Structural and chemical organization of the autonomic neuroeffector system

Handbook of the Autonomic Nervous System in Health and Disease

Volumn , Issue , 2002, Pages 1-53

  Burnstock, Geoffrey ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

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EID: 33745376308     PISSN: None     EISSN: None     Source Type: Book    
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References (311)

1. Burnstock G. Autonomic neuromuscular junctions: current developments and future directions. J Anat 1986; 146:1-30.
2. Burnstock G. The changing face of autonomic neurotransmission (The first von Euler lecture in physiology). Acta Physiol Scand 1986; 126:67-91.
3. Gabella G. Fine structure of post-ganglionic nerve fibres and autonomic neuroeffector junctions. In: Burnstock G, Hoyle CHV, eds. Autonomic Neuroeffector Mechanisms. Chur, Switzerland: Harwood Academic, 1995:1-31.
4. Campbell GR, Uehara Y, Mark G, Burnstock G. Fine structure of smooth muscle cells grown in tissue culture. J Cell Biol 1971; 49:21-34.
5. Burnstock G. Autonomic neural control mechanisms, with special reference to the airways. In: Kaliner MA, Barnes PJ, eds. The Airways: Neural Control in Health and Disease New York: Marcel Dekker, 1988:1-22.
6. Brock JA, Cunnane TC. Electrophysiology of neuroeffector transmission in smooth muscle. In: Burnstock G, Hoyle CHV, eds. Autonomic Neuroeffector Mechanisms. Chur, Switzerland: Harwood Academic, 1995:121-213.
7. Paton WDM. Central and synaptic transmission in the nervous system (pharmacological aspects). Annu Rev Physiol 1958; 20:431-455.
8. Eccles JC. The Physiology of the Synapses. New York: Academic Press, 1964.
9. Hoyle CHV, Burnstock G. Criteria for defining enteric neurotransmitters. In: Gaginella TS, ed. Handbook of Methods in Pharmacology. London: CRC Press, 1996:123-140.
10. Attwell D, Barbour B, Szatkowski M. Nonvesicular release of neurotransmitter. Neuron 1993; 11:401-407.
11. Burnstock G. Evolution of the autonomic innervation of visceral and cardiovascular systems in vertebrates. Pharmacol Rev 1969; 21:247-324.
12. Burnstock G, Campbell G, Bennett M, Holman ME. Inhibition of the smooth muscle of the taenia coli. Nature 1963; 200:581-582.
13. Martinsen J, Muren A. Excitatory and inhibitory effects of vagal stimulation on gastric motility in the cat. Acta Physiol Scand 1963; 57:309-316.
14. Burnstock G, Campbell G, Satchell D, Smythe A. Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol 1970; 40:668-688.
15. Burnstock G. Purinergic nerves. Pharmacol Rev 1972; 24:509-581.
16. Burnstock G. The past, present and future of purine nucleotides as signalling molecules. Neuropharmacology 1997; 36:1127-1139.
17. Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 1998; 50:413-492.
18. Cook RD, Burnstock G. The ultrastructure of Auerbach’s plexus in the guinea-pig. 1. Neuronal elements. J Neurocytol 1976; 5:171-194.
19. Furness JB, Costa M. The Enteric Nervous System. Edinburgh: Churchill Livingstone, 1987.
20. Gershon MD, Mawe GM, Branchek TA. 5-HT and enteric neurones. In: Fozard JR, ed. The Peripheral Actions of 5-HT. Oxford: Oxford University Press, 1989:247-273.
21. Hills JM, Jessen KR. Transmission: 7-amino butyric acid (GABA), 5-hydrox-ytryptamine (5-HT) and dopamine. In: Burnstock G, Hoyle CHV, eds. Autonomic Neuroeffector Mechanisms. Chur, Switzerland: Harwood Academic, 1995:465-507.
22. Rand MJ. Nitrergic transmission: nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission. Clin Exp Pharmacol Physiol 1992; 19:147-169.
23. Sanders KM, Ward SM. Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am J Physiol 1992; 262:G379-393.
24. Lincoln J, Hoyle CHV, Burnstock G. Nitric Oxide in Health and Disease. Cambridge: Cambridge University Press, 1997.
25. Inagaki H, Bishop AE, Escrig C, Wharton J, Allen-Mersh TG, Polak JM. Localization of endothelin-like immunoreactivity and endothelin binding sites in human colon. Gastroenterology 1991; 101:47-54.
26. Loesch A, Milner P, Burnstock G. Endothelin in perivascular nerves. An electron-immunocytochemical study of rat basilar artery. NeuroReport 1998; 9:3903-3906.
27. Schmid KW, Kunk B, Kirchmair R, Totsch M, Bocker W, Fischer-Colbrie R. Im-munohistochemical detection of secretoneurin, a novel neuropeptide endoproteolyt-ically processed from secretogranin II, in normal human endocrine and neuronal tissues. Histochem J 1995; 27:473-481.
28. Dunn NJ, Dun SL, Lin HH, Hwang LL, Saria A, Fischer-Colbrie R. Secretoneurin-like immunoreactivity in rat sympathetic, enteric and sensory ganglia. Brian Res 1997; 760:8-16.
29. Sundler F, Ekblad E, Absood A, Hakanson R, Koves K, Arimura A. Pituitary adenylate cyclase activating peptide: a novel vasoactive intestinal peptide-like neuropeptide in the gut. Neuroscience 1992; 46:439-454.
30. Burns GA, Stephens KE. Expression of mRNA for the N-methyl-D-aspartate (NM-DAR1) receptor and vasoactive intestinal polypeptide (VIP) co-exist in enteric neurons of the rat. J Auton Nerv Syst 1995; 55:207-210.
31. Rattan S, Chakder S. Inhibitory effect of CO on internal anal sphincter: heme oxygenase inhibitor inhibits NANC relaxation. Am J Physiol 1993; 265:G799-G804.
32. Werkström V, Ny L, Persson K, Andersson K-E. Carbon monoxide-induced relaxation and distribution of haem oxygenase isoenzymes in the pig urethra and lower oesophagogastric junction. Br J Pharmacol 1997; 120:312-318.
33. Thoenen H. Induction of tyrosine hydroxylase in peripheral and central adrenergic neurones by cold exposure of rats. Nature 1970; 228:861-862.
34. Zigmond R, Mohney R, Schreiber R, Shadiack A, Sun Y, Vaccariello YS, Zhou Y. Changes in gene expression in adult sympathetic neurons after axonal injury. Adv Pharmacol 1998; 42:899-903.
35. De Potter WP, De Schaepdryver AF, Moerman EJ, Smith AD. Evidence for the release of vesicle proteins together with noradrenaline upon stimulation of the splenic nerve. J Physiol 1969; 204:102-104P.
36. Fillenz M. Transmission: noradrenaline. In: Burnstock G, Hoyle CHV, eds. Autonomic Neuroeffector Mechanisms. Chur, Switzerland: Harwood Academic, 1995:323-365.
37. Bylund DB, Eikenberg DC, Hieble JB, Langer SZ, Lefkowitz RJ, Minneman KP, Molinoff PB, Ruffolo RR Jr, Trendelenburg U. International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev 1994; 46:121-136.
38. Gilman AG. G proteins: transducers of receptor generated signals. Annu Rev Biochem 1987; 56:615-649.
39. Erickson JD, Varoqui H, Schafer MK, Modi W, Diebler MF, Weihe E, Rand J, Eiden LE, Bonner TI, Usdin TB. Functional identification of a vesicular acetylcholine transporter and its expression from a “cholinergic” gene locus. J Biol Chem 1994; 269:21929-21932.
40. Usdin TB, Eiden LE, Bonner TI, Erickson JD. Molecular biology of the vesicular ACh transporter. Trends Neurosci 1995; 18:218-224.
41. Birks RI, Worsley KJ. Activation of acetylcholine synthesis in cat sympathetic ganglia: dependence on external choline and sodium-pump rate. J Physiol 1985; 367:401-417.
42. Noda M, Takahashi H, Tanabe T, Toyosato M, Furutani Y, Hirosa T, Asai M, In-ayama S, Miyata T, Numa S. Primary structure of the a-subunit precursor of the Torpedo california acetylcholine receptor deduced from cDNA sequence. Nature 1982; 299:793-797.
43. Kubo T, Maeda A, Sugimoto K, Akiba I, Mikami A, Takahashi H, Haga T, Haga K, Ichiyama A, Kangawa K, Matsuo H, Hirose T, Numa S. Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence. FEBS Lett 1986; 209:367-372.
44. Goyal RK. Muscarinic receptor subtypes. Physiology and clinical implications. N Engl J Med 1989; 321:1022-1029.
45. Zimmermann H. Signalling via ATP in the nervous system. J Auton Nerv Syst 1994; 17:420-426.
46. Hoyle CHV. Transmission: purines. In: Burnstock G., Hoyle CHV, eds. Autonomic Neuroeffector Mechanisms. Chur, Switzerland: Harwood Academic, 1995:367-407.
47. Miras-Portugal MT, Gualix J, Pintor J. The neurotransmitter role of diadenosine polyphosphates. FEBS Lett 1998; 430:78-82.
48. Burnstock G. A basis for distinguishing two types of purinergic receptor. In: Straub RW, Bolis L, eds. Cell Membrane Receptors for Drugs and Hormones: A Multidisciplinary Approach. New York: Raven Press, 1978:107-118.
49. Jacobson KA, Suzuki F. Recent developments in selective agonists and antagonists acting at purine and pyrimidine receptors. Drug Dev Res 1996; 39:289-300.
50. 2-purinoceptor? Gen Pharmacol 1985; 16:433-440.
51. Abbracchio MP, Burnstock G. Purinoceptors: Are there families of P2X and P2Y purinoceptors? Pharmacol Ther 1994; 64:445-475.
52. Burnstock G. P2 purinoceptors: historical perspective and classification. In: Chadwick DJ, Goode JA, eds. P2 Purinoceptors: Localization, Function and Transduction Mechanisms. Ciba Foundation Symposium 198. Chichester: John Wiley and Sons, 1996:1-34.
53. Dockray GJ. Transmission: peptides. In: Burnstock G, Hoyle CHV, eds. Autonomic Neuroeffector Mechanisms. Chur, Switzerland: Harwood Academic, 1995:409-464.
54. Konkoy CS, Davis TP. Ectoenzymes as sites of peptide regulation. Trends Neurosci 1996; 17:288-294.
55. Gibson A, Lilley E. Superoxide anions, free-radical scavengers, and nitrergic neurotransmission. Gen Pharmacol 1997; 28:489-493.
56. Lincoln J, Hoyle CHV, Burnstock G. Transmission: nitric oxide. In: Burnstock G, Hoyle CHV, eds. Autonomic Neuroeffector Mechanisms. Chur, Switzerland: Harwood Academic, 1995:509-539.
57. Lundberg JM. Pharmacology of cotransmission in the autonomic nervous system: integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide. Pharmacol Rev 1996; 48:113-178.
58. Boeckxstaens GE, Pelckmans PA. Nitric oxide and the non-adrenergic non-cholin-ergic neurotransmission. Comp Biochem Physiol 1997; 118A:925-937.
59. Sneddon P, Graham A. Role of nitric oxide in the autonomic innervation of smooth muscle. J Auton Pharmacol 1992; 12:445-456.
60. Lowenstein CJ, Dinerman JL, Snyder SH. Nitric oxide: a physiologic messenger. Ann Intern Med 1994; 120:227-237.
61. Feelisch M. The biochemical pathways of nitric oxide formation from nitrova-sodilators: appropriate choice of exogenous NO donors and aspects of preparation and handling of aqueous NO solutions. J Cardiovasc Pharmacol 1991; 17(suppl 3):S25-S33.
62. Rand MJ, Li CG. Differential effects of cysteine and glutathione on NO- and stimulation-induced relaxations of the rat anococcygeus muscle (abstr). Proc Aus Physiol Pharmacol Soc 1992; 23:175P.
63. Schmidt HHHW, Lohmann SM, Walter U. The nitric oxide and cGMP signal transduction system: regulation and mechanism of action. Biochim Biophys Acta 1993; 1178:153-175.
64. McDonald LJ, Murad F. Nitric oxide and cyclic GMP signaling. Proc Soc Exp Biol Med 1996; 211:1-6.
65. Griffith SG, Burnstock G. Immunohistochemical demonstration of serotonin in nerves supplying human cerebral and mesenteric blood vessels: some speculations about their involvement in vascular disorders. Lancet 1983; i:561-562.
66. Jackowski A, Crockard A, Burnstock G. 5-Hydroxytryptamine demonstrated im-munohistochemically in rat cerebrovascular nerves largely represents 5-hydrox-ytryptamine uptake into sympathetic nerve fibres. Neuroscience 1989; 29:453-462.
67. Lincoln J. Innervation of cerebral arteries by nerves containing 5-hydrox-ytryptamine and noradrenaline. Pharmacol Ther 1995; 68:473-501.
68. Jessen KR, Mirsky R, Dennison ME, Burnstock G. GABA may be a neurotransmitter in the vertebrate peripheral nervous system. Nature 1979; 281:71-74.
69. Davanger S, Hjelle OP, Babaie E, Larsson LI, Houjaard D, Storm-Mattheson J, Ot-tersen OP. Colocalization of 7-aminobutyrate and gastrin in rat antrum: an im-munocytochemical and in situ hybridization study. Gastroenterology 1994; 107:137-148.
70. Krantis A, Nichols K, Staines W. Neurochemical characterization and distribution of enteric GABA-ergic neurons and nerve fibres in the human colon. J Auton Nerv Syst 1998; 68:33-42.
71. Maines MD. Carbon monoxide: an emerging regulator of cGMP in the brain. Mol Cell Neurosci 1993; 4:389-397.
72. Dawson TM, Snyder SH. Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J Neurosci 1994; 14:5147-5159.
73. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997; 37:517-554.
74. Farrugia G, Miller SM, Rich A, Liu X, Maines MD, Rae JL, Szurszewski JH. Distribution of heme oxygenase and effects of exogenous carbon monoxide in canine jejunum. Am J Physiol 1998; 274:G350-G358.
75. Burnstock G. Do some nerves release more than one transmitter? Neuroscience 1976; 1:239-248.
76. Burnstock G. Review lecture. Neurotransmitters and trophic factors in the autonomic nervous system. J Physiol 1981; 313:1-35.
77. Burnstock G. Co-transmission. The Fifth Heymans Lecture—Ghent, February 17, 1990. Arch Int Pharmacodyn Ther 1990; 304:7-33.
78. Burnstock G (guest ed.). Purinergic Neurotransmission. Semin Neurosci 1996; 8:171-257
79. Burnstock G. Purinergic cotransmission. Brain Res Bull 1999; 50:355-357.
80. Hökfelt T, Holets VR, Staines W, Meister B, Melander T, Schalling M, Schultzber M, Freedman J, Björklund H, Olson L, Pernow B. Coexistence of neuronal messen-gers—an overview new principle in chemical transmission. Prog Brain Res 1986; 68:33-70.
81. Kupfermann I. Functional studies of cotransmission. Physiol Rev 1991; 71:683-732.
82. Morris JL, Gibbins IL. Co-transmission and neuromodulation. In: Burnstock G, Hoyle CHV, eds. Autonomic Neuroeffector Mechanisms. Chur, Switzerland: Harwood Academic, 1995:33-119.
83. Milner P, Burnstock G. Trophic factors in the control of smooth muscle development and innervation. In: Raeburn D, Giembycz MA, eds. Airways Smooth Muscle: Development and Regulation of Contractility. Basel: Birkhäuser, 1994:1-39.
84. Burnstock G. Cotransmission with particular emphasis on the involvement of ATP. In: Fuxe K, Hökfelt T, Olson L, Ottoson D, Dahlström A, Björklund A, eds. Molecular Mechanisms of Neuronal Communication. A Tribute to Nils-Ake Hillarp. Oxford: Pergamon Press, 1996:67-87.
85. Kennedy C, Saville VL, Burnstock G. The contributions of noradrenaline and ATP to the responses of the rabbit central ear artery to sympathetic nerve stimulation depend on the parameters of stimulation. Eur. J Pharmacol 1986; 122:291-300.
86. Furness JB, Pompolo S, Murphy R, Giraud A. Projections of neurons with neuromedin U-like immunoreactivity in the small intestine of the guinea-pig. Cell Tissue Res 1989; 257:415-422.
87. Rubino A, Burnstock G. Capsaicin-sensitive sensory-motor neurotransmission in the peripheral control of cardiovascular function. Cardiovasc Res 1996; 31:467-479.
88. Burnstock G. Purinergic signalling in gut. In: Abbracchio MP, Williams M, eds. Handbook of Experimental Pharmacology, Vol. 151/II. Purinergic and Pyrimidiner-gic Signalling II. Berlin: Springer-Verlag, 2001:141-238.
89. Burnstock G. Mechanisms in interaction of peptide and nonpeptide vascular neurotransmitter systems. J Cardiovasc Pharmacol 1987; 10(suppl 12):S74-S81.
90. Costa M, Brookes SJH, Steele PA, Gibbins I, Burcher E, Kandiah CJ. Neurochemical classification of myenteric neurons in the guinea-pig ileum. Neuroscience 1996; 75:949-967.
91. Morris JL, Grasby DJ, Anderson RL, Gibbins IL. Neurochemical distinction between skeletal muscle vasodilator neurons and pelvic vasodilator neurons in guinea-pigs. J Auton Nerv Syst 1998; 71:64-68.
92. Morris JL, Gibbins IL. Co-localization and plasticity of transmitters in peripheral autonomic and sensory neurons. Int J Dev Neurosci 1989; 7:521-531.
93. Sneddon P, Burnstock G. Inhibition of excitatory junction potentials in guinea-pig vas deferens by a,ß-methylene ATP: further evidence for ATP and noradrenaline as co-transmitters. Eur J Pharmacol 1984; 100:85-90.
94. Stjärne L, Lundberg JM, Astrand P. Neuropeptide Y- a cotransmitter with noradrenaline and adenosine 5'-triphosphate in the sympathetic nerves of the mouse vas deferens? A biochemical, physiological and electropharmacological study. Neuroscience 1986; 18:151-166.
95. Burnstock G. Noradrenaline and ATP as cotransmitters in sympathetic nerves. Neu-rochem Int 1990; 17:357-368.
96. Kennedy C, McLaren GJ, Westfall TD, Sneddon P. ATP as a co-transmitter with noradrenaline in sympathetic nerves—function and fate. In: Chadwick DJ, Goode JA, eds. P2 Purinoceptors: Localization, Function and Transduction Mechanisms. Ciba Foundation Symposium 198. Chichester: John Wiley and Sons, 1996:223-238.
97. Kasakov L, Ellis J, Kirkpatrick K, Milner P, Burnstock G. Direct evidence for concomitant release of noradrenaline, adenosine 5'-triphosphate and neuropeptide Y from sympathetic nerve supplying the guinea-pig vas deferens. J Auton Nerv Syst 1988; 22:75-82.
98. Lundberg JM, Rudehill A, Sollevi A, Theodorsson-Norheim E, Hamberger E. Frequency- and reserpine-dependent chemical coding of sympathetic transmission: differential release of noradrenaline and NPY from pig spleen. Neurosci Lett 1986; 63:96-100.
99. Ramme D, Regenold JT, Starke K, Busse R, Illes P. Identification of the neuroeffector transmitter in jejunal branches of the rabbit mesenteric artery. Naunyn Schmeidebergs Arch Pharmacol 1987; 336:267-273.
100. Evans RJ, Surprenant A. ATP mediates fast synaptic transmission in mammalian neurons. Nature 1992; 357:503-505.
101. 2-purinoceptors in the cardiovascular system. Circulation 1991; 84:1-14.
102. Corr L, Burnstock G. Vasodilator response of coronary smooth muscle to the sympathetic co-transmitters noradrenaline and adenosine 5'-triphosphate. Br J Pharmacol 1991; 104:337-342.
103. von Kügelgen I, Stoffel D, Starke K. P2-purinoceptors-mediated inhibition of noradrenaline release in rat atria. Br J Pharmacol 1995; 115:247-254.
104. Ellis JL, Burnstock G. Neuropeptide Y neuromodulation of sympathetic co-transmission in the guinea-pig vas deferens. Br J Pharmacol 1990; 100:457-462.
105. Wharton J, Gulbenkian S. Peptides in the mammalian cardiovascular system. Expe-rientia 1987; 43:821-872.
106. 2-purinoceptors to the control of vascular tone in the rat isolated mesenteric arterial bed. Br J Pharmacol 1995; 115:648-652.
107. Lundberg JM. Evidence for coexistence of vasoactive intestinal polypeptide (VIP) and acetylcholine in neurons of cat exocrine glands. Morphological, biochemical and functional studies. Acta Physiol Scand Suppl 1981; 496:1-57.
108. Toda N, Okamura T. Modification by L-NG-monomethyl arginine (L-NMMA) of the response to nerve stimulation in isolated dog mesenteric and cerebral arteries. Jpn J Pharmacol 1990; 52:170-173.
109. Holst JJ, Rasmussen TN, Schmidt P. Role of nitric oxide in neurally induced pancreatic exocrine secretion in pigs. Am J Physiol 1994; 266:G206-G213.
110. Nozaki K, Moskowitz MA, Maynard KI, Koketsu N, Dawson TM, Bredt DS, Snyder SH. Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibres in cerebral arteries. J Cereb Blood Flow Metab 1993; 13:70-79.
111. Mione MC, Cavanagh JFR, Lincoln J, Milner P, Burnstock G. Long-term chemical sympathectomy leads to an increase of neuropeptide Y immunoreactvity in cerebrovascular nerves and iris of the developing rat. Neuroscience 1990; 34:369-378.
112. Burnstock G, Cocks T, Crowe R, Kasakov L. Purinergic innervation of the guinea-pig urinary bladder. Br J Pharmacol 1978; 63:125-138.
113. 2x-purinoceptors and for purinergic transmission. Eur J Pharmacol 1989; 174:115-118.
114. Morris JL, Gibbins IL. Neuronal colocalization of neuropeptides, catecholamines and catecholamine synthesizing enzymes in the guinea-pig paracervical ganglia. J Neurosci 1987; 7:3117-3130.
115. Anderson RL, Gibbins IL, Morris JL. Five inhibitory transmitters coexist in pelvic autonomic vasodilator neurons. NeuroReport 1997; 8:3023-3028.
116. Holzer P. Capsaicin: cellular targets, mechanisms of action and selectivity for thin sensory neurons. Pharmacol Rev 1991; 43:143-201.
117. Burnstock G, Wood JN. Purinergic receptors: their role in nociception and primary afferent neurotransmission. Curr Opin Neurobiol 1996; 6:526-532.
118. Holton P. The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol 1959; 145:494-504.
119. Kakuyama M, Vallance P, Ahluwalia A. Endothelium-dependent sensory NANC vasodilatation: involvement of ATP, CGRP and a possible NO store. Br J Pharmacol 1998; 23:310-316.
120. Maggi CA. The dual, sensory and ‘efferent’ function of the capsaicin-sensitive primary sensory neurons in the urinary bladder and urethra. In: Maggi CA, ed. Nervous Control of the Urogenital System. Chur, Switzerland: Harwood Academic, 1993:387-422.
121. Milner P, Ralevic V, Hopwood AM, Feher E, Lincoln J, Kirkpatrick KA, Burnstock G. Ultrastructural localisation of substance P and choline acetyltransferase in endothelial cells of rat coronary artery and release of substance P and acetylcholine during hypoxia. Experientia 1989; 45:121-125.
122. Milner P, Bodin P, Loesch A, Burnstock G. Interactions between sensory perivascular nerves and the endothelium of brain microvessels. Int J Microcirc 1995; 15:1-9.
123. Gibbins IL, Furness JB, Costa M. Pathway-specific patterns of coexistence of substance P, calcitonin gene-related peptide, cholecystokinin and dynorphin in neurons of the dorsal root ganglia of the guinea-pig. Cell Tissue Res 1987; 248:417-437.
124. Aimi Y., Fujimura M, Vincent SP, Kimura H. Localization of NADPH-diaphorase-containing neurons in sensory ganglia of the rat. J Comp Neurol 1991; 306:382-392.
125. Franco-Cereceda A, Rydh M, Lou Y-P, Dalsgaard C-J, Lundberg JM. Endothelin as a putative sensory neuropeptide in the guinea-pig: different properties in comparison with calcitonin gene-related peptide. Regul Pept 1991; 32:253-265.
126. Giaid A, Gibson SJ, Ibrahim NBN, Legon S, Bloom SR, Yanagasawa M, Masaki T, Varndell IM, Polak JM. Endothelin-1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia. Proc Natl Acad Sci USA 1989; 86:7634-7638.
127. Rubino A, Hassall CJS, Burnstock G. Autonomic control of the myocardium: non-adrenergic non-cholinergic (NANC) mechanisms. In: Shepherd JT, Vatner SF, eds. Nervous Control of the Heart. Chur, Switzerland: Harwood Academic, 1996:139-177.
128. Hoyle CHV, Milner P, Burnstock G. Neuroeffector transmission in the intestine. In: Brookes SJ, Costa M, eds. Nervous Control of the Gastrointestinal Tract. Chur, Switzerland: Harwood Academic, 2002.
129. Neild TO, Shen KZ, Surprenant A. Vasodilation of arterioles by acetylcholine released from single neurones in the guinea-pig submucosal plexus. J Physiol 1990; 420:247-265.
130. Furness JB, Kunze WAA, Bertrand PP, Clerc N, Bornstein JC. Intrinsic primary afferent neurons of the intestine. Prog Neurobiol 1998; 54:1-18.
131. Kunze WAA, Furness JB. The enteric nervous system and regulation of intestinal motility. Annu Rev Physiol 1999; 61:117-142.
132. Kunze WAA, Clerc N, Furness JB, Gola M. The soma and neurites of primary afferent neurons in the guinea-pig intestine respond differentially to deformation. J Physiol 2000; 526:375-385.
133. Milner P, Lincoln J, Corr LA, Aberdeen JA, Burnstock G. Neuropeptide Y in non-sympathetic nerves of the rat: changes during maturation but not after guanethidine sympathectomy. Neuroscience 1991; 43:661-669.
134. Corr LA, Aberdeen JA, Milner P, Lincoln J, Burnstock G. Sympathetic and non-sympathetic neuropeptide Y-containing nerves in the rat myocardium and coronary arteries. Circ Res 1990; 66:1602-1609.
135. Horackova M, Kroll RP, Hopkins DA, Losier AM, Armour JA. Morphological and immunohistochemical properties of primary long-term cultures of adult guinea-pig ventricular cardiomyocytes with peripheral cardiac neurons. Tissue Cell 1996; 28:411-425.
136. Crowe R, Burnstock G. Fluorescent histochemical localisation of quinacrine-posi-tive neurones in the guinea-pig and rabbit atrium. Cardiovasc Res 1982; 16:384-390.
137. Hassall CJS, Saffrey JM, Belai A, Hoyle CHV, Moules EW, Moss J, Schmidt HHHW, Mural F, Forstermann U, Burnstock G. Nitric oxide synthase immunoreac-tivity and NADPH-diaphorase activity in a subpopulation of intrinsic neurones of the guinea-pig heart. Neurosci Lett 1992; 143:65-68.
138. Hassall CJS, Hoyle CHV. Heme oxygenase-2 and nitric oxide synthase in guinea-pig intracardiac neurones. NeuroReport 1997; 8:1043-1046.
139. Sosunov AA, Hassall CJS, Loesch A, Turmaine M, Feher E, Burnstock G. Neuropeptide Y-immunoreactive intracardiac neurones, granule containing cells and nerves associated with ganglia and blood vessels in rat and guinea-pig heart. Cell Tissue Res 1997; 289:445-454.
140. Hassall CJS, Stanford SC, Burnstock G, Buckley NJ. Co-expression of four muscarinic receptor genes by the intrinsic neurons of the rat and guinea-pig heart. Neuroscience 1993; 56:1041-1048.
141. Allen TGJ, Burnstock G. A voltage-clamp study of the electrophysiological characteristics of the intramural neurones of the rat trachea. J Physiol 1990; 423:593-614.
142. Belvisi MG, Ward JK, Mitchell JA, Barnes PJ. Nitric oxide as a neurotransmitter in human airways. Arch Int Pharmacodyn Ther 1995; 329:97-110.
143. Fischer A, Canning BJ, Kummer W. Correlation of vasoactive intestinal peptide and nitric oxide synthase with choline acetyltransferase in the airway innervation. Ann NY Acad Sci 1996; 805:717-722.
144. Smet PJ, Edyvane KA, Jonavicius J, Marshall VR. Neuropeptides and neurotransmitter-synthesising enzymes in intrinsic neurons of the human urinary bladder. J Neurocytol 1996; 25:112-124.
145. Dixon JS, Jen PY, Gosling JA. A double-label immunohistochemical study of intramural ganglia from the human male urinary bladder neck. J Anat 1997; 190:125-135.
146. Crowe R, Burnstock G, Light JK. Intramural ganglia in the human urethra. J Urol 1988; 140:183-187.
147. Dhital KK, Gerli R, Lincoln J, Milner P, Tanganelli P, Weber G, Burnstock G. Increased density of perivascular nerves to the major cerebral vessels of the spontaneously hypertensive rat: differential changes in noradrenaline and neuropeptide Y during development. Brain Res 1988; 444:33-45.
148. Dhall U, Cowen T, Haven AJ, Burnstock G. Perivascular noradrenergic and peptide-containing nerves show different patterns of changes during development and ageing in the guinea-pig. J Auton Nerv Syst 1986; 16:109-126.
149. Landis SC, Siegel RE, Schwab M. Evidence for neuroplasticity in vivo. II. Im-munocytochemical studies of the rat sweat gland innervation during development. Dev Biol 1988; 126:129-140.
150. Stevens LM, Landis SC. Target influences on transmitter choice by sympathetic neurons developing in the anterior chamber of the eye. Dev Biol 1990; 37:109-124.
151. Cowen T, Thrasivoulou C, Shaw SA, Abdel-Rahman T. Transplanted sweat glands from mature and aged donors determine cholinergic phenotype and altered density of host sympathetic nerves. J Auton Nerv Syst 1996; 60:215-224.
152. Horgan K, Van der Kooy D. Visceral targets specify calcitonin gene-related peptide and substance P enrichment in trigeminal afferent projections. J Neurosci 1992; 12:1135-1143.
153. Brauer MM, Lincoln J, Sarner S, Blundell D, Milner P, Passaro M, Corbacho A, Burnstock G. Maturational changes in sympathetic and sensory innervation of the rat uterus: effects of neonatal capsaicin treatment. Int J Dev Neurosci 1994; 12:157-171.
154. Sneddon P, McLees A. Purinergic and cholinergic contractions in adult and neonatal rabbit bladder. Eur J Pharmacol 1992; 214:7-12.
155. Cowen T, Burnstock G. Development, aging and plasticity of perivascular autonomic nerves. In: Gootman PM, ed. Development Biology of the Autonomic Nervous System. Clifton, NJ: Humana Press, 1986:211-232.
156. Burnstock G. Changes in expression of autonomic nerves in aging and disease. J Auton Nerv Syst 1990; 30:S25-S34.
157. Mione MC, Ralevic V, Burnstock G. Peptides and vasomotor mechanisms. Pharmacol Ther 1990; 46:429-468.
158. Cowen T, Gavazzi I. Plasticity in adult and ageing sympathetic neurons. Prog Neurobiol 1998; 54:249-288.
159. Edvinsson L, Edman R, Otteson A, Uddman R. Distribution, concentration and effects of neuropeptide Y (NPY), substance P (SP) and vasoactive intestinal polypeptide (VIP) in human cerebral blood vessels. J Cereb Blood Flow Metab 1985; 5(suppl):S545.
160. Li Y, Duckles SP. Effect of age on vascular content of calcitonin gene-related peptide and mesenteric vasodilator nerve activity in the rat. Eur J Pharmacol 1993; 236:373-378.
161. Glen TC, Duckles SP. Vascular responses to neuropeptide Y in the rat: effect of age. Aging 1994; 6:277-286.
162. Gabella, G. On the plasticity of form and structure of enteric ganglia. J Auton Nerv Syst 1990; 30:S59-S66.
163. Santer RM. Survival of the population of NADPH-diaphorase stained myenteric neurons in the small intestine of aged rats. J Auton Nerv Syst 1994; 49:115-121.
164. Belai A, Cooper S, Burnstock G. Effect of age on NADPH-diaphorase-containing myenteric neurones of rat ileum and proximal colon. Cell Tissue Res 1995; 279:379-387.
165. Belai A, Burnstock G. Distribution and colocalisation of nitric oxide synthase and calretinin in the myenteric neurons of developing, aging and Crohn’s disease human small intestine. Dig Dis Sci 1999; 44:1579-1587.
166. Belai A, Wheeler H, Burnstock G. Innervation of the rat gastrointestinal sphincters: changes during development and aging. Int J Dev Neurosci 1995; 13:81-95.
167. 1 receptor agonist. J Geront A Biol Sci Med Sci 1995; 50:B351-B357.
168. 1 adenosine receptor expression in pat testes. Am J Physiol 1998; 274:C1057-C1064.
169. Sjöberg N-O. Consideration of the cause of disappearance of the adrenergic neurotransmitter in the uterine nerves during pregnancy. Acta Physiol Scand 1968; 72:510-517.
170. Bell C, Malcolm SJ. Neurochemistry of the sympathetic innervation to the uterus. Clin Exp Pharmacol Physiol 1988; 15:667-674.
171. Alm P, Lundberg LM, Wharton J, Polak JM. Organization of the guinea-pig uterine innervation. Distribution of immunoreactivities for different neuronal markers. Effects of chemical and pregnancy-induced sympathectomy. Histochem J 1988; 20:290-300.
172. Amira S, Morrison JF, Rayfield KM. The effects of pregnancy and parturition on the substance P content of the rat uterus: uterine growth is accompanied by hypertrophy of its afferent innervation. Exp Physiol 1995; 80:645-650.
173. Anouar A, Schirar A, Germain G. Relaxant effect of the calcitonin gene-related peptide (CGRP) on the nonpregnant and pregnant rat uterus. Naunyn Schmeiderbergs Arch Pharmacol 1998; 357:446-453.
174. Haase EB, Buchman J, Tietz AE, Schramm LP. Pregnancy-induced uterine neuronal degeneration in the rat. Cell Tissue Res 1997; 288:293-306.
175. Mione MC, Gabella G. Nerve fibres in the uterine artery increase in number in pregnant guinea-pigs. NeuroReport 1991; 2:537-540.
176. Mione MC, Cavanagh JFR, Lincoln J, Milner P, Burnstock G. Pregnancy reduces noradrenaline but not neuropeptide Y levels in the uterine artery of the guinea-pig. Cell Tissue Res 1990; 259:503-509.
177. Mione MC, Cavanagh JFR, Burnstock G. Uptake of 5-hydroxydopamine into non-sympathetic nerves of guinea-pig uterine artery in late pregnancy. J Neurocytol 1993; 22:164-175.
178. Bell, C. Dual vasoconstrictor and vasodilator innervation of the uterine arterial supply in guinea-pig. Circ Res 1968; 23:269-279.
179. Nelson SH, Steinsland OS, Johnson RL, Suresh MS, Gifford A, Ehardt JS. Pregnancy-induced alterations of neurogenic constriction and dilation of human uterine artery. Am J Physiol 1995; 268:H1694-H1701.
180. Ralevic V, Burnstock G. Mesenteric arterial function in the rat in pregnancy: role of sympathetic and sensory-motor perivascular nerves, endothelium, smooth muscle, nitric oxide and prostaglandins. Br J Pharmacol 1996; 117:1463-1470.
181. Appenzeller O, Martignoni E. The autonomic nervous system and hypoxia: mountain medicine. J Auton Nerv Syst 1996; 57:1-12.
182. Asano K, Yanagidaira Y, Yoshimura K, Sakai A. The cGMP pathway is not responsible for the blunted hypoxic vasoconstriction in rat lungs after altitude exposure. Acta Physiol Scand 1997; 160:393-400.
183. Meyrick B, Reid L. The effect of continued hypoxia on rat pulmonary arterial circulation. An ultrastructural study. Lab Invest 1978; 38:188-200.
184. Hung, KS, McKenzie JC, Mattioli L, Klein RM, Menon CD, Poulose AK. Scanning electron microscopy of pulmonary vascular endothelium in rats with hypoxia-induced hypertension. Acta Anat 1986; 126:13-20.
185. Farinelli CC, Kayser B, Binzone T, Cerretelli P, Girardier L. Autonomic nervous control of heart rate at altitude (5050m). Eur J Appl Physiol 1994; 69:502-507.
186. Ponchia A, Noventa D, Bertaglia M, Carretta R, Zaccaria M, Miraglia G, Pascotto P, Buja G. Cardiovascular neural regulation during and after prolonged high altitude. Eur Heart J 1994; 15:1463-1469.
187. Cheng, JT, Chen CF, Shum AY, Wang JY, Chen HI. Increase in plasma neuropeptide Y-like immunoreactivity following chronic hypoxia in the rat. Neurosci Lett 1992; 140:211-214.
188. Scherrer-Crosbie M, Mardon K, Cayla J, Syrota A, Merlet P. Alterations of myocardial sympathetic innervation in response to hypoxia. J Nucl Med 1997; 38:954-957.
189. Burnstock G, Evans B, Gannon BJ, Heath JW, James V. A new method of destroying adrenergic nerves in adult animals using guanethidine. Br J Pharmacol 1971; 43:295-301.
190. Johnson EM, O’Brien F, Werbit R. Modification and characterization of the permanent sympathectomy produced by the administration of guanethidine to newborn rats. Eur J Pharmacol 1976; 37:45-54.
191. Kährström J, Hardebo JE, Nordberg C, Owman C. Experiments on cerebrovascular nerve plasticity and trophic vascular adaption in young and adult rats. In: Owman C, Hardebo JE, eds. Neural Regulation of Brain Circulation. Amsterdam: Elsevier, 1986:589-606.
192. Gibbins IL, Morris JL. Co-existence of immunoreactivity to neuropeptide Y and vasoactive intestinal polypeptide in nonadrenergic axons innervating guinea-pig cerebral arteries after sympathectomy. Brain Res 1988; 444:402-406.
193. Björklund H, Hökfelt T, Goldstein M, Terenius L, Olson L. Appearance of the noradrenergic markers tyrosine hydroxylase and neuropeptide Y in cholinergic nerves of the iris following sympathectomy. J Neurosci 1985; 5:1633-1643.
194. Fan Q, Smith PG. Decreased vasoactive intestinal polypeptide-immunoreactivity of parasympathetic neurons and target innervation following long-term sympathectomy. Regul Pept 1993; 48:337-343.
195. Morris JL, Gibbins IL, Furness JB. Increased dopamine-ß-hydroxylase-like im-munoreactivity in non-noradrenergic axons supplying the guinea-pig uterine artery after 6-hydroxydopamine treatment. J Auton Nerv Syst 1987; 21:15-27.
196. Mione MC, Sancesario G, D’Angelo V, Bernardi G. Increase in dopamine-ß-hy-droxylase immunoreactivity in non-sympathetic nerves of rat cerebral arteries following long-term sympathectomy. Neurosci Lett 1991; 123:167-171.
197. Kessler JA, Bell WO, Black IB. Interactions between the sympathetic and sensory innervation of the iris. J Neurosci 1987; 3:1301-1307.
198. Cole DF, Bloom SR, Burnstock G, Butler JM, McGregor GP, Saffrey MJ, Unger WG, Zhang SQ. Increase in SP-like immunoreactivity in nerve fibres of rabbit iris and ciliary body one to four months following sympathetic denervation. Exp Eye Res 1987; 37:191-197.
199. Schon F, Ghatei M, Allen JM, Mulderry PK, Kelly JS, Bloom SR. The effect of sympathectomy on calcitonin gene-related peptide levels in the rat trigeminovascular system. Brain Res 1985; 348:197-200.
200. Aberdeen J, Corr L, Milner P, Lincoln J, Burnstock G. Marked increases in calcitonin gene-related peptide-containing nerves in the developing rat following longterm sympathectomy with guanethidine. Neuroscience 1990; 35:175-184.
201. Aberdeen J, Milner P, Lincoln J, Burnstock G. Guanethidine sympathectomy of mature rats leads to increases in calcitonin gene-related peptide and vasoactive intestinal polypeptide-containing nerves. Neuroscience 1992; 47:453-461.
202. Van Ranst L, Lauweryns JM. Effects of long-term sensory vs sympathetic denervation on the distribution of calcitonin gene-related peptide and tyrosine hydroxylase immunoreactivities in the rat lung. J Neuroimmunol 1990; 29:131-138.
203. Milner P, Lincoln J, Belai A, Burnstock G. Plasticity in the myenteric plexus of the rat ileum after long-term sympathectomy. Int J Dev Neurosci 1995; 13:385-392.
204. Jonakait GM, Markey KA, Goldstein M, Dreyfus CF, Black IB. Selective expression of high affinity uptake of catecholamines by transiently catecholaminergic cells of the rat embryo: studies in vivo and in vitro. Dev Biol 1985; 108:6-17.
205. Belai A, Aberdeen J, Burnstock G. Differential effect of immunosympathectomy on the expression of rat enteric neurotransmitters. Neurosci Lett 1992; 139:157-160.
206. Ralevic V, Karoon P, Burnstock G. Long-term sensory denervation by neonatal capsaicin treatment augments sympathetic neurotransmission in rat mesenteric arteries by increasing levels of norepinephrine and selectively enhancing postjunctional actions. J Pharmacol Exp Ther 1995; 274:64-71.
207. Rubino A, Ralevic V, Burnstock G. Sympathetic neurotransmission in isolated rat atria after sensory-motor denervation by neonatal treatment with capsaicin. J Pharmacol Exp Ther 1997; 282:671-675.
208. Brauer MM, Lincoln J, Milner P, Sarner S, Blundell D, Passaro M, Corbacho A, Burnstock G. Plasticity of autonomic nerves: differential effects of long-term guanethidine sympathectomy on the sensory innervation of the rat uterus during maturation. Int J Dev Neurosci 1994; 12:579-586.
209. Ventura S, Bavetta S, Milner P, Ralevic V, Burnstock G. Nitric oxide synthase is colocalized with vasoactive intestinal polypeptide in postganglionic parasympathetic nerves innervating the rat vas deferens. Neuroscience 1998; 83:607-616.
210. Mione MC, Cavanagh JFR, Kirkpatrick KA, Burnstock G. Plasticity in expression of calcitonin gene-related peptide and substance P immunoreactivity in ganglia and fibres following guanethidine and/or capsaicin denervation. Cell Tissue Res 1992; 268:491-504.
211. Yunker AM, Galligan JJ. Extrinsic denervation increases myenteric oxide synthase-containing neurons and inhibitory neuromuscular transmission in guinea-pig. J Au-ton Nerv Syst 1998; 71:148-158.
212. Stadelmann AM, Telford GL, Appel DA, Walgenbach-Telford S, Hopp K, Meier DA, Koch TR. Expression of mRNA for vasoactive intestinal peptide in rat small intestine. Mol Cell Endocrinol 1996; 116:31-67.
213. Springall DR, Polak JM, Howard L, Power RF, Krausz T, Manickam S, Banner NR, Khagani A, Rose M, Yacoub M. Persistence of intrinsic neurones and possible phenotypic changes after extrinsic denervation of human respiratory tract by heart-lung transplantation. Am Rev Respir Dis 1990; 141:1538-1546.
214. Tio RA, Reyners AKL, van Veldhuisen DJ, van den Berg MP, Brouwer RMHJ, Haaksma J, Smit AJ, Crijns HJGM. Evidence for differential sympathetic and parasympathetic reinnervation after heart transplantation in humans. J Auton Nerv Syst 1997; 67:176-183.
215. de Groat WC. Anatomy and physiology of the lower urinary tract. Urol Clin North Am 1993; 20:383-401.
216. de Groat WC. A neurologic basis for the overactive bladder. Urology 1997; 50(suppl 6A):36-53.
217. Lincoln J, Burnstock G. Autonomic innervation of the urinary bladder and urethra. In: Maggi CA, ed. Nervous Control of the Urogenital System. Chur, Switzerland: Harwood Academic, 1993:33-68.
218. Hoyle CHV, Lincoln J, Burnstock G. Neural control of pelvic organs. In: Rushton DN, ed. Handbook of Neuro-Urology. New York: Marcel Dekker 1994:1-54.
219. de Groat WC, Kruse MN, Vizzard MA, Cheng C, Araki I, Yoshimura N. Modification of urinary bladder function after spinal cord injury. Adv Neurol 1997; 72:347-364.
220. de Groat WC. Mechanisms underlying the recovery of lower urinary tract function following spinal cord injury. Paraplegia 1995; 33:493-505.
221. + channels in afferent neurones innervating rat urinary bladder following spinal cord injury. J Physiol 1997; 503:269-276.
222. Yoshimura N, Erdman SL, Snider MW, de Groat WC. Effects of spinal cord injury on neurofilament immunoreactivity and capsaicin sensitivity in rat dorsal root ganglion neurons innervating the urinary bladder. Neuroscience 1998; 83:633-643.
223. Tuttle JB, Steers WD, Albo M, Nataluk E. Neural input regulates NGF and growth of the adult rat urinary bladder. J Auton Nerv Syst 1994; 49:147-158.
224. Fowler CJ, Beck RO, Gerrard S, Betts CD, Fowler CG. Intravesical capsaicin for treatment of detrusor hyperreflexia. J Neurol Neurosurg Psychiatry 1994; 57:169-173.
225. De Ridder D, Chandiramani V, Dasgupta P, Van Poppel H, Baert L, Fowler CJ. Intravesical capsaicin as a treatment for refractory detrusor hyperreflexia: a dual center study with long-term follow up. J Urol 1997; 158:2087-2092.
226. Sundin T, Dahlström A. The sympathetic innervation of the urinary bladder and urethra in the normal state and after parasympathetic denervation at the spinal root level. Scand J Urol Nephrol 1973; 7:131-149.
227. Norlen L, Dahlström A, Sundin T, Svedmyr N. The adrenergic innervation and adrenergic receptor activity of the feline urinary bladder and urethra in the normal state and after hypogastric and/or parasympathetic denervation. Scand J Urol Nephrol 1976; 10:177-184.
228. de Groat WC, Kawatani M. Reorganization of sympathetic preganglionic connections in cat bladder ganglia following parasympathetic denervation. J Physiol 1989; 409:431-449.
229. Sundin T, Dahlström A, Norlen L, Svedmyr N. The sympathetic innervation and adrenoceptor function of the human lower urinary tract in the normal state and after parasympathetic denervation. Invest Urol 1977; 14:322-328.
230. Polak JM, Bloom SR. Localisation and measurement of VIP in the genitourinary system of man and animals. Peptides 1984; 5:225-230.
231. Crowe R, Burnstock G, Light JK. Adrenergic innervation of the striated muscle of the intrinsic external urethral sphincter from patients with lower motor spinal cord lesion. J Urol 1989; 141:47-49.
232. Elbadawi A, Atta MA. Intrinsic neuromuscular defects in the neurogenic bladder: V. Autonomic re-innervation of the male feline rhabdosphincter following somatic denervation by bilateral sacral ventral rhizotomy. Neurourol Urodyn 1986; 5:65-85.
233. Flood HD, Downie JW, Awad SA. Urethral function after chronic cauda equina lesion in cats. II. the role of autonomically-innervated smooth and striated muscle in distal sphincter dysfunction. J Urol 1990; 144:1029-1035.
234. Dail WG, Walton G, Olmsted MP. Penile erection in the rat: stimulation of the hypogastric nerve elicits increases in penile pressure after chronic interruption of the sacral parasympathetic outflow. J Auton Nerv Syst 1989; 28:251-258.
235. Kihara K, Kakizaki H, de Groat WC. Reorganization of the innervation of the vas deferens after sympathetic decentralization. Am J Physiol 1996; 271:R1481-R1488.
236. Weiss HD. The physiology of human penile erection. Ann Intern Med 1972; 76:793-799.
237. Nickell K, Boone TB. Peripheral neuropathy and peripheral nerve injury. Urol Clin North Am 1996; 23:491-500.
238. Dupont MC, Persson K, Spitsbergen J, Tuttle JB, Steers WD. The neuronal response to bladder outlet obstruction, a role for NGF. Adv Exp Med Biol 1995; 385:41-54.
239. Gabella G, Uvelius B. Effect of decentralization or contralateral ganglionectomy on obstruction-induced hypertrophy of rat urinary bladder muscle and pelvic ganglion. J Neurocytol 1993; 22:827-834.
240. Steers WD, Creedon DJ, Tuttle JB. Immunity to nerve growth factor prevents afferent plasticity following urinary bladder hypertrophy. J Urol 1996; 155:379-385.
241. Steers, WD, Ciambotti, J, Erdman, S, de Groat WC. Morphological plasticity in efferent pathways to the urinary bladder of the rat following urethral obstruction. J Neurosci 1990; 10:1943-1951.
242. Steers WD, Kolbeck S, Creedon D, Tuttle JB. Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest 1991; 88:1709-1715.
243. Perlberg S, Caine M. Adrenergic response of bladder muscle in prostatic obstruction. Urology 1982; 20:524-527.
244. Sjögren C, Andersson K-E, Husted S, Mattiasson A, Möller-Madsen B. Atropine resistance of transmurally stimulated isolated human bladder muscle. J Urol 1982; 128:1368-1371.
245. Smith DJ, Chapple CR. In vitro response of human bladder smooth muscle in unstable obstructed male bladders: a study of pathophysiological causes. Neurourol Urodyn 1994; 13:411-415.
246. Burnstock G. Purinergic signalling in lower urinary tract. In: Abbracchio MP, Williams M, eds. Handbook of Experimental Pharmacology, Vol. 151/I. Purinergic and Pyrimidinergic Signalling I—Molecular, Nervous and Urinogenitary System Function. Berlin: Springer-Verlag, 2001:423-514.
247. Palea S, Artibani W, Ostardo E, Trist DG, Pietra C. Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis. J Urol 1993; 150:2007-2012.
248. Wammack R, Weihe E, Dienes H-P, Hohenfeller R. Die neurogene Blase in vitro. Akt Urol 1995; 26:16-18.
249. Elbadawi A. Interstitial cystitis: a critique of current concepts with a new proposal for pathologic diagnosis and pathogenesis. Urology 1997; 49(suppl 5A):14-40.
250. Lowe EM, Anand P, Terenghi G, Williams-Chestnut RE, Sinicropi DV. Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis. Br J Urol 1997; 79:572-577.
251. Elbadawi A, Light JK. Distinctive ultrastructural pathology of nonulcerative interstitial cystitis. Urol Int 1996; 56:137-162.
252. Christmas TJ, Rode J, Chapple CR, Milroy EJG, Turner-Warwick RT. Nerve fibre proliferation in interstitial cystitis. Virchows Arch A 1990; 416:447-451.
253. Hofmeister MA, Fang H, Ratliff TL, Mahoney T, Becich MJ. Mast cells and nerve fibers in interstitial cystitis (IC): an algorithm for histologic diagnosis via quantitative image analysis and morphometry (QIAM). Urology 1997; 49(suppl 5A):41-47.
254. Vizzard MA, Erdman SL, de Groat WC. Increased expression of neuronal nitric oxide synthase in bladder afferent pathways following chronic bladder irritation. J Comp Neurol 1996; 370:191-202.
255. Dmitrieva N, Shelton D, Rice ASC, McMahon SB. The role of nerve growth factor in a model of visceral inflammation. Neuroscience 1997; 78:449-459.
256. Dmitrieva N, McMahon SB. Sensitisation of visceral afferents by nerve growth factor in the adult rat. Pain 1996; 66:87-97.
257. Patra PB, Westfall DP. Potentiation of purinergic neurotransmission in guinea pig urinary bladder by histamine. J Urol 1994; 151:787-790.
258. Patra PB, Westfall DP. Potentiation by bradykinin and substance P of purinergic neurotransmission in urinary bladder. J Urol 1996; 156:532-535.
259. Burnstock G. A unifying purinergic hypothesis for the initiation of pain. Lancet 1996; 347:1064-1065.
260. Burnstock G. P2X receptors in sensory neurones. Br J Anaesth 2000; 84:476-488.
261. 3-deficient mice. Nature 2000; 407:1011-1015.
262. Lincoln J, Crowe R, Burnstock G. Neuropeptides and impotence. In: Kirby RS, Carson C, Webster GD, eds. Impotence: Diagnosis and Management of Male Erectile Dysfunction. Oxford: Butterworth-Heinemann Ltd., 1991:3-18.
263. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 1989; 320:1025-1030.
264. Azadzoi KM, Saenz de Tejada I. Diabetes mellitus impairs neurogenic and endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. J Urol 1992; 148:1587-1591.
265. Lincoln J, Crowe R, Blacklay PF, Pryor JP, Lumley JSP, Burnstock G. Changes in VIPergic, cholinergic and adrenergic innervation of human penile tissue in diabetic and non-diabetic impotent males. J Urol 1987; 137:1053-1059.
266. Pickard RS, Powell PH, Zar MA. Nitric oxide and cyclic GMP formation following relaxant nerve stimulation in isolated human corpus cavernosum. Br J Urol 1995; 75:516-522.
267. Choi YD, Mah SY, Xin ZC, Choi HK. The distribution of nitric oxide synthase in human corpus cavernosum on various impotent patients. Yonsei Med J 1997; 38:125-132.
268. Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, Osterloh IH, Gingell C. Sildenafil an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impotence Res 1996; 8:47-52.
269. Lazzeri, M, Barbanti G, Beneforti P, Turini D. Intraurethrally infused capsaicin induces penile erection in humans. Scand J Urol Nephrol 1994; 28:409-412.
270. Stief CG, Wetterauer U, Schaebsdau FH, Jonas U. Calcitonin-gene-related peptide: a possible role in human penile erection and its therapeutic application in impotent patients. J Urol 1991; 146:1010-1014.
271. Koch TR, Carney JA, Go L, Go VL. Idiopathic chronic constipation is associated with decreased colonic vasointestinal peptide. Gastroenterology 1988; 94:300-310.
272. Milner P, Crowe R, Kamm MA, Lennard-Jones JE, Burnstock G. Vasoactive intestinal polypeptide levels in sigmoid colon in idiopathic constipation and diverticular disease. Gastroenterology 1990; 99:666-675.
273. Lincoln J, Crowe R, Kamm MA, Burnstock G, Lennard-Jones JE. Serotonin and 5-hydroxyindoleacetic acid are increased in the sigmoid colon in severe idiopathic constipation. Gastroenterology 1990; 98:1219-1225.
274. Hutson JM, Chow CW, Borg J. Intractable constipation with a decrease in substance P immunoreactive fibres: is it a variant of neuronal intestinal dysplasia? J Ped Surg 1996; 31:580-583.
275. Tzavella K, Riepl RL, Klauser AG, Voderholzer WA, Schindlbeck NE, Lissner SA. Decreased substance P levels in rectal biopsies from patients with slow transit constipation. Eur J Gastroenterol Hepatol 1996; 8:1207-1211.
276. Gattuso JM, Hoyle CHV, Milner P, Kamm MA, Burnstock G. Enteric innervation in idiopathic megarectum and megacolon. Int J Colorect Dis 1996; 11:264-271.
277. Ralevic V, Burnstock G. Neuropeptides in blood pressure control In: Laragh JH, Bremmer BM, eds. Hypertension: Pathophysiology, Diagnosis, and Management. 2d ed. New York: Raven Press, 1995:801-831.
278. Brock JA, Van Helden DF, Dosen P, Rush R. Prevention of high blood pressure by reducing sympathetic innervation in the spontaneously hypertensive rat. J Auton Nerv Syst 1996; 61:97-102.
279. Vidal M, Hicks PE, Langer SZ. Differential effects of a,ß-methylene ATP on responses to nerve stimulation in SHR and WKY tail arteries. Naunyn Schmeider-bergs Arch Pharmacol 1986; 332:384-390.
280. Brock JA, Van Helden DF. Enhanced excitatory junction potentials in mesenteric arteries from spontaneously hypertensive rats. Pflügers Arch Eur J Physiol 1995; 430:901-908.
281. Thulin T, Erlinge D. Neuropeptide Y and hypertension. Nutrition 1995; 11:495-497.
282. Lind H, Erlinge D, Brunkwall J, Edvinsson L. Attenuation of contractile responses to sympathetic co-transmitters in veins from subjects with essential hypertension. Clin Auton Res 1997; 7:69-76.
283. 4 receptors (abstr). Br J Pharmacol 1998; 123:59P.
284. Schriffin EL. Endothelin: potential role in hypertension and vascular hypertrophy. Hypertension 1995; 25:1135-1143.
285. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362:801-809.
286. Burnstock G, Stewart-Lee A, Brizzolara A, Tomlinson A, Corr A. Dual control of nerves and endothelial cells of arterial blood flow in atherosclerosis. In: Wissler RW, Bond MG, Mercuri M, Tanganelli P, eds. Atherosclerotic Plaques. New York: Plenum Press, 1991:285-292.
287. Verbeuren TJ, Simonet S, Herman AG. Diet-induced atherosclerosis inhibit release of noradrenaline from sympathetic nerves in rabbit arteries. Eur J Pharmacol 1994; 270:27-34.
288. Stewart-Lee A, Aberdeen J, Burnstock G. The effect of atherosclerosis on neuromodulation of sympathetic neurotransmission by neuropeptide Y and calcitonin gene-related peptide in the rabbit mesenteric artery. Eur J Pharmacol 1992; 216:167-174.
289. Matucci-Cerinic M, Peitrini U, Marabini S. Local venomotor response to intravenous infusion of substance P and glyceryl trinitrate in systemic sclerosis. Clin Exp Rheumatol 1990; 8:561-565.
290. Klimiuk PS, Taylor L, Baker RD, Jayson MIV. Autonomic neuropathy in systemic sclerosis. Ann Rheum Dis 1988; 47:542-545.
291. Dessein P, Joffe B, Metz R, Millar D, Lawson M, Stenwicks A. Autonomic dysfunction in systemic sclerosis: sympathetic overactivity and instability. Am J Med 1992; 93:143-150.
292. Bunker CB, Terenghi G, Springall DR, Polak JM, Dowd PM. Deficiency of calcitonin gene-related peptide in Raynaud’s phenomenon. Lancet 1993; 336:1530-1533.
293. Dowd P, Goldsmith P, Bull H, Burnstock G, Foreman J, Marshall I. Grand round: Raynaud’s phenomenon. Lancet 1995; 346:283-290.
294. Luft D, Pagallies OB, Konz K, Mann K, Renn W, Eggstein M. Differential diagnosis of neuropathic lesions in diabetic and alcoholic patients. Clin Invest 1994; 72:200-205.
295. McDougall AJ, McLeod JG. Autonomic neuropathy I: clinical features, investigation, pathophysiology and treatment. J Neurol Sci 1996; 137:79-88.
296. Ewing J, Clarke BF. Diabetic autonomic neuropathy: present insights and future prospects. Diabetes Care 1986; 9:648-665.
297. Crowe R, Lincoln J, Blacklay PF, Pryor JP, Lumley JSP, Burnstock G. VIP-like-im-munoreactive nerves in diabetic penis: a comparison between human and streptozo-tocin-diabetes in rats. Diabetes 1983; 32:1075-1077.
298. Belai A, Lincoln J, Milner P, Burnstock G. Progressive changes in adrenergic, serotonergic and peptidergic nerves in proximal colon of streptozotocin-diabetic rats. Gastroenterology 1988; 95:1234-1241.
299. Properzi G, Francavilla S, Poccia G, Aloisi P, Gu X-H, Terenghi G, Polak JM. Early increase precedes a depletion of VIP and PGP9.5 in the skin of insulin-dependent diabetics—correlation between quantitative immunohistochemistry and clinical assessment of peripheral neuropathy. J Pathol 1993; 169:269-277.
300. Belai A, Lincoln J, Burnstock G. Lack of release of vasoactive intestinal polypeptide and calcitonin gene-related peptide during electrical stimulation of enteric nerves in streptozotocin-diabetic rats. Gastroenterology 1987; 93:1034-1040.
301. Lagnado MLJ, Crowe R, Lincoln J, Burnstock G. Reduction of nerves containing vasoactive intestinal polypeptide and serotonin, but not neuropeptide Y and catecholamine, in cerebral blood vessels of the 8 week streptozotocin-induced diabetic rat. Blood Vessels 1987; 24:169-180.
302. Lincoln J, Bokor J, Crowe R, Griffith SG, Haven AJ, Burnstock G. The myenteric plexus in streptozotocin-treated rats: neurochemical and histochemical evidence for diabetic neuropathy in the gut. Gastroenterology 1984; 86:654-661.
303. Belai A, Lincoln J, Milner P, Crowe R, Loesch A, Burnstock G. Enteric nerves in diabetic rats: increase in vasoactive intestinal polypeptide but not substance P Gastroenterology 1985; 89:967-976.
304. Belai A, Lincoln J, Milner P, Burnstock G. Differential effect of streptozotocin-in-duced diabetes on the innervation of the ileum and distal colon. Gastroenterology 1991; 100:1024-1032.
305. Horrobin DF, Carmichael HA. Essential fatty acids in relation to diabetes. In: Hor-robin DF, ed. Treatment of Diabetic Neuropathy: A New Approach. London: Churchill Livingstone, 1992:21-39.
306. Cameron NE, Cotter MA. Potential therapeutic approaches to the treatment or prevention of diabetic neuropathy: evidence from experimental studies. Diabet Med 1993; 10:593-605.
307. Cameron NE, Cotter MA. Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. Diabetes 1997; 46(suppl 2):S31-S37.
308. Stevens MJ, Feldman EL, Greene DA. The aetiology of diabetic neuropathy: the combined roles of metabolic and vascular defects. Diabet Med 1995; 12:566-579.
309. Rösen P, Ballhausen T, Bloch W, Addicks K. Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant. Di-abetologia 1995; 38:1157-1168.
310. Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care 1996; 19:257-267.
311. Ziegler D, Gries FA. a-Lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes 1997; 46(suppl 2):S62-S66.