Metabolic and vascular factors in the pathogenesis of diabetic neuropathy

Diabetes

Volumn 46, Issue SUPPL. 2, 1997, Pages

  Cameron, Norman E ^a   Cotter, Mary A ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

17,20 DIMETHYL 7 THIAPROSTAGLANDIN E1 METHYL ESTER; 2 ETHYL 4 [2' (1H TETRAZOL 5 YL)BIPHENYL 4 YLMETHOXY]QUINOLINE; 5 DIMETHYLAMINO N (3,4 DIMETHYL 5 ISOXAZOLYL) 1 NAPHTHALENESULFONAMIDE; ALDOSE REDUCTASE INHIBITOR; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BERAPROST; BOSENTAN; CALCIUM CHANNEL BLOCKING AGENT; CARNITINE; CARVEDILOL; CILOSTAZOL; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DOXAZOSIN; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; FREE RADICAL; GAMMA LINOLENIC ACID; GUANETHIDINE; ICOSANOID; ILOPROST; ISOSORBIDE DINITRATE; LIMAPROST; LISINOPRIL; NIFEDIPINE; NIMODIPINE; NITRIC OXIDE; OMEGA 6 FATTY ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASODILATOR AGENT; ZD 7155;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; DIABETIC NEUROPATHY; HYPERGLYCEMIA; NERVE CONDUCTION; NERVE DEGENERATION; NERVE INJURY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; VASODILATATION;

EID: 0030923990     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.2.s31     Document Type: Conference Paper

References (56)

1. Greene DA, Lattimer-Greene S, Sima AAF: Pathogenesis and prevention of diabetic neuropathy. Diabetes Metab Rev 4:201-221, 1988
2. Low PA: Recent advances in the pathogenesis of diabetic neuropathy. Muscle Nerve 10:121-128, 1987
3. Cameron NE, Cotter MA: The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications. Diabetes Metab Rev 10:189-224, 1994
4. Vinik AI, Newlon PG, Lauterio TJ, Liuzzi FJ, Depto AS, Pittenger GL, Richardson DW: Nerve survival and regeneration in diabetes. Diabetes Rev 3:139-157, 1995
5. Rabinowe SL: Immunology of diabetic and polyglandular neuropathy. Diabetes Metab Rev 6:169-188, 1990
6. Tilton RG, Chang K, Nyengaard JR, Van Den Enden M, Ido Y, Williamson JR: Inhibition of sorbitol dehydrogenase: effects on vascular and neural dysfunction in streptozotocin-induced diabetic rats. Diabetes 44:234-242, 1995
7. Cotter MA, Love A, Watt MJ, Cameron NE, Dines KC: Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats. Diabetologia 38:1285-1294, 1995
8. Cameron NE, Cotter MA: Reversal of peripheral nerve conduction and perfusion deficits by the free radical scavenger, BM15.0639, in diabetic rats. Naunyn Schmiedebergs Arch Pharmacol 352:685-690, 1995
9. Tuck RR, Schmelzer JD, Low PA: Endoneurial blood flow and oxygen tension in the sciatic nerves of rats with experimental diabetic neuropathy. Brain 107:935-950, 1984
10. Cameron NE, Cotter MA, Dines KC, Maxfield EK, Carey F, Mirrlees DJ: Aldose reductase inhibition, nerve perfusion, oxygenation and function in strepto zotocin-diabetic rats: dose-response considerations and independence from a myo-inositol mechanism. Diabetologia 37:651-663, 1994
11. Cameron NE, Cotter MA, Archibald V, Dines KC, Maxfield EK: Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats. Diabetologia 37:449-459, 1994
12. Maxfield EK, Cameron NE, Cotter MA, Dines KC: Angiotensin n receptor blockade improves nerve function, modulates nerve blood flow and stimulates endoneurial angiogenesis in streptozotocin-diabetic rats. Diabetologia 36:1230-1237, 1993
13. Tesfaye S, Malik R, Ward JD: Vascular factors in diabetic neuropathy. Diabetologia 37:847-854, 1994
14. Low PA, Lagerlund TD, McManis PG: Nerve blood flow and oxygen delivery in normal, diabetic and ischemic neuropathy. Int Rev Neurobiol 31:355-438, 1989
15. Cameron NE, Cotter MA, Dines KC, Maxfield EK: Pharmacological manipulation of vascular endothelium in non-diabetic and streptozotocin-diabetic rats: effects on nerve conduction, hypoxic resistance and endoneurial capillarization. Diabetologia 36:516-522, 1993
16. 1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats, comparison with aldose reductase inhibitor ONO 2235. Diabetes 38:832-338, 1989
17. Cotter MA, Dines KC, Cameron NE: Prevention and reversal of motor and sensory peripheral nerve conduction abnormalities in streptozotocin-diabetic rats by the prostacyclin analogue Uoprost. Naunyn Schmiedebergs Arch Pharmacol 347:534-540, 1993
18. +-ATPase activity and vascular supply in STZD rats. Diabetes 40:1652-1658, 1991
19. Cotter MA, Cameron NE: Neuroprotective effects of carvedilol in diabetic rats: prevention of defective peripheral nerve perfusion and conduction velocity. Naunyn Schmiedebergs Arch Pharmacol 351:630-635, 1995
20. Cameron NE, Cotter MA, Robertson S: Angiotensin converting enzyme inhibition prevents the development of muscle and nerve dysfunction and stimulates angiogenesis in streptozotocin-diabetic rats. Diabetologia 35:12-18, 1992
21. 1 receptor antagonist. Am J Physiol 269:E530-E537, 1995
22. Robertson S, Cameron NE, Cotter MA: The effect of the calcium antagonist nifedipine on peripheral nerve function in streptozotocin-diabetic rats. Diabetologia 35:1113-1117, 1992
23. 2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat. Br J Pharmacol 111:887-893, 1994
24. Cameron NE, Cotter MA: Effects of chronic treatment with a nitric oxide donor on nerve conduction abnormalities and endoneurial blood flow in streptozotocin-diabetic rats. Eur J Clin Invest 25:19-24, 1995
25. Cameron NE, Dines KC, Cotter MA: The potential contribution of endothelin-1 to neurovascular abnormalities in streptozotocin-diabetic rats. Diabetologia 37:1209-1215, 1994
26. Stevens EJ, Tomlinson DR: Effects of endothelin receptor antagonism with bosentan on peripheral nerve function in experimental diabetes. Br J Pharmacol 115:373-379, 1995
27. Cameron NE, Cotter MA: Endothelin antagonism corrects neurovascular deficits in diabetic rats: interaction with angiotensin II blockade (Abstract). Eur J Clin Invest 26 (Suppl. 1):A48, 1996
28. Hotta N, Kakuta H, Fukasawa H, Koh N, Sakakibara F, Komori H, Sakamoto N: Effect of niceritol on streptozocin-induced diabetic neuropathy in rats. Diabetes 41:587-591, 1992
29. Kihara M, Schmelzer JD, Low PA: Effect of cilostazol on experimental diabetic neuropathy in the rat. Diabetologia 38:914-918, 1995
30. Shindo H, Tawata M, Aida K, Onaya T: Clinical efficacy of a stable prostacyclin analog, iloprost, in diabetic neuropathy. Prostaglandins 41:85-96, 1991
31. Reja A, Tesfaye S, Harris ND, Ward JD: Is ACE inhibition with lisinopril helpful in diabetic neuropathy? Diabetic Med 12:307-309, 1995
32. Ward KK, Low PA, Schmelzer JD, Zochodne DW: Prostacyclin and noradrenaline in peripheral nerve of chronic experimental diabetes in rate. Brain 112:197-208, 1989
33. Cameron NE, Cotter MA: Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: role of polyol pathway activity. Diabetologia 35:1011-1019, 1992
34. Kihara M, Zollman PJ, Smithson IL, Lagerlund TD, Low PA: Hypoxic effect of exogenous insulin on normal and diabetic peripheral nerve. Am J Physiol 266:E980-E985, 1994
35. Stevens MJ, Lattimer SA, Kamijo M, Van Huysen C, Sima AAF, Greene DA: Osmotically induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy. Diabetologia 36:608-614, 1993
36. Brownlee M: Glycation products and the pathogenesis of diabetic complications. Diabetes Care 15:1835-1843, 1992
37. Hotta N, Kaskuta H, Fukasawa H, Koh N, Sakakibara F, Nakamura J, Hamada Y, Wakao T, Hara T, Mori K, Naruse K, Nakashima E, Inukai S, Sakamoto N: Effect of a potent new aldose reductase inhibitor (5-(3-thienyl)tetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats. Diabetes Res Clin Pract 27:107-117, 1995
38. +)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat. J Clin Invest 94:853-859, 1994
39. Cameron NE, Cotter MA, Hohman TC: Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. Diabetologia 39:172-182, 1996
40. Jefferys JRG, Palmano KP, Sharma AK, Thomas PK: Influence of dietary myoinositol on nerve conduction and phospholipids in normal and diabetic rats. J Neural Neurosurg Psychiatry 41:333-339, 1978
41. Cameron NE, Cotter MA, Robertson S: The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats. Q J Exp Physiol 74:917-926, 1989
42. Sredy J, Flam BR, Sawicki DR: Adenosine triphosphatase activity in sciatic nerve tissue of streptozocin-induced diabetic rats with and without high dietary sucrose: effects of aldose reductase inhibitors. Proc Soc Exp Biol Med 197:135-142, 1991
43. Cameron NE, Basso M, Hohman TC, Cotter MA: Comparison of sorbitol dehydrogenase and aldose reductase inhibitor effects on nerve blood flow, conduction velocity and polyol pathway metabolites in diabetic and nondiabetic rats (Abstract). Diabetes 45 (Suppl. 2): 211A, 1996
44. Dines KC, Cotter MA, Cameron NE: Nerve function in galactosaemic rats: effects of evening primrose oil and doxazosin. Eur J Pharmacol 281:303-309, 1995
45. 2 in human umbilical vein endothelial cells cultured in high glucose medium. Diabetologia 37:264-269, 1994
46. Bravenboer B, Kapelle AC, Hamers FPT, van Buren T, Erkelens DW, Gispen WH: Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat. Diabetologia 35:813-817, 1992
47. Cameron NE, Cotter MA, Archibald V: Chronic N-acetyl-L-cysteine treatment prevents impaired endothelium-dependent relaxation and improves peripheral nerve blood flow and conduction in diabetic rats (Abstract). Eur J Clin Invest 25 (Suppl. 2):A9, 1995
48. Baynes JW: Role of oxidative stress in the development of complications in diabetes. Diabetes 40:405-412, 1991
49. Cotter MA, Cameron NE: Reversal of neurovascular dysfunction by chronic antioxidant and aminoguanidine treatments in anaesthetized diabetic rats: modulation by nitric oxide synthase inhibition (Abstract). J Physiol 491P:16P, 1996
50. Cameron NE, Cotter MA: Neurovascular dysfunction in diabetic rats: potential contribution of autoxidation and free radicals examined using transition metal chelating agents. J Clin Invest 96:1159-1163, 1995
51. Kihara M, Schmelzer JD, Poduslo JF, Curran FF, Nickander KK, Low PA: Aminoguanidine effect on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals. Proc Natl Acad Sci USA 88:6107-6111, 1991
52. Dines KC, Cotter MA, Cameron NE: Contrasting effects of treatment with ω-3 and ω-6 essential fatty acids on peripheral nerve function and capillarization in streptozotocin-diabetic rats. Diabetologia 36:1132-1138, 1993
53. Cameron NE, Cotter MA: Effects of evening primrose oil treatment on sciatic nerve blood flow and endoneurial oxygen tension in streptozotocin-diabetic rats. Acta Diabetol 31:220-225, 1994
54. Dines KC, Cotter MA, Cameron NE: Comparison of the effects of evening primrose oil and triglycerides containing γ-linolenic acid on nerve conduction and blood flow in diabetic rats. J Pharmacol Exp Ther 273:49-55, 1995
55. Cotter MA, Cameron NE, Keegan A, Dines KC: Effects of acetyl- and proprionyl-L-carnitine on peripheral nerve function and vascular supply in experimental diabetes. Metabolism 44:1209-1214, 1995
56. Cameron NE, Cotter MA: Effects of chronic ascorbyl-γ-linolenic acid treatment on sciatic nerve blood flow and conduction in anaesthetized diabetic rats (Abstract). J Physiol 491P:16P-17P, 1996