Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

Journal of Clinical Investigation

Volumn 113, Issue 5, 2004, Pages 701-708

  Hunger, Robert E ^a   Sieling, Peter A ^a   Ochoa, Maria Teresa ^a   Sugaya, Makoto ^b   Burdick, Anne E ^c   Rea, Thomas H ^d   Brennan, Patrick J ^e   Belisle, John T ^e   Blauvelt, Andrew ^b   Porcelli, Steven A ^f   Modlin, Robert L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF MIAMI   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e Department of Environmental and Radiological Health Sciences   (United States)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; LANGERIN; LECTIN; T6 ANTIGEN; UNCLASSIFIED DRUG; CD1 ANTIGEN; CD207 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MANNOSE BINDING LECTIN; MEMBRANE ANTIGEN;

ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; INFECTION; LANGERHANS CELL; LEPROSY; MYCOBACTERIUM LEPRAE; PRIORITY JOURNAL; SKIN; T LYMPHOCYTE; CELL DIVISION; CHEMISTRY; DOSE RESPONSE; EPIDERMIS; FETUS BLOOD; FLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; PHENOTYPE; PHYSIOLOGY;

ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, CD1; ANTIGENS, SURFACE; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDERMIS; FETAL BLOOD; HUMANS; IMMUNOHISTOCHEMISTRY; LANGERHANS CELLS; LECTINS; LECTINS, C-TYPE; LEPROSY; MANNOSE-BINDING LECTINS; MICROSCOPY, FLUORESCENCE; MYCOBACTERIUM LEPRAE; PHENOTYPE; RECEPTORS, ANTIGEN; T-LYMPHOCYTES;

EID: 11144353750     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200419655     Document Type: Article

References (45)

1. Klareskog, L., Tjernlund, U., Forsum, U., and Peterson, P.A. 1977. Epidermal Langerhans cells express Ia antigens. Nature. 268:248-250.
2. Rowden, G., Lewis, M.G., and Sullivan, A.K. 1977. Ia antigen expression on human epidermal Langerhans cells. Nature. 268:247-248.
3. Romani, N., et al. 1989. Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J. Exp. Med. 169:1169-1178.
4. Cohen, P.J., and Katz, S.I. 1992. Cultured human Langerhans cells process and present intact protein antigens. J. Invest. Dermatol. 99:331-336.
5. Fithian, E., et al. 1981. Reactivity of Langerhans cells with hybridoma antibody. Proc. Natl. Acad. Sci. U. S. A. 78:2541-2544.
6. Porcelli, S., Morita, C.T., and Brenner, M.B. 1992. CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen. Nature. 360:593-597.
7. Sieling, P.A., et al. 1995. CD1-restricted T cell recognition of microbial lipoglycans. Science. 269:227-230.
8. Moody, D.B., et al. 1997. Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science. 278:283-286.
9. Moody, D.B., et al. 2000. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature. 404:884-888.
10. Valladeau, J., et al. 1999. The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface. Eur. J. Immunol. 29:2695-2704.
11. Valladeau, J., et al. 2000. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 12:71-81.
12. Ridley, D.S., and Jopling, W.H. 1966. Classification of leprosy according to immunity. A five-group system. Int. J. Lepr. 34:255-273.
13. Beckman, E.M., et al. 1996. CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family. J. Immunol. 157:2795-2803.
14. Fairhurst, R.M., Wang, C.X., Sieling, P.A., Modlin, R.L., and Braun, J. 1998. CD1 presents antigens from a gram-negarive bacterium, Haemophilus influenzae type B. Infect. Immun. 66:3523-3526.
15. Reinherz, E.L., Kung, P.C., Goldstein, G., Levey, R.H., and Schlossman, S.F. 1980. Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc. Natl. Acad. Sci. U. S. A. 77:1588-1592.
16. Behar, S.M., Porcelli, S.A., Beckman, E.M., and Brenner, M.B. 1995. A pathway of costimulation that prevents anergy in CD28-T cells: B7-independent costimulation of CD1-restricted T cells. J. Exp. Med. 182:2007-2018.
17. Melian, A., Geng, Y.J., Sukhova, G.K., Libby, P., and Porcelli, S.A. 1999. CD1 expression in human atherosclerosis. A potential mechanism for T cell activation by foam cells. Am. J. Pathol. 155:775-786.
18. Kasinrerk, W., Baumruker, T., Majdic, O., Knapp, W., and Stockinger, H. 1993. CD1 molecule expression on human monocytes induced by granulocyte-macrophage colony-stimulating factor. J. Immunol. 150:579-584.
19. Blauvelt, A., Glushakova, S., and Margolis, L.B. 2000. HIV-infected human Langerhans cells transmit infection to human lymphoid tissue ex vivo. AIDS. 14:647-651.
20. Mehra, V., et al. 1992. A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein. J. Exp. Med. 175:275-284.
21. Beckman, E.M., et al. 1994. Recognition of a lipid antigen by CD1-restricted αβ+ T cells. Nature. 372:691-694.
22. Rosat, J.P., et al. 1999. CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ αβ T cell pool. J. Immunol. 162:366-371.
23. Ochoa, M.T., et al. 2001. T-cell release of granulysin contributes to host defense in leprosy. Nat. Med. 7:174-179.
24. Tanaka, Y., et al. 1994. Nonpeptide ligands for human gamma delta T cells. Proc. Natl. Acad. Sci. U. S. A. 91:8175-8179.
25. McDermott, R., et al. 2002. Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where Langerin accumulates. Mol. Biol. Cell. 13:317-335.
26. Porcelli, S., et al. 1989. Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes. Nature. 341:447-450.
27. Sugita, M., et al. 1999. Separate pathways for antigen presentation by CD1 molecules. Immunity. 11:743-752.
28. Stambach, N.S., and Taylor, M.E. 2003. Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells. Glycobiology. 13:401-410.
29. Plzak, J., et al. 2002. Analysis of binding of mannosides in relation to Langerin (CD207) in Langerhans cells of normal and transformed epithelia. Histochem. J. 34:247-253.
30. Moody, D.B., and Porcelli, S.A. 2003. Intracellular pathways of CD1 antigen presentation. Nat. Rev. Immunol. 3:11-22.
31. Jackman, R.M., et al. 1998. The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens. Immunity. 8:341-351.
32. Sugita, M., et al. 2002. Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells. Immunity. 16:697-706.
33. Hanau, D., et al. 1987. Human epidermal Langerhans cells cointernalize by receptor-mediated endocytosis "nonclassical" major histocompatibility complex class I molecules (T6 antigens) and class II molecules (HLA-DR antigens). Proc. Natl. Acad. Sci. U. S. A. 84:2901-2905.
34. Geijtenbeek, T.B., et al. 2003. Mycobacteria target DC-SIGN to suppress dendritic cell function. J. Exp. Med 197:7-17.
35. Tailleux, L., et al. 2003. DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J. Exp. Med. 197:121-127.
36. Maeda, N., et al. 2003. The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan. J. Biol. Chem. 278:5513-5516.
37. Geijtenbeek, T.B., et al. 2000. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell. 100:575-585.
38. Kawano, T., et al. 1997. CD1d-restricted and TCR-mediated activation of vα14 NKT cells by glycosyl-ceramides. Science. 279:1626-1629.
39. Prigozy, T.I., et al. 2001. Glycolipid antigen processing for presentation by CD1d molecules. Science. 291:664-667.
40. Daffe, M., Brennan, P.J., and McNeil, M. 1990. Pre-dominant structural features of the cell wall arabinogalactan of Mycobacterium tuberculosis as revealed through characterization of oligoglycosyl alditol fragments by gas chromatography/mass spectrometry and by 1H and 13C NMR analyses. J. Biol. Chem. 265:6734-6743.
41. Zajonc, D.M., Elsliger, M.A., Teyron, L., and Wilson, I.A. 2003. Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. Nat. Immunol. 4:808-815.
42. Stingl, G., Katz, S.I., Clement, L., Green, L., and Shevach, E.M. 1978. Immunologic functions of Ia-bearing epidermal Langerhans cells. J. Immunol. 121:2005-2013.
43. Ridley, D.S. 1972. The pathogenesis of the early lesions in leprosy. J. Pathol. 111:191-206.
44. Moody, D.B., et al. 2004. T cell activation by lipopeptide antigens. Science. 303:527-531.
45. Pena-Cruz, V., Itc, S., Dascher, C.C., Brenner, M.B., and Sugita, M. 2003. Epidermal Langerhans cells efficiently mediate CD1a-dependent presentation of microbial lipid antigens to T cells. J. Invest. Dermatol. 121:517-521.