A convergent synthesis approach towards CGP60536B, a non-peptide orally potent renin inhibitor, via an enantiomerically pure ketolactone intermediate

Tetrahedron Letters

Volumn 41, Issue 51, 2000, Pages 10085-10089

  Rüeger, Heinrich ^a   Stutz, Stefan ^a   Goschke, Richard ^a   Spindler, Felix ^a   Maibaum, Jürgen ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Grignard reaction; Keto lactone; Renin inhibitor; Stereoselective hydrogenation; Butyrolactone derivatives

Indexed keywords

ALISKIREN; GAMMA BUTYROLACTONE; LACTONE; RENIN INHIBITOR;

ARTICLE; BLOOD PRESSURE REGULATION; CHEMICAL ANALYSIS; CHEMICAL REACTION; DIASTEREOISOMER; DRUG POTENCY; ENANTIOMER; STEREOCHEMISTRY; SYNTHESIS;

EID: 0034676709     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)01794-9     Document Type: Article

References (16)