Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions

EMBO Journal

Volumn 16, Issue 5, 1997, Pages 978-988

  Peles, Elior ^a   Nativ, Moshe ^a   Lustig, Marc ^b   Grumet, Martin ^b   Schilling, James ^a   Martinez, Ricardo ^a   Plowman, Gregory D ^a   Schlessinger, Joseph ^b  

^a SUGEN INC   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Caspr; Neurexin like; Neuronal cell adhesion molecules; Phosphatases

Indexed keywords

BLOOD CLOTTING FACTOR; EPIDERMAL GROWTH FACTOR; MEMBRANE RECEPTOR; PROLINE;

ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CELL MEMBRANE; CONTROLLED STUDY; EMBRYO; GLIA CELL; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CELL ADHESION MOLECULES, NEURONAL; CELL MEMBRANE; CLONING, MOLECULAR; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEURONS; PROTEIN BINDING; RATS; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0031041601     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.5.978     Document Type: Article

References (61)

1. Barnea, G. et al. (1993) Identification of a carbonic anhydrase-like domain in the extracellular region of RPTPγ defines a new subfamily of receptor tyrosine phosphatases. Mol. Cell. Biol., 13, 1497-1506.
2. Barnea, G., Grumet, M., Sap, J., Margolis, R.U. and Schlessinger, J. (1994) Close similarity between a receptor linked tyrosine phosphatase and a rat brain proteoglycan. Cell, 76, 205.
3. Beggs, H.E., Soriano, P. and Maness, P.F. (1993) p59fyn impaired neurite outgrowth of fyn-minus cerebellar neurons on cell adhesion molecule N-CAM. J. Cell Biol., 127, 825-833.
4. Brady-Kalnay, S.M. and Tonks, N.K. (1995) Protein tyrosine phosphatases as adhesion receptors. Curr. Opin. Cell Biol., 7, 650-657.
5. Brümmendorf, T., Hubert, M., Treubert, U., Leuschner, R., Tárnok, A. and Rathjen, F.G. (1993) The axonal recognition molecule F11 is a multifunctional protein: specific domains mediate interactions with Ng-CAM and restrictin. Neuron, 10, 711-727.
6. Canoll, P.D., Barnea, G., Levy, J.B., Sap, J., Ehrlich, M., Silvennoinen, O., Schlessinger, J. and Musacchio, J.M. (1993) The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system. Dev. Brain Res., 75, 293-298.
7. D'Alessandri, L., Ranscht, B., Winterhalter, K.H. and Vaughan, L. (1995) Contactin/F11 and tenascin-C co-expression in the chick retina correlates with formation of the synaptic plexiform layers. Curr. Eye Res., 14, 911-926.
8. Desai, C.J., Popova, E. and Zinn, K. (1994) A Drosophila receptor tyrosine phosphatase expressed in the embryonic CNS and larval optic lobes is a member of the set of proteins bearing the 'HRP' carbohydrate epitope. J. Neurosci., 14, 7272-7283.
9. Desai, C.J., Gindhart, J.G.J., Goldstein, L.S.B. and Zinn, K. (1996) Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. Cell, 84, 599-609.
10. Dodd, J., Morton, S.B., Karagogeos, D., Yamamoto, M. and Jessell, T.M. (1988) Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons. Neuron, 1, 105-116.
11. Doherty, P. and Walsh, S.F. (1994) Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules. Curr. Opin. Neurobiol., 4, 49-55.
12. Erplel, T. Superti-Furga, G. and Courtneidge, S.A. (1995) Mutational analysis of the src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions. EMBO J., 14, 963-975.
13. Faivre-Sarrailh, C., Gennarini, G., Goridis, C. and Rougon, G. (1992) F3/F11 cell surface molecule expression in the developing mouse cerebellum is polarized at synaptic sites and within granule cells. J. Neurosci., 12, 257-267.
14. Fischer, E.H., Charbonneau, H. and Tonks, N.K. (1991) Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science, 253, 401-406.
15. Friedman, L.S. et al. (1994) The search for BRCA1. Cancer Res., 54, 6374-6382.
16. Gabriel, J.M., Oesch, B., Kretzschmar, H., Scott, M. and Prusiner, S.B. (1992) Molecular cloning of a candidate chicken prion protein. Proc. Natl Acad. Sci. USA, 89, 9097-9101.
17. Garrity, P.A. and Zipursky, S.L. (1995) Neuronal target recognition. Cell, 83, 177-185.
18. Gehisen, K.R., Sriramarao, P., Furcht, L.T. and Skubitz, P.N. (1992) A synthetic peptide derived from the carboxy terminus of the laminin A chain represents a binding site for the a3b1 integrin. J. Cell. Biol., 117, 449-459.
19. Gennarini, G., Cibelli, G., Rougon, G., Mattei, M.G. and Goridis, C. (1989) The mouse neuronal cell surface protein F3: a phosphatidylinositol-anchored member of the immunoglobulin superfamily related to chicken contactin. J. Cell. Biol., 109, 755-788.
20. Hauser, F., Roeben, C. and Hoffmann, W. (1992) XP2, a new member of the P-domain peptide family of potential growth factors, is synthesized in Xenopus laevis skin. J. Biol. Chem., 267, 14451-14455.
21. Ignelzi, M.A.J., Miller, D.R., Soriano, P. and Maness, P. (1994) Impaired neurite outgrowth of src-minus cerebcllar neurons on cell adhesion molecule L1. Neuron, 12, 873-884.
22. Jenny, R., Pittman, D.D., Tool, J.J., Kriz, R.W., Aldape, R.A., Hewick, R.M., Kaufman, R.J. and Mann, K.C. (1987) Complete cDNA and derived amino acid sequence of human factor V. Proc. Natl Acad. Sci. USA, 84, 4846-4850.
23. Johnson, J.D., Edman, J.C. and Ruttere, W. (1993) A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. Proc. Natl Acad. Sci. USA, 90, 5677-5681.
24. Karn, T., Holtrich, U., Brauninger, A., Bohme, B., Wolf, G., Rubsamen-Waigmann, H. and Strebhardt, K. (1993) Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain. Oncogene, 8, 3433-3440.
25. Kemball-Cook, G., Edwards, S.J., Sewerin, K., Andeeson, L.O. and Barrowcliffe, T.W. (1988) Factor VIII procoagulant protein interacts with phospholipid vesicle via its 80 kDa light chain. Thromb. Haemostasis, 60, 422-446.
26. Krueger, N.X. and Saito, H. (1992) A human transmembrane protein-tyrosine-phosphatase. PTPζ, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. Proc. Natl Acad. Sci. USA, 89, 7417-7421.
27. Krueger, N.X., Van Vector, D., Wan, H.I., Gelbart, W.M., Goodman, C.S. and Saito, H. (1996) The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila. Cell, 84, 611-622.
28. Lemmon, M.A. and Schlessinger, J. (1994) Regulation of signal transduction and signal diversity by receptor oligomerization. Trends Biochem. Sci., 19, 459-463.
29. Levy, J.B. et al. (1993) The cloning of a receptor-type tyrosine phosphatase expressed in the central nervous system. J. Biol. Chem., 268, 10573-10581.
30. Lyle, R., Valleley, E.M., Sharp, P.T. and Hewitt, J.E. (1994) An alternatively spliced transcript, p65 delta 2, of the gene encoding the p65 subunit of the transcription factor NF-kappa B. Gene, 138, 265-266.
31. Masson, D. and Kreis, T.E. (1993) Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells. J. Cell Biol., 123, 357-371.
32. Matsuka, S., Edward, M., Bai, C., Parker, S., Zhang, P., Baldini, A., Harper, J.W. and Elledge, S.J. (1995) p57KIP2, a structurally distinct member of the p21CIP1 Cdk-inhibitor family, is a candidate tumor suppressor gene. Genes Dev., 9, 650-662.
33. Maurel, P., Rauch, U., Flad, M., Margolis, R.K. and Margolis, R.U. (1994) Phosphocan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type protein tyrosine phosphatase. Proc. Natl Acad. Sci. USA. 91, 2512-2516.
34. Milev, P., Friedlander, D., Sakurai, T., Karthikeyan, L., Flad, M., Margolis, R.K., Grumet, M. and Margolis, R.U. (1994) Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules. J. Cell Biol., 127, 1703-1715.
35. Mlodzik, M., Hiromi, Y., Weber, U., Goodman, C.S. and Rubin, G.M. (1990) The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell, 60, 211-224.
36. Morales, G., Hubert, M., Brümmendorf, T., Treubert, U., Táraok, A., Schwarz, U. and Rathjen, F.G. (1993) Induction of axonal growth by heterophilic interactions between the cell surface recognition protein F11 and Nr-CAM/Bravo. Neuron, 11, 1113-1122.
37. Noonan, D.M., Fulle, A., Valente, P., Cai, S., Horigan, E., Sasaki, M., Yamada, Y. and Hassell, J.R. (1991) The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule. J. Biol. Chem., 266, 22939-22946.
38. Olive, S., Dubois, C., Schachner, M. and Rougon, G. (1995) The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and fyn kinase in cerebellum. J. Neurochem., 65, 2307-2317.
39. Peles, E., Ben-Levy, R., Or, E., Ullrich, A. and Yarden, Y. (1991) Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase Cγ. EMBO J., 10, 2077-2086.
40. Peles, E. et al. (1995) The carbonic anhydrase domain of receptor tyrosine phosphatase b is a functional ligand for the axonal cell recognition molecule contactin. Cell, 82, 251-260.
41. Rathjen, F.G. and Jessell, T.M. (1991) Glycoproteins that regulate the growth and guidance of vertebrate axons: domains and dynamics of the immunoglobulin/fibronectin type III subfamily. Semin. Neurosci., 3, 297-307.
42. Rauch, U., Gao, P., Janetzko, A., Flaccus, A., Hilgenberg, L., Tekotte, H., Margolis, R.K. and Margolis, R.U. (1991) Isolation and characterization of developmentally regulated chrondroitin sulfate and chondroitin/keratan sulfate proteoglycans of brain identified with monoclonal antibodies. J. Biol. Chem., 266, 14785-14801.
43. Rothberg, J.M., Jacobs, J.R., Goodman, C.S. and Artavanis-Tsakonas, S. (1990) slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev., 4, 2169-2178.
44. Rupp, F., Payan, D.G., Magill-Solc, C., Cowan, D.M. and Scheller, R.H. (1991) Structure and expression of rat agrin. Neuron, 6, 811-823.
45. Sasaki, M., Kleinman, H.K., Huber, H., Deutzmann, R. and Yamada, Y. (1988) Laminin, a multidomain protein: the A chain has a unique globular domain and homology with the basement membrane proteoglycan and the laminin B chain. J. Biol. Chem., 263, 16536-16544.
46. Sonderegger, P. and Rathjen, F.G. (1991) Regulation of axonal growth in vertebrate nervous system by interactions between glycoproteins belonging to two subgroups of the immunoglobulin superfamily. J. Cell. Biol., 119, 1387-1394.
47. Stubbs, J.D., Lekutis, C., Singer, K.L., Bui, A., Yuzuki, D., Srinivasan, U. and Parry, G. (1990) cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences. Proc. Natl Acad. Sci. USA, 87, 8417-8421.
48. Takagi, S., Hirata, T. Agata, K., Mochii, M., Eguchi, G. and Fujisawa, H. (1991) The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors. Neuron, 7, 295-307.
49. Timpl, R. (1989) Structure and biological activity of basement membrane proteins. Eur. J. Biochem., 180, 487-502.
50. Ullrich, B., Ushkaryov, Y.A. and Sudhof, T.C. (1995) Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Neuron, 14, 497-507.
51. Umemori, H., Sato, S., Yagi, T., Aizawa, S. and Yamamoto, T. (1994) Initial events of myelination involve Fyn tyrosine kinase signaling. Nature, 367, 572-576.
52. Ushkaryov, Y.A., Petrenko, A.G., Geppert, M. and Sudohf, T.C. (1992) Neurexins: synaptic cell surface proteins related to the α-latrotoxin receptor and laminin. Science, 257, 50-56.
53. Vassin, H., Bremer, K.A., Knust, F. and Campos-Ortega, J.A. (1987) The neurogenic gene delta of Drosophila melangoster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats. EMBO J., 6, 3431-3440.
54. Waite, J.H., Hansen, D.C. and Littel, K.T. (1989) The glue protein of ribbed mussels (Geukensia demissa): a natural adhesive with some features of collagen. J. Comp. Physiol., 159, 517-525.
55. Walton, K.M. and Dixon, J.E. (1993) Protein tyrosine phosphatases. Annu. Rev. Biochem., 62, 101-120.
56. Waring, G.L., Hawley, R.G. and Schoenfeld, T. (1990) Multiple proteins are produced from the dec-1 eggshell gene in Drosophila by alternative RNA splicing and proteolytic cleavage events. Dev. Biol., 142, 1-12.
57. Wharton, K.A., Johansen, K.M., Xu, T. and Artavanis-Tsakonas, S. (1985) Nucleotide sequence from the neurogenic locus notch implies a gene product which shares homology with proteins containing EGF-like repeats. Cell, 43, 567-581.
58. Wilson, R. et al. (1994) 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature, 368, 32-38.
59. Wood, W.I. et al. (1984) Expression of active human factor VIII from recombinant cDNA clones. Nature, 312, 330-337.
60. Yoshihara, Y., Kawasaki, M., Tani, A., Tamada, A., Nagata, S., Kagamiyama, H. and Mori, K. (1994) BIG-1: a new TAG-1/F3-related member of the immunoglobulin superfamily with neurite outgrowth-promoting activity. Neuron, 13, 415-426.
61. Zisch, A.H., D'Alessandri, L., Amrein, K., Ranscht, B., Winterhalter, K.H. and Vaughan, L. (1995) The glypiated neuronal cell adhesion molecule contactin/F11 complexes with src-family protein tyrosine kinase fyn. Mol. Cell. Neurosci., 6, 263-279.