Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: Focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior

Journal of Neuroscience

Volumn 26, Issue 25, 2006, Pages 6716-6727

  Negri, Lucia ^a   Lattanzi, Roberta ^a   Giannini, Elisa ^a   Colucci, Mariantonella ^a   Margheriti, Federica ^a   Melchiorri, Pietro ^a   Vellani, Vittorio ^b   Tian, Hui ^c   De Felice, Milena ^a,d   Porreca, Frank ^d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c AMGEN INC   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

Bv8; Inflammation; Nociception; PKR1; Prokineticins; TRPV1

Indexed keywords

ACETIC ACID; ALLYL ISOTHIOCYANATE; BRADYKININ; CALCIUM ION; CAPSAICIN; FREUND ADJUVANT; PROKINETICIN RECEPTOR 1; PROKINETICIN RECEPTOR 2; PROSTAGLANDIN E2; PROTEIN; PROTEIN BV8; PROTON; RECEPTOR; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; CALCIUM; G PROTEIN COUPLED RECEPTOR; GASTROINTESTINAL HORMONE; NEUROPEPTIDE; PROK2 PROTEIN, MOUSE; TRPV1 PROTEIN, RAT; VANILLOID RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BODY TEMPERATURE; CELL STRUCTURE; CONTROLLED STUDY; HYPERALGESIA; INFLAMMATION; MECHANICAL STIMULATION; MOUSE; NOCICEPTION; NONHUMAN; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; SIGNAL TRANSDUCTION; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; GENE EXPRESSION REGULATION; GENETICS; IN SITU HYBRIDIZATION; METABOLISM; METHODOLOGY; MOUSE MUTANT; NOCICEPTIVE RECEPTOR; PAIN; PAIN ASSESSMENT; PAIN THRESHOLD; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REACTION TIME; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE CELL; SPINAL GANGLION; STIMULATION;

ANIMALS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; CALCIUM; CAPSAICIN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GANGLIA, SPINAL; GASTROINTESTINAL HORMONES; GENE EXPRESSION REGULATION; HYPERALGESIA; IN SITU HYBRIDIZATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS, AFFERENT; NEUROPEPTIDES; NOCICEPTORS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PHYSICAL STIMULATION; REACTION TIME; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRPV CATION CHANNELS;

EID: 33745772229     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5403-05.2006     Document Type: Article

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