Mutations in the cytoplasmic domain of P0 reveal a role for PKC-mediated phosphorylation in adhesion and myelination

Journal of Cell Biology

Volumn 155, Issue 3, 2001, Pages 439-445

  Xu, Wenbo ^a,d   Shy, Michael ^a   Kamholz, John ^a   Elferink, Lisa ^b   Xu, Gang ^c   Lilien, Jack ^c   Balsamo, Janne ^c  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Biomedical Marine Institute   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Adhesion; Myelination; P0; PKC; RACK1

Indexed keywords

EID: 0035851925     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.200107114     Document Type: Article

References (30)

1. Agrawal, H.C., and D. Agrawal. 1989. Tumor promoters accentuate phosphorylation of P0: evidence for the presence of protein kinase C in purified PNS myelin. Neurochem. Res. 14:409-413.
2. Aplin, A.E., A. Howe, S.K. Alahari, and R.L. Juliano. 1998. Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharm. Rev. 5:197-263.
3. Bolino, A., M. Muglia, F.L. Conforti, E. LeGuern, M.A. Salih, D.M. Georgiou, K. Christodoulou, I. Hausmanowa-Petrusewicz, P. Mandich, A. Schenone, et al. 2000. Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2. Nat. Genet. 25:17-20.
4. Crossin, K.L., and L.A. Krushel. 2000. Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily. Develop. Dyn. 218:260-279.
5. Doyle, J.P., J.G. Stempak, P. Cowin, D.R. Colman, and D. D’Urso. 1995. Protein zero, a nervous system adhesion molecule, triggers epithelial reversion in host carcinoma cells. J. Cell Biol. 131:465-482.
6. Filbin, M.T., and G.I. Tennekoon. 1993. Homophilic adhesion of the myelin P0 protein requires glycosylation of both molecules in the homophilic pair. J. Cell Biol. 122:451-459.
7. Filbin, M.T., F.S. Walsh, B.D. Trapp, J.A. Pizzey, and G.I. Tennekoon. 1990. Role of P0 protein as a homophilic adhesion molecule. Nature. 344:871-872.
8. Giese, K.P., R. Martini, G. Lemke, P. Soriano, and M. Schachner. 1992. Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons. Cell. 17:565-576.
9. Hilmi, S., M. Fournier, H. Valeins, J.C. Gandar, and J. Bonnet. 1995. Myelin P0 glycoprotein: identification of the site phosphorylated in vitro and in vivo by endogenous protein kinases. J. Neurochem. 64:902-907.
10. Iyer, S., C.L. Rowe-Rendleman, R. Bianchi, and J. Eichberg. 1996. Tyrosine phosphorylation of myelin protein P0. J. Neurosci. Res. 46:531-539.
11. Jaken, S., and P.J. Parker. 2000. Protein kinase C binding partners. Bioessays. 22: 245-254.
12. Kishimoto, A., K. Nishiyama, H. Nakanishi, Y. Uratsuji, H. Nomura, Y. Takeyama, and Y. Nishizuka. 1985. Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3: 5-monophosphatedependent protein kinase. J. Biol. Chem. 260:12492-12499.
13. Martini, R., J. Zielasek, K.V. Toyka, K.P. Giese, and M. Schachner. 1995. Protein zero (P0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies. Nat. Genet. 11:281-286.
14. Mochly-Rosen, D., H. Khaner, and J. Lopez. 1991. Identification of intracellular receptor proteins for activated protein kinase C. Proc. Natl. Acad. Sci. USA. 88:3997-4000.
15. Nelis, E., H. Neva, and C. Van Broeckhoven. 1999. Mutations in the peripheral myelin genes and associated genes in inherited peripheral neuropathies. Human Mutation. 13:11-28.
16. Rowe-Rendleman, C.L., and J. Eichberg. 1994. P0 phosphorylation in nerves from normal and diabetic rats: role of protein kinase C and turnover of phosphate groups. Neurochem. Res. 19:1023-1031.
17. Shapiro, L., J.P. Doyle, P. Hensley, D.R. Coleman, and W.A. Hendrickson. 1996. Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin. Neuron. 17:435-449
18. Sim, A.T.R., and J.D. Scott. 1999. Targeting of PKA, PKC and protein phosphatases to cellular microdomains. Cell Cal. 26:209-217.
19. Shy, M.E., J. Balsamo, J. Lilien, and J. Kamholz. 2001. A molecular basis for hereditary motor and sensory neuropathy disorders. Curr. Neurol. Neurosci. Rep. 1:77-88.
20. Suzuki, M., Y. Sakamoto, K. Kitamura, K. Fukunaga, H. Yamamoto, E. Miyamoto, and K. Uyemura. 1990. Phosphorylation of Po glycoprotein in peripheral nerve myelin. J. Neurochem. 55:1966-1971.
21. Svetlov, S., and S. Nigam. 1993. Calphostin C, a specific protein kinase C inhibitor, activates human neutrophils: effect on phospholipase A2 and aggregation. Biochim. Biophys. Acta. 1177:75-78.
22. Tamaoki, T., and H. Nakano. 1990. Potent and specific inhibitors of protein kinase C of microbial origin. Biotech. 8:732-735.
23. Vleminckx, K., and R. Kemler. 1999. Cadherins and tissue formation integrating adhesion and signaling. Bioessays. 21:211-220.
24. Warner, L.E., M.J. Hilz, S.H. Appel, J.M. Killian, E.H. Kolodry, G. Karpati, S. Carpenter, G.V. Watters, C. Wheeler, D. Witt, et al. 1996. Clinical phenotypes of different MPZ (P0) mutations may include Charcot-Marie-Tooth type 1B, Dejerine-Sottas, and congenital hypomyelination. Neuron. 17:451-460.
25. Wong, M.-H., and M.T. Filbin. 1994. The cytoplasmic domain of the myelin Po protein influences the adhesive interactions of its extracellular domain. J. Cell Biol. 126:1089-1097.
26. Wong, M.-H., and M.T. Filbin. 1996. Dominant negative effect on adhesion by myelin Po protein truncated in its cytoplasmic domain. J. Cell Biol. 134: 1531-1541.
27. Woodgett, J.R., K.L. Gould, and T. Hunter. 1986. Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements. Eur. J. Biochem. 161:177-184.
28. Wrabetz, L., M.L. Feltri, A. Quattrini, D. Imperiale, D. Previtali, M. D’Antonio, X. Yin, B.D. Trapp, L. Zhou, S.Y. Chiu, et al. 2000. P(0) glycoprotein overexpression causes congenital hypomyelination of peripheral nerves. J. Cell Biol. 148:1021-1034.
29. Xu, M., R. Zhao, X. Sui, F. Xu, and Z.J. Zhao. 2000a. Tyrosine phosphorylation of myelin P0 and its implication in signal transduction. Biochem. Biophys. Res Commun. 267:820-825.
30. Xu, W., D. Manichella, H. Jiang, J.M. Vallat, J. Lilien, P. Baron, G. Scarlato, J. Kamholz, and M.E. Shy. 2000b. Absence of P0 leads to dysregulation of myelin gene expression and myelin morphogenesis. J. Neurosci. Res. 60:714-724.