The distribution of nitric oxide synthase in human corpus cavernosum on various impotent patients

Yonsei Medical Journal

Volumn 38, Issue 3, 1997, Pages 125-132

  Choi, Young Deuk ^a,b   Mah, Sang Yol ^a   Xin, Zhong Cheng ^a   Choi, Hyung Ki ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Erection; Human; Impotence; Nitric oxide; Nitric oxide synthase

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; ENZYME LOCALIZATION; HUMAN; IMPOTENCE; MAJOR CLINICAL STUDY; MALE; NERVE FIBER; PENIS ERECTION; SMOOTH MUSCLE RELAXATION;

EID: 8544261081     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.1997.38.3.125     Document Type: Article

References (26)

1. Bishop AE, Carlei F, Lee V, Trojanowski J, Marangos PJ, Dahl D, Polak LM: Combined immunostaining of neurofilaments, neuron specific enolase, GFAP and S-100. A possible means for assessing the morphological and functional status of the enteric nervous system. Histochemistry 82: 93-97, 1985
2. Bredt DS, Snyder SH: Isolation of nitric oxide synthase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 87: 682-685, 1990
3. Brock G, Nunes L, Padma-Nathan H, Boyd S, Lue TF: Nitric oxide synthase: a new diagnostic tool for neurogenic impotence. Urology 42: 412-417, 1993
4. Burnett AL, Lowenstein CJ, Bredt DS, Chang TSK, Snyder SH: Nitric oxide: a physiologic mediator of penile erection. Science 257: 401-403, 1992
5. Burnett AL, Ricker DD, Chamness SL, Maguire MP, Crone JK, Bredt DS, Snyder SH, Chang TS: Localization of nitric oxide synthase in the reproductive organs of the male rat. Biol Reprod 52: 1-7, 1995
6. Burnett AL, Tillman SL, Chang TSK, Epstein JI, Lowenstein CJ, Bredt DS, Snyder SH, Walsh PC: Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis. J Urol 150: 73-76, 1993
7. Bush PA, Aronson WJ, Buga GM, Rajfer J, Ignarro LJ: Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. J Urol 147: 1650-1655, 1992
8. Carrier S, Zavara P, Nunes L, Kour NW, Rehman J, Lue TF: Regeneration of nitric oxide synthase-containing nerves after cavernous nerve neurotomy in the rat. J Urol 153: 1722-1727, 1995
9. Dawson TM, Bredt DS, Fotuhi M, Hwang PM, Synder SH: Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci USA 88: 7797-7801, 1991
10. Garban H, Vernet D, Freedman A, Rajfer J, Gonzalez-Cadavid NF: Effect of aging on nitric oxide-mediated penile erection in rats. Am J Physiol 268: H467-475, 1995
11. G-nitro-L-arginine on the erectile response to cavernous nerve stimulation in the rabbit. Acta Physiol Scand 143: 299-304, 1991
12. Hope BT, Michael GJ, Knigge KM, Vincent SR: Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci USA 88: 2811-2814, 1991
13. Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM, Rajfer J: Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun 170: 843-850, 1990
14. Junemann KP, Buhrle CP, Stief CG: Current trends in corpus cavernosum EMG. Int J Impot Res 5: 105-110, 1993
15. Kim N, Azadzoi KM, Goldstein I, Saenz de Tejada I: A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J Clin Invest 88: 112-118, 1991
16. Kim N, Vardi Y, Padman-Nathan H, Daley J, Goldstein I, Saenz de Tejada I: Oxygen tension regulates the nitric oxide pathway, physiologic role in penile erection. J Clin Invest 91: 437-442, 1993
17. Lavoisier P, Proulx J, Courtois F, De Carufel F: Bulbocavernous reflex: its validity as a diagnostic test of neurogenic impotence. J Urol 141: 311-314, 1989
18. Lerner SE, Melman A, Christ GJ: A review of erectile dysfunction: new insights and more questions. J Urol 149: 1246-1255, 1993
19. Lugg JA, Gonzalez-Cadavid NF, Rajfer J: The role of nitric oxide in erectile function. Am Soc Androl 16: 2-4, 1995
20. Moncada S: The L-arginine: nitric oxide pathway. Acta Physiol Scand 145: 201-227, 1992
21. Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ: Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, non-cholinergic neurotransmission. N Engl J Med 326: 90-94, 1992
22. Saenz de Tejada I, Blanco R, Goldstein I, Azadzoi K, Morenas A, Krane RJ, Cohen R: Cholinergic neurotransmission in human corpus cavernosum. I. Responses of isolated tissue. Am J Physiol 254: H459-467, 1988
23. Stief CG, Djamilian M, Anton P, de Riese W, Allohoff EP, Jonas U: Single potential analysis of cavernous electrical activity in impotent patient: possible diagnostic method for autonomic cavernous dysfunction and cavernous smooth muscle degeneration. J Urol 146: 771-776, 1991
24. Vernet D, Cai L, Garban H, Babbitt ML, Murray FT, Rajfer J, Gonzalez-Cadavid NF: Reduction of penile nitric oxide synthase in diabetic BB/WOdp (type I) and BBZ/WORdp (type II) rats with erectile dysfunction. Endocrinology 136: 5709-5717, 1995
25. Vincent SR, Hope BT: Neurons that say NO. Trends Neurosci 15: 108-113, 1992
26. Zavara P, Siofi R, Schipper HM, Begin LR, Brock GB: Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erection model. Int J Impot Res 7: 209-219, 1995