Formal total synthesis of the potent renin inhibitor aliskiren: Application of a SmI2-promoted acyl-like radical coupling

Journal of Organic Chemistry

Volumn 71, Issue 13, 2006, Pages 4766-4777

  Lindsay, Karl B ^a   Skrydstrup, Troels ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALISKIREN; POTENT RENIN INHIBITOR; PROTEASE INHIBITORS; RADICAL COUPLING;

AMINO ACIDS; CARBON; COUPLINGS; ETHYLENE; KETONES; SYNTHESIS (CHEMICAL);

ENZYME INHIBITION;

ACETONE; ACRYLIC ACID BUTYL ESTER; ALISKIREN; CGP 38560; ETHYLENE DERIVATIVE; FUNCTIONAL GROUP; HYDROXYETHYLENE; INDINAVIR; ISOPROPYL GROUP; KETONE; L 685 458; PEPTIDE FRAGMENT; PROTEINASE INHIBITOR; RADICAL; RENIN INHIBITOR; SAMARIUM DIIODIDE; SP 100; THIOESTER; UNCLASSIFIED DRUG;

ACYL LIKE RADICAL COUPLING REACTION; ADDITION REACTION; ALDOL REACTION; ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; LACTONIZATION; REACTION ANALYSIS; REDUCTION; STEREOCHEMISTRY;

AMIDES; ENZYME INHIBITORS; FREE RADICALS; FUMARATES; MOLECULAR CONFORMATION; RENIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33745437840     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo060296c     Document Type: Article

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