Interstitial cystitis: A critique of current concepts with a new proposal for pathologic diagnosis and pathogenesis

Urology

Volumn 49, Issue 5 SUPPL., 1997, Pages 14-40

  Elbadawi, Ahmad ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLADDER DISTENSION; CELL INFILTRATION; CYSTOSCOPY; DETRUSOR MUSCLE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INTERSTITIAL CYSTITIS; MAST CELL; NERVE EXCITABILITY; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SENSORY NERVE;

EID: 0030945199     PISSN: 00904295     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-4295(99)80329-X     Document Type: Article

References (258)

1. Sant GR: Interstitial cystitis: pathophysiology, clinical evaluation, and treatment, in Rous SN (ed): Urology Annual, Vol. 3. Norwalk, Appleton & Lange, 1989, pp 171-196.
2. Sant GR: Interstitial cystitis, in Stamey TA (ed): 1991 Monographs in Urology, Vol. 12. Montverde, Medical Directions Publishing Co., 1991, pp 37-63.
3. Sant GR, and Theoharides TC: The role of the mast cell in interstitial cystitis. Urol Clin North Am 21: 41-53, 1994.
4. Messing EM: The diagnosis of interstitial cystitis. Urology 29(suppl): 4-7, 1987.
5. Hanno PM: Diagnosis of interstitial cystitis. Urol Clin North Am 21: 63-66, 1994.
6. Messing EM: Interstitial cystitis and related syndromes, in Walsh PC, Retik AB, Stamey TA, and Vaughan ED Jr (eds): Campbell's Urology, Vol. 1, 6th ed. Philadelphia, WB Saunders Co, 1992, pp 982-1005.
7. Gillenwater JY, and Wein AJ: Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases workshop on interstitial cystitis. J Urol 140: 203-206, 1988.
8. Wein AJ, Hanno PM, and Gillenwater JY: Interstitial cystitis: an introduction to the problem, in Hanno PM, Staskin DR, Krane RJ, and Wein AJ (eds): Interstitial Cystitis. London, Springer-Verlag, 1990, pp 3-15.
9. Wein AJ, and Broderick GA: Interstitial cystitis: current and future approaches to diagnosis and treatment. Urol Clin North Am 21: 153-161, 1994.
10. Hunner GL: A rare type of bladder ulcer in women: report of cases. Trans South Surg Gynecol Assoc 27: 247-292, 1914.
11. Fall M, Johansson SL, and Vahlne A: A clinicopathologic and virologic study of interstitial cystitis. J Urol 133: 771-773, 1985.
12. Hanno P, Levin RM, Monson FC, Teuscher C, Zhou ZZ, Ruggieri M, Whitmore K, and Wein AJ: Diagnosis of interstitial cystitis. J Urol 143: 278-281, 1990.
13. Messing EM, and Stamey TA: Interstitial cystitis; early diagnosis, pathology, and treatment. Urology 12: 381-392, 1978.
14. Messing EM, Pauk D, Schaeffer AJ, Nieweglowski M, Nyberg LM Jr, Landis JR, Matthews YL, Simon LJ, and the ICDB Study Group: Correlating cystoscopic findings with symptoms and physical exam findings for women with interstitial cystitis. J Urol 155(5, suppl): 438A, 1995.
15. Wein AJ, Nigro DA, Foy M, Parsons CL, Williams M, Nyberg LM, Landis JR, Matthews YL, Simon LJ, and the ICDB Study Group: Associations among cystoscopic and urodynamic findings for women enrolled in the interstitial cystitis data base (ICDB). J Urol 155(5, suppl): 439A, 1995.
16. Smith BH, and Dehner LP: Chronic ulcerating interstitial cystitis (Hunner's ulcer): a study of 28 cases. Arch Path 93: 76-81, 1972.
17. Shanberg AM, and Malloy T: Treatment of interstitial cystitis with the neodymium:YAG laser. Urology 29(suppl): 31-33, 1987.
18. Holm-Bentzen M, and Lose G: Pathology and pathogenesis of interstitial cystitis. Urology 29(suppl): 8-13, 1987.
19. Holm-Bentzen M, Jacobsen F, Nerstrøm, Lose G, Kristensen JK, Pedersen RH, Krarup JF, Bates P, Barnard R, Larsen S, and Hald T: Painful bladder disease: clinical and pathoanatomical differences in 115 patients. J Urol 138: 500-502, 1987.
20. Lépinard V, Saint-André JP, and Rognon LM: La cystite interstitielle: aspects actuels. J Urol (Paris) 90: 455-465, 1984.
21. Fall M, Johansson SL, and Aldenborg F: Interstitial cystitis: a heterogeneous syndrome. J Urol 137: 35-38, 1987.
22. Johansson SL, and Fall M: Pathology of interstitial cystitis. Urol Clin North Am 21: 55-62, 1994.
23. Johansson SL: Interstitial cystitis. Mod Pathol 6: 738-742, 1993.
24. Gillespie L, Said J, Sostrin S, and Kleiwer K: Immunofluorescent and histochemical staining confirm the identification of the many diseases called interstitial cystitis. Br J Urol 66: 265-273, 1990.
25. Holm-Bentzen M: Pathology and pathophysiology of painful bladder diseases. Urol Int 44: 327-331, 1989.
26. Holm-Bentzen M, Nordling J, and Hald T: Etiology: Etiologic and pathogenetic theories in interstitial cystitis, in Hanno PM, Staskin DR, Krane RJ, and Wein AJ (eds): Interstitial Cystitis. London, Springer-Verlag, 1990, pp 63-77.
27. Witherow RO, Gillespie L, McMullen L, Goldin RD, and Walker MM: Painful bladder syndrome - a clinical and immunopathological study. Br J Urol 64: 158-161, 1989.
28. Jensen H, Nielsen K, and Frimodt-Møller C: Abacterial cystitis in urinary incontinent females. Urol Int 45: 20-24, 1990.
29. Held PJ, Hanno PM, Wein AJ, Pauly MV, and Cahn MA: Epidemiology of interstitial cystitis: 2, in Hanno PM, Staskin DR, Krane RJ, and Wein AJ (eds): Interstitial Cystitis. London, Springer-Verlag, 1990, pp 29-48.
30. Hunner GL: A rare type of bladder ulcer in women: report of cases. Boston Med Surg J 172: 660-664, 1915.
31. Warren JW: Interstitial cystitis as an infectious disease. Urol Clin North Am 21: 31-39, 1994.
32. Elliott TSJ, Slack RCB, and Bishop MC: Scanning electron microscopy of human bladder mucosa in acute and chronic urinary tract infection. Br J Urol 56: 38-43, 1984.
33. Anderström CRK, Fall M, and Johansson SL: Scanning electron microscopic findings in interstitial cystitis. Br J Urol 63: 270-275, 1989.
34. Ratliff TL, Klutke CG, and McDougall EM: The etiology of interstitial cystitis. Urol Clin North Am 21: 21-30, 1994.
35. Maskell R: Are fastidious organisms an important cause of dysuria and frequency? The case for, in Asscher AW, Brumfitt W (eds): Microbial Diseases in Nephrology. London, Wiley, 1986, pp 1-18.
36. Wilkins EGL, Payne SR, Pead PJ, Moss ST, and Maskell RM: Interstitial cystitis and the urethral syndrome: a possible answer. Br J Urol 64: 39-44, 1989.
37. Anderström C, Ekelund P, Hansson H-A, and Johansson SL: Scanning electron microscopy of polypoid cystitis - a reversible lesion of the human bladder. J Urol 131: 242-244, 1984.
38. Domingue GJ, Ghoniem GM, Bost KL, Fermin C, and Human LG: Dormant microbes in interstitial cystitis. J Urol 153: 1321-1326, 1995.
39. Linder H, Engberg I, Baltzer IM, and Svanborg-Edén C: Induction of inflammation by Escherichia coli on the mucosal level: requirement for adherence and endotoxin. Infect Immun 56: 1309-1313, 1988.
40. Domingue GJ, Ghoniem GM, Human L, Johnston K, and Wu K: Bacteriology of urinary bladder tissue and urine in interstitial cystitis. J Urol 155(5, suppl): 432A, 1996.
41. Haarala M, Jalava J, Laato M, Kiilhilma J, Nurmi M, and Alanen A: Absence of bacterial DNA in the bladder of patients with interstitial cystitis. J Urol 156: 1843-1845, 1996.
42. Powell TO: Studies on the etiology of Hunner's ulcer. J Urol 53: 823, 1945.
43. Engel WJ: Interstitial cystitis. Clev Clin Q 6: 307, 1939.
44. Hand JR: Interstitial cystitis: report of 223 cases (204 women, 19 men). J Urol 61: 291-310, 1949.
45. Fister GM: Similarity of interstitial cystitis (Hunner's ulcer) to lupus erythematosus. J Urol 40: 37-51, 1938.
46. Shipton EA: Hunner's ulcer (chronic interstitial cystitis): a manifestation of collagen disease. Br J Urol 37: 443-449, 1965.
47. Oravisto KJ, Alfthan OS, and Joniken EJ: Interstitial cystitis: clinical and immunological findings. Scand J Urol Nephrol 4: 37-42, 1970.
48. Silk MR: Bladder antibodies in interstitial cystitis. J Urol 103: 307-309, 1970.
49. Kárpáti F, Dénes L, and Büttner K: Interstitielle Zystitis = autoimmune Zystitis? Interstitielle Zystitis als Teilkrankheit des Lupus erythematosus. Z Urol Nephrol 68: 633-639, 1975.
50. Chantepie G, Leloire O, Creusy C, Duquesne G, and Vincent G: Polyarthrite rhumatoide et cystopathie interstitielle. Ann Urol 20: 333-334, 1986.
51. Zondek B, and Bromberg YM: Endocrine allergy: clinical reactions of allergy to endogenous hormones and their treatment. J Obstet Gynecol Br Emp 54: 1-19, 1947.
52. Neal DE, Jr., Dilworth J, and Kaack, M: Tamm-Horsfall autoantibodies in interstitial cystitis. J Urol 145: 37-39, 1991.
53. Anderson JB, Parivar F, Lee G, Wallington TB, MacIver AG, Bradbrook RA, and Gingell JC: The enigma of interstitial cystitis - an autoimmune disease? Br J Urol 63: 58-63, 1989.
54. Bade JJ, de Leij L, Joustra EB, Karrenbeld A, and Mensink HJA: Specific auto-antibodies in interstitial cystitis patients suggest an auto-immune etiology. J Urol 155(5, suppl): 431A, 1996.
55. Parsons CL, Schmidt JD, and Pollen JJ: Successful treatment of interstitial cystitis with sodium pentosanpoly-sulfate. J Urol 130: 51-53, 1983.
56. Parsons CL: Bladder surface glycosaminoglycan: efficient mechanism of environmental adaptation. Urology 27: 9-14, 1986.
57. Parsons CL: Sodium pentosanpolysulfate treatment of interstitial cystitis: an update. Urology 29: 14-16, 1987.
58. Mulholland SG, Sant GR, Hanno P, Staskin DR, and Parsons CL: Pentosanpolysulfate sodium for therapy of interstitial cystitis: a double-blind placebo-controlled clinical study. Urology 35: 552-558, 1990.
59. Lilly JD, and Parsons CL: Bladder surface glycosaminoglycans is a human epithelial permeability barrier. Surg Gynecol Obstet 171: 493-496, 1990.
60. Parsons CL, Boychuk D, Jones S, Hurst R, and Callahan H: Bladder surface glycosaminoglycans: an epithelial permeability barrier. J Urol 143: 139-142, 1990.
61. Parsons CL: The therapeutic role of sulfated polysaccharides in the urinary bladder. Urol Clin North Am 21: 93-100, 1994.
62. Parsons CL, Greenspan C, Moore SW, and Mulholland SG: Role of surface mucin in primary antibacterial defense of bladder. Urology 9: 48-52, 1977.
63. Shrom SH, Parsons CL, and Mulholland SG: Role of urothelial surface mucoprotein in intrinsic bladder defense. Urology 9: 526-533, 1977.
64. Parsons CL, and Mulholland SG: Bladder surface mucin. Its antibacterial effect against various bacterial species. Am J Path 93: 423-432, 1978.
65. Parsons CL, Pollen JJ, Anwar H, Stauffer C, and Schmidt JD: Antibacterial activity of bladder surface mucin duplicated in the rabbit bladder by exogenous glycosaminoglycan (sodium pentosanpolysulfate). Infect Immun 27: 876-881, 1980.
66. Parsons CL, Stauffer C, and Schmidt JD: Impairment of antibacterial effect of bladder surface mucins by protamine sulfate. J Infect Dis 144: 180, 1981.
67. Holm-Bentzen M, Ammitzbøll T, and Hald T: Glycosaminoglycans on the surface of the human urothelium: a preliminary report. Neurourol Urodyn 5: 519-523, 1986.
68. Sant GR, Ucci AA Jr, and Alroy J: Bladder surface glycosaminoglycans (GAGs) in interstitial cystitis. J Urol 135(4/ 2): 175A, 1986.
69. Moskowitz MO, Byrne DS, Callahan HJ, Parsons CL, Valderrama E, and Moldwin RM: Decreased expression of a glycoprotein component of bladder surface mucin (GPI) in interstitial cystitis. J Urol 151: 343-345, 1994.
70. Jacob J, Ludgate CM, Forde J, and Tulloch WS: Recent observations on the ultrastructure of human urothelium. 1. Normal bladder of elderly subjects. Cell Tissue Res 193: 543-560, 1978.
71. Monis B, and Zambrano D: Ultrastructure of transitional epithelium of man. Z Zellforsch 87: 101-117, 1968.
72. Hicks RM: The permeability of rat transitional epithelium: keratinization and the barrier to water. J Cell Biol 28: 21-31, 1966.
73. Koss LG: The asymmetric unit membrane of the epithelium of the urinary bladder of the rat: an electron microscopic study of a mechanism of epithelial maturation and function. Lab Invest 21: 154-168, 1969.
74. Chlapowski FJ, Bonneville MA, and Staehlin LA: Lumenal plasma membrane of the urinary bladder. II. Isolation and structure of membrane components. J Cell Biol 53: 92-104, 1972.
75. Turnbull GJ: Ultrastructural basis of the permeability barrier in urothelium. Invest Urol 11: 198-204, 1973.
76. Hicks RM: The mammalian urinary bladder: an accommodation organ. Biol Rev Camb Philos Soc 50: 215-246, 1975.
77. Konishi T: Architectural ultrastructure of the urinary bladder epithelium. II. The changes of the urine-blood barrier at the contracted and distended state in normal and inflammatory bladder. Acta Urol Jpn 34: 23-31, 1988.
78. Rodriguez-Boulan E, and Nelson WJ: Morphogenesis of the polarized epithelial cell phenotype. Science 245: 718-724, 1989.
79. Moskowitz MO, Byrne SDS, Callahan HJ, Parsons CL, Valderrama E, and Moldwin RM: Decreased expression of a glycoprotein component of bladder surface mucin (GPI) in interstitial cystitis. J Urol 151: 343-345, 1994.
80. Levin S, and Richter WR: Ultrastructure of cell surface coat (glycocalyx) in rat urinary bladder epithelium. Cell Tissue Res 158: 281-283, 1975.
81. Walker SR, Callahan HJ, Fritz R, and Mulholland SG: Distribution of rabbit mucosal glycoprotein throughout urinary tract. Urology 33: 127-130, 1989.
82. Grist M, and Chakraborty J: Identification of mucin layer in the urinary bladder. Urology 44: 26-33, 1994.
83. Monis B, and Dorfman HD: Some histochemical observations of transitional epithelium of man. J Histochem Cytochem 15: 475-481, 1967.
84. Luft JH: Ruthenium red and violet. II. Fine structural localization in animal tissues. Anat Rec 171: 369-415, 1971.
85. Cornish J, Nickel JC, Vanderwee M, and Costerton JW: Ultrastructural visualization of human bladder mucus. Urol Res 18: 263-266, 1990.
86. Nickel JC, Emerson L, and Cornish J: The bladder mucus (glycosaminoglycan) layer in interstitial cystitis. J Urol 149: 716-718, 1993.
87. Cornish J, Vanderwee M, and Miller T: Mucus stabilization in the urinary bladder. Br J Exp Pathol 68: 369-375, 1987.
88. Alroy J, Goyal V, Ucci AA, Klauber GT, Heaney JA, and Cohen SM: Cell surface coat of human and rat bladder urothelium. I. Ruthenium-red studies in non-neoplastic and neoplastic cells. Virchows Arch B Cell Pathol 42: 251-262, 1983.
89. Dixon JS, Holm-Bentzen M, Gilpin CJ, Gosling JA, Bostofte E, Hald T, and Larsen S: Electron microscopic investigation of the bladder urothelium and glycocalyx in patients with interstitial cystitis. J Urol 135: 621-625, 1986.
90. Balish MJ, Jensen J, and Uehling DT: Bladder mucin: a scanning electron microscopy study in experimental cystitis. J Urol 128: 1060-1063, 1982.
91. Davis CP, and Avots-Avotins AE: Evaluation of bacterial attachment to acid treated bladder epithelium. Scanning Electron Microsc II: 825-830, 1982.
92. Cornish J, Lecamwasam JP, Harrison G, Vanderwee MA, and Miller TE: Host defence mechanisms in the bladder. II. Disruption of the layer of mucus. Br J Exp Pathol 69: 759-770, 1988.
93. Chen ASC, Matthews J, Gardner H, DeWolf W, and Staskin D: Re-evaluation of the glycosaminoglycan layer as a significant bladder permeability barrier. J Urol 149(4/2): 509A, 1993.
94. Eldrup J, Thorup J, Nielsen SL, Hald T, and Hainau B: Permeability and ultrastructure of human bladder epithelium. Br J Urol 55: 488-492, 1983.
95. 99mTechnetium-diethylenetriaminepentaacetic acid. J Urol 151: 346-349, 1994.
96. Völter D, Bürkle G, Feine U, Ghani E, and Kummer D: Die Resorption von Harnstoff aus Kaninchenblasen. Urol Int 29: 133-147, 1974.
97. Völter D, and Schmidt B: The reabsorption of creatinine from the rabbit bladder. Urol Res 3: 183-186, 1975.
98. Engelmann U, Bürger R, and Jacobi GH: Experimental investigations on the absorption of intravesically instilled mitomycin-C in the urinary bladder of the rat. Eur Urol 8: 176-181, 1982.
99. Engelmann U, Bürger R, Rumpelt JH, and Jacobi GH: Adriamycin permeability of the rat bladder under different conditions. J Urol 129: 862-864, 1983.
100. Hohlbrugger G, Lentsch P, Pfaller K, and Madersbacher H: Permeability characteristics of the rat urinary bladder in experimental cystitis and after overdistension. Urol Int 40: 211-216, 1985.
101. Monson FC, Wein AJ, McKenna BAW, Whitmore K, and Levin RM: Indigocarmine as a quantitative indicator of urothelial integrity. J Urol 145: 842-845, 1991.
102. Kim YS, Levin RM, Wein AJ, and Longhurst PA: Effects of sensitization on the permeability of urothelium in guinea pig urinary bladder. J Urol 147: 270-273, 1992.
103. Ugaily-Thulesius L, Thulesius O, and Sabha M: The effect of urothelial damage on ureteric motility: an ultrastructural and functional study. Br J Urol 62: 19-25, 1988.
104. Said JW, Van de Velde R, and Gillespie L: Immunopathology of interstitial cystitis. Mod Pathol 2: 593-602, 1989.
105. Elbadawi A, and Light JK: Distinctive ultrastructural pathology of nonulcerative interstitial cystitis: new observations and their potential significance in pathogenesis. Urol Int 56: 137-162, 1996.
106. Clemmensen OJ, Lose G, Holm-Bentzen M, and Colstrup H: Skin reactions to urine in patients with interstitial cystitis. Urology 32: 17-20, 1988.
107. Parsons CL: Role of toxic urine in interstitial cystitis. J Urol 143(4/2): 373A, 1990.
108. Howlett AR, Hodges GM, and Rowlatt C: Epithelialstromal interactions in adult bladder: urothelium growth, differentiation and maturation on culture facsimiles of bladder stroma. Dev Biol 118: 403-415, 1986.
109. Ruggieri MR, Hanno PM, Whitmore KE, and Balagani RK: Effect of repeated instillation of interstitial cystitis urine on the rabbit urinary bladder. Urology 42: 646-652, 1993.
110. 14C-urea penetration across the bladder. J Urol 149(4/2): 508A.
111. Kohn IJ, Filer SK, and Ruggieri MR: Repeated exposure of rabbit bladder to concentrated urine: lack of effect at low intravesical infusion volume (abst). Proceedings NIDDK/ ICA Interstitial Cystitis Scientific Workshop, October 5-6, 1995. p 43.
112. Ruggieri MR: Personal communication, November 1996.
113. Fukushi Y, Orikasa S, and Kagayama M: An electron microscopic study of the interaction between vesical epithelium and E. coli. Invest Urol 17: 61-68, 1979.
114. Ruggieri MR, Chelsky MJ, Rosen SI, Shickley TJ, and Hanno PM: Current findings and future research avenues in the study of interstitial cystitis. Urol Clin North Am 21: 163-176, 1994.
115. MacDermott JP, Miller CH, Levy N, and Stone AR: Cellular immunity in interstitial cystitis. J Urol 145: 274-278, 1991.
116. Oravisto KJ: Epidemiology of interstitial cystitis: 1, in Hanno PM, Staskin DR, Krane RJ, and Wein AJ (eds): Interstitial Cystitis. London, Springer-Verlag, 1990, pp 25-28.
117. Koziol JA: Epidemiology of interstitial cystitis. Urol Clin North Am 21: 7-20, 1994.
118. Hanno PH: Amitriptyline in the treatment of interstitial cystitis. Urol Clin North Am 21: 89-92, 1994.
119. Fall M: Conservative management of chronic interstitial cystitis: transcutaneous electrical nerve stimulation and transurethral resection. J Urol 133: 774-778, 1985.
120. Fall M: Transcutaneous electrical nerve stimulation in interstitial cystitis: update on clinical experience. Urology 29(suppl): 40-42, 1987.
121. Fall M, and Lindström S: Transcutaneous electrical nerve stimulation in classic and nonulcer interstitial cystitis. Urol Clin North Am 21: 131-139, 1994.
122. Irwin PP, and Galloway NTM: Surgical management of interstitial cystitis. Urol Clin North Am 21: 145-151, 1994.
123. Galloway NTM, Gabale DR, and Irwin PP: Interstitial cystitis or reflex sympathetic dystrophy of the bladder? Semin Urol 9: 148-153, 1991.
124. Aldenborg F, Fall M, and Enerbäck L: Mast cells and interstitial cystitis, in Hanno PM, Staskin DR, Krane RJ, Wein AJ (eds): Interstitial Cystitis. London, Springer-Verlag, 1990, pp 95-106.
125. Galli SJ: New concepts about the mast cell. N Engl J Med 328: 257-265, 1993.
126. Sullivan TJ: Anaphylaxis, in Kaliner MA, Metcalfe DD (eds): The Mast Cell in Health and Disease. New York, Marcel Dekker, 1993, pp 529-543.
127. Galli SJ, Dvorak AM, and Dvorak HF: Basophils and mast cells: Morphologic insights into their biology, secretory patterns and function, in Ishizaka K (ed): Progress in Allergy, vol. 34. Basel, Karger, 1984, pp 1-141.
128. Bienenstock J, Befus AD, and Denburg JA: Mast cell heterogeneity: basic questions and clinical implications, in Befus AD, Bienenstock J, Denburg JA (eds): Mast Cell Differentiation and Heterogeneity. New York, Raven Press, 1986, pp 391-402.
129. Claman HN: Mast cells and fibrosis: hints from graft-versus-host disease and scleroderma, in Kaliner MA, Metcalfe DD (eds): The Mast Cell in Health and Disease. New York, Marcel Dekker, 1993, pp 653-667.
130. Levi-Schaffer F: Mast cell/fibroblast interactions in health and disease, in Marone G (ed): Human Basophils and Mast Cells: Biological Aspects. Chemical Immunology. Vol. 61. Basel, Karger, 1995, pp 161-165.
131. Theoharides TC, Flaris NA, Cronin CT, Ucci A, and Meares E: Mast cell activation in sterile bladder and prostate inflammation. Int Arch Allergy Appl Immunol 92: 281-286, 1990.
132. Theoharides TC, and Sant GR: Bladder mast cell activation in interstitial cystitis. Semin Urol 9: 74-87, 1991.
133. Letourneau R, Sant GR, el-Mansoury M, and Theoharides TC: Activation of bladder mast cells in interstitial cystitis. Int J Tissue React 14: 307-312, 1992.
134. Theoharides TC, Sant GR, El-Mansoury M, Letourneau R, Ucci AA Jr, and Meares EM Jr: Activation of bladder mast cells in interstitial cystitis: a light and electron microscopic study. J Urol 153: 629-636, 1995.
135. Letourneau R, Pang X, Sant GR, and Theoharides TC: Intragranular activation of bladder mast cells and their association with nerve processes in interstitial cystitis. Br J Urol 77: 41-54, 1996.
136. Vliagoftis H, Dimitriadou V, Boucher W, Rozniecki JJ, Correia I, Raam S, and Theoharides TC: Estradiol augments while tamoxifen inhibits rat mast cell secretion. Int Arch Allergy Immunol 98: 398-409, 1992.
137. Pang X, Cotreau-Bibbo MM, Sant GR, and Theoharides TC: Bladder mast cell expression of high affinity estrogen receptors in patients with interstitial cystitis. Br J Urol 75: 154-161, 1995.
138. Theoharides TC: Hydroxyzine in the treatment of interstitial cystitis. Urol Clin North Am 21: 113-119, 1994.
139. Enerbäck L: Mast cell heterogeneity: the evolution of the concept of a specific mucosal mast cell, in Befus AD, Bienenstock J, and Denburg JA (eds): Most Cell Differentiation and Heterogeneity. New York, Raven Press, 1986, pp 1-26.
140. Galli SJ: New insights into "the riddle of the mast cells": microenvironmental regulation of mast cell development and phenotypic heterogeneity. Lab Invest 62: 5-33, 1990.
141. Schwartz LB, and Austen KF: Structure and function of the chemical mediators of mast cells, in Ishizaka K (ed): Progress in Allergy, vol. 34. Basel, Karger, 1984, pp 271-321.
142. Schwartz LB: Heterogeneity of mast cells, in Kaliner MA, Metcalfe DD (eds): The Mast Cell in Health and Disease. New York, Marcel Dekker, 1993, pp 219-236.
143. Theoharides TC: The mast cell: a neuroimmunoendocrine master player. Int J Tissue React 18: 1-21, 1996.
144. Lagunoff D, Martin TW, and Read G: Agents that release histamine from mast cells. Ann Rev Pharmacol Toxicol 23: 331-351, 1983.
145. Dimitriadou V, Buzzi MG, Moskowitz MA, and Theoharides TC: Trigeminal sensory fiber stimulation induces morphologic changes reflecting secretion in rat dura mater mast cells. Neurosci 44: 97-112, 1991.
146. White MV: Mast cell secretagogues: histamine-releasing factors and neuropeptides, in Kaliner MA, Metcalfe DD (eds): The Mast Cell in Health and Disease. New York, Marcel Dekker, 1993, pp 109-128.
147. Clasper M: A case of interstitial cystitis and Hunner's ulcer in a domestic shorthaired cat. N Z Vet J 38: 158-160, 1990.
148. Osbaldiston GW, and Taussig RA: Clinical report on 46 cases of feline urological syndrome. Vet Med Small Anim Clin 65: 461-468, 1970.
149. Barsanti JA, Finco DB, Shotts EB, Blue J, and Ross L: Feline urologic syndrome: further investigation into etiology. J Am Anim Hosp Assoc 18: 391-395, 1982.
150. Osborne CA, and Lees GE: Feline cystitis, urethritis, urethral obstruction syndrome. Part 1. Etiopathogenesis and clinical manifestations. Mod Vet Pract 59: 173-180, 1978.
151. Osborne CA, Johnston GB, Polzin DJ, Kruger JM, Bell FW, Poffenbarger EM, Feeney DA, Stevens JB, and McMenomy MF: Feline urologic syndrome: a heterogeneous phenomenon? J Am Anim Hosp Assoc 20: 17-32, 1984.
152. Osborne CA, Johnston GB, Polzin DJ, Kruger JM, Poffenbarger EM, Bell FW, Feeney DA, Goyal S, Fletcher TF, Newman JA, Stevens JB, and McMenomy MF: Redefinition of the feline urologic syndrome: feline lower urinary tract disease with heterogeneous causes. Vet Clin North Am Small Anim Pract 14: 409-438, 1984.
153. Osborne CA, Polzin DJ, Johnston GR, and Fletcher TF: Diagnosis of the feline urologic syndrome. Vet Clin North Am Small Anim Pract 14: 575-583, 1984.
154. Willeberg P: Epidemiology of naturally occurring feline urologic syndrome. Vet Clin N Am Small Anim Pract 14: 455-469, 1984.
155. Buffington CAT, Blaisdell JL, Binns SP, and Woodworth BE: Decreased urine glycosaminoglycan (GAG) excretion in cats inflammatory bladder syndrome. J Urol 149(4/2): 509A, 1993.
156. Buffington CAT: Lower urinary tract disease in cats-new problems, new paradigms. J Nutr 124(12, suppl): 2643S-2651S, 1994.
157. Ratliff TL, Klutke CG, Hofmeister M, He F, Russel JH, and Becich MJ: Role of the immune response in interstitial cystitis. Clin Immunol Immunopathol 74: 209-216, 1995.
158. Lulich JP, and Osborne CA: Overview of diagnosis of feline lower urinary tract disorders. Vet Clin North Am Small Anim Pract 26: 339-352, 1996.
159. Ruggieri MR, Monson FC, Levin RM, Wein AJ, and Hanno PM: Interstitial cystitis: animal models, in Hanno PM, Staskin DR, Krane RJ, and Wein AJ (eds): Interstitial Cystitis. London, Springer-Verlag, 1990, pp 49-62.
160. Christensen MM, Keith I, Rhodes PR, Graziano FM, Madsen PO, Bruskewitz RC, and Saban R: A guinea pig model for study of bladder mast cell function: histamine release and smooth muscle contraction. J Urol 144: 1293-1300, 1990.
161. Saban R, Christensen M, Keith I, Graziano FM, Undem BJ, Aagaard JS, Bjorling DE, and Bruskewitz RC: Experimental model for the study of bladder mast cell degranulation and smooth muscle contraction. Semin Urol 9: 88-101, 1991.
162. Bullock AD, Becich MJ, Klutke CG, and Ratliff TL: Experimental autoimmune cystitis: a potential murine model for ulcerative interstitial cystitis. J Urol 148: 1951-1956, 1992.
163. Malone DG: Mast cells in arthritis, in Kaliner MA, Metcalfe DD (eds): The Mast Cell in Health and Disease. New York, Marcel Dekker, 1993, pp 699-722.
164. Johansson SL, and Fall M: Clinical features and spectrum of light microscopic changes in interstitial cystitis. J Urol 143: 1118-1124, 1990.
165. Johansson SL: Light microscopic findings in bladders of patients with interstitial cystitis, in Hanno PM, Staskin DR, Krane RJ, and Wein AJ (eds): Interstitial Cystitis. London, Springer-Verlag, 1990, pp 83-90.
166. MacDermott JP, Charpied GC, Tesluk H, and Stone AR: Can histological assessment predict the outcome in interstitial cystitis? Br J Urol 67: 44-47, 1991.
167. Lynes WL, Flynn SD, Shortliffe LD, and Stamey TA: The histology of interstitial cystitis. Am J Surg Pathol 14: 969-976, 1990.
168. Skoluda D, Wegner K, and Lemmel EM: Kritische Bemerkungen zur Immunpathogenese der interstitiellen Cystitis. Urologe 13: 15-23, 1974.
169. Saint-André JP, Lépinard V, Rognon LM, Hurez D, and Simard C: La cystite interstitielle: étude anatomoclinique de 55 observations. Arch Anat Cytol Pathol 32: 144-148, 1984.
170. Collan Y, Alfthan O, Kivilaakso E, and Oravisto KJ: Electron microscopic and histologic findings in urinary bladder epithelium in interstitial cystitis. Eur Urol 2: 242-247, 1976.
171. Lundeberg T, Lieberg H, Nordling L, Theodorsson E, Owzarski A, and Ekman P: Interstitial cystitis: correlation with nerve fibers, mast cells and histamine. Br J Urol 71: 427-429, 1993.
172. Vracko R, Thorning D, and Frederickson RG: Fate of nerve fibers in necrotic, healing, and healed rat myocardium. Lab Invest 63: 490-501, 1990.
173. Vracko R, Thorning D, and Frederickson RG: Nerve fibers in human myocardial scars. Hum Pathol 22: 138-146, 1991.
174. Christmas TJ, Rode J, Chapple CR, Milroy EJG, and Turner-Warwick RT: Nerve fiber proliferation in interstitial cystitis. Virchows Arch A Pathol Anat Histopathol 416: 447-451, 1990.
175. Hohenfellner M, Nunes L, Schmidt RA, Lampel A, Thüroff JW, and Tanagho EA: Interstitial cystitis: increased sympathetic innervation and related neuropeptide synthesis. J Urol 147: 587-591, 1992.
176. Pang X, Marchand J, Sant GR, Kream RM, and Theoharides TC: Increased number of substance P positive nerve fibres in interstitial cystitis. Br J Urol 75: 744-750, 1995.
177. Pang X, Boucher W, Triadafilopoulos G, Sant GR, and Theoharides TC: Mast cells and substance P-positive nerve involvement in a patient with both irritable bowel syndrome and interstitial cystitis. Urology 47: 436-438, 1996.
178. Mattila J: Vascular immunopathology in interstitial cystitis. Clin Immunol Immunopathol 23: 648-655, 1982.
179. Mattila J, and Linder E: Immunoglobulin deposits in bladder epithelium and vessels in interstitial cystitis: possible relationship to circulating anti-intermediate filament autoantibodies. Clin Immunol Immunopathol 32: 81-89, 1984.
180. Mattila J: Pathology of interstitial cystitis, in Hanno PM, Staskin DR, Krane RJ, Wein AJ (eds): Interstitial Cystitis. London, Springer-Verlag, 1990, pp 91-94.
181. Walther MM, Campbell WG Jr, O'Brien PO III, Wheatley JK, and Graham SD Jr: Cystitis cystica: an electron and immunofluorescence microscopic study. J Urol 137: 764-768, 1987.
182. Erickson DR, and Dabbs DJ: Inflammatory cell types and other clinical features of interstitial cystitis. J Urol 155(5, suppl): 440A, 1995.
183. Harrington DS, Fall M, and Johansson SL: Interstitial cystitis: Bladder mucosa lymphocyte immunophenotyping and peripheral blood flow cytometry analysis. J Urol 144: 868-871, 1990.
184. Fowler JE Jr, Lynes WL, Lau JLT, Ghosh L, and Mounzer A: Interstitial cystitis is associated with intraurothelial Tamm-Horsfall protein. J Urol 140: 1385-1389, 1988.
185. Stone AR, Vogelsang P, Miller CH, and MacDermott JP: Tamm-Horsfall protein as a marker in interstitial cystitis. J Urol 148: 1406-1408, 1992.
186. Truong LD, Ostrowski ML, and Wheeler TM: Tamm-Horsfall protein in bladder tissue. Morphologic spectrum and clinical significance. Am J Surg Pathol 18: 615-622, 1994.
187. Larsen S, Thompson SA, Hald T, Barnard RJ, Gilpin CJ, Dixon JS, and Gosling JA: Mast cells in interstitial cystitis. Br J Urol 54: 283-286, 1982.
188. Kastrup J, Hald T, Larsen S, and Nielsen VG: Histamine content and mast cell count of detrusor muscle in patients with interstitial cystitis and other types of chronic cystitis. Br J Urol 55: 495-500, 1983.
189. Feltis J, Perez-Marrero R, and Emerson L: Increased mast cells of the bladder in suspected cases of interstitial cystitis: a possible disease marker. J Urol 138: 42-43, 1987.
190. Aldenborg F, Fall M, and Enerbäck L: Proliferation and transepithelial migration of mucosal mast cells in interstitial cystitis. Immunology 58: 411-416, 1986.
191. Enerbäck L, Fall M, and Aldenborg F: Histamine and mucosal mast cells in interstitial cystitis. Agents Actions 26: 113-115, 1989.
192. Sant GR, Ucci AA Jr, Kilaru PG, and Meares EM Jr: Mucosal mast cell (MMC) contribution to bladder mastocytosis in interstitial cystitis. J Urol 139(4/2): 276A, 1988.
193. Wingren U, and Enerbäck L: Mucosal mast cells of the rat intestine: a re-evaluation of fixation and staining properties, with special reference to protein blocking and solubility of the granular glycosaminoglycan. Histochem J 15: 571-582, 1983.
194. Enerbäck L: Mast cell heterogeneity: the evolution of the concept of a specific mucosal mast cell, in Befus AD, Bienenstock J, and Denburg JA (eds): Mast Cell Differentiation and Heterogeneity. New York, Raven Press, 1986, pp 1-26.
195. Enerbäck L, Miller HRP, and Mayrhofer G: Methods for the identification and characterization of mast cells by light microscopy, in Befus AD, Bienenstock J, and Denburg JA (eds): Mast Cell Differentiation and Heterogeneity. New York, Raven Press, 1986, pp 405-417.
196. Lynes WL, Flynn SD, Shortliffe LD, Lemmers M, Zipser R, Roberts LJ II, and Stamey TA: Mast cell involvement in interstitial cystitis. J Urol 138: 746-752, 1987.
197. Frazer MI, Hauylen BT, and Sissons M: Do women with idiopathic sensory urgency have early interstitial cystitis? Br J Urol 66: 274-278, 1990.
198. Nielsen KK, Kromann-Andersen B, Steven K, and Hald T: Failure of combined supratrigonal cystectomy and Mainz ileocecocystoplasty in intractable interstitial cystitis: is histology and mast cell count a reliable predictor for the outcome of surgery? J Urol 144: 255-259, 1990.
199. Sant GR, and Theoharides TC: Letter to the editor, re: Dundore et al, J Urol 155: 885, 1996, Mast cell counts are not useful in the diagnosis of nonulcerative interstitial cystitis. J Urol 156: 1445-1446, 1996.
200. Sant GR, and Theoharides TC: Letter to the editor, re: Dundore et al, J Urol 155: 885, 1996, Mast cell counts are not useful in the diagnosis of nonulcerative interstitial cystitis. J Urol 156: 1445-1446, 1996.
201. Moore KH, Nickson P, Richmond DM, Sutherst JR, Manasse PR, and Helliwell TR: Detrusor mast cells in refractory idiopathic instability. Br J Urol 70: 17-21, 1992.
202. Cornish J, Vanderwee MA, Ormrod DJ, and Miller TE: Mucosal mast cells as a component of the inflammatory response to lower-urinary tract infection. Int Arch Allergy Appl Immunol 81: 337-342, 1986.
203. Christmas TJ, and Rode J: Characteristics of mast cells in normal bladder, bacterial cystitis and interstitial cystitis. Br J Urol 68: 473-478, 1991.
204. Simmons JL: Interstitial cystitis: an explanation for the beneficial effect of an antihistamine. J Urol 85: 149-155, 1961.
205. Gupta RK: Mast cell variations in prostate and urinary bladder. Arch Pathol 89: 302-305, 1970.
206. Hanno P, Ruggieri M, and Wein AJ: Current status of interstitial cystitis. World J Urol 8: 212-217, 1990.
207. Dundore PA, Schwartz AM, and Semerjian H: Mast cells are not useful in the diagnosis of nonulcerative interstitial cystitis. J Urol 155: 885-887, 1996.
208. Hofmeister MA, He F, Ratliff TL, Mahoney T, Wachtel S, Jordan M, and Becich MJ: Mast cells and nerve fibers in interstitial cystitis (IC): an algorithm for histologic diagnosis via quantitative image analysis and morphometry (QIAM). J Urol 155(5,Suppl):433A, 1995.
209. Mattila J, Pitkänen, Vaalasti T, and Seppänen J: Fine-structural evidence for vascular injury in patients with interstitial cystitis. Virchows Arch A Pathol Anat Histopathol 398: 347-355, 1983.
210. Liebert M, Grossman HB, Washington R, and Faerber G: Expression of hemidesmosomal anchoring structures in bladders of patients with interstitial cystitis. J Urol 153(4/2): 328A, 1995.
211. Hurst RE, Roy JB, Bonner R, and Hemstreet GP III: Abnormal G-actin levels in voided urine cells from interstitial cystitis patients. J Urol 155(5, suppl): 432A, 1995.
212. Dvorak AM, McLeod RS, Onderdonk AB, Monahan-Earley RA, Cullen JB, Antonioli DA, Morgan E, Blair JA, Estrella P, Cisneros RL, Cohen Z, and Silen W: Human gut mucosal cells: ultrastructural observations and anatomic variation in mast cell-nerve associations in vivo. Int J Allergy Immunol 98: 158-168, 1992.
213. Theoharides TC, Dimitriadou V, Letourneau R, Rozniecki JJ, Vliagoftis H, and Boucher W: Synergistic action of estradiol and myelin basic protein on mast cell secretion and brain myelin changes resembling early stages of demyelination. Neuroscience 57: 861-871, 1993.
214. Dvorak AM: Human mast cells, in Beck F, Hild W, Kriz W, Ortmann R, Pauly JE, and Schiebler TH (eds): Advances in Anatomy, Embryology and Cell Biology, Vol. 114. New York, Springer-Verlag, 1989, pp 1-100.
215. Dvorak AM: Human mast cells: ultrastructural observations of in situ, ex vivo, and in vitro sites, sources, and systems, in Kaliner MA, Metcalfe DD (eds): The Mast Cell in Health and Disease. New York, Marcel Dekker, 1993, pp 1-90.
216. Kops SK, Van Loveren H, Rosenstein RW, Ptak W, and Askenase PW: Mast cell activation and vascular alterations in immediate hypersensitivity-like reactions induced by a T-cell-derived antigen-binding factor. Lab Invest 50: 421-434, 1984.
217. Kops SK, Theoharides TC, Cronin CT, Kashgarian MG, and Askenase PW: Ultrastructural characteristics of rat peritoneal mast cells undergoing differential release of serotonin without histamine and without degranulation. Cell Tissue Res 262: 415-424, 1990.
218. Giorno R, Choi KL, and Claman HN: Simultaneous in situ detection of IgE receptors and cytoplasmic granules in murine cutaneous mast cells. J Immunol Methods 99: 163-166, 1987.
219. Choi KL, Giorno R, and Claman HN: Cutaneous mast cell depletion and recovery in murine graft-vs.-host disease. J Immunol 138: 4093-4101, 1987.
220. Whitmore KE: Self-care regimens for patients with interstitial cystitis. Urol Clin North Am 21: 121-130, 1994.
221. Sant GR, Theoharides TC, El-Mansoury M, Letourneau A, Ucci AA Jr, and Meares EM Jr: Mast cells are increased in number and activation in interstitial cystitis. J Urol 149(4/ 2): 507A, 1993.
222. Yun SK, Laub DJ, Weese DL, Lad PM, Leach GE, and Zimmern PE: Stimulated release of urine histamine in interstitial cystitis. J Urol 148: 1145-1148, 1992.
223. Holm-Bentzen M, Larsen S, Hainall B, and Hald T: Nonobstructive detrusor myopathy in a group of patients with chronic abacterial cystitis. Scand J Urol Nephrol 19: 21-26, 1985.
224. Christmas TJ, and Rhode J: Detrusor myopathy: an accurate predictor of bladder hypocompliance and contracture in interstitial cystitis. Br J Urol 78: 862-865, 1996.
225. Dundore PA, Schwartz AM, and Semerjian H: Reply by authors to letter to editor (GR Sant, TC Theoharides). J Urol 156: 1446, 1996.
226. Foreman JC: Peptides and neurogenic inflammation. Br Med Bull 43: 386-400, 1987.
227. McDonald DM: Neurogenic inflammation in the respiratory tract: actions of sensory nerve mediators on blood vessels and epithelium of the airway mucosa. Am Rev Respir Dis 136: 565-572, 1987.
228. McDonald DM: Neurogenic inflammation in the rat trachea. I. Changes in venules, leukocytes and epithelial cells. J Neurocytol 17: 583-603, 1988.
229. Payan DG, Levine JD, and Goetzl EJ: Modulation of immunity and hypersensitivity by sensory neuropeptides. J Immunol 132: 1601-1604, 1984.
230. Church MK, Lowman MA, Rees PH, and Benyon RC: Mast cells, neuropeptides and inflammation. Agents Actions 27: 8-16, 1989.
231. Christian EP, Udem BJ, and Weinreich D: Endogenous histamine excites neurones in the guinea-pig superior cervical ganglion in vitro. J Physiol 409: 297-312, 1989.
232. Bienenstock J, Stead RH, and Marshall JS: Mast cells and the nervous system, in Kaliner MA, Metcalfe DD (eds): The Mast Cell in Health and Disease. New York, Marcel Dekker, 1993, pp 687-698.
233. Cavanah DK, and Casale TB: Histamine, in Kaliner MA, Metcalfe DD (eds): The Mast Cell in Health and Disease. New York, Marcel Dekker, 1993, pp 321-342.
234. Newson B, Dahlström A, Enerbäck L, and Ahlman H: Suggestive evidence for a direct innervation of mucosal mast cells. Neurosci 10: 565-570, 1983.
235. Stead RH, Dixon MF, Bramwell NH, Riddell RH, and Bienenstock J: Mast cells are closely apposed to nerves in the human gastrointestinal mucosa. Gastroenterology 97: 575-585, 1989.
236. Williams RM, Bienenstock J, and Stead RH: Mast cells: the neuroimmune connection, in Marone G (ed): Human Basophils and Mast Cells: Biological Aspects. Chemical Immunology. Vol. 61. Basel, Karger, 1995, pp 208-235.
237. Cutz E, Chan W, Track NS, Goth A, and Said SI: Release of vasoactive intestinal polypeptide in mast cells by histamine liberators. Nature 275: 661, 1978.
238. Gordon JR, Burd PR, and Galli SJ: Mast cells as a source of multifunctional cytokines. Immunol Today 11: 458-464, 1990.
239. Scott T, and Kaliner M: Mast cells in asthma, in Kaliner MA, Metcalfe DD (eds): The Mast Cell in Health and Disease. New York, Marcel Dekker, 1993, pp 575-608.
240. Kovacs EJ: Fibrogenic cytokines: the role of immune mediators in the development of scar tissue. Immunol Today 12: 17-23, 1991.
241. Monroe JG, Haldar S, Prystowsky B, and Lammie P: Lymphokine regulation of inflammatory processes: interleukin-4 stimulates fibroblast proliferation. Clin Immunol Immunopathol 49: 292-298, 1988.
242. Costa JJ, Burd PR, and Mecalfe DD: Mast cell cytokines, in Kaliner MA, Metcalfe DD (eds): The Mast Cell in Health and Disease. New York, Marcel Dekker, Inc, 1993, pp 443-466.
243. Howarth PH, Bradding P, Quint D, Redington AE, and Holgate ST: Cytokines and airway inflammation. Ann NY Acad Sci 725: 69-82, 1994.
244. Goldstein SM, and Wintroub BU: Mast cell proteases, in Kaliner MA, Metcalfe DD (eds): The Mast Cell in Health and Disease. New York, Marcel Dekker, 1993, pp 343-380.
245. Claman HN: On scleroderma. Mast cells, endothelial cells, and fibroblasts. JAMA 262: 1206-1209, 1989.
246. Edwards L, Bucknall TE, and Makin C: Interstitial cystitis: possible cause and clinical study of sodium cromoglycate. Br J Urol 58: 95-96, 1986.
247. Liebert M, Wedemeyer G, Stein JA, Washington R Jr, Faerber G, Flint A, and Grossman HB: Evidence for urothelial cell activation in interstitial cystitis. J Urol 149: 470-475, 1993.
248. Felsen D, Frye S, Trimble LA, Bavendam TG, Parsons CL, Sim Y, and Vaughan ED Jr: Inflammatory mediator profile in urine and bladder wash fluid of patients with interstitial cystitis. J Urol 152: 355-361, 1994.
249. Steinert BW, Diokno AC, Robinson JE, and Mitchell BA: Complement C3, eosinophil cationic protein and symptom evaluation in interstitial cystitis. J Urol 151: 350-354, 1994.
250. Elbadawi A: Neuromorphologic basis of vesicourethral function. I. Histochemistry, ultrastructure and function of intrinsic nerves of the bladder and urethra. Neurourol Urodyn 1: 3-50, 1982.
251. Joniken EJ, Alfthan OS, and Oravisto KJ: Antitissue antibodies in interstitial cystitis. Clin Exp Immunol 11: 333-339, 1972.
252. Ochs RL, Stein TW Jr, Peebles CL, Gittes RF, and Tan EM: Autoantibodies in interstitial cystitis. J Urol 151: 587-592, 1994.
253. Miller CH, MacDermott JP, Quattrocchi KB, Broderick GA, and Stone AR: Lymphocyte function in patients with interstitial cystitis. J Urol 147: 592-595, 1992.
254. Oravisto KJ: Interstitial cystitis as an autoimmune disease: a review. Eur Urol 6: 10-13, 1980.
255. Dvorak HF, Galli SJ, and Dvorak AM: Cellular and vascular manifestations of cell-mediated immunity. Hum Pathol 17: 122-137, 1986.
256. Spanos C, Pang X, Ligris K, Letourneau R, Alferes L, Alexacos N, Sant GR, and Theoharides TC: Stress-induced bladder mast cell activation: implications for interstitial cystitis. J Urol 157: 669-672, 1997.
257. Ratner V, Slade D, and Whitmore KE: Interstitial cystitis: a bladder disease finds legitimacy. J Women's Health 1: 63-68, 1992.
258. Spanos C, El-Mansoury M, Letourneau R, Minogiannis P, Greenwood J, Siri P, Sant GR, and Theoharides TC: Carbachol-induced bladder mast cell activation: augmentation by estradiol and implications for interstitial cystitis. Urology 48: 809-816, 1996.