TLR gateways to CD1 function

Nature Immunology

Volumn 7, Issue 8, 2006, Pages 811-817

  Moody, D Branch ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; CD1 ANTIGEN; CD1D ANTIGEN; CYTOKINE; LIPID; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR; T6 ANTIGEN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; BACTERIAL INFECTION; BACTERIUM; CELL ACTIVATION; CELL DIFFERENTIATION; CYTOKINE RELEASE; DENDRITIC CELL; GRAM NEGATIVE BACTERIUM; HUMAN; HYPOTHESIS; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; INNATE IMMUNITY; LIPOGENESIS; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MAMMAL; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTOZOON; PSEUDOMONAS AERUGINOSA; RECEPTOR UPREGULATION; REVIEW; SALMONELLA TYPHIMURIUM; T LYMPHOCYTE ACTIVATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS; ANTIGENS, CD1; HUMANS; LIPIDS; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES; TOLL-LIKE RECEPTORS;

EID: 33746112990     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1368     Document Type: Review

References (96)

1. Porcelli, S., Morita, C.T. & Brenner, M.B. CD1b restricts the response of human CD4-8-T lymphocytes to a microbial antigen. Nature 360, 593-597 (1992).
2. Beckman, E.M. et al. Recognition of a lipid antigen by CD1-restricted αβ T cells. Nature 372, 691-694 (1994).
3. Sieling, P.A. et al. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 269, 227-230 (1995).
4. Schofield, L. et al. CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells. Science 283, 225-229 (1999).
5. Fischer, K. et al. Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells. Proc. Natl. Acad. Sci. USA 101, 10685-10690 (2004).
6. de la Salle, H. et al. Assistance of microbial glycolipid antigen processing by CD1e. Science 310, 1321-1324 (2005).
7. Moody, D.B. et al. Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science 278, 283-286 (1997).
8. Gilleron, M. et al. Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis. J. Exp. Med. 199, 649-659 (2004).
9. Moody, D.B. et al. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 404, 884-888 (2000).
10. Matsunaga, I. et al. Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. J. Exp. Med. 200, 1559-1569 (2004).
11. Kinjo, Y. et al. Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434, 520-525 (2005).
12. Mattner, J. et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434, 525-529 (2005).
13. Amprey, J.L. et al. A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan. J. Exp. Med. 200, 895-904 (2004).
14. Moody, D.B. et al. T cell activation by lipopeptide antigens. Science 303, 527-531 (2004).
15. Shamshiev, A. et al. Self glycolipids as T-cell autoantigens. Eur. J. Immunol. 29, 1667-1675 (1999).
16. Wu, D.Y., Segal, N.H., Sidobre, S., Kronenberg, M. & Chapman, P.B. Cross-presentation of disialoganglioside GD3 to natural killer T cells. J. Exp. Med. 198, 173-181 (2003).
17. Shamshiev, A. et al. Presentation of the same glycolipid by different CD1 molecules. J. Exp. Med. 195, 1013-1021 (2002).
18. Gumperz, J. et al. Murine CD1d-restricted T cell recognition of cellular lipids. Immunity 12, 211-221 (2000).
19. Rauch, J. et al. Structural features of the acyl chain determine self-phospholipid antigen recognition by a CD1d-restricted invariant NKT (INKT) cell. J. Biol. Chem. 278, 47508-47515 (2003).
20. Agea, E. et al. Human CD1-restricted T cell recognition of lipids from pollens. J. Exp. Med. 202, 295-308 (2005).
21. Calabi, F., Jarvis, J.M., Martin, L. & Milstein, C. Two classes of CD1 genes. Eur. J. Immunol. 19, 285-292 (1989).
22. Zeng, Z. et al. Crystal structure of moues CD1: An MHC-like fold with a large hydrophobic binding groove. Science 277, 339-345 (1997).
23. Gadola, S.D. et al. Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains. Nat. Immunol. 3, 721-726 (2002).
24. Zajonc, D.M., Elsliger, M.A., Teyton, L. & Wilson, I.A. Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 Å. Nat. Immunol. 4, 808-815 (2003).
25. Batuwangala, T. et al. The crystal structure of human CD1b with a bound bacterial glycolipid. J. Immunol. 172, 2382-2388 (2004).
26. Zajonc, D.M. et al. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat. Immunol. 6, 810-818 (2005).
27. Zajonc, D.M. et al. Molecular mechanism of lipopeptide presentation by CD1a. Immunity 22, 209-219 (2005).
28. Koch, M. et al. The crystal structure of human CD1d with and without α-galactosylceramide. Nat. Immunol. 6, 819-826 (2005).
29. Giabbal, B. et al. Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: A molecular basis for NKT cell activation. J. Immunol. 175, 977-984 (2005).
30. Kawano, T. et al. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 278, 1626-1629 (1997).
31. Grant, E.P. et al. Molecular recognition of lipid antigens by T cell receptors. J. Exp. Med. 189, 195-205 (1999).
32. Sidobre, S. et al. The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex. J. Immunol. 169, 1340-1348 (2002).
33. Gadola, S.D. et al. Structure and binding kinetics of three different human CD1d-α-galactosylceramide-specific T cell receptors. J. Exp. Med. 203, 699-710 (2006).
34. Matsuda, J.L. et al. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192, 741-754 (2000).
35. Benlagha, K., Welss, A., Beavis, A., Teyton, L. & Bendelac, A. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J. Exp. Med. 191, 1895-1903 (2000).
36. Karadimitris, A. et al. Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. Proc. Natl. Acad. Sci. USA 98, 3294-3298 (2001).
37. Grant, E.P. et al. Fine specificity of TCR complementarily-determining region residues and lipid antigen hydrophilic moleties in the recognition of a CD1-lipid complex. J. Immunol. 168, 3933-3940 (2002).
38. Melian, A. et al. Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with αβ TCRs. J. Immunol. 165, 4494-4504 (2000).
39. Kjer-Nielsen, L. et al. A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/ glycolipid recognition. J. Exp. Med. 203, 661-673 (2006).
40. De Silva, A.D. et al. Lipid protein interactions: The assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum. J. Immunol. 168, 723-733 (2002).
41. Brozovic, S. et al. CD1d function is regulated by microsomal triglyceride transfer protein. Nat. Med. 10, 535-539 (2004).
42. Manolova,V. et al. Functional CD1a is stabilized by exogenous lipids. Eur. J. Immunol. 36, 1083-1092 (2006).
43. Chiu, Y.H. et al. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tall-truncated CD1d. Nat. Immunol. 3, 55-60 (2002).
44. Chiu, Y.H. et al. Distinct subsets of CD1d-restricted T cells recognize self-antigens loaded in different cellular compartments. J. Exp. Med. 189, 103-110 (1999).
45. Jackman, R.M. et al. The tyrosine-containing cytoplasmic tall of CD1b is essential for its efficient presentation of bacterial lipid antigens. Immunity 8, 341-351 (1998).
46. Roberts, T.J. et al. Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT calls. J. Immunol. 168, 5409-5414 (2002).
47. Moody, D.B. et al. Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation. Nat. Immunol. 3, 435-442 (2002).
48. Moody, D.B., Reinhold, B.B., Reinhold, V.N., Basra, G.S. & Porcelli, S.A. Uptake and processing of glycosylated mycolates for presentation to CD1b-restricted T cells. Immunol. Lett. 65, 85-91 (1999).
49. Winau, F. et al. Saposin C is required for lipid presentation by human CD1b. Nat. Immunol. 5, 169-174 (2004).
50. Kang, S.J. & Cresswell, P. Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells. Nat. Immunol. 5, 175-181 (2004).
51. Zhou, D. et al. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science 303, 523-527 (2004).
52. van den Elzen, P. et al. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature 437, 906-910 (2005).
53. Angenieux, C. et al. Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. J. Biol. Chem. 275, 37757-37764 (2000).
54. Ernst, W.A. et al. Molecular interaction of CD1b with lipoglycan antigens. Immunity 8, 331-340 (1998).
55. Cheng, T. et al. Role of lipid trimming, acid pH and CD1 groove size in presenting lipid antigens. EMBO J. advance online publication 22 June 2006 (doi: 10.1038/sj.emboj.7601185).
56. Roura-Mir, C. et al. Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. J. Immunol. 175, 1758-1766 (2005).
57. Prigozy, T.I. et al. The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules. Immunity 6, 187-197 (1997).
58. Hunger, R.E. et al. Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. J. Clin. Invest. 113, 701-708 (2004).
59. Prigozy, T.I. et al. Glycolipid antigen processing for presentation by CD1d molecules. Science 291, 664-667 (2001).
60. Zhou, D. et al. Lysosomal glycosphingolipid recognition by NKT cells. Science 306, 1786-1789 (2004).
61. Porcelli, S.A. The CD1 family: A third lineage of antigen-presenting molecules. Adv. Immunol. 59, 1-98 (1995).
62. Berntman, E., Rolf, J., Johansson, C., Anderson, P. & Cardell, S.L. The role of CD1d-restricted NK T lymphocytes in the immune response to oral infection with Salmonella typhimurium. Eur. J. Immunol. 35, 2100-2109 (2005).
63. Nieuwenhuis, E.E. et al. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat. Med. 8, 588-593 (2002).
64. Brigi, M., Bry, L., Kent, S.C., Gumperz, J.E. & Brenner, M.S. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat. Immunol. 4, 1230-1237 (2003).
65. Jayawardena-Wolf, J., Benlagha, K., Chiu, Y.H., Mehr, R. & Bendelac, A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity 15, 897-908 (2001).
66. Elewaut, D. et al. The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Vα141 NKT cells. J. Exp. Med. 198, 1133-1146 (2003).
67. Cernadas, M. et al. Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development. J. Immunol. 171, 4149-4155 (2003).
68. De Libero, G. et al. Bacterial infections promote T cell recognition of self-glycolipids. Immunity 22, 763-772 (2005).
69. + NKT cells to initiate contact sensitivity in vivo. J. Immunol. 175, 6390-6401 (2005).
70. Sallusto, F. & Lanzavecchia, A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony- stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179, 1109-1118 (1994).
71. Krutzik, S.R. et al. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat. Med. 11, 653-660 (2005).
72. Chow, A., Toomre, D., Garrett, W. & Mellman, I. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature 418, 988-994 (2002).
73. Sanchez, D.J., Gumperz, J.E. & Ganem, D. Regulation of CD1d expression and function by a herpesvirus infection. J. Clin. Invest. 115, 1369-1378 (2005).
74. Chen, N. et al. HIV-1 down-regulates the expression of CD1d via Nef. Eur. J. Immunol. 36, 278-286 (2006).
75. Cho, S. et al. Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex. Virology 337, 242-252 (2005).
76. Skold, M., Xiong, X., Illarionov, P.A., Besra, G.S. & Behar, S.M. Interplay of cytokines and microbial signals in regulation of CD1d expression and NKT cell activation. J. Immunol. 175, 3584-3593 (2005).
77. Szatmari, I. et al. Activation of PPARγ specifies a dendritic cell subtype capable of enhanced induction of INKT cell expansion. Immunity 21, 95-106 (2004).
78. Calabi, F. & Milstein, C. A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6. Nature 323, 540-543 (1986).
79. Geng, Y., Laslo, P., Barton, K. & Wang, C.R. Transcriptional regulation of CD1D1 by Ets family transcription factors. J. Immunol. 175, 1022-1029 (2005).
80. Trombetta, E.S., Ebersold, M., Garrett, W., Pypaert, M. & Mellman, I. Activation of lysosomal function during dendritic cell maturation. Science 299, 1400-1403 (2003).
81. Steinman, R.M., Hawiger, D. & Nussenzweig, M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21, 685-711 (2003).
82. Renukaradhya, G.J. et al. Virus-induced inhibition of CD1d1-mediated antigen presentation: Reciprocal regulation by p38 and ERK. J. Immunol. 175, 4301-4308 (2005).
83. Spada, F.M. et al. Low expression level but potent antigen presenting function of CD1d on monocyte lineage cells. Eur. J. Immunol. 30, 3468-3477 (2000).
84. Cao, X. et al. CD1 molecules efficiently present antigen in immature dendritic cells and traffic independently of MHC class II during dendritic cell maturation. J. Immunol. 169, 4770-4777 (2002).
85. Ulrichs, T., Moody, D.B., Grant, E., Kaufmann, S.H. & Porcelli, S.A. T-cell responses to CD1-presented lipid antigens in humans with Mycobacterium tuberculosis infection. Infect. Immun. 71, 3076-3087 (2003).
86. Bendelac, A. & Medzhitov, R. Adjuvants of immunity: Harnessing innate immunity to promote adaptive immunity. J. Exp. Med. 195, F19-F23 (2002).
87. Sieling, P.A. et al. CD1 expression by dendritic cells in human leprosy lesions: Correlation with effective host immunity. J. Immunol. 162, 1851-1858 (1999).
88. Buettner, M. et al. Inverse correlation of maturity and antibacterial activity in human dendritic cells. J. Immunol. 174, 4203-4209 (2005).
89. Schaible, U.E. et al. Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. Nat. Med. 9, 1039-1046 (2003).
90. Janeway, C.A., Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54 Pt. 1, 1-13 (1989).
91. Akbari, O. et al. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N. Engl. J. Med. 354, 1117-1129 (2006).
92. Fujii, S., Shimizu, K., Kronenberg, M. & Steinman, R.M. Prolonged IFN-γ-producing NKT response induced with α-galactosylceramide-loaded DCs. Nat. Immunol. 3, 867-874 (2002).
93. Silk, J.D. et al. Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy. J. Clin. Invest. 114, 1800-1811 (2004).
94. Miyamoto, K., Miyake, S. & Yamamura, T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 413, 531-534 (2001).
95. Yu, K.O. et al. Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of α-galactosylceramides. Proc. Natl. Acad. Sci. USA 102, 3383-3388 (2005).
96. Vincent, M.S. et al. CD1-dependent dendritic cell instruction. Nat. Immunol. 3, 1163-1168 (2002).