Macrophage-related demyelination in peripheral nerves of mice deficient in the gap junction protein connexin 32

Neuroscience Letters

Volumn 320, Issue 1-2, 2002, Pages 17-20

  Kobsar, Igor ^a   Mäurer, Mathias ^a   Ott, Thomas ^b   Martini, Rudolf ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Degeneration; Inherited neuropathies; Knockout mice; Myelin; Peripheral nervous system; Schwann cells

Indexed keywords

CONNEXIN 32; GAP JUNCTION PROTEIN; MYELIN;

AGE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATING NEUROPATHY; DEMYELINATION; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MOUSE; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SAPHENOUS NERVE;

ANIMALS; ANTIGENS, DIFFERENTIATION; AXONS; CELL COUNT; CONNEXINS; FEMALE; GAP JUNCTIONS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; MYELIN P0 PROTEIN; PERIPHERAL NERVES; POLYRADICULONEUROPATHY; SCHWANN CELLS; UP-REGULATION;

EID: 0036499098     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00015-0     Document Type: Article

References (21)

1. Mutations in connexin 32: The molecular and biophysical bases for the X-linked form of Charcot-Marie-Tooth disease
2. Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene
3. Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32
4. On the molecular architecture of myelinated fibers
5. Functional gap junctions in the Schwann cell myelin sheath
6. Connexin mutations in X-linked Charcot-Marie-Tooth disease
7. The role of macrophages in demyelinating peripheral nervous system of mice heterozygously deficient in P0
8. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
9. T-cell and macrophage activation in experimental autoimmune neuritis and Guillain-Barre syndrome
10. The role of macrophages in immune-mediated damage to the peripheral nervous system
11. Animal models for inherited peripheral neuropathies
12. Animal models for inherited peripheral neuropathies: Chances to find treatment strategies?
13. Protein zero (P0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies
14. Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy
15. Bone marrow transfer from wild-type mice reverts the beneficial effect of genetically-mediated immune deficiency in myelin mutants
16. Classification of the hereditary motor and sensory neuropathies
17. Connexin channels in Schwann cells and the development of the X-linked form of Charcot-Marie-Tooth disease
18. Connexin32 is a myelin-related protein in the PNS and CNS
19. Connexin32-null mice develop demyelinating peripheral neuropathy
20. Immune deficiency in mouse models for inherited peripheral neuropathies leads to improved myelin maintenance
21. Reactive microglia in dysmyelination and demyelination