cell death is regulated by CD4 expression. Int. Rev. Immunol. 20, 535-546.
7. Lenardo, M., Chan, F. K-M., Hornung, F., McFarland, H., Siegel, R., Wang, J., Zheng, L. (1999) Mature T lymphocyte apoptosis - immune regulation in a dynamic and unpredictable antigenic environment. Annu. Rev. Immunol. 17, 221-253.
8. Ishida, Y., Agata, Y., Shibahara, K., Honjo, T. (1992) Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11, 3887-3895.
9. Carreno, B. M., Collins, M. (2002) The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol. 20, 29-53.
10. Agata, Y., Kawasaki, A., Nishimura, H., Ishida, Y., Tsubata, T., Yagita, H., Honjo, T. (1996) Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8, 765-772.
11. Greenwald, R. J., Latchman, Y. E., Sharpe, A. H. (2002) Negative coreceptors on lymphocytes. Curr. Opin. Immunol. 14, 391-396.
12. Nishimura, H., Okazaki, T., Tanaka, Y., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Mizoguchi, A., Hiai, H., Minato, N., Honjo, T. (2001) Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291, 319-322.
13. Nishimura, H., Nose, M., Hiai, H., Minato, N., Honjo, T. (1999) Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11, 141-151.
14. Mazanet, M. M., Hughes, C. C. (2002) B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J. Immunol. 169, 3581-3588.
15. Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T., Tsuchiya, H., Pardoll, D. M., Okumura, K., Azuma, M., Yagita, H. (2002) Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 169, 5538-5545.
16. Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., Horton, H. F., Fouser, L., Carter, L., Ling, V., Bowman, M. R., Carreno, B. M., Collins, M., Wood, C. R., Honjo, T. (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027-1034.
17. Liu, X., Gao, J. X., Wen, J., Yin, L., Li, O., Zuo, T., Gajewski, T. F., Fu, Y. X., Zheng, P., Liu, Y. (2003) B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. J. Exp. Med. 197, 1721-1730.
18. Tseng, S. Y., Otsuji, M., Gorski, K., Huang, X., Slansky, J. E., Pai, S. I., Shalabi, A., Shin, T., Pardoll, D. M., Tsuchiya, H. (2001) B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193, 839-846.
19. Dong, H., Zhu, G., Tamada, K., Chen, L. (1999) B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5, 1365-1369.
20. Tamura, H., Dong, H., Zhu, G., Sica, G. L., Flies, D. B., Tamada, K., Chen, L. (2001) B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 97, 1809-1816.
21. Latchman, Y., Wood, C. R., Chernova, T., Chaudhary, D., Borde, M., Chernova, I., Iwai, Y., Long, A. J., Brown, J. A., Nunes, R., Greenfield, E. A., Bourque, K., Boussiotis, V. A., Carter, L. L., Carreno, B. M., Malenkovich, N., Nishimura, H., Okazaki, T., Honjo, T., Sharpe, A. H., Freeman, G. J. (2001) PD-L2 is a second ligand for PD-I and inhibits T cell activation. Nat. Immunol. 2, 261-268.
22. Wang, S., Bajorath, J., Flies, D. B., Dong, H., Honjo, T., Chen, L. (2003) Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J. Exp. Med. 197, 1083-1091.
23. Carter, L., Fouser, L. A., Jussif, J., Fitz, L., Deng, B., Wood, C. R., Collins, M., Honjo, T., Freeman, G. J., Carreno, B. M. (2002) PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur. J. Immunol. 32, 634-643.
24. Ansari, M. J. I., Salama, A. D., Chitnis, T., Smith, R. N., Yagita, H., Akiba, H., Yamazaki, T., Azuma, M., Iwai, H., Khoury, S. J., Auchincloss Jr., H., Sayegh, M. H. (2003) The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 198, 63-69.
25. Dong, H., Strome, S. E., Matteson, E. L., Moder, K. G., Flies, D. B., Zhu, G., Tamura, H., Driscoll, C. L., Chen, L. (2003) Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis. J. Clin. Invest. 111, 363-370.
26. Iwai, Y., Ishida, M., Tanaka, Y., Okazaki, T., Honjo, T., Minato, N. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. USA 99, 12293-12297.
27. Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., Lennon, V. A., Celis, E., Chen, L. (2002) Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8, 793-800.
28. Iwai, Y., Terawaki, S., Ikegawa, M., Okazaki, T., Honjo, T. (2003) PD-1 inhibits antiviral immunity at the effector phase in the liver. J. Exp. Med. 198, 39-50.
29. Kanai, T., Totsuka, T., Uraushihara, K., Makita, S., Nakamura, T., Koganei, K., Fukushima, T., Akiba, H., Yagita, H., Okumura, K., Machida, U., Iwai, H., Azuma, M., Chen, L., Watanabe, M. (2003) Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J. Immunol. 171, 4156-4163.
30. Trabattoni, D., Saresella, M., Biasin, M., Boasso, A., Piacentini, L., Ferrante, P., Dong, H., Maserati, R., Shearer, G. M., Chen, L., Clerici, M. (2003) B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood 101, 2514-2520.
31. Tsushima, F., Iwai, H., Otsuki, N., Abe, M., Hirose, S., Yamazaki, T., Akiba, H., Yagita, H., Takahashi, Y., Omura, K., Azuma, M. (2003) Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. Eur. J. Immunol. 33, 2773-2782.
32. Steinman, R. M., Hawiger, D., Nussenzweig, M. C. (2003) Tolerogenic dendritic cells. Annu. Rev. Immunol. 21, 685-711.
33. Liu, Y. J. (2001) Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 106, 259-262.
34. Lanzavecchia, A., Sallusto, F. (2001) Regulation of T cell immunity by dendritic cells. Cell 106, 263-266.
35. Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y. J., Pulendran, B., Palucka, K. (2000) Immunobiology of dendritic cells. Annu. Rev. Immunol. 18, 767-811.
36. Heath, W. R., Carbone, F. R. (2001) Cross-presentation, dendritic cells, tolerance and immunity. Annu. Rev. Immunol. 19, 47-64.
37. Grohmann, U., Fallarino, F., Puccetti, P. (2003) Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol. 24, 242-248.
38. Lutz, M. B., Schuler, G. (2002) Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 23, 445-449.
39. Curiel, T. J., Wei, S., Dong, H., Alvarez, X., Cheng, P., Mottram, P., Krzysiek, R., Knutson, K. L., Daniel, B., Zimmermann, M. C., David, O., Burow, M., Gordon, A., Dhurandhar, N., Myers, L., Berggren, R., Hemminki, A., Alvarez, R. D., Emilie, D., Curiel, D. T., Chen, L., Zou, W. (2003) Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat. Med. 9, 562-567.
40. Brown, J. A., Dorfman, D. M., Ma, F. R., Sullivan, E. L., Munoz, O., Wood, C. R., Greenfield, E. A., Freeman, G. J. (2003) Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J. Immunol. 170, 1257-1266.
41. Matsue, H., Matsue, K., Walters, M., Okumura, K., Yagita, H., Takashima, A. (1999) Induction of antigen-specific immunosuppression by CD95L cDNA- transfected "killer" dendritic cells. Nat. Med. 5, 930-937.
42. Ory, D. S., Neugeboren, B. A., Mulligan, R. C. (1996) A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc. Natl. Acad. Sci. USA 93, 11400-11406.
43. Subudhi, S. K., Zhou, P., Yerian, L. M., Chin, R. K., Lo, J. C., Anders, R. A., Sun, Y., Chen, L., Wang, Y., Alegre, M-L., Fu, Y-X. (2004) Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J. Clin. Invest. 113, 694-700.
44. Xu, H., Dilulio, N. A., Fairchild, R. L. (1996) T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon γ-producing (Tc1) effector CD8+ T cells and interleukin 4/IL-10-producing (Th2) negative regulatory CD4+ T cells. J. Exp. Med. 183, 1001-1012.
45. Xu, H., Guan, H., Zu, G., Bullard, D., Hanson, J., Slater, M., Elmets, C. A. (2001) The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur. J. Immunol. 31, 3085-3093.
46. Xu, H., Banerjee, A., Dilulio, N. A., Fairchild, R. L. (1997) Development of effector CD8+ T cells in contact hypersensitivity occurs independently of CD4+ T cells. J. Immunol. 158, 4721-4728.
47. Xu, H., Heeger, P. S., Fairchild, R. L. (1997) Distinct roles of B7-1 and B7-2 determinants during priming of effector CD8+ Tc1 and regulatory CD4+ Th2 cells for contact hypersensitivity. J. Immunol. 159, 4217-4226.
48. Timares, L., Takashima, A., Johnston, S. A. (1998) Quantitative analysis of the immunopotency of genetically transfected dendritic cells. Proc. Natl. Acad. Sci. USA 95, 13147-13152.
49. Xu, S., Ariizumi, K., Caceres-Dittmmar, G., Edelbaum, D., Hashimoto, K., Bergstresser, P. R., Takashima, A. (1995) Successive generation of antigen-presenting, dendritic cell lines from murine epidermis. J. Immunol. 154, 2697-2705.
50. Grabbe, S., Schwarz, T. (1998) Immunregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol. Today 19, 37-44.
51. Xu, H., Bjarnason, B., Elmets, C. A. (2000) Sensitization versus elicitation in allergic contact dermatitis: potential differences at cellular and molecular levels. Am. J. Contact Dermat. 11, 228-234.
52. Chen, L. (2004) Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat. Rev. Immunol. 4, 336-347.
53. Matsumoto, K., Inoue, H., Nakano, T., Tsuda, M., Yoshiura, Y., Fukuyama, S., Tsushima, F., Hoshino, T., Aizawa, H., Akiba, H., Pardoll, D., Hara, N., Yagita, H., Azuma, M., Nakanishi, Y. (2004) B7-DC regulates asthmatic response by an IFN-{γ}-dependent mechanism. J. Immunol. 172, 2530-2541.
54. Shin, T., Kennedy, G., Gorski, K., Tsuchiya, H., Koseki, H., Azuma, M., Yagita, H., Chen, L., Powell, J., Pardoll, D., Housseau, F. (2003) Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. J. Exp. Med. 198, 31-38.