Transgenic Models of Nerve Degeneration

Peripheral Neuropathy

Volumn 1, Issue , 2005, Pages 535-556

  Martini, Rudolf ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

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EID: 33745240147     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-7216-9491-7.50027-2     Document Type: Chapter

References (149)

1. Abrams C.K., Oh S., Ri Y., Bargiello T.A. Mutations in connexin 32: the molecular and biophysical bases for the X-linked form of Charcot-Marie-Tooth disease. Brain Res. Rev. 2000, 32:203.
2. Adlkofer K., Martini R., Aguzzi A., et al. Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice. Nat. Genet. 1995, 11:274.
3. Aguayo A.J., Attiwell M., Trecarten J., et al. Abnormal myelination in transplanted trembler mouse Schwann cells. Nature 1977, 265:73.
4. Aguayo A.J., Charron L., Bray G.M. Potential of Schwann cells from unmyelinated nerves to produce myelin: a quantitative ultrastructural and radiographic study. J. Neurocytol. 1976, 5:565.
5. Aguayo A.J., Epps J., Charron L., Bray G.M. Multipotentiality of Schwann cells in cross-anastomosed and grafted myelinated and unmyelinated nerves: quantitative microscopy and radioautography. Brain Res. 1976, 104:1.
6. Anzini P., Neuberg D.H.H., Schachner M., et al. Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32. J. Neurosci. 1997, 17:4545.
7. Arroyo E.J., Scherer S.S. On the molecular architecture of myelinated fibers. Histochem. Cell Biol. 2000, 113:1.
8. Arroyo E.J., Xu Y.-T., Zhou L., et al. Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kvβ2, and Caspr. J. Neurocytol. 1999, 28:333.
9. Balice-Gordon R.J., Bone L.J., Scherer S.S. Functional gap junctions in the Schwann cell myelin sheath. J. Cell Biol. 1998, 142:1095.
10. Ballin R.H., Thomas P.K. Electron microscope observations on demyelination and remyelination in experimental allergic neuritis. I. Demyelination. J. Neurol. Sci. 1969, 8:1.
11. Berglund E.O., Murai K.K., Fredette B., et al. Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. Neuron 1999, 24:739.
12. Bergoffen J., Scherer S.S., Wang S., et al. Connexin mutations in X-linked Charcot-Marie-Tooth disease. Science 1993, 262:2039.
13. Bhat M.A., Rios J.C., Lu Y., et al. Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron 2001, 30:369.
14. Boerkoel C., Takashima H., Stankiewicz P., et al. Periaxin mutations cause recessive Dejerine-Sottas neuropathy. Am. J. Hum. Genet. 2001, 68:325.
15. Bosio A., Binczek E., Haupt W.F., Stoffel W. Composition and biophysical properties of myelin lipid define the neurological defects in galactocerebroside- and sulfatide-deficient mice. J. Neurochem. 1998, 70:308.
16. Bosio A., Binczek E., Stoffel W. Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebro-side synthesis. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:13280.
17. Boyle M.E., Berglund E.O., Murai K.K., et al. Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve. Neuron 2001, 30:385.
18. Bunge R.P. Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration. Curr. Opin. Neurobiol. 1993, 3:805.
19. Bunge R.P., Bunge M.B., Bates M. Movements of the Schwann cell nucleus implicate progression of the inner (axon-related) Schwann cell process during myelination. J. Cell Biol. 1989, 109:273.
20. Carenini S., Mäurer M., Werner A., et al. The role of macrophages in demyelinating peripheral nervous system of mice heterozygously deficient in P0. J. Cell Biol. 2001, 152:301.
21. Carenini S., Montag D., Cremer H., et al. Absence of myelin-associated glycoprotein (MAG) and the neural cell adhesion molecule (N-CAM) interferes with the maintenance, but not with the formation of peripheral myelin. Cell Tissue Res. 1997, 287:3.
22. Carenini S., Montag D., Schachner M., Martini R. Subtle roles of neural cell adhesion molecule and myelin-associated glycoprotein during Schwann cell spiralling in P0-deficient mice. Glia 1999, 27:203.
23. Carenini S., Neuberg D., Schachner M., et al. Localization and functional roles of PMP22 in peripheral nerves of P0-deficient mice. Glia 1999, 28:256.
24. Chan J.R., Cosgaya J.M., Wu Y.J., Shooter E.M. Neurotrophins are key mediators of the myelination program in the peripheral nervous system. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:14661.
25. Chiavegatto S., Sun J., Nelson R.J., Schnaar R.L. A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice. Exp. Neurol. 2000, 166:227.
26. Coetzee T., Fujita N., Dupree J., et al. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell 1996, 86:209.
27. Cohen N.R., Taylor J.S., Scott L.B., et al. Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1. Curr. Biol. 1998, 8:26.
28. Dahme M., Bartsch U., Martini R., et al. Disruption of the mouse L1 gene leads to malformations of the nervous system. Nat. Genet. 1997, 17:346.
29. De Bellard M.E., Filbin M.T. Myelin-associated glycoprotein, MAG, selectively binds several neuronal proteins. J. Neurosci. Res. 1999, 56:213.
30. de Waegh S.M., Lee V.M.Y., Brady S.T. Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. Cell 1992, 68:451.
31. Ding Y., Brunden K.R. The cytoplasmic domain of myelin glycoprotein P0 interacts with negatively charged phospholipid bilayers. J. Biol. Chem. 1994, 269:10764.
32. Dupree J.L., Coetzee T., SuzGBRi K., Popko B. Myelin abnormalities in mice deficient in galactocerebro-side and sulfatide. J. Neurocytol. 1998, 27:649.
33. Dupree J.L., Girault J.-A., Popko B. Axo-glial interactions regulate the localization of axonal paranodal proteins. J. Cell Biol. 1999, 147:1145.
34. Dupree J.L., Popko B. Genetic dissection of myelin galactolipid function. J. Neurocytol. 1999, 28:271.
35. D'Urso D., Ehrhardt P., Müller H.W. Peripheral myelin protein 22 and protein zero: a novel association in peripheral nervous system myelin. J. Neurosci. 1999, 19:3396.
36. Dytrych L., Sherman D.L., Gillespie C.S., Brophy P.J. Two PDZ domain proteins encoded by the murine periaxin gene are the result of alternative intron retention and are differentially targeted in Schwann cells. J. Biol. Chem. 1998, 273:5794.
37. Einheber S., Milner T.A., Giancotti F., Salzer J.L. Axonal regulation of Schwann cell integrin expression suggests a role for alpha6 beta4 in myelination. J. Cell Biol. 1993, 123:1223.
38. Einheber S., Zanazzi G., Ching W., et al. The axonal membrane protein Caspr, a homologue of neurexin IV, is a component of the septate-like paranodal junctions that assemble during myelination. J. Cell Biol. 1997, 139:1495.
39. Elder G.A., Friedrich V.L., Margita A., Lazzarini L.A. Age-related atrophy of motor axons in mice deficient in the mid-sized neurofilament subunit. J. Cell Biol. 1999, 146:181.
40. Eldridge C.F., Bunge M.B., Bunge R.P. Differentiation of axon-related Schwann cells in vitro: II. Control of myelin formation by basal lamina. J. Neurosci. 1989, 9:625.
41. Eldridge C.F., Bunge M.B., Bunge R.P., Wood P.M. Differentation of axon-related Schwann cells in vitro. I. Ascorbic acid regulates basal lamina assembly and myelin formation. J. Cell Biol. 1987, 105:1023.
42. Fassler R., Meyer M. Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev. 1995, 9:1896.
43. Feltri L., Scherer S.S., Nemni R., et al. beta;4 Integrin expression in myelinating Schwann cells is polarized, developmentally regulated and axonally dependent. Development 1994, 120:1287.
44. Feltri M.L., D'Antonio M., Quattrini A., et al. A novel P0 glycoprotein transgene activates expression of lacZ in myelin-forming Schwann cells. Eur. J. Neurol. 1999, 11:1577.
45. Feltri M.L., Graus Porta D., Previtali S.C., et al. Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axons. J. Cell Biol. 2002, 156:199.
46. Fernandez-Valle C., Fregien N., Wood P.M., Bunge M.B. Expression of the protein zero myelin gene in axon-related Schwann cells is linked to basal lamina formation. Development 1993, 119:867.
47. Fernandez-Valle C., Gwynn L., Wood P.W., et al. Anti-β1 integrin antibody inhibits Schwann cell myelination. J. Neurobiol. 1994, 25:1207.
48. Frei R., Dowling J., Carenini S., et al. Myelin formation by Schwann cells in the absence of β4 integrin. Glia 1999, 27:269.
49. Frei R., Mötzing S., Kinkelin I., et al. Loss of distal axons and sensory Merkel cells and features indicative of muscle denervation in hindlimbs of P0-deficient mice. J. Neurosci. 1999, 19:6058.
50. Fruttiger M., Montag D., Schachner M., Martini R. Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur. J. Neurosci. 1995, 7:511.
51. Gatzinsky K.P., Persson G.H., Berthold C.H. Removal of retrogradely transported material from rat lumbosacral alpha-motor axons by paranodal axon-Schwann cell networks. Glia 1997, 20:115.
52. Giese K.P., Martini R., Lemke G., et al. Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons. Cell 1992, 71:565.
53. Gillespie C.S., Sherman D.L., Blair G.E., Brophy P.J. Periaxin, a novel protein of myelinating Schwan cells with a possible role in axon ensheathment. Neuron 1994, 12:497.
54. Gillespie C.S., Sherman D.L., Fleetwood-Walker S.M., et al. Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice. Neuron 2000, 26:523.
55. Girault J.A., Peles E. Development of nodes of Ranvier. Curr. Opin. Neurobiol. 2002, 12:476.
56. Guilbot A., Williams A., Ravise N., et al. A mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot-Marie-Tooth disease. Hum. Mol. Genet. 2001, 10:415.
57. Haney C.A., Sahenk Z., Li C., et al. Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival. J. Cell Biol. 1999, 146:1173.
58. Ho T.W., McKhann G.M., Griffin J.W. Human autoimmune neuropathies. Annu. Rev. Neurosci. 1998, 21:187.
59. Huxley C., Passage E., Manson A., et al. Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA. Hum. Mol. Genet. 1996, 5:563.
60. Huxley C., Passage E., Robertson A.M., et al. Correlation between varying levels and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice. Hum. Mol. Genet. 1998, 7:449.
61. Ishibashi T., Dupree J.L., Ikenaka K., et al. A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. J. Neurosci. 2002, 22:6507.
62. Ishibashi T., Ding L., Ikenaka K., et al. Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation. J. Neurosci. 2004, 24:96.
63. Julien J.-P. Neurofilament functions in health and disease. Curr. Opin. Neurobiol. 1999, 9:554.
64. Kelm S., Schauer R., Crocker P.R. The siaload-hesins-a family of sialic acid-dependent cellular recognition molecules within the immunoglobulin superfamily. Glycoconj. J. 1996, 13:913.
65. Kirschner D.A., Ganser A.L. Compact myelin exists in the absence of basic protein in the shiverer mutant mouse. Nature 1908, 283:207.
66. Kobsar I., Berghoff M., Samsam M., et al. Preserved myelin integrity and reduced axonopathy in connexin32 deficient mice lacking the recombination activation gene-1. Brain 2003, 126:804.
67. Kobsar I., Mäurer M., Ott T., Martini R. Macrophage-related demyelination in peripheral nerves of mice deficient in the gap junction protein connexin 32. Neurosci. Lett. 2002, 320:17.
68. Lai C., Brow M.A., Nave K.A., et al. Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing. Proc. Natl. Acad. Sci. U. S. A. 1987, 84:4337.
69. Lampert P.W. Mechanism of demyelination in experimental allergic neuritis. Lab. Invest. 1969, 20:127.
70. Lemke G., Lamar E., Patterson J. Isolation and analysis of the gene encoding peripheral myelin protein zero. Neuron 1988, 1:73.
71. Li C., Tropak M.B., Gerial R., et al. Myelination in the absence of myelin-associated glycoprotein. Nature 1994, 369:747.
72. Lindberg R.L.P., Martini R., Baumgartner M., et al. Motor neuropathy in porphobilinogen deaminase-deficient mice imitiates the peripheral neuropathy of human acute porphyria. J. Clin Invest. 1999, 103:1127.
73. Mack T.G.A., Reiner M., Beurowski B., et al. Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat. Neurosci. 2001, 4:1199.
74. Magyar J.P., Martini R., Ruelicke T., et al. Impaired differentiation of Schwann cells in transgenic mice with increased PMP22 gene dosage. J. Neurosci. 1996, 16:5351.
75. Martin S., Levine A.K., Chen Z.J., et al. Deposition of the NG2 proteoglycan at nodes of Ranvier in the peripheral nervous system. J. Neurosci. 2001, 21:8119.
76. Martini R. Animal models for inherited peripheral neuropathies. J. Anat. 1997, 191:321.
77. Martini R. Animal models for inherited peripheral neuropathies: chances to find treatment strategies?. J. Neurosci. Res. 2000, 61:244.
78. Martini R. The effect of myelinating Schwann cells on axons. Muscle Nerve 2001, 24:456.
79. Martini R., Mohajeri M.H., Kasper S., et al. Mice doubly deficient in the genes for P0 and myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin. J. Neurosci. 1995, 15:4488.
80. Martini R., Schachner M. Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve. J. Cell Biol. 1986, 103:2439.
81. Martini R., Schachner M. Molecular bases of myelin formation as revealed by investigations on mice deficient in glial cell surface molecules. Glia 1997, 19:298.
82. Martini R., Zielasek J., Toyka K.V., et al. Protein zero (P0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies. Nat. Genet. 1995, 11:281.
83. Mäurer M., Schmid C.D., Bootz F., et al. Bone marrow transfer from wild type mice reverts the beneficial effect of genetically-mediated immune deficiency in myelin mutants. Mol. Cell. Neurosci. 2001, 17:1094.
84. Menegoz M., Gaspar P., Le Bert M., et al. Paranodin, a glycoprotein of neuronal paranodal membranes. Neuron 1997, 19:319.
85. Mersiyanova I.V., Perepelov A.V., Polyakov A.V., et al. A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene. Am. J. Hum. Genet. 2000, 67:37.
86. Mombaerts P., Iacomini J., Johnson R.S., et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992, 68:869.
87. Montag D., Giese K.P., Bartsch U., et al. Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron 1994, 13:229.
88. Neuberg D.H.-H., Carenini S., Schachner M., et al. Accelerated demyelination of peripheral nerves in mice deficient in connexin 32 and protein zero. J. Neurosci. Res. 1998, 53:542.
89. Oguro K., Jover T., Tanaka H., et al. Global ischemia-induced increases in the gap junctional proteins connexin 32 (Cx32) and Cx36 in hippocampus and enhanced vulnerability of Cx32 knock-out mice. J. Neurosci. 2001, 21:7534.
90. Owens G.C., Boyd C.J., Bunge R.P., Salzer J.L. Expression of recombinant myelin-associated glycoprotein in primary Schwann cells promotes the initial investment of axons by myelinating Schwann cells. J. Cell Biol. 1990, 111:1171.
91. Owens G.C., Bunge R.P. Schwann cells infected with a recombinant retrovirus expressing myelin-associated glycoprotein antisense RNA do not form myelin. Neuron 1991, 7:565.
92. Peles E., Joho K., Plowman G., Schlessinger J. Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactions. Cell 1997, 88:745.
93. Peles E., Nativ M., Lustig M., et al. Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. EMBO J. 1997, 16:978.
94. Peles E., Salzer J.L. Molecular domains of myelinated axons. Curr. Opin. Neurobiol. 2000, 10:558.
95. Perea J., Robertson A., Tolmachova T., et al. Induced myelination and demyelination in a conditional mouse model of Charcot-Marie-Tooth disease type 1A. Hum. Mol. Genet. 2001, 10:1007.
96. Poliak S., Gollan L., Martinez R., et al. Caspr2, a new member of the neurexin superfamily, is localized at juxta-paranodes of myelinated axons and associates with K+ channels. Neuron 1999, 24:1037.
97. Poliak S., Gollan L., Salomon D., et al. Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon. J. Neurosci. 2001, 21:7568.
98. Poliak S., Peles E. The local differentiation of myelinated axons at nodes of Ranvier. Nat. Rev. Neurosci. 2003, 4:968.
99. Poltorak M., Sadoul R., Keilhauer G., et al. Myelin-associated glycoprotein, a member of the L2/HNK-1 family of neural cell adhesion molecules, is involved in neuronoligodendrocyte and oligodendrocyte-oligodendrocyte interaction. J. Cell Biol. 1987, 105:1893.
100. Popko B. Myelin galactolipids: mediators of axon-glial interactions?. Glia 2000, 29:149.
101. Previtali S.C., Feltri M.L., Archelos J.J., et al. Role of integrins in the peripheral nervous system. Prog. Neurobiol. 2001, 64:35.
102. Privat A., Jacque C., Bourre J.M., et al. Absence of the major dense line in the myelin of the mutant mouse "shiverer." Neurosci. Lett. 1979, 12:107.
103. Ressot C., Bruzzone R. Connexin channels in Schwann cells and the development of the X-linked form of Charcot-Marie-Tooth disease. Brain Res. Rev. 2000, 32:192.
104. Rios J.C., Melendez-Vasquez C.V., Einheber S., et al. Contactin-associated protein (Caspr) and contactin form a complex that is targeted to the paranodal junctions during myelination. J. Neurosci. 2000, 20:8354.
105. Sahenk Z., Chen L. Abnormalities in the axonal cytoskeleton induced by a connexin32 mutation in nerve xenografts. J. Neurosci. Res. 1998, 51:174.
106. Sahenk Z., Chen L., Mendell J.R. Effects of PMP22 duplication and deletions on the axonal cytoskeleton. Ann. Neurol. 1999, 45:16.
107. Saito F., Moore S.A., Barresi R., et al. Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization. Neuron 2003, 38:747.
108. Samsam M., Frei R., Marziniak M., et al. Impaired sensory function in heterozygous P0 knockout mice is associated with nodal changes in sensory nerves. J. Neurosci. Res. 2002, 67:167.
109. Samsam M., Mi W., Wessig C., et al. The wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy. J. Neurosci. 2003, 23:2833.
110. Sancho S., Magyar J.P., Aguzzi A., Suter U. Distal axonopathy in peripheral nerves of PMP22-mutant mice. Brain 1999, 122:1563.
111. Sancho S., Young P., Suter U. Regulation of Schwann cell proliferation and apoptosis in PMP22-deficient mice and mouse models of Charcot-Marie-Tooth disease type 1A. Brain 2001, 124:2177.
112. Schachner M., Bartsch U. Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin. Glia 2000, 29:154.
113. Scherer S.S. Molecular genetics of demyelination: new wrinkles on an old membrane. Neuron 1997, 18:13.
114. Scherer S.S. Myelination: some receptors required. J. Cell Biol. 2002, 156:13.
115. Scherer S.S., Arroyo E.J. Recent progress on the molecular organization of myelinated axons. J. Peripher. Nerv. Syst. 2002, 7:1.
116. Scherer S.S., Deschênes S.M., Xu Y.T., et al. Connexin32 is a myelin-related protein in the PNS and CNS. J. Neurosci. 1995, 15:8281.
117. Scherer S.S., Xu Y.T., Bannerman P.G.C., et al. Periaxin expression in myelinating Schwann cells: modulation by axon-glial interactions and polarized localization during development. Development 1995, 121:4265.
118. Scherer S.S., Xu Y.-T., Nelles E., et al. Connexin32-null mice develop demyelinating peripheral neuropathy. Glia 1998, 24:8.
119. Schmid C.D., Stienekemeier M., Oehen S., et al. Immune deficiency in mouse models for inherited peripheral neuropathies leads to improved myelin maintenance. J. Neurosci. 2000, 20:729.
120. Sereda M., Griffiths I., Pühlhofer A., et al. A transgenic rat model of Charcot-Marie-Tooth disease. Neuron 1996, 16:1049.
121. Shapiro L., Doyle J.P., Hensley P., et al. Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin. Neuron 1996, 17:435.
122. Sheikh K.A., Deerinck T.J., Ellisman M.H., Griffin J.W. The distribution of ganglioside-like moieties in peripheral nerves. Brain 1999, 122:449.
123. Sheikh K.A., Sun J., Liu Y., et al. Mice lacking complex gangliosides develop Wallerian degeneration and myelin-ation defects. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:7532.
124. Sherman D.L., Fabrizi C., Gillespie C.S., Brophy P.J. Specific disruption of a Schwann cell dystrophin-related protein complex in a demyelinating neuropathy. Neuron 2001, 30:677.
125. Shy M.E., Arroyo E., Sladky J., et al. Heterozygous P0 knock-out mice develop a peripheral neuropathy that resembles chronic inflammatory demyelinating polyneu-ropathy. J. Neuropathol. Exp. Neurol. 1997, 56:811.
126. Simons M., Kramer E.M., Thiele C., et al. Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains. J. Cell Biol. 2000, 151:143.
127. Stephens L.E., Sutherland A.E., Klimanskaya I.V., et al. Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev. 1995, 9:1883.
128. Suter U., Snipes G.J. Biology and genetics of hereditary motor and sensory neuropathies. Annu. Rev. Neurosci. 1995, 18:45.
129. Tait S., Gunn-Moore F., Collinson J.M., et al. An oligo-dendrocyte adhesion molecule at the site of assembly of the paranodal axo-glial junction. J. Cell Biol. 2000, 150:657.
130. Taylor V., Zgraggen C., Naef R., Suter U. Membrane topology of peripheral myelin protein 22. J. Neurosci. Res. 2001, 62:15.
131. Trapp B.D., O'Connell M.F., Andrews S.B. Ultrastructural immunolocalization of MAG and P0 proteins in cryosections of peripheral nerve. J. Cell Biol. 1986, 135:228a.
132. Trapp B.D., Quarles R.H. Presence of the myelin-associated glycoprotein correlates with alterations in the periodicity of peripheral myelin. J. Cell Biol. 1982, 92:877.
133. Tropak M.B., Johnson P.W., Dunn R.J., Roder J.C. Differential splicing of MAG transcripts during CNS and PNS development. Brain Res. 1988, 464:143.
134. Weinberg H.J., Spencer P.S. Studies on the control of myelinogenesis. I. Myelination of regenerating axons after entry into a foreign unmyelinated nerve. J. Neurocytol. 1975, 4:395.
135. Werner H., Jung M., Klugmann M., et al. Mouse models of myelin disease. Brain Pathol. 1998, 8:771.
136. Williams A.C., Brophy P.J. The function of the periaxin gene during nerve repair in a model of CMT4F. J. Anat. 2002, 200:323.
137. Windebank A.J., Wood P., Bunge R.P., Dyck P.J. Myelination determines the caliber of dorsal root ganglions in culture. J. Neurosci. 1985, 56:1563.
138. Wong M.H., Filbin M.T. Dominant-negative effect on adhesion by myelin P0 protein truncated in its cyto-plasmic domain. J. Cell Biol. 1996, 134:1531.
139. Wood P.M., Schachner M., Bunge R.P. Inhibition of Schwann cell myelination in vitro by antibody to the L1 adhesion molecule. J. Neurosci. 1990, 111:3635.
140. Wrabetz L., Feltri M.L., Quattrini A., et al. P0 glyco-protein overexpression causes congenital hypomyelination of peripheral nerves. J. Cell Biol. 2000, 148:1021.
141. Xu W., Menichella D., Jiang H., et al. Absence of P0 leads to the dysregulation of myelin gene expression and myelin morphogenesis. J. Neurosci. Res. 2000, 60:714.
142. Xu W., Shy M., Kamholz J., et al. Mutations in the cyto-plasmic domain of P0 reveal a role for PKC-mediated phosphorylation in adhesion and myelination. J. Cell Biol. 2001, 155:439.
143. Yang L.J.S., Zeller C.B., Shaper N.L., et al. Gangliosides are neural ligands for myelin-associated glycoprotein. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:814.
144. Yin X., Crawford T.O., Griffin J.W., et al. Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. J. Neurosci. 1998, 18:1953.
145. Yin X., Kidd G.J., Wrabetz L., et al. Schwann cell myelin-ation requires timely and precise targeting of P0 protein. J. Cell Biol. 2000, 148:1009.
146. Young P., Suter U. Disease mechanisms and potential therapeutic strategies in Charcot-Marie-Tooth disease. Brain Res. Rev. 2001, 36:213.
147. Zhu Q., Couillard-Despres S., Julien J.-P. Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments. Exp. Neurol. 1997, 148:299.
148. Zielasek J., Martini R., Toyka K.V. Functional abnormalities in P0-deficient mice resemble human hereditary neuropathies linked to P0 gene mutations. Muscle Nerve 1996, 19:946.
149. Zoidl G., Blass-Kampmann S., D'Urso D., et al. Retroviral-mediated gene transfer of the peripheral myelin protein PMP22 in Schwann cells: modulation of cell growth. EMBO J. 1995, 14:1122.