Contactin-associated protein (Caspr) and contactin form a complex that is targeted to the paranodal junctions during myelination

Journal of Neuroscience

Volumn 20, Issue 22, 2000, Pages 8354-8364

  Rios, J C ^a   Melendez Vasquez, C V ^a   Einheber, S ^a   Lustig, M ^a   Grumet, M ^a   Hemperly, J ^a   Peles, E ^a   Salzer, J L ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axons; Caspr; Contactin; Myelin; Nodes of Ranvier; Paranode

Indexed keywords

CONTACTIN; CONTACTIN ASSOCIATED PROTEIN; PHOSPHOLIPASE C; POTASSIUM CHANNEL; PROTEIN CASPR; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME SPECIFICITY; GLIA; MOLECULAR WEIGHT; MYELINATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RANVIER NODE; RAT; SCHWANN CELL;

EID: 0034668775     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-22-08354.2000     Document Type: Article

References (55)

1. On the molecular architecture of myelinated fibers
2. Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kvβ2, and Caspr
3. Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression
4. Galactosphingolipids and axono-glial interaction in myelin of the central nervous system
5. Neural cell recognition molecule F11: Homology with fibronectin type III and immunoglobulin type C domains
6. The axonal recognition molecule F11 is a multifunctional protein: Specific domains mediate interactions with Ng-CAM and restrictin
7. Myelination in the absence of galactocerebroside and sulfatide: Normal structure with abnormal function and regional instability
8. -) and NrCAM at nodal axon segments
9. Axo-glial interactions regulate the localization of axonal paranodal proteins
10. The axonal membrane protein Caspr, a homologue of neurexin IV, is a component of the septate-like paranodal junctions that assemble during myelination
11. Axonal molecules of the immunoglobulin superfamily bearing a GPI anchor: Their role in controlling neurite outgrowth
12. The glycosylphosphatidyl inositol-anchored adhesion molecule F3/contactin is required for surface transport of paranodin/contactin-associated protein (Caspr)
13. The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth
14. Identification and cDNA cloning of a new member of the L2/HNK-1 family of neural surface glycoproteins
15. Transfected F3/F11 neuronal cell surface protein mediates intercellular adhesion and promotes neurite outgrowth
16. Protein composition of myelin of the peripheral nervous system
17. Three-dimensional fine structure of cytoskeletal-membrane interactions at nodes of Ranvier
18. Expression of the immunoglobulin superfamily cell adhesion molecule F3 by oligodendrocyte-lineage cells
19. A method for determining the sedimentation behavior of enzymes: Application to protein mixtures
20. Variation of proteins, enzyme markers, and gangliosides in myelin subfractions
21. Isolation of a high molecular weight complex from the paranodal junctions: Evidence for an association of contactin and Caspr
22. Paranodin, a glycoprotein of neuronal paranodal membranes
23. Differential distribution of closely related potassium channels in rat Schwann cells
24. Induction of axonal growth by heterophilic interactions between the cell surface recognition proteins F11 and Nr-CAM/Bravo
25. Isolation and characterization of myelin
26. Myelination in rat brain: Method of myelin isolation
27. The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and fyn kinase in cerebellum
28. The myelin-associated glycoproteins: Membrane disposition, evidence of a novel disulfide linkage between immunoglobulin-like domains, and post-translational palmitylation
29. Molecular domains of myelinated axons
30. The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin
31. Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions
32. The F3/F11 cell adhesion molecule mediates the repulsion of neurons by the extracellular matrix glycoprotein J1-160/180
33. Myelin galactolipids: Mediators of axon-glial interactions?
34. Sequence of contactin, a 130 kDa glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system
35. A sodium channel signaling complex: Modulation by associated receptor protein tyrosine phosphatase beta
36. Identification and characterization of the human cell adhesion molecule contactin
37. Caspr and contactin colocalize in the paranodal and internodal membranes of myelinated axons
38. Expression of unique sets of GPI-linked proteins by different primary neurons in vitro
39. Glial membranes and axoglial junctions
40. The structure of the ligand-binding domain of neurexin Iβ: Regulation of LNS domain function by alternative splicing
41. Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta
42. Clustering sodium channels at the node of Ranvier: Close encounters of the axon-glia kind
43. Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R
44. Distribution of particle aggregates in the internodal axolemma and adaxonal Schwann cell membrane of rodent peripheral nerve
45. An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction
46. Axolemmal differentiation in myelinated fibers of rat peripheral nerves
47. Molecular forms of acetylcholinesterase in two sublines of human erythroleukemia K562 cells: Sensitivity or resistance to phosphatidylinositol-specific phospholipase C and biosynthesis
48. Dissection of complex molecular interactions of neurofascin with axonin-1, F11, and tenascin-R, which promote attachment and neurite formation of tectal cells
49. + channels in terminal and juxtaparanodal regions of neurons
50. Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS
51. Biochemical characterization of polypeptide components involved in neurite fasciculation and elongation
52. Tenascin-R is a functional modulator of sodium channel β-subunits
53. Protein tyrosine phosphatase alpha (PTPα) and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn
54. Neuronal cell adhesion molecule contactin/F11 binds to tenascin via its immunoglobulin-like domains