Novel phenanthridinone inhibitors of poly(adenosine 5′-diphosphateribose) synthetase: Potent cytoprotective and antishock agents

Critical Care Medicine

Volumn 30, Issue 5, 2002, Pages 1071-1082

  Jagtap, Prakash ^a   Garcia Soriano, Francisco ^a   Virág, László ^a   Liaudet, Lucas ^a   Mabley, Jon ^a   Szabó, Éva ^a   Haskó, György ^a   Marton, Anita ^a   Batista Lorigados, Clara ^a   Gallyas Jr , Ferenc ^a   Sümegi, Balázs ^a   Hoyt, Dale G ^a   Baloglu, Erkan ^a   VanDuzer, John ^a   Salzman, Andrew L ^a   Southan, Garry J ^a   Szabó, Csaba ^a  

^a INOTEK CORPORATION   (United States)

Author keywords

Endothelial; Endotoxin; Gut; Liver; Lung; Malondialdehyde; Myeloperoxidase; Shock; Vascular

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CHEMOKINE; CYTOKINE; FLUORESCEIN ISOTHIOCYANATE; INTERLEUKIN 1BETA; MALONALDEHYDE; MYELOPEROXIDASE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; N (6 OXO 5,6 DIHYDROPHENANTHRIDIN 2 YL) N,N DIMETHYLACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRATE; NITRITE; PEROXYNITRITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; ENDOTHELIUM CELL; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; INTESTINE MUCOSA PERMEABILITY; KIDNEY FAILURE; LIVER FAILURE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SHOCK; THYMOCYTE;

EID: 17144447467     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200205000-00019     Document Type: Article

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